nach oben

BMC Musculoskeletal Disorders

Erschienen in:

Open Access 01.12.2020 | Research article

Open versus endoscopic carpal tunnel release: a systematic review and meta-analysis of randomized controlled trials

verfasst von: Yueying Li, Wenqi Luo, Guangzhi Wu, Shusen Cui, Zhan Zhang, Xiaosong Gu

Erschienen in: BMC Musculoskeletal Disorders | Ausgabe 1/2020

Abstract

Background

Endoscopic carpal tunnel release (ECTR) and open carpal tunnel release (OCTR) both have advantages and disadvantages for the treatment of carpal tunnel syndrome (CTS). We compared the effectiveness and safety of ECTR and OCTR based on evidence from a high-level randomized controlled trial.

Methods

We comprehensively searched PubMed, EMBASE, Cochrane Library, Web of Science, and Medline to identify relevant articles published until August 2019. Data regarding operative time, grip strength, Boston Carpal Tunnel Questionnaire scores, digital sensation, patient satisfaction, key pinch strength, return to work time, and complications were extracted and compared. All mean differences (MD) and odds ratios (OR) were expressed as ECTR relative to OCTR.

Results

Our meta-analysis contained twenty-eight studies. ECTR was associated with significantly higher satisfaction rates (MD, 3.13; 95% confidence interval [CI], 1.43 to 4.82; P = 0.0003), greater key pinch strengths (MD, 0.79 kg; 95% CI, 0.27 to 1.32; P = 0.003), earlier return to work times (MD, − 7.25 days; 95% CI, − 14.31 to − 0.19; P = 0.04), higher transient nerve injury rates (OR, 4.87; 95% CI, 1.37 to 17.25; P = 0.01), and a lower incidence of scar-related complications (OR, 0.20; 95% CI, 0.07 to 0.59; P = 0.004). The permanent nerve injury showed no significant differences between the two methods (OR, 1.93; 95% CI, 0.58 to 6.40; P = 0.28).

Conclusions

Overall, evidence from randomized controlled trials indicates that ECTR results in better recovery of daily life functions compared to OCTR, as revealed by higher satisfaction rates, greater key pinch strengths, earlier return to work times, and fewer scar-related complications. Our findings suggest that patients with CTS can be effectively managed with ECTR.

Yueying Li is the first author

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

CTS

Carpal tunnel syndrome

OCTR

Open carpal tunnel release

ECTR

Endoscopic carpal tunnel release

RCT

Randomized controlled trial

PRISMA

Preferred Reporting Items for Systematic Reviews and Meta-Analyses

BCTQ-S

Boston Carpal Tunnel Questionnaire Symptom Severity Scale

BCTQ-F

Boston Carpal Tunnel Questionnaire Functional Status Scale

RTW

Return to work

GRADE

Grading of Recommendations Assessment, Development, and Evaluation

Mean difference

Confidence interval

Odds ratio

Standard error

Background

Carpal tunnel syndrome (CTS), known as compressive median mononeuropathy at the wrist, causes tingling, numbness, and pain along the radial side of the hand [1]. The reported estimates for its annual prevalence range from 0.18 to 5% [2‐5]. CTS can be treated surgically or non-surgically; however, non-surgical management that involves wrist splinting, corticosteroid injections, and physiotherapy, is preferred over surgical management for mild and moderate CTS [6, 7]. Surgical treatments for CTS, including the open carpal tunnel release (OCTR) and endoscopic carpal tunnel release (ECTR) approach, are generally reserved for patients with severe symptoms or those who experienced conservative treatment failure [8, 9].

OCTR is a well-established surgical treatment for CTS [10]. However, it is associated with potential complications such as persistent weakness, pillar pain, formation of hypertrophic scars in the incisions that cross the wrist, scar tenderness, slow recovery, and a higher incidence of persistent pain [11]. In an attempt to avoid these complications, Chow [12] and Okutsu et al. [13] were the first to report the use of ECTR for the treatment of CTS in the English literature in 1989. This method allows for smaller skin incisions and better esthetic results than OCTR [1, 14, 15]. Nevertheless, ECTR is technically difficult, time consuming, and associated with incomplete transverse carpal ligament release and neurovascular injury [16‐20]. Several meta-analyses have compared various measures of effectiveness and safety between ECTR and OCTR [15, 21‐23]. However, these investigations failed to separate subgroups according to different follow-up times and utilized limited evaluations of patient outcomes; therefore, it is not clear which approach is associated with better clinical results [24, 25].

Therefore, we carried out a meta-analysis to compare the safety and availability between ECTR and OCTR according to randomized controlled trial (RCT) evidence. Specifically, we sought to determine if ECTR was superior to OCTR in terms of patient satisfaction, functional recovery, and complications.

Methods

Literature search

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) trial flow shows the inclusion process for the RCTs in the meta-analysis [26]. Two authors respectively used the following computerized bibliographic databases: PubMed, EMBASE, Cochrane Library, Web of Science, and Medline databases to search for relevant publications. Publications from the inception of each database to August 10, 2019 were searched. The keywords used in the searches were “carpal tunnel” plus “open incision” and “carpal tunnel” plus “endoscopic.” We also manually scanned the reference lists to identify other relevant studies, that were discovered using these search terms.

Eligibility criteria

A study was included if it was an RCT that compared OCTR and ECTR. The exclusion criteria were as follows: 1) descriptive or graphic outcomes with no standard deviation values, 2) studies that included modification surgery, 3) studies that did not coverage the follow-up time, 4) studies that only recorded limited qualitative findings, 5) studies published in a language other than English or Chinese, and 6) technique articles, abstracts, and nontherapeutic studies. Finally, two investigators independently reviewed all selected studies for inclusion.

Data abstraction

Two authors extracted valuable data from the included studies respectively. When data heterogeneity is present, it must be resolved by containing a third author until data heterogeneity was reached a consensus for all items.

The extracted data included publication year, region, sample capacity, intervention, follow-up interval, and outcomes in eligible studies. Plot-digitizing software (Plot Digitizer Version 2.6.4; Joseph Huwaldt and Scott Steinhorst, http://www.plot-digitizer.com-about.com/) was used to quantify the data only recorded graphically. The pooled analysis outcome parameters were as follows: operation duration; scores on several clinical indexes, including the Boston Carpal Tunnel Questionnaire Symptom Severity Scale (BCTQ-S), Boston Carpal Tunnel Questionnaire Functional Status Scale (BCTQ-F), Two-point Discrimination test, and Semmes-Weinstein monofilament test; grip strength; key pinch strength; time to return to work (RTW); patients’ subjective ratings of their satisfaction with symptom improvement following CTS release based on a scale of 0 to 100 points; and postoperative complications.

Validity assessment

The level of evidence was assessed by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines [27]. At least two authors respectively evaluated the risk of bias, and disagreements were discussed until a consensus was reached.

