Skip to main content
Erschienen in: Annals of Nuclear Medicine 3/2018

01.04.2018 | Review Article

Paradigm shift in theranostics of neuroendocrine tumors: conceptual horizons of nanotechnology in nuclear medicine

verfasst von: Geetanjali Arora, Gurupad Bandopadhyaya

Erschienen in: Annals of Nuclear Medicine | Ausgabe 3/2018

Einloggen, um Zugang zu erhalten

Abstract

We present a comprehensive review of Neuroendocrine Tumors (NET) and the current and developing imaging and therapeutic modalities for NET with emphasis on Nuclear Medicine modalities. Subsequently, nanotechnology and its emerging role in cancer management, especially NET, are discussed. The article is both educative and informative. The objective is to provide an insight into the developments made in nuclear medicine and nanotechnology towards management of NET, individually as well as combined together.
Literatur
1.
Zurück zum Zitat Oberg KE. Management of neuroendocrine tumors: current and future therapies. Exp Rev Endocrinol Metab. 2011;6:49–62.CrossRef Oberg KE. Management of neuroendocrine tumors: current and future therapies. Exp Rev Endocrinol Metab. 2011;6:49–62.CrossRef
2.
Zurück zum Zitat Boudreaux JP, Klimstra DS, Hassan MM, Woltering EA, Jensen RT, Goldsmith SJ, et al. The NANET consensus guideline for the diagnosis and management of neuroendocrine tumors (well-differentiated neuroendocrine tumors of the jejunum, ileum, appendix, and cecum). Pancreas. 2010;39:753–66.CrossRefPubMed Boudreaux JP, Klimstra DS, Hassan MM, Woltering EA, Jensen RT, Goldsmith SJ, et al. The NANET consensus guideline for the diagnosis and management of neuroendocrine tumors (well-differentiated neuroendocrine tumors of the jejunum, ileum, appendix, and cecum). Pancreas. 2010;39:753–66.CrossRefPubMed
3.
Zurück zum Zitat Klimstra DS, Modlin IR, Coppola D, Lloyd RV, Suster S. The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems. Pancreas. 2010;39:707–12.CrossRefPubMed Klimstra DS, Modlin IR, Coppola D, Lloyd RV, Suster S. The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems. Pancreas. 2010;39:707–12.CrossRefPubMed
4.
Zurück zum Zitat Patel YC. Somatostatin and its receptor family. Front Neuroendocrin. 1999;20:157–98.CrossRef Patel YC. Somatostatin and its receptor family. Front Neuroendocrin. 1999;20:157–98.CrossRef
5.
Zurück zum Zitat Bal CS, Gupta SK, Zaknun JJ. Radiolabeled somatostatin analogs for radionuclide imaging and therapy in patients with gastroenteropancreatic neuroendocrine tumors. Trop Gastroenterol. 2010;31:87–95.PubMed Bal CS, Gupta SK, Zaknun JJ. Radiolabeled somatostatin analogs for radionuclide imaging and therapy in patients with gastroenteropancreatic neuroendocrine tumors. Trop Gastroenterol. 2010;31:87–95.PubMed
6.
Zurück zum Zitat Bronstein-Sitton N. Somatostatin and the somatostatin receptors: versatile regulators of biological activity. Pathways No. 2 Spring. 2006:25–7. Bronstein-Sitton N. Somatostatin and the somatostatin receptors: versatile regulators of biological activity. Pathways No. 2 Spring. 2006:25–7.
7.
Zurück zum Zitat Ardill JES, O‘Dorisio TM. Circulating biomarkers in neuroendocrine tumors of the enteropancreatic tract: application to diagnosis, monitoring disease, and as prognostic indicators. Endocrinol Metab Clin N Am. 2010;39:777–90.CrossRef Ardill JES, O‘Dorisio TM. Circulating biomarkers in neuroendocrine tumors of the enteropancreatic tract: application to diagnosis, monitoring disease, and as prognostic indicators. Endocrinol Metab Clin N Am. 2010;39:777–90.CrossRef
8.
Zurück zum Zitat Rufini V, Calcagni M, Baum RP. Imaging of neuroendocrine tumors. Semin Nucl Med. 2006;36:228–47.CrossRefPubMed Rufini V, Calcagni M, Baum RP. Imaging of neuroendocrine tumors. Semin Nucl Med. 2006;36:228–47.CrossRefPubMed
9.
10.
Zurück zum Zitat Teunissen JJM, Kwekkeboom DJ, Valkema R, Krenning EP. Nuclear medicine techniques for the imaging and treatment of neuroendocrine tumors. Endocr Relat Cancer. 2011;18:S27–S51.CrossRefPubMed Teunissen JJM, Kwekkeboom DJ, Valkema R, Krenning EP. Nuclear medicine techniques for the imaging and treatment of neuroendocrine tumors. Endocr Relat Cancer. 2011;18:S27–S51.CrossRefPubMed
11.
Zurück zum Zitat Weiner RE, Thakur ML. Radiolabeled peptides in diagnosis and therapy. Semin Nucl Med. 2001;31:296–311.CrossRefPubMed Weiner RE, Thakur ML. Radiolabeled peptides in diagnosis and therapy. Semin Nucl Med. 2001;31:296–311.CrossRefPubMed
12.
