Skip to main content
Erschienen in: Journal of Interventional Cardiac Electrophysiology 2/2021

22.06.2020

Negative-pressure wound therapy (NPWT) for the treatment of pacemaker pocket infection in patients unable or unwilling to undergo CIED extraction

verfasst von: Shengwu Zheng, Xiongmei Huang, Yazhou Lin, Xiaohui Chen, Genhui Lin, Jing Zhuang

Erschienen in: Journal of Interventional Cardiac Electrophysiology | Ausgabe 2/2021

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The occurrence of cardiac pacemaker pocket infection has markedly increased and has become a new problem facing cardiovascular internists. The aim of our study was to investigate the effectiveness and safety of treating cardiac pacemaker pocket infection using negative-pressure wound therapy (NPWT) in patients who are unwilling or unable to have their cardiac implantable electronic devices (CIEDs) removed.

Methods

From March 2013 to April 2019, NPWT was applied to 26 patients with cardiac pacemaker pocket infection who were unwilling or unable to have their CIEDs removed. In the first stage, a negative-pressure drainage system was placed in the pacemaker pocket after debridement. Then, NPWT was used to seal the wound, and the negative pressure (300–400 mmHg) was sustained for 5–7 days. In the second stage, the pacemaker was relocated to the subpectoral layer, and the wound was closed.

Results

In all but three of our 26 patients, the wound healed completely without complications and without evidence of residual infection. The average follow-up period was 26.92 ± 9.46 months. Only 3 diabetic patients whose tissue bacterial cultures revealed that methicillin-resistant Staphylococcus epidermidis developed uncontrolled infections. Eventually, the entire original pacemaker systems were removed, and new pacemakers were implanted in the contralateral chest wall.