Statistical analysis

Continuous data were analyzed through the inverse-variance statistical and method and mean difference (MD) and 95% confidence intervals (CIs) were reported. Dichotomous data were analyzed through the Mantel-Haenszel statistical method and odds ratio (OR) and 95% CI were reported. All MD and OR values were collected and collated using the results from OCTR as the reference values. In addition, χ² and I² tests were percentage of total variation that were used to assess statistical heterogeneity. When the P value from the χ² test was < 0.10 or when the I² value > 50% significant heterogeneity was indicated, the possible sources of heterogeneity were examined. Pooled result of the outcome was assessed by random-effects model; otherwise, a fixed-effects model was used. All tests were two-tailed, and P < 0.05 were considered statistically significant. The funnel plot method and Egger’s test were utilized to evaluate the publication bias. Review Manager (version 5.3; The Nordic Cochrane Centre, Cochrane Collaboration, Copenhagen, Denmark) was used to further analyze the data.

Results

Studies selection and characteristics

Figure 1 summarizes the screening process of the identified articles in the final analysis. In the aggregate 5654 articles were confirmed from PubMed (n = 1416), EMBASE (n = 1755), Cochrane Library (n = 248), Web of Science (n = 1130), Medline (n = 1105), and reference lists (n = 0). After eliminated duplicates, 2248 articles remained. Reviews of the titles and abstracts decreased the articles to 103, finally this number reduced to 28 articles included in the meta-analysis after a more detailed review. Twenty-seven articles were published in English and one was published in Chinese. The included article characteristics are summed up in Table 1.

Table 1

Study characteristics of the randomized controlled trials included in the meta-analysis

Author	Year	Region	Groups, sample sizes, and techniques	Follow-up interval	Outcomes
Agee et al. [28]	1992	US	OCTR (n = 65): conventional release ECTR (n = 82): one-portal (2 cm)	1, 2, 3, 6, 9, 13, 26 week(s)	Return of hand use for ADL, time to RTW, grip strength, pinch strength, lateral/key and pulp strength, SW monofilament test, Phalen’s wrist flexion test, Tinel’s test, scar tenderness, radial and ulnar pillar tenderness, record of medication use, complications
Atroshi et al. [9]	2006	Sweden	OCTR (n = 65): 4 cm ECTR (n = 63): two-portal (1 cm)	3, 6 weeks; 3, 12 months	Pain, time to RTW, BCTQ-S, BCTQ-F, SF-12, sensation, grip strength, key pinch strength, DL, quality of life, SW monofilament test, 2PD test, complications
Atroshi et al. [29]	2009	Sweden	OCTR (n = 63): 4 cm ECTR (n = 63): two-portal (1 cm)	1, 5 year(s)	Operative time, satisfaction rating, symptom relief, BCTQ-S, BCTQ-F, pain score, complications
Atroshi et al. [25]	2015	Sweden	OCTR (n = 61): 4 cm ECTR (n = 63): two-portal (1 cm)	1, 11–16 year(s)	BCTQ-S, BCTQ-F, pain score, numbness and tingling, satisfaction score, quick DASH, pain scale, complications
Aslani et al. [30]	2012	Iran	OCTR (n = 36): conventional release OCTR (n = 28): mini-incision ECTR (n = 32): two-portal (length NR)	4 weeks; 4 months	Numbness, nocturnal pain, wrist pain, weakness and stiffness, Tinel’s test, Phalen’s wrist flexion test, EMG, NCV, strength to grasp, time to RTW and ADL, satisfaction rating, operative time, complications
Brown et al. [31]	1993	US	OCTR (n = 82): conventional release ECTR (n = 78): two-portal (2 cm)	3, 6, 12 weeks	2PD test, SW monofilament test, APB strength, thenar atrophy, grip strength, key pinch strength, pain, numbness, paresthesia, weakness, Tinel’s test, Phalen’s wrist flexion test, interstitial carpal tunnel pressure, satisfaction rating, time to RTW, rate of ADL impairment, ADL score, operative time, hospital cost, complications
Dumontier et al. [32]	1995	France	OCTR (n = 40): conventional release ECTR (n = 56): two-portal (Chow [12])	2 weeks; 1, 3, 6 month(s)	Paresthesia, pain, time to RTW, grip strength, finger mobility, complications
Ejiri et al. [33]	2012	Japan	OCTR (n = 50): 3 cm vertical incision ECTR (n = 50): one-portal (Okutsu et al. [13])	1, 3 month(s)	Paresthesia, nighttime pain, impairment of ADL, APB-DL, SW monofilament test, 2PD test, grip strength, pinch strength, key pinch strength, complications
Erdmann [34]	1994	UK	OCTR (n = 52): NR (short length) ECTR (n = 53): two-portal (Chow [12])	1, 2 week(s); 1, 3, 6 month(s); 1 year	Grip and pinch strength, time to normal grip strength, time to normal pinch strength, time to RTW, ADL, time to relief of symptoms, median nerve motor and sensory DL, VAS pain score, complications
Ferdinand and MacLean [35]	2002	UK	OCTR (n = 25): NR ECTR (n = 25): one-portal	6, 12, 26 weeks; 13 months	VAS scores (numbness, pain, and paresthesia), ADL, return to full activities, time to RTW, thenar muscle strength, lateral pinch strength, grip strength, wrist and finger movement, 2PD test, Jebson score, operative time, satisfaction rating, complications
Gümüştaş et al. [36]	2015	Turkey	OCTR (n = 20): NR (Taleisnik [37]) ECTR (n = 21): two-portal (Chow [12])	6 months	BCTQ-S, BCTQ-F, median nerve motor DL, CMAP, SCV, sensory nerve action potential, complications
Jacobson and Rahme [38]	1996	Sweden	OCTR (n = 16): conventional release ECTR (n = 16): two-portal (Chow [12])	2, 6, 24 weeks	Symptom relief, total number of analgesics, 2PD test, time to RTW, nerve conduction test, complications
Kang et al. [39]	2013	South Korea	OCTR (n = 52): mini-incision (1.5 cm) ECTR (n = 52): one-portal (Agee et al. [28])	3 months	BCTQ-S, BCTQ-F, DASH, complications
Larsen et al. [40]	2013	Denmark	OCTR (n = 30): classic incision, 7 cm OCTR (n = 30): short incision, 3 cm ECTR (n = 30): one-portal (Menon [41])	1, 2, 3, 6, 12, 24 week(s)	VAS (pain), grip strength, range of motion, pillar pain, VAS (paresthesia), time to RTW, complications
Macdermid et al. [42]	2003	Canada	OCTR (n = 32): conventional release ECTR (n = 91): two-portal (Chow [12])	1, 6, 12 week(s)	Time to RTW, McGill pain questionnaire, key pinch strength, tripod pinch strength, grip strength, symptom severity score (Likert score), sensory threshold, self-report scale, SF-36, complications
Mackenzie et al. [43]	2000	US	OCTR (n = 14): 2.5 cm palmar incision ECTR (n = 22): one-portal (Agee et al. [28])	1, 2, 4 week(s)	Grip strength, pinch strength, BCTQ-S, BCTQ-F, complications
Martínez et al. [24]	2019	Spain	OCTR (n = 52): 1 cm mini-incision ECTR (n = 35): one-portal (Menon [41])	1 week; 1, 6, 12 month(s)	Grip strength, pinch strength, VAS pain score, satisfaction questionnaire, complications
Michelotti et al. [44]	2014	US	OCTR (n = 25): 3 cm palmar incision ECTR (n = 25): one-portal (Agee et al. [28], 1.5 cm)	2, 4, 8, 12, 24 weeks	2PD test, SW monofilament test, thenar strength, grip strength, BCTQ-S, BCTQ-F, satisfaction rating, complications
Michelotti et al. [45]	2018	US	OCTR (n = 30): 3 cm palmar incision ECTR (n = 30): one-portal (Agee et al. [28], 1.5 to 2 cm)	2, 4, 8, 12, 24 weeks	VAS pain score, 2PD test, SW monofilament test, thenar strength, grip strength, BCTQ-S, BCTQ-F, satisfaction rating, complications
Oh et al. [46]	2017	South Korea	OCTR (n = 32): mini-incision (1.5 cm) ECTR (n = 35): one-portal (Agee et al. [28], 1.5 cm)	24 weeks	BCTQ-S, BCTQ-F, DASH, CSA, CSA-I, CSA-M, CSA-O, flattening ratio, complications
Rab et al. [47]	2006	Austria	OCTR (n = 10): two mini-incisions ECTR (n = 10): two-portal (Chow [12])	2, 4, 6, 12 weeks; 6, 12 months	VAS pain score, grip strength, pinch strength, key pinch strength, ADL, BCTQ-S, BCTQ-F, 2PD, DL, NCV, complications
Saw et al. [48]	2003	UK	OCTR (n = 42): 2 cm palmar incision ECTR (n = 43): one-portal (Agee et al. [28])	1, 3, 6, 12 week(s)	BCTQ-S, BCTQ-F, grip strength, VAS pain score, time to RTW, operation time, complications
Sennwald and Benedetti [49]	1995	Switzerland	OCTR (n = 22): Sennwald incision ECTR (n = 25): one-portal (Agee et al. [28], 2–3 cm)	4, 8, 12 weeks	Grip strength, key pinch strength, time to RTW, complications
Tian et al. [50]	2007	China	OCTR (n = 36): S-shaped incision ECTR (n = 34): one-portal (Okutsu et al. [13], 1 cm)	2 years	Symptom improvement, operation time, hospital stay time, time to RTW, 2PD test, grip strength, scar tenderness, complications
Trumble et al. [51]	2002	US	OCTR (n = 95): palmar incision (3 ~ 4 cm) ECTR (n = 97): one-portal (Agee et al. [28], 1 cm)	2, 4, 8, 12, 26, 52 weeks	BCTQ-S, BCTQ-F, 2PD test, satisfaction rating, grip strength, pinch strength (key pinch, three-jaw), hand dexterity, time to RTW, thenar atrophy, strength of APB, complications
Wong et al. [52]	2003	Hong Kong	OCTR (n = 30): mini-incision ECTR (n = 30): two-portal (Chow [12])	2, 4, 8, 16 weeks; 6, 12 months	VAS pain score, grip strength, pinch strength, 2PD test, operation time, symptom relief, incision length, complications
Zhang et al. [53]	2016	China	OCTR (n = 72): double small incision OCTR (n = 65): standard incision (5–7 cm) ECTR (n = 69): two-portal (Chow [12])	3 years	BCTQ-S, BCTQ-F, patient satisfaction, VAS pain score, cylindrical strength, lateral strength, pinch strength, grip strength, time to RTW, 2PD test, SW monofilament test, hospital cost, complications
Zhao et al. [54]	2004	China	OCTR (n = 21): S-shaped incision ECTR (n = 26): one-portal (Okutsu et al. [13], 1 cm)	2 years	EMG, operation time, hospital stay time, 2PD test, time to RTW, complications

