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Breast Cancer Research
Erschienen in: Breast Cancer Research 4/2006

01.08.2006 | Review

Mouse models of breast cancer metastasis

verfasst von: Anna Fantozzi, Gerhard Christofori

Erschienen in: Breast Cancer Research | Ausgabe 4/2006

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Abstract

Metastatic spread of cancer cells is the main cause of death of breast cancer patients, and elucidation of the molecular mechanisms underlying this process is a major focus in cancer research. The identification of appropriate therapeutic targets and proof-of-concept experimentation involves an increasing number of experimental mouse models, including spontaneous and chemically induced carcinogenesis, tumor transplantation, and transgenic and/or knockout mice. Here we give a progress report on how mouse models have contributed to our understanding of the molecular processes underlying breast cancer metastasis and on how such experimentation can open new avenues to the development of innovative cancer therapy.
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Metadaten
Titel
Mouse models of breast cancer metastasis
verfasst von
Anna Fantozzi
Gerhard Christofori
Publikationsdatum
01.08.2006
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 4/2006
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1530

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