Background
Methods
Results
Parameter | Tamale | Afigya Sekyere | P |
---|---|---|---|
No. | 1086 | 964 | |
Proportion girls (%) | 50.2 | 49.3 | 0.68 |
Examination for present study (15 months of age) in rainy season (%) | 89.6 | 49.3 | < 0.0001 |
SP group : placebo group | 542 : 544 | 485 : 479 | 0.86 |
Current P. falciparum infection | |||
by microscopy (%; n/n) | 11.0 (119/1084) | 24.3 (229/944) | < 0.0001 |
GMPD (parasites/μL, 95%CI) | 2312 (1599-3344) | 1455 (1105-1917) | 0.03 |
by PCR (%) | 23.6 (248/1049) | n.a. | - |
Current malaria episode (%, n/n) | 7.4 (80/1084) | 11.3 (107/944) | 0.002 |
Febrile (%, n/n) | 12.8 (138/1082) | 6.1 (59/964) | < 0.0001 |
History of fever within 48 h (%, n/n) | 31.7 (344/1086) | 31.8 (307/964) | 0.93 |
Haemoglobin (g/dL; mean, range) | 8.91 (4.7-12.7) | 9.90 (2.0-15.0) | < 0.0001 |
Proportion anaemic (Hb < 11 g/dL; %, n/n) | 94.0 (1019/1084) | 74.4 (715/961) | < 0.0001 |
Proportion severely anaemic (Hb < 7 g/dL; %, n/n) | 8.0 (87/1084) | 4.9 (47/961) | 0.004 |
Proportion with prior episode(s) of malaria (%, n/n) | 47.4 (515/1086) | 57.6 (555/964) | < 0.0001 |
No. of previous malaria episodes (mean, range) | 0.67 (0-5) | 1.23 (0-7) | < 0.0001 |
Stratum | No. IPTI : placebo | mean MOI (median, range) |
P
| Proportion of polyclonal infections (%) |
P
| ||
---|---|---|---|---|---|---|---|
Previous IPTi | Previous Placebo | Previous IPTi | Previous Placebo | ||||
All | 191 : 198 | 2.25 (2, 1-5) | 2.33 (2, 1-6) | 0.55 | 69.6 | 69.7 | 0.99 |
All microscopically positive | 135 : 142 | 2.42 (2, 1-5) | 2.38 (2, 1-6) | 0.78 | 74.8 | 72.5 | 0.67 |
Afigya Sekyere | 85 : 88 | 2.29 (2, 1-5) | 2.31 (2, 1-6) | 0.92 | 69.4 | 71.6 | 0.75 |
Tamale, all | 106 : 110 | 2.22 (2, 1-5) | 2.35 (2, 1-5) | 0.49 | 69.8 | 68.2 | 0.80 |
Tamale, microscopically positive | 50 : 54 | 2.64 (2.5, 1-5) | 2.50 (2, 1-5) | 0.59 | 84.0 | 74.1 | 0.22 |
Tamale, submicroscopic | 56 : 56 | 1.84 (2, 1-5) | 2.20 (2, 1-5) | 0.17 | 57.1 | 62.5 | 0.56 |
Parameter | No. | Mean MOI (median, range) |
P
| Multivariate analysisa | Polyclonal infections (%) | OR (95%CI) |
P
| Multivariate analysisb | |||
---|---|---|---|---|---|---|---|---|---|---|---|
b | SE |
P
| aOR (95%CI |
P
| |||||||
Previous IPTi-SP | |||||||||||
No | 142 | 2.38 (2, 1-6) | 72.5 | 1 | 1 | ||||||
Yes | 135 | 2.42 (2, 1-5) | 0.78 | -0.05 | 0.22 | 0.82 | 74.8 | 1.12 (0.64-1.99) | 0.67 | 0.93 (0.52-1.64) | 0.79 |
Cohort | |||||||||||
Tamale | 104 | 2.57 (2, 1-5) | 78.8 | 1 | 1 | ||||||
Afigya Sekyere | 173 | 2.30 (2, 1-6) | 0.07 | -0.67 | 0.26 | 0.01 | 70.5 | 0.64 (0.35-1.18) | 0.13 | 0.53 (0.28-1.03) | 0.06 |
Current malaria episode | |||||||||||
No | 114 | 2.21 (2, 1-6) | 64.0 | 1 | 1 | ||||||
Yes | 163 | 2.53 (2, 1-5) | 0.01 | 0.55 | 0.24 | 0.02 | 80.4 | 2.30 (1.29-4.11) | 0.002 | 2.35 (1.27-4.32) | 0.006 |
Parasite density (/μL) | |||||||||||
Log10 | 277 | n.a. | 0.049 | 0.24 | 0.13 | 0.07 | n.a. | 1.48 (1.08-2.03) | 0.01 | 1.38 (0.99-1.94) | 0.06 |
Prior malaria episodes | |||||||||||
None | 72 | 2.50 (2, 1-5) | 81.9 | 1 | 1 | ||||||
Any | 205 | 2.37 (2, 1-6) | 0.30 | -0.19 | 0.26 | 0.46 | 70.7 | 0.53 (0.26-1.09) | 0.06 | 0.51 (0.25-1.05)c, d | 0.07 |
Season | |||||||||||
Dry season | 92 | 2.49 (2, 1-5) | 79.3 | 1 | 1 | ||||||
Rainy season | 185 | 2.36 (2, 1-6) | 0.32 | -0.77 | 0.27 | 0.004 | 70.8 | 1.58 (0.84-3.01) | 0.13 | 0.36 (0.18-0.72) | 0.004 |