Background
Purpose
Methods
Sampling procedure
Interview
Skin examination
Clinical oral examination
Diagnostic criteria for oral mucosal lesions
Statistical analysis
Results
Sample profile
Variables | Female n (%) | Male n (%) | Total n (%) |
---|---|---|---|
Age
| |||
Younger (18-32 yrs) | 144 (51.6) | 135 (48.4) | 279 (52.2) |
Older (33-85 yrs) | 123 (48.2) | 132 (51.8) | 255 (47.8) |
Occupation
| |||
Employed | 89 (27.4) | 236 (72.6)* | 325 (59.9) |
Unemployed | 183 (83.9) | 35 (16.1) | 218 (40.1) |
Education
| |||
Lower education (illiterate/primary school) | 143 (53.6) | 124 (46.4) | 267 (49.9) |
Higher education | 126 (47) | 142 (53) | 268 (50.1) |
Residence
| |||
Residence last 5 yr: Khartoum | 207 (49.9) | 208 (50.1) | 415 (77) |
Residence last 5 yr: outside | 65 (52.4) | 59 (47.6) | 124 (23) |
Medical history
| |||
No systemic condition | 138 (46.5) | 159 (53.5) | 297 (54.6) |
Presence of systemic condition | 134 (54.3) | 113 (45.7) | 247 (45.4) |
Smoking
| |||
Never | 263 (59.5) | 179 (40.5) | 442 (82.3) |
Former/current use | 6 (6.3) | 89 (93.7)** | 95 (17.7) |
Toombak use
| |||
Never | 263 (56.3) | 204 (43.7) | 467 (87.3) |
Former/current use | 8 (11.8) | 60 (88.2)** | 68 (12.7) |
Alcohol use
| |||
Never | 269 (52.5) | 243 (47.5) | 512 (95.7) |
Former/current use | 2 (8.7) | 21 (91.3)** | 23 (4.3) |
Skin diseases profile
Oral mucosal lesions profile
Oral mucosal lesions | Proportion with a specific lesion in the total group of patients (n = 544) | Proportion with a specific lesion in the total group of patients with any OML (n = 315) | Proportion with specific lesion within 14 OML groups | Biopsy |
---|---|---|---|---|
Tongue lesions
|
n (%)
|
%
|
%
| |
Coated tongue | 61 (11.2) | 19.4 | 48.0 | |
Fissured tongue | 26 (4.8) | 8.3 | 20.5 | |
Geographic tongue | 23 (4.2) | 7.3 | 18.1 | 2(+ve)* |
Atrophy of tongue papillae | 17 (3.1) | 5.4 | 13.4 | 1(+ve) |
Geographic tongue+Fissured tongue | 12 (2.2) | 3.8 | 9.4 | |
Tongue-tie | 4 (0.7) | 1.3 | 3.1 | |
Total number of patients with any tongue lesion ¶ | 127 (23.3) | 40.3 | ||
White lesions
| ||||
Snuff dipper's lesion | 30 (5.5) | 9.5 | 28.8 | 8(+ve) |
Frictional lesions | 25 (4.6) | 7.9 | 24.0 | 4(+ve) |
Leukoplakia | 17 (3.1) | 5.4 | 16.3 | 5(+ve) |
Vitiligo | 16 (2.9) | 5.1 | 15.4 | |
Nicotine stomatitis | 7 (1.3) | 2.2 | 6.7 | |
Lichen planus | 5 (0.9) | 1.6 | 4.8 | 3(+ve) |
Lupus erythematosus | 4 (0.7) | 1.3 | 3.8 | 1(-ve)§ |
Unspecified nicotine stomatitis | 3 (0.6) | 1.0 | 2.9 | |
Lichenoid lesions | 1 (0.2) | 0.3 | 1.0 | 1(+ve) |
Total number of patients with any white lesion ¶ | 104 (19.1) | 33.0 | ||
Red and blue lesions
| ||||
Erythema | 29 (5.3) | 9.2 | 48.3 | 2(-ve) |
Petechia | 25 (4.6) | 7.9 | 41.7 | |
Erosion | 7 (1.3) | 2.2 | 11.7 | |
