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International Urology and Nephrology

Erschienen in:

01.12.2014 | Nephrology - Review

Organ cross talk and remote organ damage following acute kidney injury

verfasst von: Rele Ologunde, Hailin Zhao, Kaizhi Lu, Daqing Ma

Erschienen in: International Urology and Nephrology | Ausgabe 12/2014

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Abstract

Increasing evidence suggests that acute kidney injury (AKI) mediates a systemic response that can lead to multiple organ failure. AKI may manifest in a variety of clinical scenarios including kidney transplantation and is associated with a significantly high mortality. It has been postulated that specific pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α, may mediate a systemic response, resulting in recruitment of pro-inflammatory cells leading to organ failure. However, the specific mechanism by which the cytokine cascade results in distant organ damage is yet to be determined. Furthermore, it remains unclear as to whether cytokines mediate similar or differing responses in different end organs. This review summarizes the effects of AKI on remote organs and explores the role of systemic cytokines in mediating distant organ damage.

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Titel: Organ cross talk and remote organ damage following acute kidney injury
verfasst von: Rele Ologunde
Hailin Zhao
Kaizhi Lu
Daqing Ma
Publikationsdatum: 01.12.2014
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 12/2014
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-014-0766-2

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Immer mehr jüngere Menschen leiden unter Vorhofflimmern. Betroffene unter 65 Jahren haben viele Risikofaktoren und ein signifikant erhöhtes Sterberisiko verglichen mit Gleichaltrigen ohne die Erkrankung.

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Die Leitlinien für Ärztinnen und Ärzte, Digitale Mammographien links in kraniokaudaler Projektion./© Weigel, S. et al. / all rights reserved Springer Medizin Verlag GmbH, Operation bei Blasenkrebs/© anistidesign / Fotolia, Medizinische Fachangestellte sitzt erschöpft auf der Treppe/© Courtney Haas / peopleimages.com /stock.adobe.com (Symbolbild mit Fotomodell), Mann wird von Ärztin untersucht/© Tashi-Delek, Getty Images, iStock (Symbolbild mit Fotomodellen)

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