2PD Two-point Discrimination, ADL activities of daily living, APB abductor pollicis brevis, BCTQ-F Boston Carpal Tunnel Questionnaire Functional Status Scale, BCTQ-S Boston Carpal Tunnel Questionnaire Symptom Severity Scale, CMAP compound muscle action potential, CSA cross-sectional area, CSA-I inlet at the distal wrist crease level, CSA-M the middle of the tunnel at the level of the pisiform, CSA-O the tunnel outlet at the level of the hamate hook, DASH Disability of Arm, Shoulder, and Hand Questionnaire, DL distal latency, ECTR endoscopic carpal tunnel release, EMG electromyography, NCV nerve conduction velocity, NR not reported, OCTR open carpal tunnel release, RTW return to work, SCV sensory conduction velocity, SF-12 12-Item Short Form Health Survey, SF-36 36-Item Short Form Health Survey, SW Semmes-Weinstein, UK United Kingdom, US United States, VAS Visual Analog Scale

Quality assessment

In line with GRADE guidelines, 19 RCTs reported adequate methods for selection bias of random sequence generation. Only 8 RCTs had low risks of blinding of outcome assessment for results. The majority of RCTs (25/28) had risk of performance bias. Incomplete outcome data was judged as low risk for 22 RCTs. All RCTs were at a low risk of reporting bias (Fig. 2).

Results of meta-analysis

There were no significant differences in the operative time (MD, − 5.81 min; 95% CI, − 17.85 to 6.23; P = 0.34; n = 261; random-effects model, I² = 99%; P < 0.00001; Fig. 3) [35, 39, 52, 54], grip strength at 3 months post-surgery (MD, 1.99 kg; 95% CI, − 0.43 to 4.42; P = 0.11; n = 297; fixed-effects model, I² = 0%; P = 0.79; Fig. 4) [9, 31], BCTQ-S score at 1 year post-surgery (MD, 0.15; 95% CI, − 0.04 to 0.35; P = 0.13; n = 592; random-effects model, I² = 92%; P < 0.00001; Fig. 5) [25, 51, 53], and BCTQ-F score at 1 year post-surgery (MD, 0.17; 95% CI, − 0.02 to 0.36; P = 0.08; n = 592; random-effects model, I² = 91%; P < 0.00001; Fig. 6) [25, 51, 53] between the ECTR and OCTR groups. Similarly, there were no differences in digital sensation, including the Semmes-Weinstein monofilament test score at 3 months post-surgery (MD, 0.06; 95% CI, − 0.09 to 0.21; P = 0.43; n = 297; fixed-effects model, I² = 0%; P = 0.65; Fig. 7) [9, 31] and Two-point Discrimination test score at 1 year post-surgery (MD, − 0.16; 95% CI, − 0.45 to 0.12; P = 0.26; n = 402; fixed-effects model, I² = 35%; P = 0.20; Fig. 8) [50, 52, 53], between the two groups.