Zurück zum Zitat Balon HR, Goldsmith SJ, Siegel BA, Silberstein EB, Donohoe KJ, Krenning EP, et al. Society of nuclear medicine procedure guideline for somatostatin receptor scintigraphy with In-111 pentetreotide (version 1.0, approved February 21, 2001). Society of nuclear medicine procedure guidelines manual; 2002. p. 147–51. Balon HR, Goldsmith SJ, Siegel BA, Silberstein EB, Donohoe KJ, Krenning EP, et al. Society of nuclear medicine procedure guideline for somatostatin receptor scintigraphy with In-111 pentetreotide (version 1.0, approved February 21, 2001). Society of nuclear medicine procedure guidelines manual; 2002. p. 147–51.
13.
Zurück zum Zitat Dimitroulopoulos D, Zisimopoulos A, Xinopoulos D, Tsamakidis K, Andriotis E, Fotopoulou E, et al. Somatostatin receptor scintigraphy with In-111 Octreotide in the detection of gastroenteropancreatic carcinoids and their metastases. Ann Gastroenterol. 2003;16:339–45. Dimitroulopoulos D, Zisimopoulos A, Xinopoulos D, Tsamakidis K, Andriotis E, Fotopoulou E, et al. Somatostatin receptor scintigraphy with In-111 Octreotide in the detection of gastroenteropancreatic carcinoids and their metastases. Ann Gastroenterol. 2003;16:339–45.
14.
Zurück zum Zitat Schillaci O. Functional–anatomical image fusion in neuroendocrine tumors. Cancer Biother Radiopharm. 2004;19:129–34.CrossRefPubMed Schillaci O. Functional–anatomical image fusion in neuroendocrine tumors. Cancer Biother Radiopharm. 2004;19:129–34.CrossRefPubMed
15.
Zurück zum Zitat Decristoforo C, Maina T, Nock B, Gabriel M, Cordopatis P, Moncayo R. 99mTc-Demotate 1: first data in tumor patients-results of a pilot/ phase 1 study. Eur J Nucl Med Mol Imaging. 2003;30:1211–9.CrossRefPubMed Decristoforo C, Maina T, Nock B, Gabriel M, Cordopatis P, Moncayo R. 99mTc-Demotate 1: first data in tumor patients-results of a pilot/ phase 1 study. Eur J Nucl Med Mol Imaging. 2003;30:1211–9.CrossRefPubMed
16.
Zurück zum Zitat Kopecky M, Trejtnar F, Laznicek M, Laznickova A, Semecky V, Maina T, et al. 99mTc Demotate 1: biodistribution and elimination characteristics in rats. Nucl Med Commun. 2005;26:549–54.CrossRefPubMed Kopecky M, Trejtnar F, Laznicek M, Laznickova A, Semecky V, Maina T, et al. 99mTc Demotate 1: biodistribution and elimination characteristics in rats. Nucl Med Commun. 2005;26:549–54.CrossRefPubMed
17.
Zurück zum Zitat Maina T, Nock BA, Cordopatis P, Bernard BF, Breeman WA, van Gameren A, et al. 99mTc Demotate 2 in the detection of SST2-positive tumors: a preclinical comparison with 111In DOTA-TATE. Eur J Nucl Med Mol Imaging. 2006;33:831–40.CrossRefPubMed Maina T, Nock BA, Cordopatis P, Bernard BF, Breeman WA, van Gameren A, et al. 99mTc Demotate 2 in the detection of SST2-positive tumors: a preclinical comparison with 111In DOTA-TATE. Eur J Nucl Med Mol Imaging. 2006;33:831–40.CrossRefPubMed
18.
Zurück zum Zitat Cwikla JB, Mikolajczak R, Pawlak D, Buscombe JR, Nasierowska-Guttmejer A, Bator A, et al. Initial direct comparison of 99mTc-TOC and 99mTc-TATE in identifying sites of disease in patients with proven GEP NET. J Nucl Med. 2008;49:1060–5.CrossRefPubMed Cwikla JB, Mikolajczak R, Pawlak D, Buscombe JR, Nasierowska-Guttmejer A, Bator A, et al. Initial direct comparison of 99mTc-TOC and 99mTc-TATE in identifying sites of disease in patients with proven GEP NET. J Nucl Med. 2008;49:1060–5.CrossRefPubMed
19.
Zurück zum Zitat Hofmann M, Maecke H, Borner R, Weckesser E, Schoffski P, Oei L, et al. Biokinetics and imaging with the somatostatin receptor PET radioligand (68)Ga-DOTATOC: preliminary data. Eur J Nucl Med. 2001;28:1751–7.CrossRefPubMed Hofmann M, Maecke H, Borner R, Weckesser E, Schoffski P, Oei L, et al. Biokinetics and imaging with the somatostatin receptor PET radioligand (68)Ga-DOTATOC: preliminary data. Eur J Nucl Med. 2001;28:1751–7.CrossRefPubMed
20.
Zurück zum Zitat Gabriel M, Decristoforo C, Kendler D, Dobrozemsky G, Heute D, Uprimny C, et al. 68Ga-DOTA-Tyr3-Octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT. J Nucl Med. 2007;48:508–18.CrossRefPubMed Gabriel M, Decristoforo C, Kendler D, Dobrozemsky G, Heute D, Uprimny C, et al. 68Ga-DOTA-Tyr3-Octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT. J Nucl Med. 2007;48:508–18.CrossRefPubMed
21.
