14.07.2023 | Bild
Checkpoint-Inhibitoren-assoziierte Nephritis und Vaskulitis
Checkpoint-Inhibitoren-assoziierte tubulointerstitielle Nephritis und granulomatöse Vaskulitis
Tubulointerstitial nephritis and granulomatous vasculitis. (A) Tubulointerstitial nephritis developed with focal but extensive infiltration of inflammatory cells in the tubulointerstitium. (B) Tubulointerstitial nephritis was noted, but glomerular lesions could not be seen. (C) Mononuclear cells including eosinophils (arrowhead) infiltrated the interstitium with mild tubulitis (arrow). (D, E) Non-necrotizing and granulomatous vasculitis developed in interlobular arteries. (F) Infiltration of mononuclear inflammatory cells were found in arterial intima, arterial media (arrowhead), and
the arterial adventitia to the perivascular area without fibrinoid necrosis, indicating non-necrotizing and granulomatous arteritis. (A-C) HE stain; (D-F) PAM stain; (A) × 100, (B) × 200; (C, F) × 1,000; (D, E) × 400
Tominaga K. et al. doi.org/10.1186/s12882-023-03091-8 unter CC-BY 4.0 | Tominaga et al. BMC Nephrology 2023; 24(1):48 https://doi.org/10.1186/s12882-023-03091-8 veröffentlicht unter Creative Commons Namensnennung 4.0 International Lizenz (https://creativecommons.org/licenses/by/4.0/deed.de)