Satisfaction rate

The overall level of satisfaction with the outcome was based on a scale of 0 to 100 points. Two articles provided comparative data on the satisfaction rate [31, 53]. A portion of the data from Zhang et al. [53] reported a satisfaction rate of up to 90%, with high heterogeneity; therefore, some of the satisfaction data from that study were eliminated from the present meta-analysis. The pooled data of the two articles showed that the satisfaction rate was significantly higher in the ECTR group than that in the OCTR group (MD, 3.13; 95% CI, 1.43 to 4.82; P = 0.0003; n = 303; I² = 0%; P = 0.57) [31, 53], and the clinical heterogeneity I² was null (Fig. 9).

Key pinch strength

The pooled data showed that the key pinch strength of patients who were treated with ECTR was significantly greater than the key pinch strength of patients who were treated with OCTR at 3-months post-surgery (MD, 0.79 kg; 95% CI, 0.27 to 1.32; P = 0.003; n = 297; fixed-effects model, I² = 0%; P = 0.70) [9, 31] (Fig. 10).

RTW

Four studies [30, 38, 48, 54] evaluated the time needed to return to work for patients who underwent CTS. The pooled data showed that the RTW times were significantly faster in patients in the ECTR group than those in the OCTR group (MD, − 7.25 days; 95% CI, − 14.31 to − 0.19; P = 0.04; n = 357; random-effects model, I² = 98%; P < 0.00001) (Fig. 11); however, divergences between studies resulted in large between-study heterogeneity.

Complications

Twenty-five studies [9, 24, 28, 30‐36, 38‐40, 42, 43, 45‐54] included complete complication rate data and were included in the pooled analysis of overall complications. There were no significant differences between all complications rates (OR, 1.06; 95% CI, 0.69 to 1.64; P = 0.78; n = 2320; fixed-effects model, I² = 16%; P = 0.27) (Fig. 12). The rates of transient nerve injury were higher in patients who underwent ECTR than those in patients who underwent OCTR (OR, 4.87; 95% CI, 1.37 to 17.25; P = 0.01; n = 2320; fixed-effects model, I² = 0%; P = 0.98) (Fig. 13); however, the studies provided evidence that the presence of permanent nerve injury was not significantly different between the two groups (OR, 1.93; 95% CI, 0.58 to 6.40; P = 0.28; n = 2320; fixed-effects model, I² = 29%; P = 0.24) (Fig. 14). The rates of scar-related complications (scar hypertrophy, scar hyperesthesia, scar pain) were lower in patients who underwent ECTR than those in patients who underwent OCTR (OR, 0.20; 95% CI, 0.07 to 0.59; P = 0.004; n = 2320; fixed-effects model, I² = 0%; P = 0.90) (Fig. 15). Other complications, such as hematoma, wound infection, superficial palmar arch injury, persistent symptoms, pillar pain, reflex sympathetic dystrophy, and tendon injury, different were not significantly between the two groups. All outcome variables are summed up and displayed in Table 2.

Table 2

Summary estimates of outcome variables in the current study

Outcome	No. of studies	Heterogeneity I^2a (%)	Pooled odds ratio^b	Mean difference^c	95% confidence interval (lower bound)	95% confidence interval (upper bound)
Operative time	4	99	NA	−5.81	−17.85	6.23
Grip strength	2	0	NA	1.99	−0.43	4.42
BCTQ-S score	3	92	NA	0.15	−0.04	0.35
BCTQ-F score	3	91	NA	0.17	−0.02	0.36
SW monofilament test score	2	0	NA	0.06	−0.09	0.21
2PD test score	3	35	NA	−0.16	−0.45	0.12
Satisfaction rate	2	0	NA	3.13	1.43	4.82
Key pinch strength	2	0	NA	0.79	0.27	1.32
Return to work	4	98	NA	−7.25	−14.31	−0.19
Complications	25	16	1.06	NA	0.69	1.64
Transient nerve injury	25	0	4.87	NA	1.37	17.25
Permanent nerve injury	25	29	1.93	NA	0.58	6.4
Scar-related complications	25	0	0.2	NA	0.07	0.59
Hematoma	25	0	1.60	NA	0.36	7.16
Wound infection	25	0	0.53	NA	0.15	1.97
Superficial palmar arch injury	25	NA	3.07	NA	0.12	76.48
Persistent symptoms	25	0	2.17	NA	0.85	5.55
Pillar pain	25	35	0.95	NA	0.32	2.82
Reflex sympathetic dystrophy	25	0	0.40	NA	0.10	1.65
Tendon injury	25	NA	0.26	NA	0.01	6.50

2PD Two-point Discrimination, BCTQ-F Boston Carpal Tunnel Questionnaire Functional Status Scale, BCTQ-S Boston Carpal Tunnel Questionnaire Symptom Severity Scale, ECTR endoscopic carpal tunnel release, NA not applicable, OCTR open carpal tunnel release, SW Semmes-Weinstein

^aHeterogeneity test: I² > 50%, random-effects analysis model; I² < 50%, fixed-effects analysis model

^bIf odds ratio > 1, favors ECTR; if odds ratio < 1, favors OCTR

^cIf mean difference > 0, favors ECTR; if mean difference < 0, favors OCTR

Publication bias

Publication bias was assessed by the funnel plot method and Egger’s test. The funnel plot shape and Egger’s test (P = 0.869) appeared essentially symmetric (Fig. 16), indicating no overt publication bias in the analysis of complications.

Discussion

Since the development of ECTR by Chow (12) and Okutsu et al. [13] in 1989, there has been controversy regarding the superiority of ECTR over OCTR. Accordingly, many original articles have been published on this issue; moreover, several meta-analyses have compared ECTR with OCTR as treatment options for CTS [14, 15, 21‐23, 55‐57]. However, previous meta-analyses included fewer studies than ours, did not classify the data into subgroups according to different follow-up times, featured only a few assessments of patient outcome, and included central tendency data but not standard deviation. Therefore, we accomplished a large sample-size meta-analysis of published articles to compare the safety and effectiveness between OCTR and ECTR. The publication bias in this meta-analysis was also minimal, as demonstrated by the results of the funnel plot analysis and Egger’s test.