Zurück zum Zitat Poeppel TD, Binse I, Petersenn S, Lahner H, Schott M, Antoch G, et al. 68Ga-DOTATOC versus 68Ga-DOTATATE PET/CT in functional imaging of neuroendocrine tumors. J Nucl Med. 2011;52:1864–70.CrossRefPubMed Poeppel TD, Binse I, Petersenn S, Lahner H, Schott M, Antoch G, et al. 68Ga-DOTATOC versus 68Ga-DOTATATE PET/CT in functional imaging of neuroendocrine tumors. J Nucl Med. 2011;52:1864–70.CrossRefPubMed
22.
Zurück zum Zitat Al-Nahhas A, Win Z, Szyszko T, Singh A, Nanni C, Fanti S, et al. Gallium-68 PET: a new frontier in receptor cancer imaging. Anticancer Res. 2007;27:4087–94.PubMed Al-Nahhas A, Win Z, Szyszko T, Singh A, Nanni C, Fanti S, et al. Gallium-68 PET: a new frontier in receptor cancer imaging. Anticancer Res. 2007;27:4087–94.PubMed
23.
Zurück zum Zitat Laverman P, McBride WJ, Sharkey RM, Eek A, Joosten L, Oyen WJG, et al. A novel facile method of labeling octreotide with 18F-fluorine. J Nucl Med. 2010;51:454–61.CrossRefPubMedPubMedCentral Laverman P, McBride WJ, Sharkey RM, Eek A, Joosten L, Oyen WJG, et al. A novel facile method of labeling octreotide with 18F-fluorine. J Nucl Med. 2010;51:454–61.CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat Laverman P, D’Souza CA, Eek A, McBride WJ, Sharkey RM, Oyen WJG, et al. Optimized labeling of NOTA-conjugated octreotide with F-18. Tumor Biol. 2012;33:427–34.CrossRef Laverman P, D’Souza CA, Eek A, McBride WJ, Sharkey RM, Oyen WJG, et al. Optimized labeling of NOTA-conjugated octreotide with F-18. Tumor Biol. 2012;33:427–34.CrossRef
25.
Zurück zum Zitat Binderup T, Knigge U, Loft A, Mortensen J, Pfeifer A, Federspiel B, Hansen CP, et al. Functional imaging of neuroendocrine tumors: a head-to-head comparison of somatostatin receptor scintigraphy, 123I-MIBG scintigraphy, and 18F-FDG PET. J Nucl Med. 2010;51:704–12.CrossRefPubMed Binderup T, Knigge U, Loft A, Mortensen J, Pfeifer A, Federspiel B, Hansen CP, et al. Functional imaging of neuroendocrine tumors: a head-to-head comparison of somatostatin receptor scintigraphy, 123I-MIBG scintigraphy, and 18F-FDG PET. J Nucl Med. 2010;51:704–12.CrossRefPubMed
26.
Zurück zum Zitat Jager PL, Chirakal R, Marriott CJ, Brouwers AH, Koopmans KP, Gulenchyn KY, et al. 6-L-18F-Fluorodihydroxyphenylalanine PET in neuroendocrine tumors: basic aspects and emerging clinical applications. J Nucl Med. 2008;49:573–86.CrossRefPubMed Jager PL, Chirakal R, Marriott CJ, Brouwers AH, Koopmans KP, Gulenchyn KY, et al. 6-L-18F-Fluorodihydroxyphenylalanine PET in neuroendocrine tumors: basic aspects and emerging clinical applications. J Nucl Med. 2008;49:573–86.CrossRefPubMed
27.
Zurück zum Zitat Minn H, Kauhanen S, Seppanen M, Nuutila P. 18F-FDOPA: a multiple-target molecule. J Nucl Med. 2009;50:1915–8.CrossRefPubMed Minn H, Kauhanen S, Seppanen M, Nuutila P. 18F-FDOPA: a multiple-target molecule. J Nucl Med. 2009;50:1915–8.CrossRefPubMed
28.
Zurück zum Zitat Lewington VJ. Targeted radionuclide therapy for neuroendocrine tumours. Endocr Relat Cancer. 2003;10:497–501.CrossRefPubMed Lewington VJ. Targeted radionuclide therapy for neuroendocrine tumours. Endocr Relat Cancer. 2003;10:497–501.CrossRefPubMed
29.
Zurück zum Zitat Gedik GK, Hoefnagel CA, Bais E, Olmos RAV. 131I-MIBG therapy in metastatic pheochromocytoma and paraganglioma. Eur J Nucl Med Mol Imaging. 2008;35:725–33.CrossRefPubMed Gedik GK, Hoefnagel CA, Bais E, Olmos RAV. 131I-MIBG therapy in metastatic pheochromocytoma and paraganglioma. Eur J Nucl Med Mol Imaging. 2008;35:725–33.CrossRefPubMed
30.
Zurück zum Zitat Bomanji JB, Wong W, Gaze MN, Cassoni A, Waddington W, Solano J, et al. Treatment of neuroendocrine tumours in adults with 131I-MIBG therapy. Clin Oncol (R Coll Radiol). 2003;15:193–8.CrossRef Bomanji JB, Wong W, Gaze MN, Cassoni A, Waddington W, Solano J, et al. Treatment of neuroendocrine tumours in adults with 131I-MIBG therapy. Clin Oncol (R Coll Radiol). 2003;15:193–8.CrossRef
31.
