Patients with Complex Chronic Diseases: Perspectives on Supporting Self-Management

According to Thorne, the goals of chronically ill patients often diverge from those of their health care providers. Patients are trapped between their effort to obtain appropriate medical care and a desire to live a normal life.13 This description is likely to be particularly applicable to those trying to manage multiple diseases and is consistent with our example. Dr. D is frustrated by his patient’s lack of compliance to the medical regimen, whereas Mr. S struggles to manage his life and conditions in the face of having lost his wife. When faced with an apparent lack of agreement regarding the nature of the problem, how can providers elicit in patients like Mr. S a desire to engage in good self-management?

Efforts to increase patient participation in care through collaborative goal-setting and planning of treatment have been suggested by Wagner et al.,14 to be an essential component of chronic disease management. Collaborative goal-setting has been found to be effective in interventions to enhance diabetes self-management,15 and reduce health risks.16,17 Motivational interviewing (MI) is a theory-based counseling approach that has been shown in the health promotion and substance abuse literature to be effective in engaging patients and providers in mutual goal-setting around self-management.18 With MI, the counselor helps clients verbally express their own reasons for and against behavior change, how current health behavior may conflict with their health goals, and how their current behavior or health status affects their ability to achieve their life goals. MI requires a nonjudgmental, empathetic, and encouraging communication style.19 Whereas MI techniques have not been widely applied to CCDs, such approaches may be particularly helpful for engaging patients such as Mr. S. in contemplating what he thinks is possible regarding his self-care requirements. If effective in CCD, MI may result in activated patients and plans of care that are patient-centered.

Patient–provider communication is not only important for engaging patients in self-care, it continues to be important as patients become informed participants in their care.20‐22 In studies of patient–physician communication, patients report that communication skills are 1 of the top 3 competencies that a physician should possess, ranking it higher than other attributes such as promotion of preventive care, consideration of costs to the patient, correct use of technology, and cooperation with other health care professionals.23 Table 1 summarizes the findings of a systematic review of the literature on the association of communication characteristics and patient outcomes.24 Quality communication has been shown to be directly associated with optimal self-care,25 to result in better continuity of care, and to increase provision of preventive services.26

Although they have not been evaluated in the CCD population, a number of interventions have been tested to improve the process of patient–provider communication. Patient-targeted approaches have been shown to improve health outcomes and include techniques such as patient activation through skills training (e.g., coaching patients to take a more active role in the clinic visit) and use of previsit questionnaires to identify pertinent patient concerns.21,22,27,28 These approaches may be particularly useful for CCD patients such as Mr. S, who are likely to have complicated educational and other needs that would otherwise go unnoticed in health care encounters that are driven solely by the provider.

Provider-based approaches such as communication skills training, discussion of behavior change, and interventions to improve patient-centeredness have shown variable results with regards to their effects on patent satisfaction and health outcomes.29‐31 Multilevel interventions targeting both the patient and provider have also been developed with 1 study reporting a decrease in mortality among a geriatric population and improvement in functional status in which provider education and patient activation techniques were employed.32

In addition to good communication, those caring for patients with CCD must be skilled in fostering behavior change. To understand the deterioration in Mr. S’s current self-management behavior and the leverage points for possible intervention, we must first consider how individuals, in general, change their health behaviors.

Figure 1 is a representation of the common determinants of behavior change.33 The concepts and variables listed in Figure 1 are derived mainly from 3 well-known theories/models: The Health Belief Model, Social Cognitive Theory, and the Theory of Reasoned Action.33 Three critical determinants of a person’s intentions or behaviors can be found in these theories and include ...“1) the person’s attitude toward performing the behavior, which is based on one’s beliefs about the positive and negative consequences (i.e., costs and benefits) of performing [the] behavior; 2) perceived norms, which include the perception that those with whom the individual interacts most closely support the person’s adoption of the behavior and that others in the community are performing the behavior; and, 3) self-efficacy, which involves the person’s confidence that he or she can perform the behavior under a variety of challenging circumstances.”34

With regard to our case, it is not clear to what extent Mr. S. understands the serious nature of his diseases or the consequences of nonadherence. He does not seem to have concluded that the benefits of self-management are worth the costs. In addition, Mr. S. has lost his wife, an important source of support for self-management of his diabetes and end-stage renal disease. It is not clear if there are others in his social network who can support him in his efforts to adhere to his regimen. Finally, Mr. S. has likely been told that his glycemic control has worsened and that he is consuming too much sodium and, as our case states, he feels as though he is being lectured by his physician. Such encounters with health care professionals are not likely to inspire Mr. S’s self-confidence in his ability to manage his condition.

