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Erschienen in: Sleep and Breathing 3/2021

06.01.2021 | Sleep Breathing Physiology and Disorders • Original Article

Obstructive sleep apnea syndrome as a potential cause of sexual dysfunction in women

Sexual dysfunction in women

verfasst von: Mehmet Kabak, Mahir Akbudak

Erschienen in: Sleep and Breathing | Ausgabe 3/2021

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Abstract

Background

Obstructive sleep apnea (OSA) is defined as the cessation of respiration due to recurrent and partial or complete blockade of the upper airways during sleep. Nocturnal hypoxemia due to OSA may accompany these conditions, with significant negative impact on the life quality of patients leading to mental and/or sexual dysfunction. OSA as a cause of sexual dysfunction in women has been subject to very little research. The goal of this study was to examine the effect of OSA on sexual functions in women suffering from this disorder.

Methods

Patients with OSA were categorized into two groups, those with and those without sexual dysfunction.

Results

When women with OSA and healthy women were compared, age (p < 0.001), body mass index (BMI) (p < 0.001), Beck Anxiety Inventory (BAI) (p < 0.001), Beck Depression Inventory (BDI) (p = 0.001), there was a significant difference in the Arizona Sexual Experience Scale (ASEX), (p = 0.02). When women with OSA were compared in terms of sexual dysfunction, a significant difference was found in apnea-hypopnea index (AHI) (p = 0.01) and ASEX (p < 0.001). There were no significant differences in hormonal parameters between the two groups.