Our meta-analysis reviewed 28 RCTs that consisted of 2320 idiopathic CTS hands treated with two different approaches the OCTR or the ECTR. In the results it can be clearly indicated that there were no significant between-group differences in the operative time, grip strength, BCTQ-S score, BCTQ-F score, digital sensation scores, and the presence of permanent nerve injury. However, the ECTR group exhibited several clinically important advantages over the OCTR group, including higher patient satisfaction rates, greater key pinch strengths, earlier RTW times, and fewer scar-related complications.

Consistent with the present results, previous studies demonstrated that the satisfaction rates of patients in the ECTR group were higher than those of patients in the OCTR group [24, 44, 45]. Compared with the standard open approach, generally small incisions decrease scar tenderness, reduced scarring, mild wound-related complications [53], and improvements in the major functional outcomes (key pinch strength, activities of daily living, and RTW) [31] after endoscopic release is plausible. However, it should be noted that when assessing the patient satisfaction rates, a portion of the data published by Zhang et al. [53] exhibited high heterogeneity. Therefore, these data were excluded from the present meta-analysis. The high heterogeneity was mainly because of the fact that the data compared mini-incisions with endoscopic incisions. Mini-incisions are not directly comparable to the standard incisions in OCTR, as they yield a better appearance and tend to have fewer wound-related complications than standard incisions [58].

Herein, the key pinch strength of patients was significantly greater in the ECTR group than that in the OCTR group at 3 months postoperatively [9, 31]. Additionally, previous studies reported that OCTR was associated with considerable morbidity, including increased and prolonged scar tenderness [11]. Furthermore, other studies revealed that patients who underwent ECTR experienced fewer limitations in their ability to perform daily life activities than did patients who underwent an open technique [30, 59‐61]. Michelotti et al. [44] reported early differences in grip and pinch strength after ECTR; however, data were lost as the follow-up duration increased. Further studies should include a more uniform follow-up duration, and additional controlled studies with longer follow-up durations are required to clarify the effects of each technique on activities of daily living.

The finding of our meta-analysis of RCTs suggest that compared to patients treated with OCTR, those who treated with ECTR returned to work or daily activities earlier. Consistent with our results, Vasiliadis et al. [22] and Paryavi et al. [56] reported that patients who underwent ECTR experienced less surgical trauma than those who underwent an open technique, and this resulted in less time off work, faster recovery, and better performance of daily activities. However, regarding the RTW data, we noticed that divergences between the studies had large heterogeneity. A possible explanation for this large heterogeneity is that the work flexibility and the nature of the work and daily activities may have been different to a great extend in the included studies. Furthermore, while Sanati et al. [57] demonstrated the minimally invasive techniques have a great superiority over conventional open release in terms of recovery time, they highlighted the remarkable variability in how RTW as an outcome measure was examined across studies. Nevertheless, the effects of such inconsistencies were rather small when only RCTs were considered, similar to that observed in our study. Patients undergoing endoscopic release can return to work and their daily activities sooner when compared with open release.

Our meta-analysis revealed that lower scar-related complication rates and better healing were achieved in the ECTR group while compared to the OCTR group. This may be because of the long palmar incision made during OCTR that may prolong the immobilization time and augment postoperative pain and the risk for hypertrophic or hypersensitive scar formation [22]. In contrast, ECTR uses a small incision and divides the transverse carpal ligament from below, thereby preserving the overlying skin and muscle and resulting in fewer minor complications [62, 63], particularly those related to cutaneous scars. However, previous studies demonstrated that ECTR is associated with more nerve injury; therefore, the technique is less favorable owing to its higher risk of the cutaneous branch of the median nerve iatrogenic injury [15, 19, 53]. Contrary to expectations, our study did not find a significant difference in the occurrence of permanent nerve injury between the two surgical approaches; furthermore, most noted nerve injuries were transient, and patients still achieved full recovery after surgery [29, 38, 48, 49]. Moreover, Martin et al. [64] developed a novel endoscopic system which may avoid the transient nerve injury occurring with other ECTR methods.

Limitations

This research had two limitations. Firstly, subgroup analyses of the various ECTR techniques (one-portal and two-portal techniques) and OCTR techniques (mini-incision and long incision) were not performed. Use of different techniques may be associated with different outcomes, however, restricted by the rather limited studies and available data we were unable to divide the patients into subgroup to perform analyses. Secondly, though we included only RCTs, methodological flaws still exist, including unblinded assessments of outcomes.

Nevertheless, our study is novel since it includes the largest number of RCTs to compare ECTR and OCTR techniques. Furthermore, this is the first study to group results into different follow-up times and assess different patient outcomes, thus making the data more comparable. This study is also the first to demonstrate that ECTR is associated with better patient outcomes; we found that after careful manipulation during endoscopic surgery, ECTR can substitute OCTR.

Conclusions

The present meta-analysis determined that ECTR was superior to OCTR in terms of higher satisfaction rates, improved key pinch strengths, earlier RTW times, and fewer scar-related complications. Our findings suggest that patients with CTS can be effectively managed with ECTR; however, the possibility of transient nerve injury should be considered.

Acknowledgments

Not applicable.

This article does not contain any studies involving human participants conducted by any of the authors.

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Devana SK, Jensen AR, Yamaguchi KT, D'Oro A, Buser Z, Wang JC, et al. Trends and complications in open versus endoscopic carpal tunnel release in private payer and medicare patient populations. Hand (N Y). 2019;14:455–61. https://doi.org/10.1177/1558944717751196.CrossRef

Atroshi I, Gummesson C, Johnsson R, Ornstein E, Ranstam J, Rosén I. Prevalence of carpal tunnel syndrome in a general population. JAMA. 1999;282:153–8. https://doi.org/10.1001/jama.282.2.153.PubMedCrossRef

Bongers FJ, Schellevis FG, van den Bosch WJ, van der Zee J. Carpal tunnel syndrome in general practice (1987 and 2001): incidence and the role of occupational and non-occupational factors. Br J Gen Pract. 2007;57:36–9.PubMedPubMedCentral

Burton CL, Chen Y, Chesterton LS, Van der Windt DA. Trends in the prevalence, incidence, and surgical management of carpal tunnel syndrome between 1993 and 2013: an observational analysis of UK primary care records. BMJ Open. 2018;8:e020166. https://doi.org/10.1136/bmjopen-2017-020166.PubMedPubMedCentralCrossRef

Middleton SD, Anakwe RE. Carpal tunnel syndrome. BMJ. 2014;349:g6437. https://doi.org/10.1136/bmj.g6437.PubMedCrossRef

Gerritsen AA, de Vet HC, Scholten RJ, Bertelsmann FW, de Krom MC, Bouter LM. Splinting vs surgery in the treatment of carpal tunnel syndrome: a randomized controlled trial. JAMA. 2002;288:1245–51. https://doi.org/10.1001/jama.288.10.1245.PubMedCrossRef

Chesterton LS, Blagojevic-Bucknall M, Burton C, Dziedzic KS, Davenport G, Jowett SM, et al. The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomised controlled trial. Lancet. 2018;392:1423–33. https://doi.org/10.1016/S0140-6736(18)31572-1.PubMedPubMedCentralCrossRef

Ebenbichler GR, Resch KL, Nicolakis P, Wiesinger GF, Uhl F, Ghanem AH, et al. Ultrasound treatment for treating the carpal tunnel syndrome: randomised “sham” controlled trial. BMJ. 1998;316:731–5. https://doi.org/10.1136/bmj.316.7133.731.PubMedPubMedCentralCrossRef

Atroshi I, Larsson GU, Ornstein E, Hofer M, Johnsson R, Ranstam J. Outcomes of endoscopic surgery compared with open surgery for carpal tunnel syndrome among employed patients: randomised controlled trial. BMJ. 2006;332:1473. https://doi.org/10.1136/bmj.38863.632789.1F.PubMedPubMedCentralCrossRef

10.

