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Erschienen in: Current Treatment Options in Oncology 1/2020

01.01.2020 | Head and Neck Cancer (CP Rodriguez, Section Editor)

Multimodal Therapy for Sinonasal Malignancies: Updates and Review of Current Treatment

verfasst von: Mayur D. Mody, MD, Nabil F. Saba, MD, FACP

Erschienen in: Current Treatment Options in Oncology | Ausgabe 1/2020

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Opinion statement

Sinonasal malignancies pose a significant challenge in management due to their low incidence, biologic diversity, and significant symptom burden. Even though surgery remains the primary therapeutic modality, a multi-modality approach has been shown to benefit a significant proportion of patients and its success depends largely on stage and histologic type. Non-surgical approaches such as novel radiation approaches as well as intensification with systemic therapy hold promise in altering the organ preservation rate as well as overall survival for patients. Practice changing randomized trials to test these novel modalities are overdue and desperately needed.
Literatur
1.
Zurück zum Zitat Roush GC. Epidemiology of cancer of the nose and paranasal sinuses: current concepts. Head Neck Surg. 1979;2(1):3–11.CrossRef Roush GC. Epidemiology of cancer of the nose and paranasal sinuses: current concepts. Head Neck Surg. 1979;2(1):3–11.CrossRef
2.
Zurück zum Zitat Muir CS, Nectoux J. Descriptive epidemiology of malignant neoplasms of nose, nasal cavities, middle ear and accessory sinuses. Clin Otolaryngol Allied Sci. 1980;5(3):195–211.CrossRef Muir CS, Nectoux J. Descriptive epidemiology of malignant neoplasms of nose, nasal cavities, middle ear and accessory sinuses. Clin Otolaryngol Allied Sci. 1980;5(3):195–211.CrossRef
6.
Zurück zum Zitat El-Mofty SK, Lu DW. Prevalence of high-risk human papillomavirus DNA in nonkeratinizing (cylindrical cell) carcinoma of the sinonasal tract: a distinct clinicopathologic and molecular disease entity. Am J Surg Pathol. 2005;29(10):1367–72.CrossRef El-Mofty SK, Lu DW. Prevalence of high-risk human papillomavirus DNA in nonkeratinizing (cylindrical cell) carcinoma of the sinonasal tract: a distinct clinicopathologic and molecular disease entity. Am J Surg Pathol. 2005;29(10):1367–72.CrossRef
8.
Zurück zum Zitat Torjussen W. Occupational nasal cancer caused by nickel and nickel compounds. Rhinology. 1985;23(2):101–5.PubMed Torjussen W. Occupational nasal cancer caused by nickel and nickel compounds. Rhinology. 1985;23(2):101–5.PubMed
9.
Zurück zum Zitat Luce D, Leclerc A, Morcet JF, Casal-Lareo A, Gerin M, Brugere J, et al. Occupational risk factors for sinonasal cancer: a case-control study in France. Am J Ind Med. 1992;21(2):163–75.CrossRef Luce D, Leclerc A, Morcet JF, Casal-Lareo A, Gerin M, Brugere J, et al. Occupational risk factors for sinonasal cancer: a case-control study in France. Am J Ind Med. 1992;21(2):163–75.CrossRef
10.
Zurück zum Zitat Schwaab G, Julieron M, Janot F. Epidemiology of cancers of the nasal cavities and paranasal sinuses. Neurochirurgie. 1997;43(2):61–3.PubMed Schwaab G, Julieron M, Janot F. Epidemiology of cancers of the nasal cavities and paranasal sinuses. Neurochirurgie. 1997;43(2):61–3.PubMed
16.
Zurück zum Zitat • Husain Q, Joshi RR, Cracchiolo JR, Roman BR, Ganly I, Tabar V, et al. Surgical management patterns of sinonasal malignancy: a population-based study. J Neurol Surg B Skull Base. 2019;80(4):371–9. https://doi.org/10.1055/s-0038-1675233 Assessment of over 10,000 patients from National Cancer Data Base showing sinonasal cancers managed with endoscopic surgery had comparable outcomes to open resection.CrossRefPubMed • Husain Q, Joshi RR, Cracchiolo JR, Roman BR, Ganly I, Tabar V, et al. Surgical management patterns of sinonasal malignancy: a population-based study. J Neurol Surg B Skull Base. 2019;80(4):371–9. https://​doi.​org/​10.​1055/​s-0038-1675233 Assessment of over 10,000 patients from National Cancer Data Base showing sinonasal cancers managed with endoscopic surgery had comparable outcomes to open resection.CrossRefPubMed
23.
Zurück zum Zitat Goepfert H. The vex and fuss about nasal vestibule cancer. Head Neck. 1999;21(5):383–4.CrossRef Goepfert H. The vex and fuss about nasal vestibule cancer. Head Neck. 1999;21(5):383–4.CrossRef
32.