Conclusion

Sexual dysfunction in females is a largely under-recognized but important condition. Symptoms caused by OSA may include sexual dysfunction which may increase the prevalence of depression and anxiety, further reducing the quality of life.
Literatur
1.
Zurück zum Zitat Malhotra A, White DP (2002) Obstructive sleep apnea. Lancet 360:237–245CrossRef Malhotra A, White DP (2002) Obstructive sleep apnea. Lancet 360:237–245CrossRef
2.
Zurück zum Zitat Kapur VK, Auckley DH, Chowdhuri S, Kuhlmann DC, Mehra R, Ramar K, Harrod CG (2017) Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American academy of sleep medicine clinical practice guideline. J Clin Sleep Med 13(3):479–504CrossRef Kapur VK, Auckley DH, Chowdhuri S, Kuhlmann DC, Mehra R, Ramar K, Harrod CG (2017) Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American academy of sleep medicine clinical practice guideline. J Clin Sleep Med 13(3):479–504CrossRef
3.
Zurück zum Zitat Khafagy A, Khafagy A (2012) Treatment of obstructive sleep apnoea as a therapeutic modality for associated erectile dysfunction. Int J Clin Pract 66:1204–1208CrossRef Khafagy A, Khafagy A (2012) Treatment of obstructive sleep apnoea as a therapeutic modality for associated erectile dysfunction. Int J Clin Pract 66:1204–1208CrossRef
4.
Zurück zum Zitat Hanak V, Jacobson D, McGree M, Sauver J, Lieber M, Olson E et al (2008) Snoring as a risk factor for sexual dysfunction in community men. J Sex Med 5:898–908CrossRef Hanak V, Jacobson D, McGree M, Sauver J, Lieber M, Olson E et al (2008) Snoring as a risk factor for sexual dysfunction in community men. J Sex Med 5:898–908CrossRef
5.
Zurück zum Zitat Chen CM, Tsai MJ, Wei PJ, Su YC, Yang CJ, Wu MN, Hsu CY, Hwang SJ, Chong IW, Huang MS (2015) Erectile dysfunction in patients with sleep apnea- a nationwide population-based study. PLoS One 10:e0132510CrossRef Chen CM, Tsai MJ, Wei PJ, Su YC, Yang CJ, Wu MN, Hsu CY, Hwang SJ, Chong IW, Huang MS (2015) Erectile dysfunction in patients with sleep apnea- a nationwide population-based study. PLoS One 10:e0132510CrossRef
6.
Zurück zum Zitat Onem K, Bulent E, Sanli O, Kadioglu P, Yalin AS, Canik U et al (2008) Is sexual dysfunction in women with obstructive sleep apnea-hypopnea syndrome associated with the severity of the disease? A pilot study. J Sex Med 5:2600–2609CrossRef Onem K, Bulent E, Sanli O, Kadioglu P, Yalin AS, Canik U et al (2008) Is sexual dysfunction in women with obstructive sleep apnea-hypopnea syndrome associated with the severity of the disease? A pilot study. J Sex Med 5:2600–2609CrossRef
7.
Zurück zum Zitat Köseoglu N, Köseoglu H, Itil O, Öztura I, Baklan B, Ikiz AO et al (2007) Sexual function status in women with obstructive sleep apnea syndrome. J Sex Med 4:1352–1357CrossRef Köseoglu N, Köseoglu H, Itil O, Öztura I, Baklan B, Ikiz AO et al (2007) Sexual function status in women with obstructive sleep apnea syndrome. J Sex Med 4:1352–1357CrossRef
8.
Zurück zum Zitat Subramanian S, Bopparaju S, Desai A, Wiggins T, Rambaud C, Surani S (2010) Sexual dysfunction in women with obstructive sleep apnea. Sleep Breath 14:59–62CrossRef Subramanian S, Bopparaju S, Desai A, Wiggins T, Rambaud C, Surani S (2010) Sexual dysfunction in women with obstructive sleep apnea. Sleep Breath 14:59–62CrossRef
9.
Zurück zum Zitat Kammerer-Doak D, Rogers RG (2008) Female sexual function and dysfunction. ObstetGynecolClin North Am 35:169–183 Kammerer-Doak D, Rogers RG (2008) Female sexual function and dysfunction. ObstetGynecolClin North Am 35:169–183
10.
Zurück zum Zitat Addis IB, Van Den Eeden SK, Wassel-Fyr CL, Vittinghoff E, Brown JS, Thom DH (2006) Sexual activity and function in middle aged and older women. Obstet Gynecol 107:755–764CrossRef Addis IB, Van Den Eeden SK, Wassel-Fyr CL, Vittinghoff E, Brown JS, Thom DH (2006) Sexual activity and function in middle aged and older women. Obstet Gynecol 107:755–764CrossRef
11.
Zurück zum Zitat Kaviani H, Mousavi A (2008) Psychometric properties of the Persian version of Beck Anxiety Inventory (BAI). Tehran University Medical Journal TUMS Publications 2:136–140 Kaviani H, Mousavi A (2008) Psychometric properties of the Persian version of Beck Anxiety Inventory (BAI). Tehran University Medical Journal TUMS Publications 2:136–140
12.
Zurück zum Zitat Ulusoy M, Şahin N, Erkman H (1998) Turkish version of the Beck Anxiety Inventory: psychometric properties. J Cognitive Psychotherapy: Int Quaterly 12:28–35 Ulusoy M, Şahin N, Erkman H (1998) Turkish version of the Beck Anxiety Inventory: psychometric properties. J Cognitive Psychotherapy: Int Quaterly 12:28–35