Phalen GS. The carpal-tunnel syndrome, seventeen years’ experience in diagnosis and treatment of six hundred fifty-four hands. J Bone Joint Surg Am. 1966;48:211–28.PubMedCrossRef

11.

Boya H, Özcan Ö, Özteki NHH. Long-term complications of open carpal tunnel release. Muscle Nerve. 2008;38:1443–6. https://doi.org/10.1002/mus.21068.PubMedCrossRef

12.

Chow JC. Endoscopic release of the carpal ligament: a new technique for carpal tunnel syndrome. Arthroscopy. 1989;5:19–24. https://doi.org/10.1016/0749-8063(89)90085-6.PubMedCrossRef

13.

Okutsu I, Ninomiya S, Takatori Y, Ugawa Y. Endoscopic management of carpal tunnel syndrome. Arthroscopy. 1989;5:11–8. https://doi.org/10.1016/0749-8063(89)90084-4.PubMedCrossRef

14.

Chen L, Duan X, Huang X, Lv J, Peng K, Xiang Z. Effectiveness and safety of endoscopic versus open carpal tunnel decompression. Arch Orthop Trauma Surg. 2014;134:585–93. https://doi.org/10.1007/s00402-013-1898-z.PubMedCrossRef

15.

Sayegh ET, Strauch RJ. Open versus endoscopic carpal tunnel release: a meta-analysis of randomized controlled trials. Clin Orthop Relat Res. 2015;473:1120–32. https://doi.org/10.1007/s11999-014-3835-z.PubMedCrossRef

16.

Cobb TK, Knudson GA, Cooney WP. The use of topographical landmarks to improve the outcome of Agee endoscopic carpal tunnel release. Arthroscopy. 1995;11:165–72. https://doi.org/10.1016/0749-8063(95)90062-4.PubMedCrossRef

17.

Concannon MJ, Brownfield ML, Puckett CL. The incidence of recurrence after endoscopic carpal tunnel release. Plast Reconstr Surg. 2000;105:1662–5. https://doi.org/10.1097/00006534-200004050-00010.PubMedCrossRef

18.

Makowiec RL, Nagle DJ, Chow JC. Outcome of first-time endoscopic carpal tunnel release in a teaching environment. Arthroscopy. 2002;18:27–31. https://doi.org/10.1053/jars.2002.29903.PubMedCrossRef

19.

Murphy RX Jr, Jennings JF, Wukich DK. Major neurovascular complications of endoscopic carpal tunnel release. J Hand Surg [Am]. 1994;19:114–8. https://doi.org/10.1016/0363-5023(94)90233-X.CrossRef

20.

Chung KC, Walters MR, Greenfield ML, Chernew M. Endoscopic versus open carpal tunnel release: a cost-effectiveness analysis. Plast Reconstr Surg. 1998;102:1089–99. https://doi.org/10.1097/00006534-199809040-00026.PubMedCrossRef

21.

Zuo D, Zhou Z, Wang H, Liao Y, Zheng L, Hua Y, et al. Endoscopic versus open carpal tunnel release for idiopathic carpal tunnel syndrome: a meta-analysis of randomized controlled trials. J Orthop Surg Res. 2015;10:12. https://doi.org/10.1186/s13018-014-0148-6.PubMedPubMedCentralCrossRef

22.

Vasiliadis HS, Nikolakopoulou A, Shrier I, Lunn MP, Brassington R, Scholten RJ, et al. Endoscopic and open release similarly safe for the treatment of carpal tunnel syndrome. A systematic review and meta-analysis. PLoS One. 2015;10:e0143683. https://doi.org/10.1371/journal.pone.0143683.PubMedPubMedCentralCrossRef

23.

Hu K, Zhang T, Xu W. Intraindividual comparison between open and endoscopic release in bilateral carpal tunnel syndrome: a meta-analysis of randomized controlled trials. Brain Behav. 2016;6:e00439. https://doi.org/10.1002/brb3.439.PubMedPubMedCentralCrossRef

24.

Martínez-Catasús A, Lobo-Escolar L, García-Bonet J, Corrales-Rodríguez M, Pasarín-Martínez A, Berlanga-de-Mingo D. Comparison between single portal endoscopic, 1-cm open carpal tunnel release. Hand Surg Rehabil. 2019;38:202–6. https://doi.org/10.1016/j.hansur.2019.02.003.PubMedCrossRef

25.

Atroshi I, Hofer M, Larsson GU, Ranstam J. Extended follow-up of a randomized clinical trial of open vs endoscopic release surgery for carpal tunnel syndrome. JAMA. 2015;314:1399–401. https://doi.org/10.1001/jama.2015.12208.PubMedCrossRef

26.

Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement Ann Intern Med 2009;151:264–269. doi:https://doi.org/10.7326/0003-4819-151-4-200908180-00135.

27.

Guyatt GH, Oxman AD, Schünemann HJ, Tugwell P, Knottnerus A. GRADE guidelines: a new series of articles in the journal of clinical epidemiology. J Clin Epidemiol. 2011;64:380–2. https://doi.org/10.1016/j.jclinepi.2010.09.011.PubMedCrossRef

28.

Agee JM, McCarroll HR Jr, Tortosa RD, Berry DA, Szabo RM, Peimer CA. Endoscopic release of the carpal tunnel: a randomized prospective multicenter study. J Hand Surg [Am]. 1992;17:987–95. https://doi.org/10.1016/s0363-5023(09)91044-9.CrossRef

29.

Atroshi I, Hofer M, Larsson GU, Ornstein E, Johnsson R, Ranstam J. Open compared with 2-portal endoscopic carpal tunnel release: a 5-year follow-up of a randomized controlled trial. J Hand Surg [Am]. 2009;34:266–72. https://doi.org/10.1016/j.jhsa.2008.10.026.CrossRef

30.