Zurück zum Zitat Navalkissoor S, Alhashimi DM, Quigley AM, Caplin ME, Buscombe JR. Efficacy of using a standard activity of 131I-MIBG therapy in patients with disseminated neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2010;37:904–12.CrossRefPubMed Navalkissoor S, Alhashimi DM, Quigley AM, Caplin ME, Buscombe JR. Efficacy of using a standard activity of 131I-MIBG therapy in patients with disseminated neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2010;37:904–12.CrossRefPubMed
32.
Zurück zum Zitat Riad R, Kotb M, Omar W, Zaher A, Ebied E, Pitman AG, et al. I-131 mibg therapy for advanced stage III and IV neuroblastoma. J Cancer Ther. 2011;2:481–9.CrossRef Riad R, Kotb M, Omar W, Zaher A, Ebied E, Pitman AG, et al. I-131 mibg therapy for advanced stage III and IV neuroblastoma. J Cancer Ther. 2011;2:481–9.CrossRef
33.
Zurück zum Zitat Grunwald F, Ezziddin S. 131I-Metaiodobenzylguanidine therapy of neuroblastoma and other neuroendocrine tumors. Semin Nucl Med. 2010;40:153–63.CrossRefPubMed Grunwald F, Ezziddin S. 131I-Metaiodobenzylguanidine therapy of neuroblastoma and other neuroendocrine tumors. Semin Nucl Med. 2010;40:153–63.CrossRefPubMed
35.
Zurück zum Zitat Brechbiel MW. Bifunctional chelates for metal nuclides. Q J Nucl Med Mol Imaging. 2008;52:166–73.PubMed Brechbiel MW. Bifunctional chelates for metal nuclides. Q J Nucl Med Mol Imaging. 2008;52:166–73.PubMed
36.
Zurück zum Zitat de Jong M, Valkema R, Jamar F, Kvols LK, Kwekkeboom DJ, Breeman WAP, et al. Somatostatin receptor-targeted radionuclide therapy of tumors: preclinical and clinical findings. Semin Nucl Med. 2002;32:133–40.CrossRefPubMed de Jong M, Valkema R, Jamar F, Kvols LK, Kwekkeboom DJ, Breeman WAP, et al. Somatostatin receptor-targeted radionuclide therapy of tumors: preclinical and clinical findings. Semin Nucl Med. 2002;32:133–40.CrossRefPubMed
37.
Zurück zum Zitat Kwekkeboom DJ, Kam BL, van Essen M, Teunissen JJM, van Eijck CHJ, Valkema R, et al. Somatostatin receptor-based imaging and therapy of gastroenteropancreatic neuroendocrine tumors. Endocr Relat Cancer. 2010;17:R53–R73.CrossRefPubMed Kwekkeboom DJ, Kam BL, van Essen M, Teunissen JJM, van Eijck CHJ, Valkema R, et al. Somatostatin receptor-based imaging and therapy of gastroenteropancreatic neuroendocrine tumors. Endocr Relat Cancer. 2010;17:R53–R73.CrossRefPubMed
38.
Zurück zum Zitat Ozkan E, Tokmak E, Kucuk NO. Efficacy of adding high-dose In-111 octreotide therapy during sandostatin treatment in patients with disseminated neuroendocrine tumors: clinical results of 14 patients. Ann Nucl Med. 2011;25:425–31.CrossRefPubMed Ozkan E, Tokmak E, Kucuk NO. Efficacy of adding high-dose In-111 octreotide therapy during sandostatin treatment in patients with disseminated neuroendocrine tumors: clinical results of 14 patients. Ann Nucl Med. 2011;25:425–31.CrossRefPubMed
39.
Zurück zum Zitat Otte A, Herrmann R, Heppeler A, Behe M, Jermann E, Powell P, et al. Yttrium-90 DOTATOC: first clinical results. Eur J Nucl Med. 1999;26:1439–47.CrossRefPubMed Otte A, Herrmann R, Heppeler A, Behe M, Jermann E, Powell P, et al. Yttrium-90 DOTATOC: first clinical results. Eur J Nucl Med. 1999;26:1439–47.CrossRefPubMed
40.
Zurück zum Zitat Waldherr C, Pless M, Maecke HR, Haldemann A, Mueller-Brand J. The clinical value of [90Y-Dota]-D-Phe1Tyr3Octreotide (90Y-DOTATOC) in the treatment of neuroendocrine tumours: a clinical phase II study. Ann Oncol. 2001;12:41–945.CrossRef Waldherr C, Pless M, Maecke HR, Haldemann A, Mueller-Brand J. The clinical value of [90Y-Dota]-D-Phe1Tyr3Octreotide (90Y-DOTATOC) in the treatment of neuroendocrine tumours: a clinical phase II study. Ann Oncol. 2001;12:41–945.CrossRef
41.
Zurück zum Zitat Kunikowska J, Królicki L, Hubalewska-Dydejczyk A, Mikołajczak R, Sowa-Staszczak A, Pawlak D. Clinical results of radionuclide therapy of neuroendocrine tumours with 90Y-DOTATATE and Tandem 90Y/177Lu- DOTATATE: which is a better therapy option. Eur J Nucl Med Mol Imaging. 2011;38:1788–97.CrossRefPubMedPubMedCentral Kunikowska J, Królicki L, Hubalewska-Dydejczyk A, Mikołajczak R, Sowa-Staszczak A, Pawlak D. Clinical results of radionuclide therapy of neuroendocrine tumours with 90Y-DOTATATE and Tandem 90Y/177Lu- DOTATATE: which is a better therapy option. Eur J Nucl Med Mol Imaging. 2011;38:1788–97.CrossRefPubMedPubMedCentral
42.
