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Erschienen in: Journal of Natural Medicines 3/2018

01.06.2018 | Original Paper

New geranyl flavonoids from the leaves of Artocarpus communis

verfasst von: Masamitsu Inoue, Yuki Hitora, Hikaru Kato, Fitje Losung, Remy E. P. Mangindaan, Sachiko Tsukamoto

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2018

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Abstract

Four new geranyl flavonoids 14 and four known flavonoids 58 were obtained from the leaves of Artocarpus communis collected in Indonesia. The planar structures of flavonoids were elucidated by analyses of MS and NMR spectroscopic data. Absolute configurations of 1 and 2 were determined by ECD spectroscopy. Analyses by HPLC with a chiral-phase column and ECD spectra confirmed that 3 and 4 were stereoisomeric mixtures and 7 and 8 were racemic mixtures. The compounds obtained in this study inhibited the enzymatic activities of ubiquitin-specific protease 7 (USP7) and the chymotrypsin-like activity of the proteasome. Among the geranyl flavonoids tested in this experiment, the USP7 inhibitory activity of 6 (IC50 value, 0.094 μM) was 55 times more potent than the commercially available positive control, P5091 (IC50 value, 5.2 μM).
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Metadaten
Titel
New geranyl flavonoids from the leaves of Artocarpus communis
verfasst von
Masamitsu Inoue
Yuki Hitora
Hikaru Kato
Fitje Losung
Remy E. P. Mangindaan
Sachiko Tsukamoto
Publikationsdatum
01.06.2018
Verlag
Springer Singapore
Erschienen in
Journal of Natural Medicines / Ausgabe 3/2018
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-018-1192-z

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