Very little behavior change research has been conducted in CCD patient populations. A number of meta-analyses of studies in patients with diabetes, a single (but arguably complicated) disease, have shown that traditional approaches to patient education may not be sufficient for helping patients with self-management. Ellis et al.35 demonstrated that diabetes self-management intervention approaches employing behavioral methods (e.g., goal setting, problem solving, cognitive reframing) are more effective than traditional didactic education in producing and maintaining behavior changes. Norris showed that the degree of glycemic control is directly related to the frequency of contact and that intervention effects attenuate within 2–3 months of the intervention, suggesting that continued contact may be required to sustain effects.36 A recent meta-analysis of 6 randomized trials in diabetes tentatively concluded that social support interventions affect patient self-care and outcomes.37 In their synthesis of the literature, Marks et al.38 show that interventions to enhance self-efficacy (e.g., incremental goal setting, self-monitoring and self-appraisal, problem solving, modeling, etc.) to be effective in improving behavioral and clinical outcomes in a variety of patient populations.

Multiple diseases are likely to require the introduction of multifactorial self-management regimens. Although they do not include CCD patient populations, multifactorial behavioral interventions do appear in the literature (e.g., the Diabetes Prevention Program,39 the Multiple Risk Factor Intervention Trial,40 and Look Ahead41). The goal of these studies is to examine risk factor reductions that can occur through behavior change, rather than to test the effectiveness of alternative self-management strategies. For example, Look Ahead is an ongoing clinical trial to determine whether weight loss among obese people with diabetes results in a reduction in cardiovascular events. To accomplish weight loss, Look Ahead involves a 5-year intervention that includes an intensive behavioral weight loss intervention (i.e., weekly meetings for 6 months, biweekly meetings for the rest of the first year, with the frequency and mode of meetings decreasing in intensity over the subsequent 4 years). Whereas some important insights into the impact of weight loss on cardiovascular risk in obese people with diabetes will be gained from Look Ahead, the goal is not to determine the best approach for engaging patients in better self-management. Furthermore, such an intensive intervention is not likely to be feasible within a health service delivery system. Such studies provide health care professionals with limited information on best approaches for engaging patients in good self-care.

The results of studies comparing single versus multifactorial behavioral interventions in patients with single diseases (diabetes, hypertension) or unhealthy lifestyle behaviors (smoking, sun exposure, and high fat diet) have varied.42,43,44 Consequently, in helping CCD patients with self-management, the literature is not clear if self-care regimens requiring multiple behavior changes should be introduced simultaneously or sequentially.

Lorig et al. have developed a Chronic Disease Self-Management Program that includes generic content on exercise, symptom management, managing negative emotions, physician–patient communication, nutrition, fatigue management, and other topics that would be applicable to patients with any condition including those with multimorbidity. Whereas the program has been found to be effective in improving a variety of participant outcomes, it is not clear to what extent it is equally effective for those with CCD versus uncomplicated disease states.45‐47

Even the best informed, motivated, self-confident patients with CCD may fail in their efforts at self-management because of the complexity of information that must be manipulated for making good self-management decisions. Because problem-solving occurs within a person’s short-term memory,48,49 when memory capacity is exceeded, patients will resort to heuristics or “rules of thumb” that result in less than optimal decision-making.50 Even if health care professionals succeed in helping patients solve problems and make the initial behavioral changes, research has shown that new behaviors are often not maintained.34,51 The reason for this is perhaps because of the fact that information vigilance (i.e., maintaining information needed for good decision-making in short-term memory) is burdensome. Consequently, as new behaviors become routine (e.g., taking a daily pill with breakfast) patients begin to pay less attention to what they are doing and relapse to former behavior patterns.52,53

Two meta-analyses do suggest that information burden may play a role in self-management. In a systematic review of adherence to diabetes medications, Cramer54 showed adherence to be inversely related to the number of doses prescribed per day. In a meta-analysis of regimen adherence in several patient populations, DiMatteo, showed that patients are more adherent to circumscribed regimens (e.g., medication taking) than regimens requiring pervasive behavior change that impose greater information processing demands on the patient (e.g., diet).55