Zurück zum Zitat Kwekkeboom DJ, Teunissen JJ, Bakker WH, Kooij PP, de Herder WW, Feelders RA, et al. Radiolabeled somatostatin analog [177Lu-DOTA0,Tyr3] octreotate in patients with endocrine gastroenteropancreatic tumors. J Clin Oncol. 2005;23:2754–62.CrossRefPubMed Kwekkeboom DJ, Teunissen JJ, Bakker WH, Kooij PP, de Herder WW, Feelders RA, et al. Radiolabeled somatostatin analog [177Lu-DOTA0,Tyr3] octreotate in patients with endocrine gastroenteropancreatic tumors. J Clin Oncol. 2005;23:2754–62.CrossRefPubMed
43.
Zurück zum Zitat Teunissen JJ, Kwekkeboom DJ, Krenning EP. Quality of life in patients with gastroenteropancreatic tumors treated with [177Lu-DOTA0,Tyr3] octreotate. J Clin Oncol. 2004;22:2724–9.CrossRefPubMed Teunissen JJ, Kwekkeboom DJ, Krenning EP. Quality of life in patients with gastroenteropancreatic tumors treated with [177Lu-DOTA0,Tyr3] octreotate. J Clin Oncol. 2004;22:2724–9.CrossRefPubMed
44.
Zurück zum Zitat Kwekkeboom DJ, de Herder WW, Kam BL, van Eijck CH, van Essen M, Kooij PP, et al. Treatment with the radiolabeled somatostatin analog [177Lu-DOTA0,Tyr3] Octreotate: toxicity, efficacy, and survival. J Clin Oncol. 2008;26:2124–30.CrossRefPubMed Kwekkeboom DJ, de Herder WW, Kam BL, van Eijck CH, van Essen M, Kooij PP, et al. Treatment with the radiolabeled somatostatin analog [177Lu-DOTA0,Tyr3] Octreotate: toxicity, efficacy, and survival. J Clin Oncol. 2008;26:2124–30.CrossRefPubMed
45.
Zurück zum Zitat Bodei L, Cremonesi M, Grana CM, Fazio N, Iodice S, Baio SM, et al. Peptide receptor radionuclide therapy with 177Lu-DOTATATE: the IEO phase I-II study. Eur J Nucl Med Mol Imaging. 2011;38:2125–35.CrossRefPubMed Bodei L, Cremonesi M, Grana CM, Fazio N, Iodice S, Baio SM, et al. Peptide receptor radionuclide therapy with 177Lu-DOTATATE: the IEO phase I-II study. Eur J Nucl Med Mol Imaging. 2011;38:2125–35.CrossRefPubMed
46.
Zurück zum Zitat Esser JP, Krenning EP, Teunissen JJ, Kooij PP, van Gameren AL, Bakker WH, et al. Comparison of [177Lu-DOTA0,Tyr3] Octreotate and [177Lu- DOTA0, Tyr3] Octreotide: which peptide is preferable for PRRT. Eur J Nucl Med Mol Imaging. 2006;33:1346–51.CrossRefPubMed Esser JP, Krenning EP, Teunissen JJ, Kooij PP, van Gameren AL, Bakker WH, et al. Comparison of [177Lu-DOTA0,Tyr3] Octreotate and [177Lu- DOTA0, Tyr3] Octreotide: which peptide is preferable for PRRT. Eur J Nucl Med Mol Imaging. 2006;33:1346–51.CrossRefPubMed
47.
Zurück zum Zitat Wehrmann C, Senftleben S, Zachert C, Muller D, Baum RP. Results of individual patient dosimetry in peptide receptor radionuclide therapy with 177Lu-DOTA-TATE and 177Lu-DOTA-NOC. Cancer Biother Radiopharm. 2007;22:406–16.CrossRefPubMed Wehrmann C, Senftleben S, Zachert C, Muller D, Baum RP. Results of individual patient dosimetry in peptide receptor radionuclide therapy with 177Lu-DOTA-TATE and 177Lu-DOTA-NOC. Cancer Biother Radiopharm. 2007;22:406–16.CrossRefPubMed
48.
Zurück zum Zitat de Jong M, Breeman WAP, Valkema R, Bernard BF, Krenning EP. Combination radionuclide therapy using 177Lu- and 90Y-labeled somatostatin analogs. J Nucl Med. 2005;46:13S–17S.PubMed de Jong M, Breeman WAP, Valkema R, Bernard BF, Krenning EP. Combination radionuclide therapy using 177Lu- and 90Y-labeled somatostatin analogs. J Nucl Med. 2005;46:13S–17S.PubMed
49.
Zurück zum Zitat Seregni E, Maccauro M, Coliva A, Castellani MR, Bajetta E, Aliberti G, et al. Treatment with Tandem [90Y]DOTA-TATE and [177Lu]DOTA-TATE of neuroendocrine tumors refractory to conventional therapy: preliminary results. Q J Nucl Med Mol Imaging. 2010;54:84–91.PubMed Seregni E, Maccauro M, Coliva A, Castellani MR, Bajetta E, Aliberti G, et al. Treatment with Tandem [90Y]DOTA-TATE and [177Lu]DOTA-TATE of neuroendocrine tumors refractory to conventional therapy: preliminary results. Q J Nucl Med Mol Imaging. 2010;54:84–91.PubMed
50.