Aslani HR, Alizadeh K, Eajazi A, Karimi A, Karimi MH, Zaferani Z, et al. Comparison of carpal tunnel release with three different techniques. Clin Neurol Neurosurg. 2012;114:965–8. https://doi.org/10.1016/j.clineuro.2012.02.017.PubMedCrossRef

31.

Brown RA, Gelberman RH, Seiler JG 3rd, Abrahamsson SO, Weiland AJ, Urbaniak JR, et al. Carpal tunnel release. A prospective, randomized assessment of open and endoscopic methods. J Bone Joint Surg Am. 1993;75:1265–75. https://doi.org/10.2106/00004623-199309000-00002.PubMedCrossRef

32.

Dumontier C, Sokolow C, Leclerq C, Chauvin P. Early results of conventional versus two-portal endoscopic carpal tunnel release. A prospective study. J Hand Surg (Br). 1995;20:658–62. https://doi.org/10.1016/s0266-7681(05)80130-5.CrossRef

33.

Ejiri S, Kikuchi S, Maruya M, Sekiguchi Y, Kawakami R, Konno S. Short-term results of endoscopic (Okutsu method) versus palmar incision open carpal tunnel release: a prospective randomized controlled trial. Fukushima J Med Sci. 2012;58:49–59. https://doi.org/10.5387/fms.58.49.PubMedCrossRef

34.

Erdmann MW. Endoscopic carpal tunnel decompression. J Hand Surg (Br). 1994;19:5–13. https://doi.org/10.1016/0266-7681(94)90038-8.CrossRef

35.

Ferdinand RD, MsacLean JG. Endoscopic versus open carpal tunnel release in bilateral carpal tunnel syndrome. A prospective, randomised, blinded assessment. J Bone Joint Surg (Br). 2002;84:375–9. https://doi.org/10.1302/0301-620X.84B3.12224.CrossRef

36.

Gümüştaş SA, Ekmekçi B, Tosun HB, Orak MM, Bekler Hİ. Similar effectiveness of the open versus endoscopic technique for carpal tunnel syndrome: a prospective randomized trial. Eur J Orthop Surg Traumatol. 2015;25:1253–60. https://doi.org/10.1007/s00590-015-1696-0.PubMedCrossRef

37.

Taleisnik J. The palmar cutaneous branch of the median nerve and the approach to the carpal tunnel. J Bone Joint Surg Am. 1973;55:1212–7.PubMedCrossRef

38.

Jacobsen MB, Rahme H. A prospective, randomized study with an independent observer comparing open carpal tunnel release with endoscopic carpal tunnel release. J Hand Surg (Br). 1996;21:202–4. https://doi.org/10.1016/s0266-7681(96)80097-0.CrossRef

39.

Kang HJ, Koh IH, Lee TJ, Choi YR. Endoscopic carpal tunnel release is preferred over mini-open despite similar outcome: a randomized trial. Clin Orthop Relat Res. 2013;471:1548–54. https://doi.org/10.1007/s11999-012-2666-z.PubMedCrossRef

40.

Larsen MB, Sørensen AI, Crone KL, Weis T, Boeckstyns ME. Carpal tunnel release: a randomized comparison of three surgical methods. J Hand Surg Eur Vol. 2013;38:646–50. https://doi.org/10.1177/1753193412475247.PubMedCrossRef

41.

Menon J. Endoscopic carpal tunnel release: a single-portal technique. Contemp Orthop. 1993;26:109–16.PubMed

42.

Macdermid JC, Richards RS, Roth JH, Ross DC, King GJ. Endoscopic versus open carpal tunnel release: a randomized trial. J Hand Surg [Am]. 2003;28:475–80. https://doi.org/10.1053/jhsu.2003.50080.CrossRef

43.

Mackenzie DJ, Hainer R, Wheatley MJ. Early recovery after endoscopic vs. short-incision open carpal tunnel release. Ann Plast Surg. 2000;44:601–4. https://doi.org/10.1097/00000637-200044060-00004.PubMedCrossRef

44.

Michelotti B, Romanowsky D, Hauck RM. Prospective, randomized evaluation of endoscopic versus open carpal tunnel release in bilateral carpal tunnel syndrome: an interim analysis. Ann Plast Surg. 2014;73(Suppl 2):S157–60. https://doi.org/10.1097/SAP.0000000000000203.PubMedCrossRef

45.

Michelotti BM, Vakharia KT, Romanowsky D, Hauck RM. A prospective, randomized trial comparing open and endoscopic carpal tunnel release within the same patient. Hand (N Y). 2018;21:1558944718812129. https://doi.org/10.1177/1558944718812129.CrossRef

46.

Oh WT, Kang HJ, Koh IH, Jang JY, Choi YR. Morphologic change of nerve and symptom relief are similar after mini-incision and endoscopic carpal tunnel release: a randomized trial. BMC Musculoskelet Disord. 2017;18:65. https://doi.org/10.1186/s12891-017-1438-z.PubMedPubMedCentralCrossRef

47.

Rab M, Grünbeck M, Beck H, Haslik W, Schrögendorfer KF, Schiefer HP, et al. Intra-individual comparison between open and 2-portal endoscopic release in clinically matched bilateral carpal syndrome. J Plast Reconstr Aesthet Surg. 2006;59:730–6. https://doi.org/10.1016/j.bjps.2005.11.018.PubMedCrossRef

48.

Saw NL, Jones S, Shepstone L, Meyer M, Chapman PG, Logan AM. Early outcome and cost-effectiveness of endoscopic versus open carpal tunnel release: a randomized prospective trial. J Hand Surg (Br). 2003;28:444–9. https://doi.org/10.1016/s0266-7681(03)00097-4.CrossRef

49.

Sennwald GR, Benedetti R. The value of one-portal endoscopic carpal tunnel release: a prospective randomized study. Knee Surg Sports Traumatol Arthrosc. 1995;3:113–6. https://doi.org/10.1007/BF01552386.PubMedCrossRef

50.

Tian Y, Zhao H, Wang T. Prospective comparison of endoscopic and open surgical methods for carpal tunnel syndrome. Chin Med Sci J. 2007;22:104–7.PubMed

51.

Trumble TE, Diao E, Abrams RA, Gilbert-Anderson MM. Single-portal endoscopic carpal tunnel release compared with open release: a prospective, randomized trial. J Bone Joint Surg Am. 2002;84:1107–15. https://doi.org/10.2106/00004623-200207000-00003.PubMedCrossRef

52.

Wong KC, Hung LK, Ho PC, Wong JM. Carpal tunnel release. A prospective, randomised study of endoscopic versus limited-open methods. J Bone Joint Surg (Br). 2003;85:863–8. https://doi.org/10.1302/0301-620X.85B6.13759.CrossRef

53.

