Background
Methods
Design, setting and study population
Coding and selection of diseases
Multimorbidity definition
Variables
Statistical analysis
Statistics of multimorbidity patterns
Results
Women n (%) 217,823 (82.2) | Men n (%) 191,171 (73.9) | |
---|---|---|
Number of diagnoses† | ||
2 | 26,106 (12.0) | 33,850 (17.7) |
3 | 28,243 (13.0) | 33,515 (17.5) |
4 | 28,274 (13.0) | 30,356 (15.9) |
≥ 5 | 135,200 (62.1) | 93,450 (48.9) |
Median number of diagnoses (IQR)‡ | 5 (4–8) | 4 (3–7) |
Number of diagnoses included | 79 | 73 |
Cluster n (%)a | Blocks of diagnoses | Prevalence in cluster (%)b | Prevalence in women (%)c | O/E ratiod | Exclusivity (%) | Centrality | Mean Age | Median number of diagnoses |
---|---|---|---|---|---|---|---|---|
1
| E70-E90:Metabolic disorders | 25.9 | 35.4 | 0.73 | 29.8 | 0.8 | 53.0 | 3 |
88,657 (40.7) | M50-M54:Other dorsopathies | 23.6 | 35.8 | 0.66 | 26.9 | |||
F10-F19:Mental and behavioural disorders due to psychoactive substance use | 21.1 | 18.6 | 1.13 | 46.1 | ||||
F40-F48:Neurotic. stress-related and somatoform disorders | 20.0 | 27.3 | 0.73 | 29.9 | ||||
N80-N98:Noninflammatory disorders of female genital tract | 17.6 | 24.2 | 0.73 | 29.6 | ||||
I10-I15:Hypertensive diseases | 15.6 | 25.6 | 0.61 | 24.9 | ||||
M70-M79:Other soft tissue disorders | 13.9 | 27.0 | 0.52 | 21.0 | ||||
E00-E07:Disorders of thyroid gland | 11.8 | 14.9 | 0.79 | 32.3 | ||||
D10-D36:Benign neoplasms | 10.4 | 16.2 | 0.65 | 26.3 | ||||
2
| M50-M54:Other dorsopathies | 55.4 | 35.8 | 1.55 | 23.0 | 1.6 | 57.4 | 7 |
32,249 (14.8) | E70-E90:Metabolic disorders | 53.6 | 35.4 | 1.52 | 22.4 | |||
M15-M19:Arthrosis
|
48.2
|
15.7
|
3.08
|
45.6
| ||||
M70-M79:Other soft tissue disorders | 47.5 | 27.0 | 1.76 | 26.1 | ||||
M80-M85:Disorders of bone density and structure
|
38.7
|
11.3
|
3.41
|
50.5
| ||||
M20-M25:Other joint disorders | 33.0 | 18.6 | 1.78 | 26.3 | ||||
F40-F48:Neurotic. stress-related and somatoform disorders | 30.1 | 27.3 | 1.10 | 16.3 | ||||
I10-I15:Hypertensive diseases | 29.3 | 25.6 | 1.14 | 16.9 | ||||
I80-I89:Diseases of veins. Lymphatic vessels and lymph nodes. Not elsewhere classified | 29.2 | 18.3 | 1.60 | 23.7 | ||||
F30-F39:Mood [affective] disorders | 20.8 | 14.6 | 1.43 | 21.1 | ||||
N80-N98:Noninflammatory disorders of female genital tract | 20.5 | 24.2 | 0.85 | 12.5 | ||||
E65-E68:Obesity and other hyperalimentation | 20.5 | 19.0 | 1.08 | 16.0 | ||||
G50-G59:Nerve. nerve root and plexus disorders
|
20.0
|
8.5
|
2.34
|
34.7
| ||||
M45-M49:Spondylopathies
|
19.7
|
4.3
|
4.56
|
67.4
| ||||
E00-E07:Disorders of thyroid gland | 17.8 | 14.9 | 1.20 | 17.7 | ||||
M40-M43:Deforming dorsopathies
|
15.1
|
3.8
|
3.96
|
58.6
| ||||
D10-D36:Benign neoplasms | 12.4 | 16.2 | 0.77 | 11.4 | ||||
K20-K31:Diseases of oesophagus. Stomach and duodenum | 12.0 | 11.4 | 1.05 | 15.6 | ||||
