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Osteoporosis International

Erschienen in:

01.08.2006 | Original Article

No effect of vitamin K₁ intake on bone mineral density and fracture risk in perimenopausal women

verfasst von: L. Rejnmark, P. Vestergaard, P. Charles, A. P. Hermann, C. Brot, P. Eiken, L. Mosekilde

Erschienen in: Osteoporosis International | Ausgabe 8/2006

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Abstract

Introduction

Vitamin K functions as a co-factor in the post-translational carboxylation of several bone proteins, including osteocalcin.

Aim

The aim of this study was to investigate the relationship between vitamin K₁ intake and bone mineral density (BMD) and fracture risk in a perimenopausal Danish population.

Design

The study was performed within the Danish Osteoporosis Prevention Study (DOPS), including a population-based cohort of 2,016 perimenopausal women. During the study approximately 50% of the women received hormone replacement therapy (HRT). Associations between vitamin K₁ intake and BMD were assessed at baseline and after 5-years of follow-up (cross-sectional design). Moreover, associations between vitamin K₁ intake and 5-year and 10-year changes in BMD were studied (follow-up design). Finally, fracture risk was assessed in relation to vitamin K₁ intake (nested case–control design).

Results

In our cohort, dietary vitamin K₁ intake (60 μg/day) was close to the daily intake recommended by the Food and Agriculture Organization (FAO). Cross-sectional and longitudinal analyses showed no associations between intake of vitamin K₁ and BMD of the femoral neck or lumbar spine. Neither did BMD differ between those 5% that had the highest vitamin K₁ intake and those 5% that had the lowest. During the 10-years of follow-up, 360 subjects sustained a fracture (cases). In a comparison between the cases and 1,440 controls, logistic regression analyses revealed no difference in vitamin K₁ intake between cases and controls.

Conclusion

In a group of perimenopausal and early postmenopausal women, vitamin K₁ intake was not associated with effects on BMD or fracture risk.

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Titel: No effect of vitamin K1 intake on bone mineral density and fracture risk in perimenopausal women
verfasst von: L. Rejnmark
P. Vestergaard
P. Charles
A. P. Hermann
C. Brot
P. Eiken
L. Mosekilde
Publikationsdatum: 01.08.2006
Verlag: Springer-Verlag
Erschienen in: Osteoporosis International / Ausgabe 8/2006
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-005-0044-3

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Abstract

Introduction

Aim

Design

Results

Conclusion

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