13.
Zurück zum Zitat Ghassemzadeh H, Mojtabai R, Karamghadiri N, Ebrahimkhani N (2005) Psychometric properties of a Persian-language version of the Beck Depression Inventory-second edition: BDI-II-PERSIAN. Depression and Anxiety 4:185–192CrossRef Ghassemzadeh H, Mojtabai R, Karamghadiri N, Ebrahimkhani N (2005) Psychometric properties of a Persian-language version of the Beck Depression Inventory-second edition: BDI-II-PERSIAN. Depression and Anxiety 4:185–192CrossRef
14.
Zurück zum Zitat Hisli N A study on the validity of the Beck Depression Inventory. Turk Psychol J 6:118–123 Hisli N A study on the validity of the Beck Depression Inventory. Turk Psychol J 6:118–123
15.
Zurück zum Zitat McGahuey CA, Gelenberg AJ, Laukes CA, Moreno AM, Delgado PD, McKnnight MK et al (2006) The Arizona Sexual Experience Scale (ASEX): reliability and validity. J Sex Marital Ther 26(1):25 McGahuey CA, Gelenberg AJ, Laukes CA, Moreno AM, Delgado PD, McKnnight MK et al (2006) The Arizona Sexual Experience Scale (ASEX): reliability and validity. J Sex Marital Ther 26(1):25
16.
Zurück zum Zitat Soykan A (2004) The reliability and validity of Arizona sexual experiences scale in Turkish ESRD patients undergoing hemodialysis. Int J Import Res 16:531–534CrossRef Soykan A (2004) The reliability and validity of Arizona sexual experiences scale in Turkish ESRD patients undergoing hemodialysis. Int J Import Res 16:531–534CrossRef
17.
Zurück zum Zitat Jafari H, Lahsaeizadeh S, Jafari P, Karimi M (2008) Quality of life in thalassemia major: reliability and validity of the Persian version of the SF-36 questionnaire. J Postgrad Med 4:273 Jafari H, Lahsaeizadeh S, Jafari P, Karimi M (2008) Quality of life in thalassemia major: reliability and validity of the Persian version of the SF-36 questionnaire. J Postgrad Med 4:273
18.
Zurück zum Zitat Koçyiğit H, Aydemir Ö, Ölmez N, Memiş AK Reliability and validity of the Turkish version of short form-36 (SF-36): a study in a group of patients will rheumatic diseases. Turk J Drugs Ther 12:102–106 Koçyiğit H, Aydemir Ö, Ölmez N, Memiş AK Reliability and validity of the Turkish version of short form-36 (SF-36): a study in a group of patients will rheumatic diseases. Turk J Drugs Ther 12:102–106
19.
Zurück zum Zitat Rezaeitalab F, Moharrari F, Saberi S, Asadpour H, Rezaeetalab F (2014) The correlation of anxiety and depression with obstructive sleep apnea syndrome. J Res Med Sci 19(3):205–210PubMedPubMedCentral Rezaeitalab F, Moharrari F, Saberi S, Asadpour H, Rezaeetalab F (2014) The correlation of anxiety and depression with obstructive sleep apnea syndrome. J Res Med Sci 19(3):205–210PubMedPubMedCentral
20.
Zurück zum Zitat Valipour A (2012) Gender-related differences in the obstructive sleep apnea syndrome. Pneumologie. 66:584–588CrossRef Valipour A (2012) Gender-related differences in the obstructive sleep apnea syndrome. Pneumologie. 66:584–588CrossRef
21.
Zurück zum Zitat Daabis R, Gharraf H (2012) Predictors of anxiety and depression in patients with obstructive sleep apnea. Egypt J Chest Dis Tuberc 61:171–177CrossRef Daabis R, Gharraf H (2012) Predictors of anxiety and depression in patients with obstructive sleep apnea. Egypt J Chest Dis Tuberc 61:171–177CrossRef
22.
Zurück zum Zitat Shahraki Z, Ghajarzadeh M, Ganjali M (2019) Depression, anxiety, quality of life and sexual dysfunction in Zabol women with infertility. MAEDICA – a Journal of Clinical Medicine 14(2):131–134PubMed Shahraki Z, Ghajarzadeh M, Ganjali M (2019) Depression, anxiety, quality of life and sexual dysfunction in Zabol women with infertility. MAEDICA – a Journal of Clinical Medicine 14(2):131–134PubMed
23.
Zurück zum Zitat Basson R, Gilks T (2018) Women’s sexual dysfunction associated with psychiatric disorders and their treatment. Womens Health (Lond) 14:1745506518762664 Basson R, Gilks T (2018) Women’s sexual dysfunction associated with psychiatric disorders and their treatment. Womens Health (Lond) 14:1745506518762664
24.
Zurück zum Zitat El-sherbini AM, Bediwy AS, El-metwalli A (2011) Association between obstructive sleep apnea (OSA) and depression and the effect of continuous positive airway pressure (CPAP) treatment. Neuropsychiatric Dis Treatment 7:715–721 El-sherbini AM, Bediwy AS, El-metwalli A (2011) Association between obstructive sleep apnea (OSA) and depression and the effect of continuous positive airway pressure (CPAP) treatment. Neuropsychiatric Dis Treatment 7:715–721