Conclusions

When warranted by strictly selected indications, the method of NPWT without CIED extraction can be considered as a new and effective treatment for patients with pacemaker pocket infection who are unwilling or unable to have the device removed.
Literatur
1.
Zurück zum Zitat Baddour LM, Epstein AE, Erickson CC, Knight BP, Levison ME, Lockhart PB, et al. Update on cardiovascular implantable electronic device infections and their management: a scientific statement from the American Heart Association. Circulation. 2010;121(3):458–77.CrossRef Baddour LM, Epstein AE, Erickson CC, Knight BP, Levison ME, Lockhart PB, et al. Update on cardiovascular implantable electronic device infections and their management: a scientific statement from the American Heart Association. Circulation. 2010;121(3):458–77.CrossRef
2.
Zurück zum Zitat Greenspon AJ, Patel JD, Lau E, Ochoa JA, Frisch DR, Ho RT, et al. 16-year trends in the infection burden for pacemakers and implantable cardioverter-defibrillators in the United States 1993 to 2008. J Am Coll Cardiol. 2011;58(10):1001–6.CrossRef Greenspon AJ, Patel JD, Lau E, Ochoa JA, Frisch DR, Ho RT, et al. 16-year trends in the infection burden for pacemakers and implantable cardioverter-defibrillators in the United States 1993 to 2008. J Am Coll Cardiol. 2011;58(10):1001–6.CrossRef
3.
Zurück zum Zitat Wilkoff BL, Love CJ, Byrd CL, Bongiorni MG, Carrillo RG, Crossley GH 3rd, et al. Transvenous lead extraction: Heart Rhythm Society expert consensus on facilities, training, indications, and patient management: this document was endorsed by the American Heart Association (AHA). Heart Rhythm. 2009;6(7):1085–104.CrossRef Wilkoff BL, Love CJ, Byrd CL, Bongiorni MG, Carrillo RG, Crossley GH 3rd, et al. Transvenous lead extraction: Heart Rhythm Society expert consensus on facilities, training, indications, and patient management: this document was endorsed by the American Heart Association (AHA). Heart Rhythm. 2009;6(7):1085–104.CrossRef
4.
Zurück zum Zitat Harrison JL, Prendergast BD, Sandoe JA. Guidelines for the diagnosis, management and prevention of implantable cardiac electronic device infection. Heart. 2015;101(4):250–2.CrossRef Harrison JL, Prendergast BD, Sandoe JA. Guidelines for the diagnosis, management and prevention of implantable cardiac electronic device infection. Heart. 2015;101(4):250–2.CrossRef
5.
Zurück zum Zitat Klug D, Balde M, Pavin D, Hidden-Lucet F, Clementy J, Sadoul N, et al. Risk factors related to infections of implanted pacemakers and cardioverter-defibrillators: results of a large prospective study. Circulation. 2007;116(12):1349–55.CrossRef Klug D, Balde M, Pavin D, Hidden-Lucet F, Clementy J, Sadoul N, et al. Risk factors related to infections of implanted pacemakers and cardioverter-defibrillators: results of a large prospective study. Circulation. 2007;116(12):1349–55.CrossRef
6.
Zurück zum Zitat Smith MC, Love CJ. Extraction of transvenous pacing and ICD leads. Pacing Clin Electrophysiol. 2008;31(6):736–52.CrossRef Smith MC, Love CJ. Extraction of transvenous pacing and ICD leads. Pacing Clin Electrophysiol. 2008;31(6):736–52.CrossRef
7.
Zurück zum Zitat Ipek EG, Guray U, Demirkan B, Guray Y, Aksu T. Infections of implantable cardiac rhythm devices: predisposing factors and outcome. Acta Cardiol. 2012;67(3):303–10.CrossRef Ipek EG, Guray U, Demirkan B, Guray Y, Aksu T. Infections of implantable cardiac rhythm devices: predisposing factors and outcome. Acta Cardiol. 2012;67(3):303–10.CrossRef
8.
Zurück zum Zitat Margey R, McCann H, Blake G, Keelan E, Galvin J, Lynch M, et al. Contemporary management of and outcomes from cardiac device related infections. Europace. 2010;12(1):64–70.CrossRef Margey R, McCann H, Blake G, Keelan E, Galvin J, Lynch M, et al. Contemporary management of and outcomes from cardiac device related infections. Europace. 2010;12(1):64–70.CrossRef
9.
Zurück zum Zitat Athan E, Chu VH, Tattevin P, Selton-Suty C, Jones P, Naber C, et al. Clinical characteristics and outcome of infective endocarditis involving implantable cardiac devices. Jama. 2012;307(16):1727–35.CrossRef Athan E, Chu VH, Tattevin P, Selton-Suty C, Jones P, Naber C, et al. Clinical characteristics and outcome of infective endocarditis involving implantable cardiac devices. Jama. 2012;307(16):1727–35.CrossRef
10.