J30-J39:Other diseases of upper respiratory tract | 11.2 | 9.4 | 1.19 | 17.6 | ||||
G40-G47:Episodic and paroxysmal disorders | 11.2 | 10.5 | 1.06 | 15.7 | ||||
J00-J06:Acute upper respiratory infections | 11.1 | 12.6 | 0.88 | 13.0 | ||||
H90-H95:Other disorders of ear | 10.2 | 6.3 | 1.60 | 23.7 | ||||
3
| N80-N98:Noninflammatory disorders of female genital tract | 48.1 | 24.2 | 1.99 | 25.6 | 1.7 | 53.0 | 8 |
28,024 (12.9) | M50-M54:Other dorsopathies | 46.9 | 35.8 | 1.31 | 16.9 | |||
M70-M79:Other soft tissue disorders | 38.8 | 27.0 | 1.44 | 18.5 | ||||
M20-M25:Other joint disorders | 33.6 | 18.6 | 1.81 | 23.3 | ||||
D10-D36:Benign neoplasms
|
32.8
|
16.2
|
2.03
|
26.1
| ||||
I80-I89:Diseases of veins. Lymphatic vessels and lymph nodes. Not elsewhere classified | 29.3 | 18.3 | 1.60 | 20.6 | ||||
L20-L30:Dermatitis and eczema
|
28.4
|
9.3
|
3.05
|
39.2
| ||||
E70-E90:Metabolic disorders | 27.7 | 35.4 | 0.78 | 10.1 | ||||
F40-F48:Neurotic. stress-related and somatoform disorders | 26.3 | 27.3 | 0.96 | 12.4 | ||||
K00-K14:Diseases of oral cavity. Salivary glands and jaws | 23.3 | 12.1 | 1.93 | 24.9 | ||||
B35-B49:Mycoses
|
19.8
|
5.7
|
3.46
|
44.5
| ||||
D50-D53:Nutritional anaemias
|
19.7
|
8.3
|
2.38
|
30.6
| ||||
N60-N64:Disorders of breast
|
19.2
|
7.5
|
2.56
|
32.9
| ||||
J00-J06:Acute upper respiratory infections | 16.9 | 12.6 | 1.34 | 17.2 | ||||
H53-H54:Visual disturbances and blindness
|
16.8
|
4.4
|
3.84
|
49.4
| ||||
E00-E07:Disorders of thyroid gland | 16.7 | 14.9 | 1.13 | 14.5 | ||||
L60-L75:Disorders of skin appendages
|
16.7
|
4.8
|
3.51
|
45.2
| ||||
I10-I15:Hypertensive diseases | 15.9 | 25.6 | 0.62 | 8.0 | ||||
E65-E68:Obesity and other hyperalimentation | 15.4 | 19.0 | 0.81 | 10.4 | ||||
J30-J39:Other diseases of upper respiratory tract | 15.2 | 9.4 | 1.61 | 20.8 | ||||
G40-G47:Episodic and paroxysmal disorders | 14.0 | 10.5 | 1.33 | 17.1 | ||||
B00-B09:Viral infections characterized by skin and mucous membrane lesions
|
13.9
|
4.3
|
3.21
|
41.2
| ||||
H90-H95:Other disorders of ear
|
12.9
|
6.3
|
2.03
|
26.2
| ||||
H49-H52:Disorders of ocular muscles. Binocular movement. Accommodation and refraction
|
12.9
|
3.5
|
3.64
|
46.8
| ||||
L80-L99:Other disorders of the skin and subcutaneous tissue
|
12.8
|
3.3
|
3.83
|
49.3
| ||||
H10-H13:Disorders of conjunctiva
|
12.2
|
3.8
|
3.21
|
41.3
| ||||
F30-F39:Mood [affective] disorders | 11.7 | 14.6 | 0.80 | 10.3 | ||||
K55-K63:Other diseases of intestines | 11.3 | 8.6 | 1.32 | 17.0 | ||||
M15-M19:Arthrosis | 11.1 | 15.7 | 0.71 | 9.2 | ||||
K20-K31:Diseases of oesophagus. Stomach and duodenum | 10.3 | 11.4 | 0.91 | 11.7 |
Cluster n (%)a | Blocks of diagnoses | Prevalence in cluster (%)b | Prevalence in men (%)c | O/E ratiod | Exclusivity (%) | Centrality | Mean Age | Median number of diagnoses |