25.
Zurück zum Zitat Lee SA, Paek JH, Han SH (2016) REM-related sleep disordered breathing is associated with depressive symptoms in men but not in women. Sleep Breath 20(3):995–1002CrossRef Lee SA, Paek JH, Han SH (2016) REM-related sleep disordered breathing is associated with depressive symptoms in men but not in women. Sleep Breath 20(3):995–1002CrossRef
26.
Zurück zum Zitat Gupta MA, Simpson FC Obstructive sleep apnea and psychiatric disorders: a systematic review. J Clin Sleep Med 11(2):165–175 Gupta MA, Simpson FC Obstructive sleep apnea and psychiatric disorders: a systematic review. J Clin Sleep Med 11(2):165–175
27.
Zurück zum Zitat Çelik M, Sarıkaya Y, Acar M, Kalenderoğlu A, Doğan S, Kaskalan E, Karataş M (2016 Winter) Effect of continuous positive airway pressure treatment on depression, anxiety and perceived stress levels in patients with obstructive sleep apnea syndrome. Turk J Psychiatry 27(4):244–250 Çelik M, Sarıkaya Y, Acar M, Kalenderoğlu A, Doğan S, Kaskalan E, Karataş M (2016 Winter) Effect of continuous positive airway pressure treatment on depression, anxiety and perceived stress levels in patients with obstructive sleep apnea syndrome. Turk J Psychiatry 27(4):244–250
29.
Zurück zum Zitat Kawahara S, Akashiba T, Akahoshi T, Horie T (2005) Nasal CPAP improves the quality of life and lessens the depressive symptoms in patients with obstructive sleep apnea syndrome. Intern Med 44(5):422–427CrossRef Kawahara S, Akashiba T, Akahoshi T, Horie T (2005) Nasal CPAP improves the quality of life and lessens the depressive symptoms in patients with obstructive sleep apnea syndrome. Intern Med 44(5):422–427CrossRef
32.
Zurück zum Zitat Popovic RM, White DP (1998) Upper airway muscle activity in normal women: influence of hormonal status. J Appl Physio 84:1055–1062CrossRef Popovic RM, White DP (1998) Upper airway muscle activity in normal women: influence of hormonal status. J Appl Physio 84:1055–1062CrossRef
33.
Zurück zum Zitat Jurado-Gámez B, Fernandez-Marin MC, Gómez-Chaparro JL, Muñoz-Cabrera L, Lopez-Barea J, Perez-Jimenez F et al (2011) Relationship of oxidative stres and endothelial dusfunction in sleep apnoea. EurRespir J 37:873–879CrossRef Jurado-Gámez B, Fernandez-Marin MC, Gómez-Chaparro JL, Muñoz-Cabrera L, Lopez-Barea J, Perez-Jimenez F et al (2011) Relationship of oxidative stres and endothelial dusfunction in sleep apnoea. EurRespir J 37:873–879CrossRef
34.
Zurück zum Zitat Petersen M, Kristensen E, Berg S, Giraldi A, Midgren B (2011) Sexual function in female patients with obstructive sleep apnea. J Sex Med 8:2560–2568CrossRef Petersen M, Kristensen E, Berg S, Giraldi A, Midgren B (2011) Sexual function in female patients with obstructive sleep apnea. J Sex Med 8:2560–2568CrossRef
35.
Zurück zum Zitat Stavaras C, Pastaka C, Papala M, Gravas S, Tzortzis V, Melekos M et al. Sexual function in pre- and post-menopausal women with obstructive sleep apnea syndrome International Journal of Impotence Research (2012) 24, 228–233 Stavaras C, Pastaka C, Papala M, Gravas S, Tzortzis V, Melekos M et al. Sexual function in pre- and post-menopausal women with obstructive sleep apnea syndrome International Journal of Impotence Research (2012) 24, 228–233
37.
Zurück zum Zitat Skoczyński S, Nowosielski K, Minarowski L, Brożek G, Oraczewska A, Glinka K et al. Sexual disorders and dyspnea among women with obstructive sleep apnea. Advances in Medical Sciences 65 (2020) 189–196190 Skoczyński S, Nowosielski K, Minarowski L, Brożek G, Oraczewska A, Glinka K et al. Sexual disorders and dyspnea among women with obstructive sleep apnea. Advances in Medical Sciences 65 (2020) 189–196190
38.
Zurück zum Zitat Liu L, Kang R Zhao S, Zhang T, Zhu W, Li E et al. Sexual dysfunction in patients with obstructive sleep apnea: a systematic review and meta-analysis J Sex Med 2015 ;12:1992–2003 Liu L, Kang R Zhao S, Zhang T, Zhu W, Li E et al. Sexual dysfunction in patients with obstructive sleep apnea: a systematic review and meta-analysis J Sex Med 2015 ;12:19922003
Metadaten
Titel
Obstructive sleep apnea syndrome as a potential cause of sexual dysfunction in women
Sexual dysfunction in women
verfasst von
Mehmet Kabak
Mahir Akbudak
Publikationsdatum
06.01.2021
Verlag
Springer International Publishing
Erschienen in
Sleep and Breathing / Ausgabe 3/2021
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-020-02275-y

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