Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Die Folgen des Klimwandels haben einen direkten Einfluss auf die Primärversorgung in Deutschland: Hitzeschutz insbesondere bei älteren Patienten, die Zunahme von Infektionen und die Verlängerung der Allergiesesaison spielen medizinisch eine bedeutsame Rolle. Aber auch in der Prävention und der Aufklärung der Patienten kommt den Hausärztinnen und -ärzten eine besondere Rolle zu. Direkt aus der Praxis berichtet im Live-Webinar am 13. Mai von 18 bis 19 Uhr unser Experte Dr. med. Robin Maitra.
Erweiterte Suche
Anmelden
nach oben
Current Bladder Dysfunction Reports
Erschienen in: Current Bladder Dysfunction Reports 2/2019

02.05.2019 | Voiding Dysfunction Evaluation (B Brucker and B Peyronnet, Section Editors)

Molecular Characteristics of Underactive Bladder

verfasst von: Yuan-Hong Jiang, Hann-Chorng Kuo

Erschienen in: Current Bladder Dysfunction Reports | Ausgabe 2/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Underactive bladder (UAB) is a common urological problem in elderly patients presenting with urinary retention and lower urinary tract symptoms. UAB causes chronic urinary retention or a large post-void residual urine which is usually difficult to manage. Treatment of UAB is a challenge to urologists. The underlying pathophysiology has not been completely elucidated. Molecular diagnosis for the clinical characteristics of UAB is important for us to understand the pathogenesis and develop new therapeutic modalities.

Recent Findings

The urodynamic finding of UAB might be detrusor acontractility of low contractility and is often termed detrusor underactivity. UAB is frequently encountered in elderly patients with chronic medical or neurological diseases. The pathophysiology of UAB may involve neurogenic, myogenic, and bladder outlet pathologies. Recent studies also reveal that increased suburothelial inflammation and altered sensory protein expressions in bladder mucosa were prominent in patients with UAB. Impaired urothelial signaling and sensory transduction pathways might be associated with impaired bladder sensation as well as impaired detrusor contractility. In addition, the bladder outlet obstruction, inflammation, or bladder ischemia-induced oxidative stress might also decrease the energy of the detrusor and result in UAB. Neurogenic inhibition, myogenic factor, and psychogenic inhibition might also be the causes for UAB.

