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European Journal of Nuclear Medicine and Molecular Imaging
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 10/2008

01.10.2008 | Original Article

Non-invasive estimation of hepatic blood perfusion from H2 15O PET images using tissue-derived arterial and portal input functions

verfasst von: N. Kudomi, L. Slimani, M. J. Järvisalo, J. Kiss, R. Lautamäki, G. A. Naum, T. Savunen, J. Knuuti, H. Iida, P. Nuutila, P. Iozzo

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 10/2008

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Abstract

Purpose

The liver is perfused through the portal vein and the hepatic artery. When its perfusion is assessed using positron emission tomography (PET) and 15O-labeled water (H2 15O), calculations require a dual blood input function (DIF), i.e., arterial and portal blood activity curves. The former can be generally obtained invasively, but blood withdrawal from the portal vein is not feasible in humans. The aim of the present study was to develop a new technique to estimate quantitative liver perfusion from H2 15O PET images with a completely non-invasive approach.

Methods

We studied normal pigs (n = 14) in which arterial and portal blood tracer concentrations and Doppler ultrasonography flow rates were determined invasively to serve as reference measurements. Our technique consisted of using model DIF to create tissue model function and the latter method to simultaneously fit multiple liver time–activity curves from images. The parameters obtained reproduced the DIF. Simulation studies were performed to examine the magnitude of potential biases in the flow values and to optimize the extraction of multiple tissue curves from the image.

Results

The simulation showed that the error associated with assumed parameters was <10%, and the optimal number of tissue curves was between 10 and 20. The estimated DIFs were well reproduced against the measured ones. In addition, the calculated liver perfusion values were not different between the methods and showed a tight correlation (r = 0.90).

Conclusion

In conclusion, our results demonstrate that DIF can be estimated directly from tissue curves obtained through H2 15O PET imaging. This suggests the possibility to enable completely non-invasive technique to assess liver perfusion in patho-physiological studies.
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Metadaten
Titel
Non-invasive estimation of hepatic blood perfusion from H2 15O PET images using tissue-derived arterial and portal input functions
verfasst von
N. Kudomi
L. Slimani
M. J. Järvisalo
J. Kiss
R. Lautamäki
G. A. Naum
T. Savunen
J. Knuuti
H. Iida
P. Nuutila
P. Iozzo
Publikationsdatum
01.10.2008
Verlag
Springer-Verlag
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 10/2008
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-008-0796-z

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