Zurück zum Zitat Gabriel M, Andergassen U, Putzer D, Kroiss A, Waitz D, Von Guggenberg E, et al. Individualized peptide-related-radionuclide-therapy concept using different radiolabelled somatostatin analogs in advanced cancer patients. Q J Nucl Med Mol Imaging. 2010;54:92–9.PubMed Gabriel M, Andergassen U, Putzer D, Kroiss A, Waitz D, Von Guggenberg E, et al. Individualized peptide-related-radionuclide-therapy concept using different radiolabelled somatostatin analogs in advanced cancer patients. Q J Nucl Med Mol Imaging. 2010;54:92–9.PubMed
51.
Zurück zum Zitat Pach D, Sowa-Staszczak A, Kunikowska J, Królicki L, Trofimiuk M, Stefanska A, et al. Repeated cycles of peptide receptor radionuclide therapy (PRRT)—results and side-effects of the radioisotope 90Y-DOTA TATE, 177Lu-DOTA TATE Or 90Y/177Lu-DOTA TATE therapy in patients with disseminated NET. Radiother Oncol. 2012;102:45–50.CrossRefPubMed Pach D, Sowa-Staszczak A, Kunikowska J, Królicki L, Trofimiuk M, Stefanska A, et al. Repeated cycles of peptide receptor radionuclide therapy (PRRT)—results and side-effects of the radioisotope 90Y-DOTA TATE, 177Lu-DOTA TATE Or 90Y/177Lu-DOTA TATE therapy in patients with disseminated NET. Radiother Oncol. 2012;102:45–50.CrossRefPubMed
52.
Zurück zum Zitat Cremonesi M, Botta F, Dia AD, Ferrari M, Bodei L, De Cicco C, et al. Dosimetry for treatment with radiolabelled somatostatin analogues. a review. Q J Nucl Med Mol Imaging. 2010;54:37–51.PubMed Cremonesi M, Botta F, Dia AD, Ferrari M, Bodei L, De Cicco C, et al. Dosimetry for treatment with radiolabelled somatostatin analogues. a review. Q J Nucl Med Mol Imaging. 2010;54:37–51.PubMed
53.
Zurück zum Zitat Vegt E, de Jong M, Wetzels JFM, Masereeuw R, Melis M, Oyen WJG, et al. Renal toxicity of radiolabeled peptides and antibody fragments: mechanisms, impact on radionuclide therapy, and strategies for prevention. J Nucl Med. 2010;51:1049–58.CrossRefPubMed Vegt E, de Jong M, Wetzels JFM, Masereeuw R, Melis M, Oyen WJG, et al. Renal toxicity of radiolabeled peptides and antibody fragments: mechanisms, impact on radionuclide therapy, and strategies for prevention. J Nucl Med. 2010;51:1049–58.CrossRefPubMed
54.
Zurück zum Zitat Wang X, Yang L, Chen Z, Shin DM. Application of nanotechnology in cancer therapy and imaging. CA Cancer J Clin. 2008;58:97–110.CrossRefPubMed Wang X, Yang L, Chen Z, Shin DM. Application of nanotechnology in cancer therapy and imaging. CA Cancer J Clin. 2008;58:97–110.CrossRefPubMed
56.
Zurück zum Zitat Kairemo K, Erba P, Bergstrom K, Pauwels EKJ. Nanoparticles in cancer. Curr Radiopharm. 2008;1:30–6.CrossRef Kairemo K, Erba P, Bergstrom K, Pauwels EKJ. Nanoparticles in cancer. Curr Radiopharm. 2008;1:30–6.CrossRef
57.
Zurück zum Zitat Emfietzoglou D, Kostarelos K, Sgouros G. An analytic dosimetry study for the use of radionuclide–liposome conjugates in internal radiotherapy. J Nucl Med. 2001;42:499–504.PubMed Emfietzoglou D, Kostarelos K, Sgouros G. An analytic dosimetry study for the use of radionuclide–liposome conjugates in internal radiotherapy. J Nucl Med. 2001;42:499–504.PubMed
58.
Zurück zum Zitat Harrington KJ, Mohammadtaghi S, Uster PS, Glass D, Peters A, Vile RG, et al. Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes. Clin Cancer Res. 2001;7:243–54.PubMed Harrington KJ, Mohammadtaghi S, Uster PS, Glass D, Peters A, Vile RG, et al. Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes. Clin Cancer Res. 2001;7:243–54.PubMed
59.
Zurück zum Zitat Wang SX, Bao A, Herrera SJ, Phillips WT, Goins B, Santoyo C, et al. Intraoperative 186Re-liposome radionuclide therapy in a head and neck squamous cell carcinoma xenograft positive surgical margin model. Clin Cancer Res. 2008;14:3975–83.CrossRefPubMed Wang SX, Bao A, Herrera SJ, Phillips WT, Goins B, Santoyo C, et al. Intraoperative 186Re-liposome radionuclide therapy in a head and neck squamous cell carcinoma xenograft positive surgical margin model. Clin Cancer Res. 2008;14:3975–83.CrossRefPubMed
60.