Summary

This article reviews recent researches on the pathophysiology and molecular characteristics of UAB. Neurogenic, myogenic, urotheliogenic, bladder outlet, and psychogenic factors might all contribute to UAB. Comprehensive clinical investigations and basic researches may provide a better understanding and effective treatment for this common but difficult bladder disorder.
Literatur
1.
Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, et al. The standardisation of terminology of lower urinary tract function: report from the standardisation Subcommittee of the International Continence Society. Neurourol Urodyn. 2002;21:167–78.CrossRef
2.
• Chapple CR, Osman NI, Birder L, Dmochowski R, Drake MJ, van Koeveringe G, et al. Terminology report from the international continence society (ICS) working group on underactive bladder (UAB). Neurourol Urodyn. 2018;37:2928–31. A clear clinical definition of underactive bladder. CrossRefPubMed
3.
Tarcan T, Rademakers K, Arlandis S, von Gontard A, van Koeveringe GA, Abrams P. Do the definitions of the underactive bladder and detrusor underactivity help in managing patients: international consultation on incontinence research society (ICI-RS) think tank 2017? Neurourol Urodyn. 2018;37(S4):S60–8.CrossRefPubMed
4.
Thomas AW, Cannon A, Bartlett E, Ellis-Jones J, Abrams P. The natural history of lower urinary tract dysfunction in men: the influence of detrusor underactivity on the outcome after transurethral resection of the prostate with a minimum 10-year urodynamic follow-up. BJU Int. 2004;93:745–50.CrossRefPubMed
5.
Smith PP. Aging and the underactive detrusor: a failure of activity or activation? Neurourol Urodyn. 2010;29:408–12.PubMed
6.
7.
Cucchi A, Quaglini S, Rovereto B. Proposal for a urodynamic redefinition of detrusor underactivity. J Urol. 2009;181:225–9.CrossRefPubMed
8.
Cucchi A, Quaglini S, Rovereto B. Development of idiopathic detrusor underactivity in women: from isolated decrease in contraction velocity to obvious impairment of voiding function. Urology. 2008;71:844–8.CrossRefPubMed
9.
• Chancellor MB, Bartolone SN, DeVries EM, Diokno AC, Gibbons M, Jankowski R, et al. New technology assessment and current and upcoming therapies for underactive bladder. Neurourol Urodyn. 2018;37:2932–7. This paper pointed out the inclusion criteria of UAB, the tools of assessment, and development of UAB questionnaire. CrossRefPubMed
10.
•• Osman NI, Esperto F, Chapple CR. Detrusor underactivity and the underactive bladder: a systematic review of preclinical and clinical studies. Eur Urol. 2018;74:633–43. A comprehensive meta-analysis of recently published epidemiology and pathophysiogenesis of UAB. CrossRefPubMed
11.
•• Jiang YH, Lee CL, Kuo HC. Urothelial dysfunction, suburothelial inflammation and altered sensory protein expression in men with bladder outlet obstruction and various bladder dysfunctions: correlation with urodynamics. J Urol. 2016;196:831–7. A study of the urothelial dysfunction in the pathophysiology of UAB related to the different severity of bladder outlet obstruction. CrossRefPubMed
12.
Sasaki K, Yoshimura N, Chancellor MB. Implications of diabetes mellitus in urology. Urol Clin North Am. 2003;30:1–12.CrossRefPubMed
13.
Choi YS, Kim JC, Lee KS, Seo JT, Kim HJ, Yoo TK, et al. Analysis of female voiding dysfunction: a prospective, multi-center study. Int Urol Nephrol. 2013;45(4):989–94.
14.
Chung DE, Dillon B, Kurta J, Maschino A, Cronin A, Sandhu JS. Detrusor underactivity is prevalent after radical prostatectomy: a urodynamic study including risk factors. Can Urol Asso J. 2013;7:E33–7.CrossRef
15.
Miyazato M, Yoshimura N, Chancellor MB. The other bladder syndrome: underactive bladder. Rev Urol. 2013;15:11–22.PubMedPubMedCentral
16.
Drake MJ, Williams J, Bijos DA. Voiding dysfunction due to detrusor underactivity: an overview. Nat Rev Urol. 2014;11:454–64.CrossRefPubMed
17.
Andersson KE. The many faces of impaired bladder emptying. Curr Opin Urol. 2014;24:363–9.CrossRef
18.