Zurück zum Zitat Sandoe JA, Barlow G, Chambers JB, Gammage M, Guleri A, Howard P, et al. Guidelines for the diagnosis, prevention and management of implantable cardiac electronic device infection. Report of a joint Working Party project on behalf of the British Society for Antimicrobial Chemotherapy (BSAC, host organization), British Heart Rhythm Society (BHRS), British Cardiovascular Society (BCS), British Heart Valve Society (BHVS) and British Society for Echocardiography (BSE). J Antimicrob Chemother. 2015;70(2):325–59.CrossRef Sandoe JA, Barlow G, Chambers JB, Gammage M, Guleri A, Howard P, et al. Guidelines for the diagnosis, prevention and management of implantable cardiac electronic device infection. Report of a joint Working Party project on behalf of the British Society for Antimicrobial Chemotherapy (BSAC, host organization), British Heart Rhythm Society (BHRS), British Cardiovascular Society (BCS), British Heart Valve Society (BHVS) and British Society for Echocardiography (BSE). J Antimicrob Chemother. 2015;70(2):325–59.CrossRef
11.
Zurück zum Zitat Traykov V, Bongiorni MG, Boriani G, Burri H, Costa R, Dagres N, et al. Clinical practice and implementation of guidelines for the prevention, diagnosis and management of cardiac implantable electronic device infections: results of a worldwide survey under the auspices of the European Heart Rhythm Association. Europace. 2019. Traykov V, Bongiorni MG, Boriani G, Burri H, Costa R, Dagres N, et al. Clinical practice and implementation of guidelines for the prevention, diagnosis and management of cardiac implantable electronic device infections: results of a worldwide survey under the auspices of the European Heart Rhythm Association. Europace. 2019.
12.
Zurück zum Zitat Fleck T, Fleck M. Negative pressure wound therapy for the treatment of sternal wound infections after cardiac surgery. Int Wound J. 2014;11(3):240–5.CrossRef Fleck T, Fleck M. Negative pressure wound therapy for the treatment of sternal wound infections after cardiac surgery. Int Wound J. 2014;11(3):240–5.CrossRef
13.
Zurück zum Zitat Kanakaris NK, Thanasas C, Keramaris N, Kontakis G, Granick MS, Giannoudis PV. The efficacy of negative pressure wound therapy in the management of lower extremity trauma: review of clinical evidence. Injury. 2007;38(Suppl 5):S9–18.PubMed Kanakaris NK, Thanasas C, Keramaris N, Kontakis G, Granick MS, Giannoudis PV. The efficacy of negative pressure wound therapy in the management of lower extremity trauma: review of clinical evidence. Injury. 2007;38(Suppl 5):S9–18.PubMed
14.
Zurück zum Zitat Petzina R, Hoffmann J, Navasardyan A, Malmsjo M, Stamm C, Unbehaun A, et al. Negative pressure wound therapy for post-sternotomy mediastinitis reduces mortality rate and sternal re-infection rate compared to conventional treatment. Eur J Cardiothorac Surg. 2010;38(1):110–3.CrossRef Petzina R, Hoffmann J, Navasardyan A, Malmsjo M, Stamm C, Unbehaun A, et al. Negative pressure wound therapy for post-sternotomy mediastinitis reduces mortality rate and sternal re-infection rate compared to conventional treatment. Eur J Cardiothorac Surg. 2010;38(1):110–3.CrossRef
15.
Zurück zum Zitat McGarry TJ, Joshi R, Kawata H, Patel J, Feld G, Birgersdotter-Green UM, et al. Pocket infections of cardiac implantable electronic devices treated by negative pressure wound therapy. Europace. 2014;16(3):372–7.CrossRef McGarry TJ, Joshi R, Kawata H, Patel J, Feld G, Birgersdotter-Green UM, et al. Pocket infections of cardiac implantable electronic devices treated by negative pressure wound therapy. Europace. 2014;16(3):372–7.CrossRef
16.
Zurück zum Zitat Poller WC, Schwerg M, Melzer C. Therapy of cardiac device pocket infections with vacuum-assisted wound closure-long-term follow-up. Pacing Clin Electrophysiol. 2012;35(10):1217–21.CrossRef Poller WC, Schwerg M, Melzer C. Therapy of cardiac device pocket infections with vacuum-assisted wound closure-long-term follow-up. Pacing Clin Electrophysiol. 2012;35(10):1217–21.CrossRef
17.
Zurück zum Zitat Dy Chua J, Abdul-Karim A, Mawhorter S, Procop GW, Tchou P, Niebauer M, et al. The role of swab and tissue culture in the diagnosis of implantable cardiac device infection. Pacing Clin Electrophysiol. 2005;28(12):1276–81.CrossRef Dy Chua J, Abdul-Karim A, Mawhorter S, Procop GW, Tchou P, Niebauer M, et al. The role of swab and tissue culture in the diagnosis of implantable cardiac device infection. Pacing Clin Electrophysiol. 2005;28(12):1276–81.CrossRef
18.
Zurück zum Zitat Cabell CH, Heidenreich PA, Chu VH, Moore CM, Stryjewski ME, Corey GR, et al. Increasing rates of cardiac device infections among Medicare beneficiaries: 1990-1999. Am Heart J. 2004;147(4):582–6.CrossRef Cabell CH, Heidenreich PA, Chu VH, Moore CM, Stryjewski ME, Corey GR, et al. Increasing rates of cardiac device infections among Medicare beneficiaries: 1990-1999. Am Heart J. 2004;147(4):582–6.CrossRef
19.