Zurück zum Zitat Reis CP, Neufeld RJ, Ribeiro AJ, Veiga F. Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine. 2006;2:8–21.CrossRefPubMed Reis CP, Neufeld RJ, Ribeiro AJ, Veiga F. Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine. 2006;2:8–21.CrossRefPubMed
61.
Zurück zum Zitat Lee SC, Oh JT, Jang MH, Chung S. Quantitative analysis of polyvinyl alcohol on the surface of poly-(d,l-lactide-co-glycolide) microparticles prepared by solvent evaporation method: effect of particle size and PVA concentration. J Control Release. 1999;59:123–32.CrossRefPubMed Lee SC, Oh JT, Jang MH, Chung S. Quantitative analysis of polyvinyl alcohol on the surface of poly-(d,l-lactide-co-glycolide) microparticles prepared by solvent evaporation method: effect of particle size and PVA concentration. J Control Release. 1999;59:123–32.CrossRefPubMed
62.
Zurück zum Zitat Zolnik BS, Gonzalez-Fernandez A, Sadrieh N, Dobrovolskaia MA. Minireview: nanoparticles and the immune system. Endocrinology. 2010;151:458–65.CrossRefPubMed Zolnik BS, Gonzalez-Fernandez A, Sadrieh N, Dobrovolskaia MA. Minireview: nanoparticles and the immune system. Endocrinology. 2010;151:458–65.CrossRefPubMed
63.
Zurück zum Zitat Dobrovolskaia MA, McNeil SE. Immunological properties of engineered nanomaterials. Nat Nanotechnol. 2007;2:469–78.CrossRefPubMed Dobrovolskaia MA, McNeil SE. Immunological properties of engineered nanomaterials. Nat Nanotechnol. 2007;2:469–78.CrossRefPubMed
64.
Zurück zum Zitat Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev. 2001;53:283–318.PubMed Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev. 2001;53:283–318.PubMed
65.
Zurück zum Zitat Owens DE III, Peppas NA. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm. 2006;307:93–102.CrossRefPubMed Owens DE III, Peppas NA. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm. 2006;307:93–102.CrossRefPubMed
66.
Zurück zum Zitat Fazel-Rezai R. Biomedical engineering—from theory to applications. Ebook published by InTech 2011, ISBN 978-953-307-637-9, Chapter 13. Fazel-Rezai R. Biomedical engineering—from theory to applications. Ebook published by InTech 2011, ISBN 978-953-307-637-9, Chapter 13.
67.
Zurück zum Zitat Harrington KJ, Lewanski CR, Stewart JS. Liposomes as vehicles for targeted therapy of cancer. Part 1: preclinical development. Clin Oncol (R Coll Radiol). 2000;12:2–15. Harrington KJ, Lewanski CR, Stewart JS. Liposomes as vehicles for targeted therapy of cancer. Part 1: preclinical development. Clin Oncol (R Coll Radiol). 2000;12:2–15.
68.
Zurück zum Zitat Harrington KJ, Lewanski CR, Stewart JS. Liposomes as vehicles for targeted therapy of cancer. Part 2: clinical development. Clin Oncol (R Coll Radiol). 2000;12:16–24. Harrington KJ, Lewanski CR, Stewart JS. Liposomes as vehicles for targeted therapy of cancer. Part 2: clinical development. Clin Oncol (R Coll Radiol). 2000;12:16–24.
69.
Zurück zum Zitat Rossin R, Pan D, Qi K, Turner JL, Sun X, Wooley KL, et al. 64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: synthesis, radiolabeling, and biologic evaluation. J Nucl Med. 2005;46:1210–8.PubMed Rossin R, Pan D, Qi K, Turner JL, Sun X, Wooley KL, et al. 64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: synthesis, radiolabeling, and biologic evaluation. J Nucl Med. 2005;46:1210–8.PubMed
70.
Zurück zum Zitat Shukla J, Bandopadhyaya GP, Varma IK. 188Rhenium(V)-Dimercaptosuccinic acid loaded Poly-(Lactic-Co-Glycolic) acid microspheres for targeted radiotherapy: production and effectivity. Pharmazie. 2005;60:583–7.PubMed Shukla J, Bandopadhyaya GP, Varma IK. 188Rhenium(V)-Dimercaptosuccinic acid loaded Poly-(Lactic-Co-Glycolic) acid microspheres for targeted radiotherapy: production and effectivity. Pharmazie. 2005;60:583–7.PubMed
71.
Zurück zum Zitat DeNardo SJ, DeNardo GL, Natarajan A, Miers LA, Foreman AR, Gruettner C, et al. Thermal Dosimetry Predictive Of Efficacy of 111In-ChL6 nanoparticle AMF–induced thermoablative therapy for human breast cancer in mice. J Nucl Med. 2007;48:437–44.CrossRefPubMed DeNardo SJ, DeNardo GL, Natarajan A, Miers LA, Foreman AR, Gruettner C, et al. Thermal Dosimetry Predictive Of Efficacy of 111In-ChL6 nanoparticle AMF–induced thermoablative therapy for human breast cancer in mice. J Nucl Med. 2007;48:437–44.CrossRefPubMed
72.
Zurück zum Zitat McDevitt MR, Chattopadhyay D, Kappel BJ, Jaggi JS, Schiffman SR, Antczak C, et al. Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. J Nucl Med. 2007;48:1180–9.CrossRefPubMed McDevitt MR, Chattopadhyay D, Kappel BJ, Jaggi JS, Schiffman SR, Antczak C, et al. Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. J Nucl Med. 2007;48:1180–9.CrossRefPubMed
73.
