Background
Methods
Study population
Echocardiographic investigation
Laboratory analysis
Statistical analysis
Results
Description of patients
Parameter | No MAC (n = 144) | MAC (n = 79) | p-value |
---|---|---|---|
Age (years) | 59,48 ± 10,41 | 69,15 ± 7,79 | <0,01* |
BMI (kg/m2) | 28,51 ± 5,19 | 27,52 ± 4,93 | 0,160 |
SBP (mmHg | 129,69 ± 15,63 | 131,70 ± 17,76 | 0,387 |
DBP (mmHg) | 77,77 ± 11,03 | 73,18 ± 11,10 | 0,004* |
HR (bpm) | 70,56 ± 12,67 | 70,51 ± 14,26 | 0,976 |
Na (mmol/l) | 138,72 ± 2,60 | 139,24 ± 3,09 | 0,184 |
K (mmol/l) | 4,06 ± 0,48 | 4,09 ± 0,42 | 0,607 |
Cl (mmol/l) | 103,78 ± 4,01 | 104,11 ± 3,30 | 0,532 |
Uric acid (mg/dl) | 6,58 ± 2,13 | 6,99 ± 2,15 | 0,182 |
Creatinine (mg/dl) | 1,06 ± 0,40 | 1,30 ± 0,93 | 0,008* |
BUN (mg/dl) | 18.06 ± 10,53 | 24,32 ± 13,34 | <0,01* |
Triglycerides (mg/dl) | 163,65 ± 94,13 | 136,55 ± 60,83 | 0,023* |
Cholesterol (mg/dl) | 175,96 ± 51,08 | 174,31 ± 47,38 | 0,814 |
HDL (mg/dl) | 43,60 ± 12,22 | 47,61 ± 14,11 | 0,040* |
LDL (mg/dl | 103,21 ± 39,42 | 104,95 ± 44,45 | 0,780 |
HbA1C (rel%) | 6,13 ± 1,05 | 6,46 ± 1,20 | 0,057 |
Erythrocytes (T/l) | 4,59 ± 0,58 | 4,38 ± 0,61 | 0,010* |
Haemoglobin (mg/dl) | 13,51 ± 1,79 | 12,58 ± 1,77 | <0,01* |
Haematocrit rel% | 40,05 ± 4,67 | 37,93 ± 5,00 | 0,002* |
Thrombocytes (G/l) | 239,87 ± 82,23 | 235,48 ± 82,96 | 0,705 |
Leukocytes (G/l) | 7,93 ± 2,74 | 7,27 ± 2,43 | 0,200 |
TSH (mycroU/ml) | 2,09 ± 1,70 | 2,13 ± 1,71 | 0,876 |
proBNP (ng/ml) | 1372,70 ± 2585,22 | 3655,18 ± 6918,58 | 0,001* |
Hypertension | 92,4 | 93,7 | 0,728 |
Hypercholesterinemia | 93,1 | 87,3 | 0,149 |
Diabetes mellitus | 20,7 | 43,0 | <0,01* |
Adipositas (BMI >30 kg/m2) | 40,3 | 44,2 | 0,100 |
Beta-blockers | 84,0 | 77,2 | 0,210 |
ACE-Inhibitors | 59,0 | 50,6 | 0,228 |
Ca++-antagonists | 9,7 | 17,7 | 0,085 |
Diuretics | 29,9 | 48,1 | 0,007* |
Statins | 85,4 | 77,2 | 0,124 |
Coronary score (points) | 6,66 | 8,96 | 0,003* |
Stenosis left main | 15,2 | 16,5 | |
Stenosis LAD (prox./med./dist.) | 51,0/53,1/20,7 | 55,7/59,5/17,7 | |
Stenosis CX (prox./med./dist.) | 25,5/17,9/13,1 | 36,7/26,6/12,7 | |
Stenosis RCA (prox./med./dist.) | 42,1/38,6/26,9 | 57,0/48,1/38,0 |
Severity of coronary artery disease
OPN in MAC
OPN (ng/ml) | |
---|---|
No MAC (n = 144) | 102,9/22,7/480,2 |
Mild MAC (n = 47) | 122,7/57,8/389,8 |
Mod./Sev. MAC (n = 32) | 187,0/55,2/348,8 |
Regression coefficient B | Standard error | Wald | Significance | Odds ratio eb | |
---|---|---|---|---|---|
Age (years) | .090 | .019 | 21,533 | <0,001 | 1,094 |
Coronary score (points) | .068 | .031 | 4,943 | 0,026 | 1,071 |
OPN (ng/ml) | .007 | .003 | 7,443 | 0,006 | 1,007 |
Constant | −7,891 | 1,329 | 35,261 | <0,001 |