Skip to main content
Erschienen in: HSS Journal ® 1/2012

01.02.2012 | HSS Osteoarthritis Symposium: Frontiers in OA

Pathologic and Pathogenic Processes in Osteoarthritis: The Effects of Synovitis

verfasst von: Carla R. Scanzello, MD, PhD

Erschienen in: HSS Journal ® | Ausgabe 1/2012

Einloggen, um Zugang zu erhalten

Excerpt

Synovitis (inflammation of the synovial lining) is increasingly recognized as a characteristic of the osteoarthritic joint. Over the past decade, many have documented that synovitis is present in various stages of the disease and is detectable by advanced imaging techniques [3], the presence of soluble mediators [5], or histopathologic assessment [9]. Despite using different methods of detection and different outcome measurements, studies from these multiple research groups have often led to similar conclusions. …
Literatur
1.
Zurück zum Zitat Ashraf, S., Mapp, P. I., and Walsh, D. A. Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis. Arthritis Rheum 63:2700–10; 2011.PubMedCrossRef Ashraf, S., Mapp, P. I., and Walsh, D. A. Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis. Arthritis Rheum 63:270010; 2011.PubMedCrossRef
2.
Zurück zum Zitat Ayral, X., Pickering, E. H., Woodworth, T. G., Mackillop, N., and Dougados, M. Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage 13:361–7; 2005.PubMedCrossRef Ayral, X., Pickering, E. H., Woodworth, T. G., Mackillop, N., and Dougados, M. Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage 13:3617; 2005.PubMedCrossRef
3.
Zurück zum Zitat Guermazi, A., Roemer, F. W., Hayashi, D., Crema, M. D., Niu, J., Zhang, Y., Marra, M. D., Katur, A., Lynch, J. A., El-Khoury, G. Y., Baker, K., Hughes, L. B., Nevitt, M. C., and Felson, D. T. Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study. Ann Rheum Dis 70:805–11; 2011.PubMedCrossRef Guermazi, A., Roemer, F. W., Hayashi, D., Crema, M. D., Niu, J., Zhang, Y., Marra, M. D., Katur, A., Lynch, J. A., El-Khoury, G. Y., Baker, K., Hughes, L. B., Nevitt, M. C., and Felson, D. T. Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study. Ann Rheum Dis 70:80511; 2011.PubMedCrossRef
4.
Zurück zum Zitat Hunter, D. J., Zhang, W., Conaghan, P. G., Hirko, K., Menashe, L., Reichmann, W. M., and Losina, E. Responsiveness and reliability of MRI in knee osteoarthritis: a meta-analysis of published evidence. Osteoarthritis Cartilage 19:589–605; 2011.PubMedCrossRef Hunter, D. J., Zhang, W., Conaghan, P. G., Hirko, K., Menashe, L., Reichmann, W. M., and Losina, E. Responsiveness and reliability of MRI in knee osteoarthritis: a meta-analysis of published evidence. Osteoarthritis Cartilage 19:589605; 2011.PubMedCrossRef
5.
Zurück zum Zitat Ishijima, M., Watari, T., Naito, K., Kaneko, H., Futami, I., Yoshimura-Ishida, K., Tomonaga, A., Yamaguchi, H., Yamamoto, T., Nagaoka, I., Kurosawa, H., Poole, R. A., and Kaneko, K. Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis. Arthritis Res Ther 13:R22; 2011.PubMedCrossRef Ishijima, M., Watari, T., Naito, K., Kaneko, H., Futami, I., Yoshimura-Ishida, K., Tomonaga, A., Yamaguchi, H., Yamamoto, T., Nagaoka, I., Kurosawa, H., Poole, R. A., and Kaneko, K. Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis. Arthritis Res Ther 13:R22; 2011.PubMedCrossRef
6.
Zurück zum Zitat Krasnokutsky, S., Belitskaya-Levy, I., Bencardino, J., Samuels, J., Attur, M., Regatte, R., Rosenthal, P., Greenberg, J., Schweitzer, M., Abramson, S. B., and Rybak, L. Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis. Arthritis Rheum 63:2983–91; 2011.PubMedCrossRef Krasnokutsky, S., Belitskaya-Levy, I., Bencardino, J., Samuels, J., Attur, M., Regatte, R., Rosenthal, P., Greenberg, J., Schweitzer, M., Abramson, S. B., and Rybak, L. Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis. Arthritis Rheum 63:298391; 2011.PubMedCrossRef
7.
Zurück zum Zitat Ling, S. M., Patel, D. D., Garnero, P., Zhan, M., Vaduganathan, M., Muller, D., Taub, D., Bathon, J. M., Hochberg, M., Abernethy, D. R., Metter, E. J., and Ferrucci, L. Serum protein signatures detect early radiographic osteoarthritis. Osteoarthritis Cartilage 17:43–8; 2009.PubMedCrossRef Ling, S. M., Patel, D. D., Garnero, P., Zhan, M., Vaduganathan, M., Muller, D., Taub, D., Bathon, J. M., Hochberg, M., Abernethy, D. R., Metter, E. J., and Ferrucci, L. Serum protein signatures detect early radiographic osteoarthritis. Osteoarthritis Cartilage 17:438; 2009.PubMedCrossRef
8.
Zurück zum Zitat Pearle, A. D., Scanzello, C. R., George, S., Mandl, L. A., DiCarlo, E. F., Peterson, M., Sculco, T. P., and Crow, M. K. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis. Osteoarthritis Cartilage 15:516–23; 2007.PubMedCrossRef Pearle, A. D., Scanzello, C. R., George, S., Mandl, L. A., DiCarlo, E. F., Peterson, M., Sculco, T. P., and Crow, M. K. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis. Osteoarthritis Cartilage 15:51623; 2007.PubMedCrossRef
9.
Zurück zum Zitat Pessler, F., Dai, L., Diaz-Torne, C., Gomez-Vaquero, C., Paessler, M. E., Zheng, D. H., Einhorn, E., Range, U., Scanzello, C., and Schumacher, H. R. The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis. Ann Rheum Dis 67:1184–7; 2008.PubMedCrossRef Pessler, F., Dai, L., Diaz-Torne, C., Gomez-Vaquero, C., Paessler, M. E., Zheng, D. H., Einhorn, E., Range, U., Scanzello, C., and Schumacher, H. R. The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis. Ann Rheum Dis 67:11847; 2008.PubMedCrossRef
10.
Zurück zum Zitat Roemer, F. W., Zhang, Y., Niu, J., Lynch, J. A., Crema, M. D., Marra, M. D., Nevitt, M. C., Felson, D. T., Hughes, L. B., El-Khoury, G. Y., Englund, M., and Guermazi, A. Tibiofemoral joint osteoarthritis: risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis study. Radiology 252:772–80; 2009.PubMedCrossRef Roemer, F. W., Zhang, Y., Niu, J., Lynch, J. A., Crema, M. D., Marra, M. D., Nevitt, M. C., Felson, D. T., Hughes, L. B., El-Khoury, G. Y., Englund, M., and Guermazi, A. Tibiofemoral joint osteoarthritis: risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis study. Radiology 252:77280; 2009.PubMedCrossRef
11.
Zurück zum Zitat Scanzello, C. R., McKeon, B., Swaim, B. H., DiCarlo, E., Asomugha, E. U., Kanda, V., Nair, A., Lee, D. M., Richmond, J. C., Katz, J. N., Crow, M. K., and Goldring, S. R. Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms. Arthritis Rheum 63:391–400; 2011.PubMedCrossRef Scanzello, C. R., McKeon, B., Swaim, B. H., DiCarlo, E., Asomugha, E. U., Kanda, V., Nair, A., Lee, D. M., Richmond, J. C., Katz, J. N., Crow, M. K., and Goldring, S. R. Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms. Arthritis Rheum 63:391400; 2011.PubMedCrossRef
12.
Zurück zum Zitat Scanzello, C. R., Umoh, E., Pessler, F., Diaz-Torne, C., Miles, T., Dicarlo, E., Potter, H. G., Mandl, L., Marx, R., Rodeo, S., Goldring, S. R., and Crow, M. K. Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease. Osteoarthritis Cartilage 17:1040–8; 2009.PubMedCrossRef Scanzello, C. R., Umoh, E., Pessler, F., Diaz-Torne, C., Miles, T., Dicarlo, E., Potter, H. G., Mandl, L., Marx, R., Rodeo, S., Goldring, S. R., and Crow, M. K. Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease. Osteoarthritis Cartilage 17:10408; 2009.PubMedCrossRef
13.
Zurück zum Zitat Sowers, M., Karvonen-Gutierrez, C. A., Jacobson, J. A., Jiang, Y., and Yosef, M. Associations of anatomical measures from MRI with radiographically defined knee osteoarthritis score, pain, and physical functioning. J Bone Joint Surg Am 93:241–51; 2011.PubMedCrossRef Sowers, M., Karvonen-Gutierrez, C. A., Jacobson, J. A., Jiang, Y., and Yosef, M. Associations of anatomical measures from MRI with radiographically defined knee osteoarthritis score, pain, and physical functioning. J Bone Joint Surg Am 93:24151; 2011.PubMedCrossRef
Metadaten
Titel
Pathologic and Pathogenic Processes in Osteoarthritis: The Effects of Synovitis
verfasst von
Carla R. Scanzello, MD, PhD
Publikationsdatum
01.02.2012
Verlag
Springer-Verlag
Erschienen in
HSS Journal ® / Ausgabe 1/2012
Print ISSN: 1556-3316
Elektronische ISSN: 1556-3324
DOI
https://doi.org/10.1007/s11420-011-9228-x