---|---|---|---|---|---|---|---|---|
1
| E70-E90:Metabolic disorders | 38.4 | 42.2 | 0.91 | 35.3 | 0.8 | 53.3 | 3 |
73,979 (38.7) | I10-I15:Hypertensive diseases | 28.1 | 32.5 | 0.86 | 33.4 | |||
F10-F19:Mental and behavioural disorders due to psychoactive substance use | 25.4 | 33.6 | 0.76 | 29.2 | ||||
M50-M54:Other dorsopathies | 20.8 | 27.8 | 0.75 | 28.9 | ||||
M70-M79:Other soft tissue disorders | 10.7 | 16.9 | 0.63 | 24.6 | ||||
E65-E68:Obesity and other hyperalimentation | 10.6 | 14.6 | 0.73 | 28.2 | ||||
2
|
F10-F19:Mental and behavioural disorders due to psychoactive substance use
|
77.3
|
33.6
|
2.30
|
34.9
| 1.5 | 52.6 | 4 |
28,951 (15.1) | E70-E90:Metabolic disorders | 26.4 | 42.2 | 0.63 | 9.5 | |||
F40-F48:Neurotic. stress-related and somatoform disorders | 25.1 | 13.5 | 1.86 | 28.1 | ||||
M50-M54:Other dorsopathies | 23.7 | 27.8 | 0.85 | 12.9 | ||||
K00-K14:Diseases of oral cavity. Salivary glands and jaws | 23.2 | 12.0 | 1.93 | 29.2 | ||||
J40-J47:Chronic lower respiratory diseases
|
19.4
|
9.3
|
2.09
|
31.6
| ||||
F30-F39:Mood [affective] disorders
|
17.0
|
6.3
|
2.72
|
41.2
| ||||
B15-B19:Viral hepatitis
|
16.6
|
3.2
|
5.13
|
77.6
| ||||
I10-I15:Hypertensive diseases | 14.2 | 32.5 | 0.44 | 6.6 | ||||
K70-K77:Diseases of liver
|
12.5
|
5.2
|
2.38
|
36.1
| ||||
K20-K31:Diseases of oesophagus. Stomach and duodenum | 12.3 | 11.5 | 1.06 | 16.1 | ||||
M70-M79:Other soft tissue disorders | 10.4 | 16.9 | 0.62 | 9.4 | ||||
3
| E70-E90:Metabolic disorders | 43.4 | 42.2 | 1.03 | 12.1 | 1.9 | 55.2 | 6 |
22,458 (11.8) |
K20-K31:Diseases of oesophagus. Stomach and duodenum
|
40.0
|
11.5
|
3.47
|
40.7
| |||
K40-K46:Hernia
|
31.3
|
8.8
|
3.57
|
41.9
| ||||
N40-N51:Diseases of male genital organs
|
30.9
|
12.1
|
2.54
|
29.9
| ||||
I10-I15:Hypertensive diseases | 30.3 | 32.5 | 0.93 | 10.9 | ||||
M50-M54:Other dorsopathies | 29.6 | 27.8 | 1.06 | 12.5 | ||||
I80-I89:Diseases of veins. Lymphatic vessels and lymph nodes. Not elsewhere classified
|
29.6
|
10.0
|
2.95
|
34.7
| ||||
K55-K63:Other diseases of intestines
|
28.2
|
6.4
|
4.39
|
51.6
| ||||
D10-D36:Benign neoplasms
|
21.1
|
8.6
|
2.46
|
28.9
| ||||
F10-F19:Mental and behavioural disorders due to psychoactive substance use | 20.8 | 33.6 | 0.62 | 7.3 | ||||
F40-F48:Neurotic. stress-related and somatoform disorders | 19.7 | 13.5 | 1.46 | 17.2 | ||||
J30-J39:Other diseases of upper respiratory tract
|
16.1
|
8.0
|
2.01
|
23.6
| ||||
M70-M79:Other soft tissue disorders | 15.6 | 16.9 | 0.92 | 10.9 | ||||
G40-G47:Episodic and paroxysmal disorders | 13.1 | 7.4 | 1.77 | 20.8 | ||||
N20-N23:Urolithiasis
|
13.0
|
4.3
|
3.00
|
35.3
| ||||
J40-J47:Chronic lower respiratory diseases | 12.0 | 9.3 | 1.29 | 15.1 | ||||
H90-H95:Other disorders of ear | 10.8 | 7.7 | 1.40 | 16.5 |