Zurück zum Zitat Voigt A, Shalaby A, Saba S. Continued rise in rates of cardiovascular implantable electronic device infections in the United States: temporal trends and causative insights. Pacing Clin Electrophysiol. 2010;33(4):414–9.CrossRef Voigt A, Shalaby A, Saba S. Continued rise in rates of cardiovascular implantable electronic device infections in the United States: temporal trends and causative insights. Pacing Clin Electrophysiol. 2010;33(4):414–9.CrossRef
20.
Zurück zum Zitat Kirkfeldt RE, Johansen JB, Nohr EA, Jorgensen OD, Nielsen JC. Complications after cardiac implantable electronic device implantations: an analysis of a complete, nationwide cohort in Denmark. Eur Heart J. 2014;35(18):1186–94.CrossRef Kirkfeldt RE, Johansen JB, Nohr EA, Jorgensen OD, Nielsen JC. Complications after cardiac implantable electronic device implantations: an analysis of a complete, nationwide cohort in Denmark. Eur Heart J. 2014;35(18):1186–94.CrossRef
21.
Zurück zum Zitat Wazni O, Wilkoff BL. Considerations for cardiac device lead extraction. Nat Rev Cardiol. 2016;13(4):221–9.CrossRef Wazni O, Wilkoff BL. Considerations for cardiac device lead extraction. Nat Rev Cardiol. 2016;13(4):221–9.CrossRef
22.
Zurück zum Zitat Zhou X, Jiang H, Ma J, Bakhai A, Li J, Zhang Y, et al. Comparison of standard and modified transvenous techniques for complex pacemaker lead extractions in the context of cardiac implantable electronic device-related infections: a 10-year experience. Europace. 2013;15(11):1629–35.CrossRef Zhou X, Jiang H, Ma J, Bakhai A, Li J, Zhang Y, et al. Comparison of standard and modified transvenous techniques for complex pacemaker lead extractions in the context of cardiac implantable electronic device-related infections: a 10-year experience. Europace. 2013;15(11):1629–35.CrossRef
23.
Zurück zum Zitat Klug D, Wallet F, Lacroix D, Marquie C, Kouakam C, Kacet S, et al. Local symptoms at the site of pacemaker implantation indicate latent systemic infection. Heart. 2004;90(8):882–6.CrossRef Klug D, Wallet F, Lacroix D, Marquie C, Kouakam C, Kacet S, et al. Local symptoms at the site of pacemaker implantation indicate latent systemic infection. Heart. 2004;90(8):882–6.CrossRef
24.
Zurück zum Zitat Satsu T, Onoe M. Vacuum-assisted wound closure for pacemaker infection. Pacing and clinical electrophysiology. 2010;33(4):426–30.CrossRef Satsu T, Onoe M. Vacuum-assisted wound closure for pacemaker infection. Pacing and clinical electrophysiology. 2010;33(4):426–30.CrossRef
25.
Zurück zum Zitat Puri R, Psaltis PJ, Nelson AJ, Sanders P, Young GD. Povidone-iodine irrigation-a possible alternative to lead extraction. Indian Pacing Electrophysiol J. 2011;11(4):115–9.PubMedPubMedCentral Puri R, Psaltis PJ, Nelson AJ, Sanders P, Young GD. Povidone-iodine irrigation-a possible alternative to lead extraction. Indian Pacing Electrophysiol J. 2011;11(4):115–9.PubMedPubMedCentral
26.
Zurück zum Zitat Tarakji KG, Chan EJ, Cantillon DJ, Doonan AL, Hu T, Schmitt S, et al. Cardiac implantable electronic device infections: presentation, management, and patient outcomes. Heart Rhythm. 2010;7(8):1043–7.CrossRef Tarakji KG, Chan EJ, Cantillon DJ, Doonan AL, Hu T, Schmitt S, et al. Cardiac implantable electronic device infections: presentation, management, and patient outcomes. Heart Rhythm. 2010;7(8):1043–7.CrossRef
27.
Zurück zum Zitat Morykwas MJ, Argenta LC, Shelton-Brown EI, McGuirt W. Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg. 1997;38(6):553–62.CrossRef Morykwas MJ, Argenta LC, Shelton-Brown EI, McGuirt W. Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg. 1997;38(6):553–62.CrossRef
28.
Zurück zum Zitat Morykwas MJ, Simpson J, Punger K, Argenta A, Kremers L, Argenta J. Vacuum-assisted closure: state of basic research and physiologic foundation. Plast Reconstr Surg. 2006;117(7 Suppl):121S–6S.CrossRef Morykwas MJ, Simpson J, Punger K, Argenta A, Kremers L, Argenta J. Vacuum-assisted closure: state of basic research and physiologic foundation. Plast Reconstr Surg. 2006;117(7 Suppl):121S–6S.CrossRef
29.
Zurück zum Zitat Saxena V, Hwang CW, Huang S, Eichbaum Q, Ingber D, Orgill DP. Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plast Reconstr Surg. 2004;114(5):1086–96 discussion 97-8.CrossRef Saxena V, Hwang CW, Huang S, Eichbaum Q, Ingber D, Orgill DP. Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plast Reconstr Surg. 2004;114(5):1086–96 discussion 97-8.CrossRef
30.
Zurück zum Zitat Wang J, Zhang H, Wang S. Application of vacuum sealing drainage in the treatment of internal fixation instrument exposure after early postoperative infection. Minerva Chir. 2015;70(1):17–22.PubMed Wang J, Zhang H, Wang S. Application of vacuum sealing drainage in the treatment of internal fixation instrument exposure after early postoperative infection. Minerva Chir. 2015;70(1):17–22.PubMed