Birder LA, Ruggieri M, Takeda M, van Koeveringe G, Veltkamp S, Korstanje C, et al. How does the urothelium affect bladder function in health and diseases? ICI-RS 2011. Neurourol Urodyn. 2012;31:293–9.CrossRefPubMedPubMedCentral
19.
Resnick NM, Yalla SV, Laurino E. The pathophysiology of urinary incontinence among institutionalized elderly persons. N Engl J Med. 1989;320:1–7.CrossRefPubMed
20.
Jeong SJ, Kim HJ, Lee YJ, Lee JK, Lee BK, Choo YM, et al. Prevalence and clinical features of detrusor underactivity among elderly with lower urinary tract symptoms: a comparison between men and women. Korean J Urol. 2012;53:342–8.CrossRefPubMedPubMedCentral
21.
Diokno AC, Brown MB, Goldstein NG, Herzog AR. Urinary flow rates and voiding pressures in elderly men living in a community. J Urol. 1994;151:1550–3.CrossRefPubMed
22.
Gotoh M, Yoshikawa Y, Ohshima S. Pathophysiology and subjective symptoms in women with impaired bladder emptying. Int J Urol. 2006;13:1053–7.CrossRefPubMed
23.
Sakakibara R, Yamamoto T, Uchiyama T, Liu Z, Ito T, Yamazaki M, et al. Is lumbar spondylosis a cause of urinary retention in elderly women? J Neurol. 2005;252:953–7.CrossRefPubMed
24.
Ueda T, Yoshimura N, Yoshida O. Diabetic cystopathy: relationship to autonomic neuropathy detected by sympathetic skin response. J Urol. 1997;157:590–4.CrossRef
25.
Lin TL, Chen GD, Chen YC, Huang CN, Ng SC. Aging and recurrent urinary tract infections are associated with bladder dysfunction in type 2 diabetes. Taiwan J Obstet Gynecol. 2012;51:381–6.CrossRefPubMed
26.
Bansal R, Agarwal MM, Modi M, Mandal AK, Singh SK. Urodynamic profile of diabetic patients with lower urinary tract symptoms: association of diabetic cystopathy with autonomic and peripheral neuropathy. Urology. 2011;77:699–705.CrossRefPubMed
27.
Lee WC, Wu HP, Tai TY, Yu HJ, Chiang PH. Investigation of urodynamic characteristics and bladder sensory function in the early stages of diabetic bladder dysfunction in women with type 2 diabetes. J Urol. 2009;181:198–203.CrossRefPubMed
28.
Pizzi A, Falsini C, Martini M, Rossetti MA, Verdesca S, Tosto A. Urinary incontinence after ischemic stroke: clinical and urodynamic studies. Neurourol Urodyn. 2014;33:420–5.CrossRefPubMed
29.
• Lee KH, Kuo HC. Recovery of voiding efficiency and bladder function in male patients with non-neurogenic detrusor underactivity after transurethral bladder outlet surgery. Urology. 2018. https://​doi.​org/​10.​1016/​j.​urology.​2018.​09.​030. A clinical study demonstrating that active surgical treatment such as TURP or TUIP may help bladder function recovery in male patients with DU, 2019.
30.
Andersson KE. Detrusor underactivity/ underactive bladder: new research initiatives needed. J Urol. 2010;184:1829–30.CrossRefPubMed
31.
• Jiang YH, Kuo HC. Video-urodynamic characteristics of non-neurogenic, idiopathic underactive bladder in men - a comparison of men with normal tracing and bladder outlet obstruction. PLoS One. 2017;12:e0174593. Through videourodynamic study, idiopathic UAB in elderly men could be attributed to detrusor underactivity and poor relaxation of external sphincter. CrossRefPubMedPubMedCentral
32.
Chen YC, Kuo HC. Clinical and video urodynamic characteristics of adult women with dysfunctional voiding. J Formos Med Assoc. 2014;113:161–5.CrossRefPubMed
33.
Van Koeveringe GA, Vahabi B, Andersson KE, Kirschner-Herrmans R, Oelke M. Detrusor underactivity: a plea for new approaches to a common bladder dysfunction. Neurourol Urodyn. 2011;30:723–8.CrossRefPubMed
34.
Chancellor MB, Blaivas JG. Clasification of neurogenic bladder disease. In: Chancellor MB, editor. Practical Neurourology. Boston: Butterworth. Heinemann; 1995. p. 25–32.
35.
VaKoeveringe GA, Rademakers KL, Birder LA, Korstanje C, Daneshgari F, Ruggieri MR, et al. Detrusor underactivity: pathophysiological considerations, models and proposals for future research. ICI-RS 2013. Neurourol Urodyn. 2014;33:591–6.CrossRef
36.