Weitere Artikel der Ausgabe 1/2012

HSS Journal ® 1/2012 Zur Ausgabe

HSS OSTEOARTHRITIS SYMPOSIUM: FRONTIERS IN OA

Mechanisms of Pain in Osteoarthritis

HSS Osteoarthritis Symposium: Frontiers in OA

Osteoarthritis: Health Insurance Perspective

HSS OSTEOARTHRITIS SYMPOSIUM: FRONTIERS IN OA

Degeneration of the Meniscus and Progression of Osteoarthritis

HSS OSTEOARTHRITIS SYMPOSIUM: FRONTIERS IN OA

Impact of Race/Ethnicity in OA Treatment

HSS Osteoarthritis Symposium: Frontiers in OA

The Osteoarthritis Initiative: A NIH Public–Private Partnership

HSS Osteoarthritis Symposium: Frontiers in OA

Tissue Engineering Strategies for Skeletal Repair

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Arthroskopie kann Knieprothese nicht hinauszögern

25.04.2024 Gonarthrose Nachrichten

Ein arthroskopischer Eingriff bei Kniearthrose macht im Hinblick darauf, ob und wann ein Gelenkersatz fällig wird, offenbar keinen Unterschied.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 Leitsymptom Rückenschmerzen Nachrichten

Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.