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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.07.2009 | Editorial

Navigating beyond the 6^th dimension: a challenge in the era of multi-parametric molecular imaging

verfasst von: Habib Zaidi

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 7/2009

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Excerpt

This is an exciting time for molecular imaging as we are witnessing a convergence and combination of various imaging modalities driven by an unprecedented multidisciplinary collaboration between scientists. A consequence of this growth is a paradigm shift in health care delivery that is now revolutionizing clinical practice. Within the spectrum of macroscopic medical imaging, sensitivity ranges from the detection of millimolar to submillimolar concentrations of contrast media with computed tomography (CT) and magnetic resonance imaging (MRI), respectively, to picomolar concentrations in positron emission tomography (PET): a 10⁸–10⁹ difference [1]. Despite the remarkable progress and outstanding scientific innovations achieved and the much worthwhile successful research carried out both in academic and corporate settings, there are still plenty of open research questions that offer ample opportunities for the new generation of molecular imaging scientists [2]. There is no shortage of challenges and opportunities nowadays for developing novel molecular imaging probes and technologies and for establishing their role through innovative applications in clinical and research settings. The only limit is the imagination and creativity of the investigators and the challenge is the ability of opinion leaders to attract the best scientists into this discipline. …

Jones T. Molecular imaging with PET—the future challenges. Br J Radiol 2002;75:S6–15.PubMed

Rahmim A, Zaidi H. PET versus SPECT: strengths, limitations and challenges. Nucl Med Commun 2008;29:193–207. doi:10.1097/MNM.0b013e3282f5d2de.PubMedCrossRef

Piwnica-Worms DR. Introduction to molecular imaging. J Am Coll Radiol 2004;1:2–3. doi:10.1016/S1546–1440(03)00024–3.PubMedCrossRef

Fullerton GD, Hazle JD. The development of technologies for molecular imaging should be driven principally by biological questions to be addressed rather than by simply modifying existing imaging technologies. Med Phys 2005;32:1231–3. doi:10.1118/1.1866141.PubMedCrossRef

Zaidi H, Alavi A. Current trends in PET and combined (PET/CT and PET/MR) systems design. PET Clin 2007;2:109–23. doi:10.1016/j.cpet.2007.10.004.CrossRef

Levin CS, Zaidi H. Current trends in preclinical PET system design. PET Clin 2007;2:125–60. doi:10.1016/j.cpet.2007.12.001.CrossRef

Ntziachristos V. Fluorescence molecular imaging. Annu Rev Biomed Eng 2006;8:1–33. doi:10.1146/annurev.bioeng.8.061505.095831.PubMedCrossRef

Seo Y, Mari C, Hasegawa BH. Technological development and advances in single-photon emission computed tomography/computed tomography. Semin Nucl Med 2008;38:177–98. doi:10.1053/j.semnuclmed.2008.01.001.PubMedCrossRef

Townsend DW. Positron emission tomography/computed tomography. Semin Nucl Med 2008;38:152–66. doi:10.1053/j.semnuclmed.2008.01.003.PubMedCrossRef

10.

Pichler BJ, Wehrl HF, Kolb A, Judenhofer MS. Positron emission tomography/magnetic resonance imaging: the next generation of multimodality imaging? Semin Nucl Med 2008;38:199–208. doi:10.1053/j.semnuclmed.2008.02.001.PubMedCrossRef

11.

Beyer T, Pichler B. A decade of combined imaging: from a PET attached to a CT to a PET inside an MR. Eur J Nucl Med Mol Imaging 2009; In press.

12.

Schlemmer HP, Pichler BJ, Schmand M, Burbar Z, Michel C, Ladebeck R, et al. Simultaneous MR/PET imaging of the human brain: feasibility study. Radiology 2008;248:1028–35. doi:10.1148/radiol.2483071927.PubMedCrossRef

13.

Gaa J, Rummeny EJ, Seemann MD. Whole-body imaging with PET/MRI. Eur J Med Res 2004;9:309–12.PubMed

14.

Seemann MD. Whole-body PET/MRI: the future in oncological imaging. Technol Cancer Res Treat 2005;4:577–82.PubMed

15.

Ruf J, Lopez Hanninen E, Bohmig M, Koch I, Denecke T, Plotkin M, et al. Impact of FDG-PET/MRI image fusion on the detection of pancreatic cancer. Pancreatology 2006;6:512–9. doi:10.1159/000096993.PubMedCrossRef

16.

Schlemmer HP, Pichler BJ, Krieg R, Heiss WD. An integrated MR/PET system: prospective applications. Abdom Imaging 2009; In press.

17.

Holdsworth SJ, Bammer R. Magnetic resonance imaging techniques: fMRI, DWI, and PWI. Semin Neurol 2008;28:395–406. doi:10.1055/s-0028–1083697.PubMedCrossRef

18.

Del Guerra A, Bartoli A, Belcari N, Herbert D, Motta A, Vaiano A, et al. Performance evaluation of the fully engineered YAP-(S)PET scanner for small animal imaging. IEEE Trans Nucl Sci 2006;53:1078–83. doi:10.1109/TNS.2006.871900.CrossRef

19.

Douraghy A, Rannou FR, Silverman RW, Chatziioannou AF. FPGA electronics for OPET: a dual-modality optical and positron emission tomograph. IEEE Trans Nucl Sci 2008;55:2541–5. doi:10.1109/TNS.2008.2002257.CrossRef

20.

Gulsen G, Birgul O, Unlu MB, Shafiiha R, Nalcioglu O. Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals. Technol Cancer Res Treat 2006;5:351–63.PubMed

21.