Yamamoto T, Asahina M, Yamanaka Y, Uchiyama T, Hirano S, Fuse M, et al. Postvoid residual predicts the diagnosis of multiple system atrophy in Parkinsonian syndrome. J Neurol Sci. 2017;381:230–4.CrossRefPubMed
37.
38.
Yoshimura N, Chancellor MB, Andersson KE, Christ GJ. Recent advances in understanding the biology of diabetes-associated bladder complications and novel therapy. BJU Int. 2005;95:733–8.CrossRefPubMed
39.
Mirone V, Imbimbo C, Longo N, Fusco F. The detrusor muscle: an innocent victim of bladder outlet obstruction. Eur Urol. 2007;51:57–66.CrossRefPubMed
40.
Yamaguchi O, Nomiya M, Andersson KE. Functional consequences of chronic bladder ischemia. Neurourol Urodyn. 2014;33:54–8.CrossRefPubMed
41.
Taylor JA 3rd, Kuchel GA. Detrusorunderactivity: clinical features and pathogenesis of an underdiagnosed geriatric condition. J Am Geriatr Soc. 2006;54:1920–32.CrossRefPubMed
42.
Oelke M, Rademakers KL, van Koeveringe GA. Detrusor contraction power parameters (BCI and W max) rise with increasing bladder outlet obstruction grade in men with lower urinary tract symptoms: results from a urodynamic database analysis. World J Urol. 2014;35:1177–83.CrossRef
43.
Brierly RD, Hindley RG, McLarty E, Harding DM, Thomas PJ. A prospective controlled quantitative study of ultrastructural changes in the underactive detrusor. J Urol. 2003;169:1374–8.CrossRefPubMed
44.
Cucchi A, Quaglini S, Rovereto B. Different evolution of voiding function in underactive bladders with and without detrusor overactivity. J Urol. 2010;183:229–33.CrossRefPubMed
45.
Chopra B, Barrick S, Meyers S, Beckel JM, Zeidel ML, Ford AP, et al. Expression and function of bradykininB1 and B2 receptors in normal and inflamed rat urinary bladder urothelium. J Physiol. 2005;562:859–71.CrossRefPubMed
46.
Murray E, Malley S, Qiao LY, Hu VY, Vizzard MA. Cyclophosphamide induced cystitis alters neurotrophin and receptor tyrosine kinase expression in pelvic ganglia and bladder. J Urol. 2004;172:2434–9.CrossRefPubMed
47.
Birder LA, Ruan H, Chopra B, Xiang Z, Barrick S, Buffington CA, et al. Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis. Am J Phys. 2004;287:F1084–91.
48.
Lee HY, Bardini M, Burnstock G. Distribution of P2X receptors in the urinary bladder and the ureter of the rat. J Urol. 2000;163:2002–7.CrossRefPubMed
49.
Tempest HV, Dixon A, Turner WH, Elneil S, Sellers LA, Ferguson DR. P2X receptor expression in human bladder urothelium and changes in interstitial cystitis. BJU Int. 2004;93:1344–8.CrossRefPubMed
50.
Birder LA, Apodaca G, De Groat WC, Kanai AJ. Adrenergic- and capsaicin-evoked nitric oxide release from urothelium and afferent nerves in urinary bladder. Am J Phys. 1998;275:F226–9.
51.
Birder LA, Nealen M, Kiss S, de Groat WC, Caterina MJ, Wang E, et al. Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells. J Neurosci. 2002;22:8063–70.CrossRefPubMed
52.
Beckel JM, Kanai A, Lee SJ, de Groat WC, Birder LA. Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells. Am J Phys. 2006;290:F103–10.
53.
Chess-Williams R. Muscarinic receptors of the urinary bladder: detrusor urothelial and prejunctional. Auton Autacoid Pharmacol. 2002;22:133–45.CrossRefPubMed
54.
Birder LA, Kanai A, de Groat WC, Kiss S, Nealen ML, Burke NE, et al. Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proc Natl Acad Sci U S A. 2001;98:13396–401.CrossRefPubMedPubMedCentral
55.
Birder LA, Nakamura Y, Kiss S, Nealen ML, Barrick S, Kanai AJ, et al. Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci. 2002;5:856–60.CrossRefPubMed
56.
Birder LA, Kullmann F, Lee H, Barrick S, de Groat W, Kanai A, et al. Activation of urothelial transient receptor potential vanilloid 4 by 4-alpha-phorbol 12,13-didecanote contributes to altered bladder reflexes in the rat. J Pharmacol Exp Ther. 2007;323:227–335.CrossRefPubMed
57.
Stein RJ, Santos S, Nagatomi J, Hayashi Y, Minnery BS, Xavier M, et al. Cool (TRPM8) and hot (TRPV1) receptors in the bladder and male genital tract. J Urol. 2004;172:1175–8.CrossRefPubMed
58.
Streng T, Axelsson HE, Hedlund P, Andersson DA, Jordt SE, Bevan S, et al. Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. Eur Urol. 2008;53:391–9.CrossRefPubMed