31.
Zurück zum Zitat Pawar DRL, Mitchell SJ, Jeyapalina S, Hawkes JE, Florell SR, Bachus KN. Peri-prosthetic tissue reaction to discontinuation of negative pressure wound therapy around porous titanium percutaneous devices. J Biomed Mater Res B Appl Biomater. 2018. Pawar DRL, Mitchell SJ, Jeyapalina S, Hawkes JE, Florell SR, Bachus KN. Peri-prosthetic tissue reaction to discontinuation of negative pressure wound therapy around porous titanium percutaneous devices. J Biomed Mater Res B Appl Biomater. 2018.
32.
Zurück zum Zitat Santarpino G, Gazdag L, Sirch J, Vogt F, Ledwon M, Fischlein T, et al. A retrospective study to evaluate use of negative pressure wound therapy in patients undergoing bilateral internal thoracic artery grafting. Ostomy Wound Manage. 2015;61(12):26–30.PubMed Santarpino G, Gazdag L, Sirch J, Vogt F, Ledwon M, Fischlein T, et al. A retrospective study to evaluate use of negative pressure wound therapy in patients undergoing bilateral internal thoracic artery grafting. Ostomy Wound Manage. 2015;61(12):26–30.PubMed
33.
Zurück zum Zitat Copeland H, Newcombe J, Yamin F, Bhajri K, Mille VA, Hasaniya N, et al. Role of negative pressure wound care and hyperbaric oxygen therapy for sternal wound infections after pediatric cardiac surgery. World J Pediatr Congenit Heart Surg. 2018;9(4):440–5.CrossRef Copeland H, Newcombe J, Yamin F, Bhajri K, Mille VA, Hasaniya N, et al. Role of negative pressure wound care and hyperbaric oxygen therapy for sternal wound infections after pediatric cardiac surgery. World J Pediatr Congenit Heart Surg. 2018;9(4):440–5.CrossRef
34.
Zurück zum Zitat Petit-Clair N, Smith M, Chernev I. Modified NPWT using round channel drain for pacemaker pocket non-healing complex wound: a case report.pdf. J Wound Care. 2014;23(9):453–5.CrossRef Petit-Clair N, Smith M, Chernev I. Modified NPWT using round channel drain for pacemaker pocket non-healing complex wound: a case report.pdf. J Wound Care. 2014;23(9):453–5.CrossRef
35.
Zurück zum Zitat Thomas S, Nicolas D, Christopher P, Sebastian H, Friedrich WM. Vacuum-assisted treatment of severe pacemaker pocket infection. Herzschrittmacherther Elektrophysiol. 2008;19(4):181–4.CrossRef Thomas S, Nicolas D, Christopher P, Sebastian H, Friedrich WM. Vacuum-assisted treatment of severe pacemaker pocket infection. Herzschrittmacherther Elektrophysiol. 2008;19(4):181–4.CrossRef
36.
Zurück zum Zitat Mahmood M, Kendi AT, Farid S, Ajmal S, Johnson GB, Baddour LM, et al. Role of (18)F-FDG PET/CT in the diagnosis of cardiovascular implantable electronic device infections: a meta-analysis. J Nucl Cardiol. 2019;26(3):958–70.CrossRef Mahmood M, Kendi AT, Farid S, Ajmal S, Johnson GB, Baddour LM, et al. Role of (18)F-FDG PET/CT in the diagnosis of cardiovascular implantable electronic device infections: a meta-analysis. J Nucl Cardiol. 2019;26(3):958–70.CrossRef
37.
Zurück zum Zitat Juneau D, Golfam M, Hazra S, Zuckier LS, Garas S, Redpath C et al. Positron emission tomography and single-photon emission computed tomography imaging in the diagnosis of cardiac implantable electronic device infection: a systematic review and meta-analysis. Circ Cardiovasc Imaging. 2017;10(4). Juneau D, Golfam M, Hazra S, Zuckier LS, Garas S, Redpath C et al. Positron emission tomography and single-photon emission computed tomography imaging in the diagnosis of cardiac implantable electronic device infection: a systematic review and meta-analysis. Circ Cardiovasc Imaging. 2017;10(4).
38.
Zurück zum Zitat Sollini M, Berchiolli R, Delgado Bolton RC, Rossi A, Kirienko M, Boni R, et al. The “3M” approach to cardiovascular infections: multimodality, multitracers, and multidisciplinary. Semin Nucl Med. 2018;48(3):199–224.CrossRef Sollini M, Berchiolli R, Delgado Bolton RC, Rossi A, Kirienko M, Boni R, et al. The “3M” approach to cardiovascular infections: multimodality, multitracers, and multidisciplinary. Semin Nucl Med. 2018;48(3):199–224.CrossRef
Metadaten
Titel
Negative-pressure wound therapy (NPWT) for the treatment of pacemaker pocket infection in patients unable or unwilling to undergo CIED extraction
verfasst von
Shengwu Zheng
Xiongmei Huang
Yazhou Lin
Xiaohui Chen
Genhui Lin
Jing Zhuang
Publikationsdatum
22.06.2020
Verlag
Springer US
Erschienen in
Journal of Interventional Cardiac Electrophysiology / Ausgabe 2/2021
Print ISSN: 1383-875X
Elektronische ISSN: 1572-8595
DOI
https://doi.org/10.1007/s10840-020-00805-y

