Erschienen in:
01.12.2002 | Paper Report
NSAIDs inhibit p38 MAPK activation
verfasst von:
Cheryl Smythe
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2001
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Excerpt
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity. Predominantly acting on macrophages and neutrophils, they have also been shown to suppress T-cell proliferation, expression of surface markers of activation and the secretion of cytokines. NSAIDs mediate these immunosuppressive effects by blocking transcription factors such as nuclear factor of activated T cells (NF-AT) and NF-?B. The effects of NSAIDs on components of the T-cell antigen receptor (TCR) signalling cascade proximal to transcription factor activation were investigated in this study. …