59.
Downie JW, Karmazny M. Mechanical trauma to bladder epithelium liberates prostanoids which modulate neurotransmission in rabbit detrusormuscle. J Pharmacol Exp Ther. 1984;230:445–9.PubMed
60.
Ferguson DR, Kennedy I, Burton TJ. ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes—a possible sensory mechanism? J Physiol. 1997;505:503–11.CrossRefPubMedPubMedCentral
61.
Wang EC, Lee J, Ruiz WG, Balestreire EM, von Bodungen M, Barrick S, et al. ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells. J Clin Invest. 2005;115:2412–22.CrossRefPubMedPubMedCentral
62.
Yoshida M, Inadome A, Maeda Y, Satoji Y, Masunaga K, Sugiyama Y, et al. Non-neuronal cholinergic system inhuman bladder urothelium. Urology. 2006;67:425–30.CrossRefPubMed
63.
64.
•• Cho KJ, Koh JS, Choi J, Kim JC. Changes in adenosine triphosphate and nitric oxide in the urothelium of patients with benign prostatic hyperplasia and detrusor underactivity. J Urol. 2017;198:1392–6. This study found the mean level of adenosine triphosphate in the detrusor underactivity group was significantly lower than in the no detrusor underactivity group, reflecting that deficient ATP is important in the development of DU. CrossRefPubMed
65.
66.
Valentini FA, Nelson PP, Zimmern PE, Robain G. Detrusor contractility in women: influence of ageing and clinical conditions. Prog Urol. 2016;26:425–31.CrossRefPubMed
67.
Beltrame F, Ferreira FT, Lorenzetti F, Dambros M, Bisogni S, Dambros M. Bladder function in obstructed men - does age matter? Aging Male. 2015;18:143–8.CrossRefPubMed
68.
• Kamei J, Ito H, Aizawa N, Hotta H, Kojima T, Fujita Y, et al. Age-related changes in function and gene expression of the male and female mouse bladder. Sci Rep. 2018;8:2089. Genomic study revealed decrease of M3 muscarinic receptors in aged male mice and beta-2 adrenoceptors in aged females, resulting in voiding and storage dysfunction mimicking DHIC. CrossRefPubMedPubMedCentral
69.
Zhao Z, Azad R, Yang JH, Siroky MB, Azadzoi KM. Progressive changes in detrusor function and micturition patterns with chronic bladder ischemia. Investig Clin Urol. 2016;57:249–59.CrossRefPubMedPubMedCentral
70.
Bravo G, Massa H, Rose'Meyer R, Chess-Williams R, McDermott C, Sellers DJ. Effect of short-term androgen deficiency on bladder contractility and urothelial mediator release. Naunyn Schmiedeberg's Arch Pharmacol. 2017;390:547–56.CrossRef
71.
Gilpin SA, Gilpin CJ, Dixon JS, Gosling JA, Kirby RS. The effect of age on the autonomic innervation of the urinary bladder. Br J Urol. 1986;58:378–81.CrossRefPubMed
72.
Lepor H, Sunaryadi I, Hartanto V, Shapiro E. Quantitative morphometry of the adult human bladder. J Urol. 1992;148:414–7.CrossRefPubMed
73.
Elbadawi A, Yalla SV, Resnick NM. Structural basis of geriatric voiding dysfunction. II. Aging detrusor: normal versus impaired contractility. J Urol. 1993;150:1657–67.CrossRefPubMed
74.
Mansfield KJ, Liu L, Mitchelson FJ, Moore KH, Millard RJ, Burcher E. Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by radioligand binding and quantitative competitive RT-PCR: changes in ageing. Br J Pharmacol. 2005;144:1089–99.CrossRefPubMedPubMedCentral
75.
Ito H, Aizawa N, Fujita Y, Suzuki M, Fukuhara H, Homma Y, et al. Long-term caloric restriction in rats may prevent age related impairment of in vitro bladder function. J Urol. 2015;193:2123–30.CrossRefPubMed
76.
77.
Johnston L, Woolsey S, Cunningham RM, O'Kane H, Duggan B, Keane P, et al. Morphological expression of KIT positive interstitial cells of Cajal in human bladder. J Urol. 2010;184:370–7.CrossRefPubMedPubMedCentral
78.
79.
Daneshgari F, Liu G, Birder L, Hanna-Mitchell AT, Chacko S. Diabetic bladder dysfunction: current translational knowledge. J Urol. 2009;182(6 Suppl):S18–26.PubMedPubMedCentral
80.
Nomiya M, Yamaguchi O, Akaihata H, Hata J, Sawada N, Kojima Y, et al. Progressive vascular damage may lead to bladder underactivity in rats. J Urol. 2014;191:1462–9.CrossRefPubMed
81.