Hemangioma | 3 (0.6) | 1.0 | 5.0 | |
Total number of patients with any red and blue lesion ¶ | 60 (11) | 19.0 | 100 | |
Vesiculobullous diseases
| ||||
Pemphigus vulgaris | 15(2.8) | 4.8 | 46.9 | 9(8+ve) |
Chickenpox | 8(1.5) | 2.5 | 25 | |
Bullous pemphigoid | 6(1.1) | 1.9 | 18.7 | 3(-ve) |
Herpes labialis | 2(0.4) | 0.6 | 6.2 | |
Vesiculobullous lesion (not verified) | 1(0.2) | 0.3 | 3.1 | |
Total number of patients with any vesiculobullous disease | 32 (6) | 10.2 | 100 | |
Ulcerative conditions
| ||||
RAS | 16 (2.9) | 5.1 | 66.7 | 1(+ve) |
Drug reaction | 3 (0.6) | 1.0 | 12.5 | |
Stevens-Johonson syndrome | 2 (0.4) | 0.6 | 8.3 | |
Erythema multiforme | 1 (0.2) | 0.3 | 4.2 | |
Traumatic ulcer | 1 (0.2) | 0.3 | 4.2 | |
Unspecified ulcer | 1 (0.2) | 0.3 | 4.2 | |
Total number of patients with any ulcerative condition | 24 (4.5) | 7.6 | 100 | |
Pigmented Lesions
| ||||
Melanotic macules | 20 (3.7) | 6.3 | 95 | 1(+ve) |
Gingival tattoo | 1 (0.2) | 0.3 | 4.8 | |
Total number of patients with any pigmented Lesion | 21 (3.9) | 6.7 | 100 | |
Connective tissue lesions
| ||||
Fibroepithelial polyp | 9 (1.7) | 2.9 | 81.8 | 4(+ve) |
Denture induced fibrous hyperplasia | 2 (0.4) | 0.6 | 18.2 | |
Total number of patients with any connective tissue lesion | 11 (2.1) | 3.5 | 100 | |
Fungal infections
| ||||
Acute erythematous candidiasis | 3 (0.6) | 1.0 | 30 | 1(-ve) |
Median rhomboid glossitis | 3 (0.6) | 1.0 | 30 | |
Pseodomembranous candidiasis | 3 (0.6) | 1.0 | 30 | |
Angular cheilitis | 2 (0.4) | 0.6 | 20 | |
Chronic hyperplastic candidiasis | 1 (0.2) | 0.3 | 10 | |
Total number of patients with any fungal infection ¶ | 10 (1.8) | 3.2 | 100 | |
Benign nonodontogenic tumors
| ||||
Soft tumor like lesion | 4 (0.7) | 1.3 | 66.7 | 1(-ve) |
Exostosis | 1 (0.2) | 0.3 | 16.7 | |
Palatal tori | 1 (0.2) | 0.3 | 16.7 | |
Total number of patients with any benign nonodontogenic tumor | 6 (11) | 1.9 | 100 | |
Perioral lesions
| ||||
Perioral dermatitis | 4 (0.7) | 1.3 | 80 | |
Perioral wart | 1 (0.2) | 0.3 | 20 | |
Total number of patients with any perioral lesion | 5 (0.9) | 1.6 | 100 | |
Lip lesions
| ||||
Unspecified cheilitis | 2 (0.4) | 0.6 | 40 | |
Hypopigmented lips | 2 (0.4) | 0.6 | 40 | |
Cheilitis glandularis | 1 (0.2) | 0.3 | 20 | |
Total number of patients with any lip lesion | 5 (1.0) | 1.6 | 100 | |
Verrucal papillary lesions
| ||||
Papillary hyperplasia | 3 (0.6) | 1.0 | 75 | 1(+ve) |
Focal epithelial hyperplasia | 1 (0.2) | 0.3 | 25 | |
Total number of patients with any verrucal papillary lesion | 4 (0.7) | 1.3 | 100 | |
Salivary gland diseases
| ||||
Mucocele | 2 (0.4) | 0.6 | 100 | 2(+ve) |
Total number of patients with any salivary gland disease | 2 | |||
Malignant tumours
| ||||
Kaposi sarcoma | 1 (0.2) | 0.3 | 100 | |
