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Breast Cancer Research

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01.12.2009 | Short communication

Next-generation sequencing

verfasst von: Jorge S Reis-Filho

Erschienen in: Breast Cancer Research | Sonderheft 3/2009

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Abstract

Next-generation sequencing (also known as massively parallel sequencing) technologies are revolutionising our ability to characterise cancers at the genomic, transcriptomic and epigenetic levels. Cataloguing all mutations, copy number aberrations and somatic rearrangements in an entire cancer genome at base pair resolution can now be performed in a matter of weeks. Furthermore, massively parallel sequencing can be used as a means for unbiased transcriptomic analysis of mRNAs, small RNAs and noncoding RNAs, genome-wide methylation assays and high-throughput chromatin immunoprecipitation assays. Here, I discuss the potential impact of this technology on breast cancer research and the challenges that come with this technological breakthrough.

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Titel: Next-generation sequencing
verfasst von: Jorge S Reis-Filho
Publikationsdatum: 01.12.2009
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe Sonderheft 3/2009
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2431

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