In our case, consider the information that Mr. S should consider in deciding what to eat for lunch. As a person with diabetes, he should know the carbohydrate content of the meal he plans to eat. As a person on dialysis he should limit his dietary potassium, phosphorus, and sodium. If Mr. S has experienced protein energy malnutrition (common in dialysis patients), his dietitian may have urged him to eat more calories and high-quality protein. Complicating this picture is the fact that single foods have multiple nutritional components, with differing health consequences depending on the condition of the patient. For example, increasing one’s intake of fresh vegetables and legumes (a common recommendation for those with diabetes), may result in consumption of additional potassium and phosphorus (which should be limited in the dialysis diet).

The literature on information processing/vigilance with regard to self-management in CCD is lacking. However, information management in patient decision-making is likely to be a significant problem in CCD not only because of the complexity of regimens, but because many chronic diseases are also associated with deficits in cognitive function.56‐64 Those with CCD are often older and, thus, normal age-related declines in cognitive function65 may also interfere with CCD self-management.66

One approach to minimizing information processing burden are Interactive Health Communication Applications (IHCAs), which are computer-based information packages that combine health information with social support, decision support, or behavior change support. IHCAs that have been evaluated in the literature include self-management educational programs for children with asthma; online discussion groups for those living with breast cancer or family caregivers of those with dementia; and dietary management programs. In a recent meta-analysis of 24 RCTs involving 3,739 participants who had a single chronic disease, Murray et al.67 found IHCAs appear to have largely positive effects on users in that users tend to become more knowledgeable, feel better socially supported, and have improved behavioral and clinical outcomes compared to nonusers.

HRQL, a standard outcome in medical care and research68‐70 is defined as, “those attributes valued by patients, including: their resultant comfort or sense of well-being; the extent to which they [are] able to maintain reasonable physical, emotional, and intellectual function; and the degree to which they retain their ability to participate in valued activities within the family, in the work place, and in the community”. There are 3 main processes linking self-management of CCD to HRQL: 1) direct effects inherent to the disease(s); compounded by: 2) effects from the prescribed treatment, including adverse and beneficial effects; and, 3) psychosocial strain or distress from coping with disease or treatment.

Regarding our scenario, the direct effect of disease on Mr. S’s HRQL include physical symptoms, functional disability, psychosocial and role limitations, and loss of vitality owing to diabetes complicated by end-stage kidney disease. The impact of the treatment regimen on HRQL includes the need for Mr. S to adhere to his diabetes medication and dietary regimen, and to monitor his glycemic control. As a patient on hemodialysis, Mr. S must devote 3 days each week to his dialysis treatments, adhere to a renal diet, and take additional medications. Given his high interdialytic weight gains, Mr. S is likely to experience cramping and hypotension during dialysis and to feel “washed-out” afterward. Mr. S may also experience improved well-being from clearance of renal solutes and hemodynamic stability.71‐73 Mr. S is likely to have undergone a long period of adaptation and adjustment to living with diabetes and kidney failure. Like Mr. S, people with CCD are likely to be older and, because of the loss of friends and family to death, may have a reduced social network. In our case, Mr. S has lost his wife, which simultaneously adds to his stress and reduces his ability to adapt. As noted previously, patients who experience net negative effects of CCD treatments may decide that the cost, in terms of HRQL, may outweigh the benefits of treatment and, like Mr. S., may choose not to adhere to the regimen. Such choices may result in tension between the patient who wants to normalize his life and the clinician whose goal is to optimize clinical outcomes.

Interventions to improve or maximize HRQL would be expected to have positive benefits for self-management. For example, controlling symptoms associated chronic disease and its treatment would be expected to improve capacity and willingness to perform self-management tasks.74,75 Health care delivery system interventions to enhance care coordination and continuity may improve HRQL and, in turn, reduce barriers to self-management. A key area where patient HRQL gains have been demonstrated is in interventions to improve the transition from institutional (e.g., hospital) to home setting,76‐79 although improvements are not consistently shown.80 Combining patient education with postdischarge management has also been shown to be effective in improving HRQL in patients with respiratory disease.81