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Journal of Natural Medicines

Erschienen in:

21.08.2021 | Original Paper

New monoterpenoids from the stigmas of Crocus sativus

verfasst von: Qing-Wei Fang, Wen-Wei Fu, Jin-Ling Yang, Yue Lu, Jiang-Cheng Chen, Pei-Ying Wu, Xue Zhang, Hong-Xi Xu

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2022

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Abstract

One new compound, crocusatin M (1), and three new glycosidic compounds, crocusatins N-P (2–4), along with nine known compounds were isolated from the dried stigmas of Crocus sativus. The structures of new compounds were elucidated on the basis of spectroscopic analysis, and the absolute configurations of 1, 2, and 3 were unambiguously assigned by the comparison of experimental and calculated ECD data. This is the first report of the isolation of 4 with the HMG moiety from the genus Crocus. Compounds 1 and 4 exhibited weak anti-inflammatory activities on inhibiting lipopolysaccharide (LPS)-induced NO production.

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Titel: New monoterpenoids from the stigmas of Crocus sativus
verfasst von: Qing-Wei Fang
Wen-Wei Fu
Jin-Ling Yang
Yue Lu
Jiang-Cheng Chen
Pei-Ying Wu
Xue Zhang
Hong-Xi Xu
Publikationsdatum: 21.08.2021
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2022
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-021-01559-1

Springer Medizin

Abstract

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