Fry CH, Meng E, Young JS. The physiological function of lower urinary tract smooth muscle. Auton Neurosci. 2010;154:3–13.CrossRefPubMed
82.
Svalø J, Nordling J, Bouchelouche K, Andersson KE, Korstanje C, Bouchelouche P. The novel β3-adrenoceptor agonist mirabegron reduces carbachol-induced contractile activity in detrusor tissue from patients with bladder outflow obstruction with or without detrusor overactivity. Eur J Pharmacol. 2013;699:101–5.CrossRefPubMed
83.
Persyn S, Eastham J, De Wachter S, Gillespie J. Adrenergic signaling elements in the bladder wall of the adult rat. Auton Neurosci. 2016;201:40–8.CrossRefPubMed
84.
•• Jiang YH, Kuo HC. Urothelial barrier deficits, suburothelial inflammation and altered sensory protein expression in detrusor underactivity. J Urol. 2017;197:197–203. Impaired urothelial signaling and sensory transduction pathways appear to reflect the pathophysiology of detrusor underactivity. CrossRefPubMed
85.
86.
Oshiro T, Miyazato M, Saito S. Relationship between connexin43-derived gap junction proteins in the bladder and age-related detrusor underactivity in rats. Life Sci. 2014;116:37–42.CrossRefPubMed
87.
Sui GP, Rothery S, Dupont E, Fry CH, Severs NJ. Gap junctions and connexin expression in human suburothelial interstitial cells. BJU Int. 2002;90:118–29.CrossRefPubMed
88.
Ikeda Y, Fry CH, Hayashi F, Stolz D, Griffiths D, Kanai A. Role of gap junctions in spontaneous activity of the rat bladder. Am J Phys. 2007;293:F1018–25.
89.
Kullmann FA, Artim DE, Birder LA, De Groat WC. Activation of muscarinic receptors in rat bladder sensory pathways alters reflex bladder activity. J Neurosci. 2008;28:1977–87.CrossRefPubMedPubMedCentral
90.
91.
Smith PP, DeAngelis A, Kuchel GA. Detrusor expulsive strength is preserved, but responsiveness to bladder filling and urinary sensitivity is diminished in the aging mouse. Am J Phys Regul Integr Comp Phys. 2012;302:R577–86.
92.
Mohammed H, Hannibal J, Fahrenkrug J, Santer R. Distribution and regional variation of pituitary adenylate cyclase activating polypeptide and other neuropeptides in the rat urinary bladder and ureter: effects of age. Urol Res. 2002;30:248–55.CrossRefPubMed
93.
Smith PP, Chalmers DJ, Feinn RS. Does defective volume sensation contribute to detrusor underactivity? Neurourol Urodyn. 2015;34:752–6.CrossRefPubMed
94.
95.
Daly DM, Nocchi L, Liaskos M, McKay NG, Chapple C, Grundy D. Age-related changes in afferent pathways and urothelial function in the male mouse bladder. J Physiol. 2014;592:537–49.CrossRefPubMedPubMedCentral
96.
Mochizuki T, Sokabe T, Araki I, Fujishita K, Shibasaki K, Uchida K, et al. The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures. J Biol Chem. 2009;284:21257–64.CrossRefPubMedPubMedCentral
97.
• Deruyver Y, Weyne E, Dewulf K, Rietjens R, Pinto S, Van Ranst N, et al. Intravesical activation of the cation channel TRPV4 improves bladder function in a rat model for detrusor underactivity. Eur Urol. 2018;74:336–45. This study demonstrated that the sensory protein transient receptor potential vanilloid 4 (TRPV4) can be targeted to improve bladder function in animals that have bilateral pelvic nerve. CrossRefPubMed
98.
Chapple C. Chapter 2: pathophysiology of neurogenic detrusor overactivity and the symptom complex of "overactive bladder". Neurourol Urodyn. 2014;33(Suppl 3):S6–13.CrossRefPubMed
99.
Schulte-Baukloh H, Priefert J, Knispel HH, Lawrence GW, Miller K, Neuhaus J. Botulinum toxin A detrusor injections reduce postsynaptic muscular M2, M3, P2X2, and P2X3 receptors in children and adolescents who have neurogenic detrusor overactivity: a single-blind study. Urology. 2013;81:1052–7.CrossRefPubMed
100.
Chancellor MB. The overactive bladder progression to underactive bladder hypothesis. Int Urol Nephrol. 2014;46(Suppl 1):S23–7.CrossRefPubMed
101.
Sui GP, Wu C, Roosen A, Ikeda Y, Kanai AJ, Fry CH. Modulation of bladder myofibroblast activity: implications for bladder function. Am J Phys. 2008;295:F688–97.
102.