Del Guerra A, Belcari N. State-of-the-art of PET, SPECT and CT for small animal imaging. Nucl Instr Methods A 2007;583:119–24. doi:10.1016/j.nima.2007.08.187.CrossRef

22.

Parnham KB, Chowdhury S, Li J, Wagenaar DJ, Patt BE. Second-generation, tri-modality pre-clinical imaging system. IEEE Nuclear Science Symposium Conference Record 2006;3:1802–5.

23.

Peter J, Semmler W. A modular design triple-modality SPECT-CT-ODT small animal imager. Eur J Nucl Med Mol Imaging 2007;34:S158. abstract.

24.

Bidaut LM, Pascual-Marqui R, Delavelle J, Naimi A, Seeck M, Michel C, et al. Three- to five-dimensional biomedical multisensor imaging for the assessment of neurological (dys) function. J Digit Imaging 1996;9:185–98.PubMedCrossRef

25.

Martinez-Möller A, Zikic D, Botnar R, Bundschuh R, Howe W, Ziegler S, et al. Dual cardiac respiratory gated PET: implementation and results from a feasibility study. Eur J Nucl Med Mol Imaging 2007;34:1447–54. doi:10.1007/s00259–007–0374–9.PubMedCrossRef

26.

Kummer C, Winkeler A, Dittmar C, Bauer B, Rueger MA, Rueckriem B, et al. Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector. Mol Imaging 2007;6:181–92.PubMed

27.

Tian J, Yang X, Yu L, Chen P, Xin J, Ma L, et al. A multicenter clinical trial on the diagnostic value of dual-tracer PET/CT in pulmonary lesions using 3′-deoxy-3′-18F-fluorothymidine and 18F-FDG. J Nucl Med 2008;49:186–94. doi:10.2967/jnumed.107.044966.PubMedCrossRef

28.

Nakamura M, Takeda K, Ichihara T, Motomura N, Shimizu H, Saito Y, et al. Feasibility of simultaneous stress 99mTc-sestamibi/rest 201Tl dual-isotope myocardial perfusion SPECT in the detection of coronary artery disease. J Nucl Med 1999;40:895–903.PubMed

29.

El Fakhri G, Moore SC, Maksud P, Aurengo A, Kijewski MF. Absolute activity quantitation in simultaneous 123I/99mTc brain SPECT. J Nucl Med 2001;42:300–8.PubMed

30.

de Jong HW, Beekman FJ, Viergever MA, van Rijk PP. Simultaneous (99m)Tc/(201)Tl dual-isotope SPET with Monte Carlo-based down-scatter correction. Eur J Nucl Med Mol Imaging 2002;29:1063–71. doi:10.1007/s00259–002–0834–1.PubMedCrossRef

31.

Ouyang J, El Fakhri G, Moore SC. Fast Monte Carlo based joint iterative reconstruction for simultaneous 99mTc/ 123I SPECT imaging. Med Phys 2007;34:3263–72. doi:10.1118/1.2756601.PubMedCrossRef

32.

Komar G, Seppanen M, Eskola O, Lindholm P, Gronroos TJ, Forsback S, et al. 18F-EF5: a new PET tracer for imaging hypoxia in head and neck cancer. J Nucl Med 2008;49:1944–51. doi:10.2967/jnumed.108.053785.PubMedCrossRef

33.

Kadrmas DJ, Rust TC. Feasibility of rapid multitracer PET tumor imaging. IEEE Trans Nucl Sci 2005;52:1341–7. doi:10.1109/TNS.2005.858230.CrossRef

34.

Rust TC, Kadrmas DJ. Rapid dual-tracer PTSM+ATSM PET imaging of tumour blood flow and hypoxia: a simulation study. Phys Med Biol 2006;51:61–75. doi:10.1088/0031–9155/51/1/005.PubMedCrossRef

35.

Rust TC, DiBella EVR, McGann CJ, Christian PE, Hoffman JM, Kadrmas DJ. Rapid dual-injection single-scan 13N-ammonia PET for quantification of rest and stress myocardial blood flows. Phys Med Biol 2006;51:5347–62. doi:10.1088/0031–9155/51/20/018.PubMedCrossRef

36.

Black NF, Kadrmas DJ. Measurement of secondary tracers in FDG tumor imaging by rapid multi-tracer PET. Proceedings IEEE Nuclear Science Symposium and Medical Imaging Conference; 2007; Honolulu, Hawaii; vol. 4. p. 2825–32.

37.

Black NF, McJames S, Rust TC, Kadrmas DJ. Evaluation of rapid dual-tracer (62)Cu-PTSM + (62)Cu-ATSM PET in dogs with spontaneously occurring tumors. Phys Med Biol 2008;53:217–32. doi:10.1088/0031–9155/53/1/015.PubMedCrossRef

38.

Verhaeghe J, D’Asseler Y, De Winter O, Staelens S, Lemahieu I. Simultaneous dual tracer NH3/FDG cardiac PET imaging: a simulation study. J Nucl Med 2005;46:56P. abstract.

39.

El Fakhri G, Sitek A, Guérin B. Simultaneous dual tracer PET using generalized factor analysis of dynamic sequences. Proceedings IEEE Nuclear Science Symposium and Medical Imaging Conference; 2006; San Diego, CA. p. 2128–30.

Titel: Navigating beyond the 6th dimension: a challenge in the era of multi-parametric molecular imaging
verfasst von: Habib Zaidi
Publikationsdatum: 01.07.2009
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 7/2009
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-009-1095-z

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