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Erschienen in: Current Reviews in Musculoskeletal Medicine 3/2011

01.09.2011

Non-surgical treatment of osteoarthritis-related pain in the elderly

verfasst von: Saulat Mushtaq, Rabeea Choudhary, Carla R. Scanzello

Erschienen in: Current Reviews in Musculoskeletal Medicine | Ausgabe 3/2011

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Abstract

Osteoarthritis (OA), the third most common diagnosis in the elderly [1], causes significant pain leading to disability and decreased quality of life in subjects 65 years and older [2]. Traditionally, clinicians have relied heavily on the use of non-steroidal anti-inflammatory drugs (NSAIDs) to treat the pain of OA, as numerous studies have proven these agents to be effective. The cardiovascular, gastrointestinal, renal and hepatic toxicities of NSAIDs have limited their use, particularly in the elderly. Acetaminophen has been recommended as initial therapy due to relative safety. Several other topical, oral and intra-articular agents are available today, with use limited by efficacy and side effect profiles. Many non-pharmacologic approaches are available but underused, and may be attractive choices to avoid poly-pharmacy in older patients. We will attempt to highlight the evidence behind available non-surgical therapies for OA while paying specific attention to issues in geriatric patients.
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Zurück zum Zitat • Chevalier X, Goupille P, Beaulieu AD, et al.: Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthrit Care Res 2009;61:344–52. A 12-week RCT of this agent, originally developed to treat Rheumatoid Arthritis. In this study, anakinra was used as a single injection intra-articularly, and failed to show improvement in OA pain. Although results were disappointing, IL-1 blockade using longer-acting agents and different regimens are currently being studied, and may become available in the future. • Chevalier X, Goupille P, Beaulieu AD, et al.: Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthrit Care Res 2009;61:344–52. A 12-week RCT of this agent, originally developed to treat Rheumatoid Arthritis. In this study, anakinra was used as a single injection intra-articularly, and failed to show improvement in OA pain. Although results were disappointing, IL-1 blockade using longer-acting agents and different regimens are currently being studied, and may become available in the future.
86.
Zurück zum Zitat Watson JJ, Allen SJ, Dawbarn D. Targeting nerve growth factor in pain: what is the therapeutic potential? BioDrugs. 2008;22:349–59.PubMedCrossRef Watson JJ, Allen SJ, Dawbarn D. Targeting nerve growth factor in pain: what is the therapeutic potential? BioDrugs. 2008;22:349–59.PubMedCrossRef
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Zurück zum Zitat •• Lane NE, Schnitzer TJ, Birbara CA, et al.: Tanezumab for the treatment of pain from osteoarthritis of the knee. N Engl J Med 2010;363:1521–1531. Tanezumab™, a novel agent targeted nerve-growth factor, produced significant pain reduction compared with placebo but caused headaches, URIs and hypoesthesias. Although initially promising,recent concerns that this agent may have hastened the need for joint replacement in study patients resulted in the discontinuation of this trial. •• Lane NE, Schnitzer TJ, Birbara CA, et al.: Tanezumab for the treatment of pain from osteoarthritis of the knee. N Engl J Med 2010;363:1521–1531. Tanezumab™, a novel agent targeted nerve-growth factor, produced significant pain reduction compared with placebo but caused headaches, URIs and hypoesthesias. Although initially promising,recent concerns that this agent may have hastened the need for joint replacement in study patients resulted in the discontinuation of this trial.
88.
Zurück zum Zitat • Dekker J, van Dijk GM, Veenhof C: Risk factors for functional decline in osteoarthritis of the hip or knee. Curr Opin Rheumatol 2009;21:520–524. A useful review of the risk factors for functional decline in the elderly, which include physical impairments from osteoarthritis (pain, stiffness, reduced muscle strength, joint instability, proprioceptive inaccuracy, poor balance and impaired range of motion), as well as cognitive and visual impairments, comorbidities, psychological and social factors, health behaviors and socio-demographic factors. This can be useful for patients and physicians and encourages the approach of treating the “whole patient”, not just the osteoarthritis. • Dekker J, van Dijk GM, Veenhof C: Risk factors for functional decline in osteoarthritis of the hip or knee. Curr Opin Rheumatol 2009;21:520–524. A useful review of the risk factors for functional decline in the elderly, which include physical impairments from osteoarthritis (pain, stiffness, reduced muscle strength, joint instability, proprioceptive inaccuracy, poor balance and impaired range of motion), as well as cognitive and visual impairments, comorbidities, psychological and social factors, health behaviors and socio-demographic factors. This can be useful for patients and physicians and encourages the approach of treating the “whole patient”, not just the osteoarthritis.
Metadaten
Titel
Non-surgical treatment of osteoarthritis-related pain in the elderly
verfasst von
Saulat Mushtaq
Rabeea Choudhary
Carla R. Scanzello
Publikationsdatum
01.09.2011
Verlag
Current Science Inc.
Erschienen in
Current Reviews in Musculoskeletal Medicine / Ausgabe 3/2011
Elektronische ISSN: 1935-9748
DOI
https://doi.org/10.1007/s12178-011-9084-9

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