Braverman AS, Lebed B, Linder M, Ruggieri MR. M2 mediated contractions of human bladder from organ donors is associated with an increase in urothelial muscarinic receptors. Neurourol Urodyn. 2007;26:63–70.CrossRefPubMedPubMedCentral
103.
Thompson SA, Copeland CR, Reich DH, Tung L. Mechanical coupling between myofibroblasts and cardiomyocytes slows electric conduction in fibrotic cell monolayers. Circulation. 2011;123:2083–93.CrossRefPubMedPubMedCentral
104.
Janssen DA, Hoenderop JG, Jansen KC, Kemp AW, Heesakkers JP, Schalken JA. The mechanoreceptor TRPV4 is localized in adherence junctions of the human bladder urothelium: a morphological study. J Urol. 2011;186:1121–7.CrossRefPubMed
105.
Sancho M, Ferrero JJ, Triguero D, Torres M, Garcia-Pascual A. Altered neuronal and endothelial nitric oxide synthase expression in the bladder and urethra of cyclophosphamide-treated rats. Nitric Oxide. 2014;39:8–19.CrossRefPubMed
106.
Cho KH, Hyun JH, Chang YS, Na YG, Shin JH, Song KH. Expression of nitric oxide synthase and aquaporin-3 in cyclophosphamide treated rat bladder. Int Neurourol J. 2010;14:149–56.CrossRefPubMedPubMedCentral
107.
Tong YC, Cheng JT. Alteration of M(3) subtype muscarinic receptors in the diabetic rat urinary bladder. Pharmacology. 2002;64:148–51.CrossRefPubMed
108.
•• Chen SF, Jiang YH, Kuo HC. Urinary biomarkers in patients with detrusor underactivity with and without bladder function recovery. Int Urol Nephrol. 2017;49:1763–70. This study revealed that urinary proteins PGE2 and BDNF levels might provide prognostic value to detrusor underactivity with bladder function recovery after treatment. CrossRefPubMed
109.
Richter HE, Moalli P, Amundsen CL, Malykhina AP, Wallace D, Rogers R, et al. Urinary biomarkers in women with refractory urgency urinary incontinence randomized to sacral neuromodulation versus onabotulinumtoxinA compared to controls. J Urol. 2017;197:1487–95.CrossRefPubMedPubMedCentral
110.
Cho KJ, Kim HS, Koh JS, Kim JC. Changes in urinary nerve growth factor and prostaglandin E2 in women with overactive bladder after anticholinergics. Int Urogynecol J. 2013;24:325–30.CrossRefPubMed
111.
Fry CH, Sahai A, Vahabi B, Kanai AJ, Birder LA. What’s the role for biomarkers for lower urinary tract disorders. Neurourol Urodyn. 2014;33:602–5.CrossRefPubMedPubMedCentral
112.
Steers WD, Tuttle JB. Mechanisms of disease: the role of nerve growth factor in the pathophysiology of bladder disorders. Nat Clin Pract Urol. 2006;3:101–10.CrossRefPubMed
113.
Kim JC, Park EY, Seo SI, Park YH, Hwang TK. Nerve growth factor and prostaglandins in the urine of female patients with overactive bladder. J Urol. 2006;175:1773–6.CrossRefPubMed
114.
Kuo HC. Potential biomarkers utilized to define and manage overactive bladder syndrome. Low Urin Tract Symptoms. 2012;4(Suppl 1):32–41.CrossRefPubMed
115.
Antunes-Lopes T, Pinto R, Barros SC, Botelho F, Silva CM, Cruz CD, et al. Urinary neurotrophic factors in healthy individuals and patients with overactive bladder. J Urol. 2013;189:359–65.CrossRefPubMed
116.
Wang LW, Han XM, Chen CH, Ma Y, Hai B. Urinary brain-derived neurotrophic factor: a potential biomarker for objective diagnosis of overactive bladder. Int Urol Nephrol. 2014;46:341–7.CrossRefPubMed
117.
Cruz CD. Neurotrophins in bladder function: what do we know and where do we go from here? Neurourol Urodyn. 2014;3:39–45.CrossRef
118.
Munoz A, Smith CP, Boone TB, Somogyi GT. Overactive and underactive bladder dysfunction is reflected by alterations in urothelial ATP and NO release. Neurochem Int. 2011;58:295–300.CrossRefPubMed
119.
Cartwright R, Afshan I, Derpapas A, Vijaya G, Khullar V. Novel biomarkers for overactive bladder. Nat Rev Urol. 2011;8:139–45.CrossRefPubMed
Metadaten
Titel
Molecular Characteristics of Underactive Bladder
verfasst von
Yuan-Hong Jiang
Hann-Chorng Kuo
Publikationsdatum
02.05.2019
Verlag
Springer US
Erschienen in
Current Bladder Dysfunction Reports / Ausgabe 2/2019
Print ISSN: 1931-7212
Elektronische ISSN: 1931-7220
DOI
https://doi.org/10.1007/s11884-019-00512-z