Zurück zum Zitat • Russo AL, Adams JA, Weyman EA, Busse PM, Goldberg SI, Varvares M, et al. Long-term outcomes after proton beam therapy for sinonasal squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2016;95(1):368–76. https://doi.org/10.1016/j.ijrobp.2016.02.042 Single institution review from Massachusetts General Hospital reporting data on long-term outcomes in patients with sinonasal squamous cell carcinoma treated with proton therapy.CrossRefPubMed • Russo AL, Adams JA, Weyman EA, Busse PM, Goldberg SI, Varvares M, et al. Long-term outcomes after proton beam therapy for sinonasal squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2016;95(1):368–76. https://​doi.​org/​10.​1016/​j.​ijrobp.​2016.​02.​042 Single institution review from Massachusetts General Hospital reporting data on long-term outcomes in patients with sinonasal squamous cell carcinoma treated with proton therapy.CrossRefPubMed
40.
Zurück zum Zitat Lee MM, Vokes EE, Rosen A, Witt ME, Weichselbaum RR, Haraf DJ. Multimodality therapy in advanced paranasal sinus carcinoma: superior long-term results. Cancer J Sci Am. 1999;5(4):219–23.PubMed Lee MM, Vokes EE, Rosen A, Witt ME, Weichselbaum RR, Haraf DJ. Multimodality therapy in advanced paranasal sinus carcinoma: superior long-term results. Cancer J Sci Am. 1999;5(4):219–23.PubMed
44.
50.
Zurück zum Zitat Le QT, Fu KK, Kaplan M, Terris DJ, Fee WE, Goffinet DR. Treatment of maxillary sinus carcinoma: a comparison of the 1997 and 1977 American Joint Committee on cancer staging systems. Cancer. 1999;86(9):1700–11.CrossRef Le QT, Fu KK, Kaplan M, Terris DJ, Fee WE, Goffinet DR. Treatment of maxillary sinus carcinoma: a comparison of the 1997 and 1977 American Joint Committee on cancer staging systems. Cancer. 1999;86(9):1700–11.CrossRef
52.
Zurück zum Zitat •• Robin TP, Jones BL, Gordon OM, Phan A, Abbott D, McDermott JD, et al. A comprehensive comparative analysis of treatment modalities for sinonasal malignancies. Cancer. 2017;123(16):3040–9. https://doi.org/10.1002/cncr.30686 Recent retrospective analysis of data obtained from National Cancer Data Base of treatment outcomes for over 11,000 patients with sinonasal malignances.CrossRefPubMedPubMedCentral •• Robin TP, Jones BL, Gordon OM, Phan A, Abbott D, McDermott JD, et al. A comprehensive comparative analysis of treatment modalities for sinonasal malignancies. Cancer. 2017;123(16):3040–9. https://​doi.​org/​10.​1002/​cncr.​30686 Recent retrospective analysis of data obtained from National Cancer Data Base of treatment outcomes for over 11,000 patients with sinonasal malignances.CrossRefPubMedPubMedCentral
54.
Zurück zum Zitat • Pare A, Blanchard P, Rosellini S, Auperin A, Gorphe P, Casiraghi O, et al. Outcomes of multimodal management for sinonasal squamous cell carcinoma. J Craniomaxillofac Surg. 2017;45(8):1124–32. https://doi.org/10.1016/j.jcms.2017.05.006 Single institutional data from France suggesting multimodal therapy combining neoadjuvant chemotherapy followed by wide resection and adjuvant radiation therapy seems to provide promising results in management of SCC SNC.CrossRefPubMed • Pare A, Blanchard P, Rosellini S, Auperin A, Gorphe P, Casiraghi O, et al. Outcomes of multimodal management for sinonasal squamous cell carcinoma. J Craniomaxillofac Surg. 2017;45(8):1124–32. https://​doi.​org/​10.​1016/​j.​jcms.​2017.​05.​006 Single institutional data from France suggesting multimodal therapy combining neoadjuvant chemotherapy followed by wide resection and adjuvant radiation therapy seems to provide promising results in management of SCC SNC.CrossRefPubMed
65.
Zurück zum Zitat Day TA, Beas RA, Schlosser RJ, Woodworth BA, Barredo J, Sharma AK, et al. Management of paranasal sinus malignancy. Curr Treat Options in Oncol. 2005;6(1):3–18.CrossRef Day TA, Beas RA, Schlosser RJ, Woodworth BA, Barredo J, Sharma AK, et al. Management of paranasal sinus malignancy. Curr Treat Options in Oncol. 2005;6(1):3–18.CrossRef
74.
Zurück zum Zitat Edmonson JH. Chemotherapeutic approaches to soft tissue sarcomas. Semin Surg Oncol. 1994;10(5):357–63.CrossRef Edmonson JH. Chemotherapeutic approaches to soft tissue sarcomas. Semin Surg Oncol. 1994;10(5):357–63.CrossRef
Metadaten
Titel
Multimodal Therapy for Sinonasal Malignancies: Updates and Review of Current Treatment
verfasst von
Mayur D. Mody, MD
Nabil F. Saba, MD, FACP
Publikationsdatum
01.01.2020
Verlag
Springer US
Erschienen in
Current Treatment Options in Oncology / Ausgabe 1/2020
Print ISSN: 1527-2729
Elektronische ISSN: 1534-6277
DOI
https://doi.org/10.1007/s11864-019-0696-4

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