Total number of patients with any malignant tumour | 1 |
Skin diseases (groups) | Patients with any OML (n = 315) | Tongue (n = 127) | White (n = 104) | Red (n = 60) | Vesiculobullous (n = 32) | Ulcerative (n = 24) | Pigmented (n = 21) | Connective (n = 11) | Fungal (n = 10) | Others (n = 23) |
---|---|---|---|---|---|---|---|---|---|---|
Spongiotic
| 59 | 27 | 22 | 16 | - | 3 | 6 | - | 1 | 5 |
(n = 126)
| (46.8) | (21.4) | (17.5) | (12.7) | (02.4) | (04.8) | (00.8) | (04.0) | ||
Infectious lesions
| 65 | 25 | 18 | 12 | 9 | 2 | 3 | - | 1 | 7 |
(n = 115)
| (56.5) | (21.7) | (15.7) | (10.4) | (07.8) | (01.7) | (02.6) | (00.9) | (06.1) | |
Vesiculobullous
| 39 | 11 | 3 | - | 22 | 5 | 3 | 1 | 4 | 2 |
(n = 54)
| (72.2) | (20.4) | (05.6) | (40.7) | (09.3) | (05.6) | (01.9) | (07.4) | (03.7) | |
Cutaneous
| 26 | 9 | 9 | 3 | - | 3 | 1 | 3 | - | 1 |
(n = 48)
| (54.2) | (18.8) | (18.8) | (06.3) | (06.3) | (02.1) | (06.3) | (02.1) | ||
Pigmentation
| 24 | 7 | 18 | 7 | - | - | 1 | 2 | - | - |
(n = 41)
| (58.5) | (17.1) | (43.9) | (17.1) | (02.4) | (04.9) | ||||
Lichenoid
| 23 | 11 | 13 | 5 | - | 2 | 1 | 1 | 1 | |
(n = 38)
| (60.5) | (28.9) | (34.2) | (13.2) | (05.3) | (02.6) | (02.6) | (02.6) | ||
Psoriasiform
| 17 | 10 | 7 | 5 | - | - | 1 | 1 | 1 | 1 |
(n = 30)
| (56.7) | (33.3) | (23.3) | (16.7) | (03.3) | (03.3) | (03.3) | (03.3) | ||
Vasculopathic
| 13 | 8 | 2 | 3 | - | 3 | 1 | - | 1 | - |
(n = 25)
| (52.0) | (32.0) | (08.0) | (12.0) | (12.0) | (04.0) | (04.0) | |||
Tumour
| 8 | 3 | 1 | - | - | 1 | 1 | - | 2 | |
(n = 12)
| (66.7) | (25.0) | (08.3) | (08.3) | (08.3) | (16.7) | ||||
Others
| 41 | 16 | 11 | 9 | 1 | 5 | 4 | 2 | 1 | 5 |
(n = 55)
| (74.5) | (29.1) | (20.0) | (16.4) | (01.8) | (09.1) | (07.3) | (03.6) | (01.8) | (09.1) |
Skin disease with OML | Skin disease with ≥ 2 oral lesions | |
---|---|---|
N = 315 | N = 113 | |
Age
|
n (%)
|
n (%)
|
Younger (18-32 yrs) | 147 (52.7) | 42 (28.6) |
Older (33-85 yrs) | 159 (62.4)* | 69 (43.4) |
Sex
| ||
Females | 143 (52.6) | 43 (30.1) |
Males | 172 (63.2)* | 70 (40.7) |
Employment status
| ||
Employed | 197 (60.6) | 69 (35) |
Non employed | 117 (53.7) | 44 (37.6) |
Education
| ||
Lower education (illiterate/primary school) | 162 (60.7) | 65 (40.1) |
Higher education | 146 (54.5) | 47 (32.2) |
Residence
| ||
Khartoum | 235 (56.6) | 88 (37.4) |
Outside Khartoum | 77 (62.1) | 24 (31.2) |
Medical diagnosis
| ||
No systemic condition | 154 (51.9) | 53 (34.4) |
Presence of systemic condition | 161 (65.2)* | 60 (37.3) |
Toombak use
| ||
Never | 256 (54.8) | 90 (35.2) |
Former/current use | 53 (77.9)** | 22 (41.5) |
Smoking
| ||
Never | 251 (56.8) | 89 (35.5) |
Former/current use | 60 (63.2) | 23 (38.3) |
Alcohol
| ||
Never | 293 (57.2) | 103 (35.2) |
Former/current use | 16 (69.6) | 9 (56.3) |