Zhang X, Huang X, Wang X, Wen S, Sun J, Shao X. A randomized comparison of double small, standard, and endoscopic approaches for carpal tunnel release. Plast Reconstr Surg. 2016;138:641–7. https://doi.org/10.1097/PRS.0000000000002511.PubMedCrossRef

54.

Zhao H, Zhao Y, Tian Y, Yang B, Qiu GX. Comparison of endoscopic versus open surgical treatment of carpal tunnel syndrome. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26:657–60.PubMed

55.

Thoma A, Veltri K, Haines T, Duku E. A meta-analysis of randomized controlled trials comparing endoscopic and open carpal tunnel decompression. Plast Reconstr Surg. 2004;114:1137–46. https://doi.org/10.1097/01.prs.0000135850.37523.d0.PubMedCrossRef

56.

Paryavi E, Zimmerman RM, Means KR Jr. Endoscopic compared with open operative treatment of carpal tunnel syndrome. JBJS Rev. 2016;4. https://doi.org/10.2106/JBJS.RVW.15.00071.

57.

Sanati KA, Mansouri M, Macdonald D, Ghafghazi S, Macdonald E, Yadegarfar G. Surgical techniques and return to work following carpal tunnel release: a systematic review and meta-analysis. J Occup Rehabil. 2011;21:474–81. https://doi.org/10.1007/s10926-011-9310-8.PubMedCrossRef

58.

Li G, Kong L, Kou N, Wang Y, Yu K, Bai J, et al. Tian, The comparison of limited-incision versus standard-incision in treatment of carpal tunnel syndrome: a meta-analysis of randomized controlled trials. Medicine (Baltimore). 2019;98:e15372. https://doi.org/10.1097/MD.0000000000015372.CrossRef

59.

Gellman H, Kan D, Gee V, Kuschner SH, Botte MJ. Analysis of pinch and grip strength after carpal tunnel release. J Hand Surg [Am]. 1989;14:863–4. https://doi.org/10.1016/s0363-5023(89)80091-7.CrossRef

60.

Cotton P. Symptoms may return after carpal tunnel surgery. JAMA. 1991;265:1922–5. https://doi.org/10.1001/jama.265.15.1922b.PubMedCrossRef

61.

Macfarlane D, Williams TG. Efficacy of provocative tests for diagnosis of carpal tunnel syndrome. Lancet. 1990;335:727. https://doi.org/10.1016/0140-6736(90)90843-t.PubMedCrossRef

62.

Kim PT, Lee HJ, Kim TG, Jeon IH. Jeon, current approaches for carpal tunnel syndrome. Clin Orthop Surg. 2014;6:253–7. https://doi.org/10.4055/cios.2014.6.3.253.PubMedPubMedCentralCrossRef

63.

Padua L, Coraci D, Erra C, Pazzaglia C, Paolasso I, Loreti C, et al. Carpal tunnel syndrome: clinical features, diagnosis, and management. Lancet Neurol. 2016;15:1273–84. https://doi.org/10.1016/S1474-4422(16)30231-9.PubMedCrossRef

64.

Martin KD, Dützmann S, Sobottka SB, Rambow S, Mellerowicz HA, Pinzer T, et al. Retractor-endoscopic nerve decompression in carpal and cubital tunnel syndromes: outcomes in a small series. World Neurosurg. 2014;82:e361–70. https://doi.org/10.1016/j.wneu.2013.09.026.PubMedCrossRef

Titel: Open versus endoscopic carpal tunnel release: a systematic review and meta-analysis of randomized controlled trials
verfasst von: Yueying Li
Wenqi Luo
Guangzhi Wu
Shusen Cui
Zhan Zhang
Xiaosong Gu
Publikationsdatum: 01.12.2020
Verlag: BioMed Central
Erschienen in: BMC Musculoskeletal Disorders / Ausgabe 1/2020
Elektronische ISSN: 1471-2474
DOI: https://doi.org/10.1186/s12891-020-03306-1

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen.
» Jetzt entdecken

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Aquatherapie bei Fibromyalgie wirksamer als Trockenübungen

03.05.2024 Fibromyalgiesyndrom Nachrichten

Bewegungs-, Dehnungs- und Entspannungsübungen im Wasser lindern die Beschwerden von Patientinnen mit Fibromyalgie besser als das Üben auf trockenem Land. Das geht aus einer spanisch-brasilianischen Vergleichsstudie hervor.

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärzte und Psychotherapeuten.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders scheint das auf weibliche Kranke zuzutreffen, wie eine Studie zeigt.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Open versus endoscopic carpal tunnel release: a systematic review and meta-analysis of randomized controlled trials

Abstract

Background

Methods

Results

Conclusions

Publisher’s Note

Background

Methods

Literature search

Eligibility criteria

Data abstraction

Validity assessment

Statistical analysis

Results

Studies selection and characteristics

Quality assessment

Results of meta-analysis

Satisfaction rate

Key pinch strength

RTW

Complications

Publication bias

Discussion

Limitations

Conclusions

Acknowledgments

Competing interests

Publisher’s Note

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Aquatherapie bei Fibromyalgie wirksamer als Trockenübungen

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

Proximale Humerusfraktur: Auch 100-Jährige operieren?

Sind Frauen die fähigeren Ärzte?

Update Orthopädie und Unfallchirurgie

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

Publisher’s Note

Background

Methods

Literature search

Eligibility criteria

Data abstraction

Validity assessment

Statistical analysis

Results

Studies selection and characteristics

Quality assessment

Results of meta-analysis

Satisfaction rate

Key pinch strength

RTW

Complications

Publication bias

Discussion

Limitations

Conclusions

Acknowledgments

Ethics approval and consent to participate

Consent for publication

Competing interests

Publisher’s Note

Weitere Artikel der Ausgabe 1/2020

The effect of Kinesio taping on cervical proprioception in athletes with mechanical neck pain—a placebo-controlled trial

Spinal cord injury in an adult patient with thoracic butterfly vertebra: a case report and review of the literature

Study protocol for the DEFENDD trial: an RCT on the Dynamic Locking Blade Plate (DLBP) versus the Dynamic Hip Screw (DHS) for displaced femoral neck fractures in patients 65 years and younger

Adolescent idiopathic scoliosis: evaluating perioperative back pain through a simultaneous morphological and biomechanical approach

Association between serum zinc and copper concentrations and copper/zinc ratio with the prevalence of knee chondrocalcinosis: a cross-sectional study

Effects of focal metallic implants on opposing cartilage – an in-vitro study with an abrasion test machine

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Aquatherapie bei Fibromyalgie wirksamer als Trockenübungen

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

Proximale Humerusfraktur: Auch 100-Jährige operieren?

Sind Frauen die fähigeren Ärzte?

Update Orthopädie und Unfallchirurgie