Weitere Artikel der Ausgabe 2/2021

Journal of Interventional Cardiac Electrophysiology 2/2021 Zur Ausgabe

Das Risiko für Vorhofflimmern in der Bevölkerung steigt

02.05.2024 Vorhofflimmern Nachrichten

Das Risiko, im Lauf des Lebens an Vorhofflimmern zu erkranken, ist in den vergangenen 20 Jahren gestiegen: Laut dänischen Zahlen wird es drei von zehn Personen treffen. Das hat Folgen weit über die Schlaganfallgefährdung hinaus.

VHF-Ablation nützt wohl nur bei reduzierter Auswurfleistung

02.05.2024 Ablationstherapie Nachrichten

Ob die Katheterablation von Vorhofflimmern bei Patienten mit Herzinsuffizienz die Komplikationsraten senkt, scheint davon abzuhängen, ob die Auswurfleistung erhalten ist oder nicht. Das legen die Ergebnisse einer Metaanalyse nahe.

Weniger Extremitätenischämien mit dualer Plättchenhemmung

02.05.2024 Thrombozytenaggregationshemmer Nachrichten

Eine Behandlung mit Ticagrelor zusätzlich zu ASS kann das Risiko für Revaskularisierungen und Amputationen von Extremitäten bei Diabetikern mit stabiler KHK deutlich reduzieren, vor allem für solche mit PAVK. Dafür spricht eine Auswertung der Interventionsstudie THEMIS.

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärzte und Psychotherapeuten.

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.