Zurück zum Zitat Helbok A, Decristoforo C, Dobrozemsky G, Rangger C, Diederen E, Stark B, et al. Radiolabeling of lipid-based nanoparticles for diagnostics and therapeutic applications: a comparison using different radiometals. J Liposome Res 2010;20:219–27.CrossRefPubMed Helbok A, Decristoforo C, Dobrozemsky G, Rangger C, Diederen E, Stark B, et al. Radiolabeling of lipid-based nanoparticles for diagnostics and therapeutic applications: a comparison using different radiometals. J Liposome Res 2010;20:219–27.CrossRefPubMed
75.
Zurück zum Zitat Ocampo-García BE, Ramírez Fde M, Ferro-Flores G, De León-Rodríguez LM, Santos-Cuevas CL, Morales-Avila E, et al. (99 m)Tc-labelled gold nanoparticles capped with HYNIC-peptide/mannose for sentinel lymph node detection. Nucl Med Biol. 2011;38:1–11.CrossRefPubMed Ocampo-García BE, Ramírez Fde M, Ferro-Flores G, De León-Rodríguez LM, Santos-Cuevas CL, Morales-Avila E, et al. (99 m)Tc-labelled gold nanoparticles capped with HYNIC-peptide/mannose for sentinel lymph node detection. Nucl Med Biol. 2011;38:1–11.CrossRefPubMed
76.
Zurück zum Zitat Tang QS, Chen DZ, Xue WQ, Xiang JY, Gong YC, Zhang L, et al. Preparation and biodistribution of 188Re-labeled folate conjugated human serum albumin magnetic cisplatin nanoparticles (188Re-Folate-CDDP/HSA Mnps) in vivo. Int J Nanomed. 2011;6:3077–85. Tang QS, Chen DZ, Xue WQ, Xiang JY, Gong YC, Zhang L, et al. Preparation and biodistribution of 188Re-labeled folate conjugated human serum albumin magnetic cisplatin nanoparticles (188Re-Folate-CDDP/HSA Mnps) in vivo. Int J Nanomed. 2011;6:3077–85.
78.
80.
Zurück zum Zitat Surujpaul PP, Gutiérrez-Wing C, Ocampo-García B, Ramírez F, de Murphy CA, Pedraza-López M, et al. Gold nanoparticles conjugated to [Tyr3]Octreotide peptide. Biophys Chem. 2008;138:83–90.CrossRefPubMed Surujpaul PP, Gutiérrez-Wing C, Ocampo-García B, Ramírez F, de Murphy CA, Pedraza-López M, et al. Gold nanoparticles conjugated to [Tyr3]Octreotide peptide. Biophys Chem. 2008;138:83–90.CrossRefPubMed
81.
Zurück zum Zitat Dubey N, Varshney R, Shukla J, Ganeshpurkar A, Hazari PP, Bandopadhaya GP, et al. Synthesis and evaluation of biodegradable PCL/PEG nanoparticles for neuroendocrine tumor targeted delivery of somatostatin analog. Drug Deliv. 2012;19:132–42.CrossRefPubMed Dubey N, Varshney R, Shukla J, Ganeshpurkar A, Hazari PP, Bandopadhaya GP, et al. Synthesis and evaluation of biodegradable PCL/PEG nanoparticles for neuroendocrine tumor targeted delivery of somatostatin analog. Drug Deliv. 2012;19:132–42.CrossRefPubMed
82.
Zurück zum Zitat Dubey N, Shukla J, Hazari PP, Varshney R, Ganeshpurkar A, Mishra AK, et al. Preparation and biological evaluation of paclitaxel loaded biodegradable PCL/PEG nanoparticles for the treatment of human neuroendocrine pancreatic tumor in mice. Hell J Nucl Med. 2012;15:9–15.PubMed Dubey N, Shukla J, Hazari PP, Varshney R, Ganeshpurkar A, Mishra AK, et al. Preparation and biological evaluation of paclitaxel loaded biodegradable PCL/PEG nanoparticles for the treatment of human neuroendocrine pancreatic tumor in mice. Hell J Nucl Med. 2012;15:9–15.PubMed
84.
Zurück zum Zitat Arora G, Dubey P, Shukla J, Ghosh S, Bandopadhyaya G. Evaluation of cytotoxic and tumor targeting capability of (177)Lu-DOTATATE-nanoparticles: a trailblazing strategy in peptide receptor radionuclide therapy. Ann Nucl Med. 2016;30:334–45.CrossRefPubMed Arora G, Dubey P, Shukla J, Ghosh S, Bandopadhyaya G. Evaluation of cytotoxic and tumor targeting capability of (177)Lu-DOTATATE-nanoparticles: a trailblazing strategy in peptide receptor radionuclide therapy. Ann Nucl Med. 2016;30:334–45.CrossRefPubMed
Metadaten
Titel
Paradigm shift in theranostics of neuroendocrine tumors: conceptual horizons of nanotechnology in nuclear medicine
verfasst von
Geetanjali Arora
Gurupad Bandopadhyaya
Publikationsdatum
01.04.2018
Verlag
Springer Japan
Erschienen in
Annals of Nuclear Medicine / Ausgabe 3/2018
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-018-1235-2

Weitere Artikel der Ausgabe 3/2018

Annals of Nuclear Medicine 3/2018 Zur Ausgabe