Weitere Artikel der Ausgabe 2/2019

Current Bladder Dysfunction Reports 2/2019 Zur Ausgabe

Inflammatory/Infectious Bladder Disorders (MS Mourad, Section Editor)

The Inflammatory Contracted Bladder

Voiding Dysfunction Evaluation (B Brucker and B Peyronnet, Section Editors)

Urinary Biomarkers and Benign Prostatic Hyperplasia

Inflammatory/Infectious Bladder Disorders (MS Mourad, Section Editor)

Effects and Complications of Intravesical Instillation of Bacillus Calmette-Guerin Therapy

BPH-Related Voiding Dysfunction (R Lee, Section Editor)

New Diagnostics for Male Lower Urinary Tract Symptoms

Post-Prostatectomy and Acquired Voiding Dysfunction (V Tse, Section Editor)

The Effect of Major Pelvic Extirpative Surgery on Lower Urinary Tract Function

BPH-Related Voiding Dysfunction (R Lee, Section Editor)

The WATER Study: a Review

Neu im Fachgebiet Urologie

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Hypertherme Chemotherapie bietet Chance auf Blasenerhalt

07.05.2024 Harnblasenkarzinom Nachrichten

Eine hypertherme intravesikale Chemotherapie mit Mitomycin kann für Patienten mit hochriskantem nicht muskelinvasivem Blasenkrebs eine Alternative zur radikalen Zystektomie darstellen. Kölner Urologen berichten über ihre Erfahrungen.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Klinik aktuell Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Männern mit Zystitis Schmalband-Antibiotika verordnen

03.05.2024 Zystitis Nachrichten

Die akute Zystitis von Männern und ihre Therapie sind wenig erforscht. Norwegische Forscher haben das nachgeholt. Ihr Rat: Erst einmal keine Breitbandantibiotika verordnen.

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise