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Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 9/2007

01.09.2007 | Editorial

PET/CT in head and neck cancer

verfasst von: Liselotte Højgaard, Lena Specht

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 9/2007

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Excerpt

Head and neck cancer is the third most frequent cancer worldwide, with 500,000 new cases every year [1]. It is a heterogeneous group of neoplasms arising in the upper aerodigestive tract with different pathophysiologies, histologies and staging paradigms [2]. PET/CT is emerging as the “method of choice” for diagnosis in head and neck cancer [3], and nuclear medicine physicians may regard this diagnostic entity as a rather simple challenge: the cancer, the large nodes and the metastases are often clearly visible on FDG PET/CT and we can just describe what we see and regard the case as closed. …
Literatur
1.
Zurück zum Zitat Hermans R. Tumours of the pharynx, tongue and mouth. In: Husband JE, Reznek RH, editors. Imaging in oncology, 2nd edn. London: Taylor & Francis, 2004. Hermans R. Tumours of the pharynx, tongue and mouth. In: Husband JE, Reznek RH, editors. Imaging in oncology, 2nd edn. London: Taylor & Francis, 2004.
2.
Zurück zum Zitat Macapinlac HH. Head, neck, thyroid. In: Wahl RL, editor. Principles and practice of positron emission tomgraphy. Philadelphia: Lippincott, Williams & Wilkins; 2002; p. 157–65. Macapinlac HH. Head, neck, thyroid. In: Wahl RL, editor. Principles and practice of positron emission tomgraphy. Philadelphia: Lippincott, Williams & Wilkins; 2002; p. 157–65.
3.
Zurück zum Zitat Frank SJ, Caho KS, Schwartz DL, Weber RS, Apisarnthanarax S, Macapinlac HA. Technology insight: PET and PET/CT in head and neck tumour staging and radiation therapy planning. Nat Clin Pract Oncol 2005;2(10):526–33.PubMedCrossRef Frank SJ, Caho KS, Schwartz DL, Weber RS, Apisarnthanarax S, Macapinlac HA. Technology insight: PET and PET/CT in head and neck tumour staging and radiation therapy planning. Nat Clin Pract Oncol 2005;2(10):526–33.PubMedCrossRef
4.
Zurück zum Zitat Kristensen CA, Kjær-Kristoffersen F, Sapru W, Berthelsen AK, Loft A, Specht L. Nasopharyngeal carcinoma. Treatment planning with IMRT or conformal 3D-radiotherapy. Acta Oncol 2007;in press. Kristensen CA, Kjær-Kristoffersen F, Sapru W, Berthelsen AK, Loft A, Specht L. Nasopharyngeal carcinoma. Treatment planning with IMRT or conformal 3D-radiotherapy. Acta Oncol 2007;in press.
5.
Zurück zum Zitat Borgwardt L, Larsen HJ, Pedersen K, Hojgaard L. Practical use and implementation of PET in children in a hospital PET center. Eur J Nucl Med Mol Imaging 2003;30:1389–97.PubMedCrossRef Borgwardt L, Larsen HJ, Pedersen K, Hojgaard L. Practical use and implementation of PET in children in a hospital PET center. Eur J Nucl Med Mol Imaging 2003;30:1389–97.PubMedCrossRef
6.
Zurück zum Zitat Frank SJ, Chao KS, Schwartz DL, Weber RS, Apisarnthanarax S, Macapinlac HA. Technology insight: PET and PET/CT in head and neck tumour staging and radiation therapy planning. Nat Clin Pract Oncol 2005;2:526–33.PubMedCrossRef Frank SJ, Chao KS, Schwartz DL, Weber RS, Apisarnthanarax S, Macapinlac HA. Technology insight: PET and PET/CT in head and neck tumour staging and radiation therapy planning. Nat Clin Pract Oncol 2005;2:526–33.PubMedCrossRef
7.
Zurück zum Zitat Chen YK, Su CT, Ding HJ, Chi KH, Liang JA, Shen YY, et al. Clinical usefulness of fused PET/CT compared with PET alone or CT alone in nasopharyngeal carcinoma patients. Anticancer Rese 2006;26:1471–7. Chen YK, Su CT, Ding HJ, Chi KH, Liang JA, Shen YY, et al. Clinical usefulness of fused PET/CT compared with PET alone or CT alone in nasopharyngeal carcinoma patients. Anticancer Rese 2006;26:1471–7.
8.
Zurück zum Zitat Ng SH, Yen TC, Chang JT, Chan SC, Ko SF, Wang HM, et al. Prospective study of [18F]fluorodeoxyglucose positron emission tomography and computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with palpably negative neck. J Clin Oncol 2006;24:4371–6.PubMedCrossRef Ng SH, Yen TC, Chang JT, Chan SC, Ko SF, Wang HM, et al. Prospective study of [18F]fluorodeoxyglucose positron emission tomography and computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with palpably negative neck. J Clin Oncol 2006;24:4371–6.PubMedCrossRef
9.
Zurück zum Zitat Gourin CG, Williams HT, Seabolt WN, Herdman AV, Howington JW, Terris DJ. Utility of positron emission tomography-computed tomography in identification of residual nodal disease after chemoradiation for advanced head and neck cancer. Laryngoscope 2006;116:705–10.PubMedCrossRef Gourin CG, Williams HT, Seabolt WN, Herdman AV, Howington JW, Terris DJ. Utility of positron emission tomography-computed tomography in identification of residual nodal disease after chemoradiation for advanced head and neck cancer. Laryngoscope 2006;116:705–10.PubMedCrossRef
10.
Zurück zum Zitat Schoder H, Carlson DL, Kraus DH, Stambuk HE, Gonen M, Erdi YE, et al. 18F-FDG PET/CT for detecting nodal metastases in patients with oral cancer staged N0 by clinical examination and CT/MRI. J Nucl Med 2006;47:755–62.PubMed Schoder H, Carlson DL, Kraus DH, Stambuk HE, Gonen M, Erdi YE, et al. 18F-FDG PET/CT for detecting nodal metastases in patients with oral cancer staged N0 by clinical examination and CT/MRI. J Nucl Med 2006;47:755–62.PubMed
11.
Zurück zum Zitat Bilde A, Von Buchwald C, Mortensen J, Marving J, Therkildsen MH, Kirkegaard J, et al. The role of SPECT-CT in the lymphoscintigraphic identification of sentinel nodes in patients with oral cancer. Acta Otolaryngol 2006;126:1096–103.PubMedCrossRef Bilde A, Von Buchwald C, Mortensen J, Marving J, Therkildsen MH, Kirkegaard J, et al. The role of SPECT-CT in the lymphoscintigraphic identification of sentinel nodes in patients with oral cancer. Acta Otolaryngol 2006;126:1096–103.PubMedCrossRef
12.
Zurück zum Zitat Fischer BM, Olsen MW, Ley CD, Klausen TL, Mortensen J, Hojgaard L, et al. How few cancer cells can be detected by positron emission tomography? A frequent question addressed by an in vitro study. Eur J Nucl Med Mol Imaging 2006;33:697–701.PubMedCrossRef Fischer BM, Olsen MW, Ley CD, Klausen TL, Mortensen J, Hojgaard L, et al. How few cancer cells can be detected by positron emission tomography? A frequent question addressed by an in vitro study. Eur J Nucl Med Mol Imaging 2006;33:697–701.PubMedCrossRef
13.
Zurück zum Zitat Gutzeit A, Antoch G, Kuhl H, Egelhof T, Fischer M, Hauth E, et al. Unknown primary tumours: detection wtih dual-modality PET/CT—initial experience. Radiology 2005;234:227–34.PubMedCrossRef Gutzeit A, Antoch G, Kuhl H, Egelhof T, Fischer M, Hauth E, et al. Unknown primary tumours: detection wtih dual-modality PET/CT—initial experience. Radiology 2005;234:227–34.PubMedCrossRef
14.
Zurück zum Zitat Nanni C, Rubello D, Castellucci P, Farsad M, Franchi R, Toso S, et al. Role of 18F-FDG PET-CT imaging for the detection of an unknown primary tumour: preliminary results in 21 patients. Eur J Nucl Med Mol Imaging 2005;32:589–92.PubMedCrossRef Nanni C, Rubello D, Castellucci P, Farsad M, Franchi R, Toso S, et al. Role of 18F-FDG PET-CT imaging for the detection of an unknown primary tumour: preliminary results in 21 patients. Eur J Nucl Med Mol Imaging 2005;32:589–92.PubMedCrossRef
15.
Zurück zum Zitat Zimmer LA, Snyderman C, Fukui MB, Blodgett T, McCook B, Townsend DW, et al. The use of combined PET/CT for localizing recurrent head and neck cancer: the Pittsburgh experience. Ear Nose Throat J 2005;84:104, 106, 108–10. Zimmer LA, Snyderman C, Fukui MB, Blodgett T, McCook B, Townsend DW, et al. The use of combined PET/CT for localizing recurrent head and neck cancer: the Pittsburgh experience. Ear Nose Throat J 2005;84:104, 106, 108–10.
16.
Zurück zum Zitat Andrade RS, Heron DE, Degirmenci B, Filho PA, Branstetter BF, Seethala RR, et al. Posttreatment assessment of response using FDG-PET/CT for patients treated with definitive radiation therapy for head and neck cancers. Int J Radiat Oncol Biol Phys 2006;65:1315–22.PubMedCrossRef Andrade RS, Heron DE, Degirmenci B, Filho PA, Branstetter BF, Seethala RR, et al. Posttreatment assessment of response using FDG-PET/CT for patients treated with definitive radiation therapy for head and neck cancers. Int J Radiat Oncol Biol Phys 2006;65:1315–22.PubMedCrossRef
17.
Zurück zum Zitat Ha PK, Hdeib A, Goldenberg D, Jacene H, Patel P, Koch W, et al. The role of positron emission tomography and computed tomography fusion in the management of early-stage and advanced-stage primary head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2006;132:12–6.PubMedCrossRef Ha PK, Hdeib A, Goldenberg D, Jacene H, Patel P, Koch W, et al. The role of positron emission tomography and computed tomography fusion in the management of early-stage and advanced-stage primary head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2006;132:12–6.PubMedCrossRef
18.
Zurück zum Zitat Gordin A, Daitzchman M, Doweck I, Yefremov N, Golz A, Keidar Z, et al. Fluorodeoxyglucose-positron emission tomography/computed tomography imaging in patients with carcinoma of the larynx: diagnostic accuracy and impact on clinical management. Laryngoscope 2006;116:273–8.PubMedCrossRef Gordin A, Daitzchman M, Doweck I, Yefremov N, Golz A, Keidar Z, et al. Fluorodeoxyglucose-positron emission tomography/computed tomography imaging in patients with carcinoma of the larynx: diagnostic accuracy and impact on clinical management. Laryngoscope 2006;116:273–8.PubMedCrossRef
19.
Zurück zum Zitat Iagaru A, Masamed R, Singer PA, Conti PS. 2-Deoxy-2-[18F]fluoro-D-glucose-positron emission tomography and positron emission tomography/computed tomography diagnosis of patients with recurrent papillary thyroid cancer. Mol Imaging Biol 2006;8:309–14.PubMedCrossRef Iagaru A, Masamed R, Singer PA, Conti PS. 2-Deoxy-2-[18F]fluoro-D-glucose-positron emission tomography and positron emission tomography/computed tomography diagnosis of patients with recurrent papillary thyroid cancer. Mol Imaging Biol 2006;8:309–14.PubMedCrossRef
20.
Zurück zum Zitat Berthelsen AK, Holm S, Loft A, Klausen TL, Andersen F, Højgaard L. PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients. Eur J Nucl Med Mol Imaging 2005;32:1167–75.PubMedCrossRef Berthelsen AK, Holm S, Loft A, Klausen TL, Andersen F, Højgaard L. PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients. Eur J Nucl Med Mol Imaging 2005;32:1167–75.PubMedCrossRef
21.
Zurück zum Zitat Daisne J-F, Duprez T, Weynand B, Lonneux M, Hamoir M, Reychler H, et al. Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen. Radiology 2004;233:93–100.PubMedCrossRef Daisne J-F, Duprez T, Weynand B, Lonneux M, Hamoir M, Reychler H, et al. Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen. Radiology 2004;233:93–100.PubMedCrossRef
22.
Zurück zum Zitat Wang D, Schultz CJ, Jursinic PA, Bialkowski M, Zhu XR, Brown WD, et al. Initial experience of FDG-PET/CT guided IMRT of head and neck carcinoma. Int J Radiat Oncol Biol Phys 2006;65:143–51.PubMedCrossRef Wang D, Schultz CJ, Jursinic PA, Bialkowski M, Zhu XR, Brown WD, et al. Initial experience of FDG-PET/CT guided IMRT of head and neck carcinoma. Int J Radiat Oncol Biol Phys 2006;65:143–51.PubMedCrossRef
23.
Zurück zum Zitat Riegel AC, Berson AM, Destian S, NG T, Tena LB, Mitnick RJ, et al. Variability of gross tumour volume delineation in head and neck cancer using CT and PET/CT fusion. Int J Radiat Oncol Biol Phys 2006;65:726–32.PubMed Riegel AC, Berson AM, Destian S, NG T, Tena LB, Mitnick RJ, et al. Variability of gross tumour volume delineation in head and neck cancer using CT and PET/CT fusion. Int J Radiat Oncol Biol Phys 2006;65:726–32.PubMed
24.
Zurück zum Zitat Ciernik IF, Dizendorf E, Baumert BG, Reiner B, Burger C, Davis JB, et al. Radiation treatment planning with an integrated positron emission and computer tomography (PET/CT): a feasibility study. Int J Radiat Oncol Biol Phys 2003;57:853–63.PubMedCrossRef Ciernik IF, Dizendorf E, Baumert BG, Reiner B, Burger C, Davis JB, et al. Radiation treatment planning with an integrated positron emission and computer tomography (PET/CT): a feasibility study. Int J Radiat Oncol Biol Phys 2003;57:853–63.PubMedCrossRef
25.
Zurück zum Zitat Buus S, Grau C, Munk OL, Bender D, Jensen K, Keiding S. 11C-methionine PET, a novel method for measuring regional salivary gland function after radiotherapy of head and neck cancer. Radiother Oncol 2004;73:289–96.PubMedCrossRef Buus S, Grau C, Munk OL, Bender D, Jensen K, Keiding S. 11C-methionine PET, a novel method for measuring regional salivary gland function after radiotherapy of head and neck cancer. Radiother Oncol 2004;73:289–96.PubMedCrossRef
27.
Zurück zum Zitat Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, et al. Prognostic value of tumour oxygenation in 397 head and neck tumours after primary radiation therapy. An international multi-center study. Radiother Oncol 2005;77:18–24.PubMedCrossRef Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, et al. Prognostic value of tumour oxygenation in 397 head and neck tumours after primary radiation therapy. An international multi-center study. Radiother Oncol 2005;77:18–24.PubMedCrossRef
28.
Zurück zum Zitat Rajendran JG, Hendrickson KR, Spence AM, Muzi M, Krohn KA, Mankoff DA. Hypoxia imaging-directed radiation treatment planning. Eur J Nucl Med Mol Imaging 2006;33 Suppl 1:44–53.PubMedCrossRef Rajendran JG, Hendrickson KR, Spence AM, Muzi M, Krohn KA, Mankoff DA. Hypoxia imaging-directed radiation treatment planning. Eur J Nucl Med Mol Imaging 2006;33 Suppl 1:44–53.PubMedCrossRef
29.
Zurück zum Zitat Zimny M, Gagel B, Dimartino E, Hamacher K, Coenen HH, Westhofen M, et al. FDG—a marker of tumour hypoxia? A comparison with [18F]fluoromisonidazole and pO2-polarography in metastatic head and neck cancer. Eur J Nucl Med Mol Imaging 2006;33:1426–31.PubMedCrossRef Zimny M, Gagel B, Dimartino E, Hamacher K, Coenen HH, Westhofen M, et al. FDG—a marker of tumour hypoxia? A comparison with [18F]fluoromisonidazole and pO2-polarography in metastatic head and neck cancer. Eur J Nucl Med Mol Imaging 2006;33:1426–31.PubMedCrossRef
30.
Zurück zum Zitat Thorwarth D, Eschmann SM, Scheiderbauer J, Paulsen F, Alber M. Kinetic analysis of dynamic 18F-fluoromisonidazole PET correlates with radiation treatment outcome in head-and-neck cancer. BMC Cancer 2005;5:152.PubMedCrossRef Thorwarth D, Eschmann SM, Scheiderbauer J, Paulsen F, Alber M. Kinetic analysis of dynamic 18F-fluoromisonidazole PET correlates with radiation treatment outcome in head-and-neck cancer. BMC Cancer 2005;5:152.PubMedCrossRef
31.
Zurück zum Zitat Rischin D, Hicks RJ, Fisher R, Binns D, Corry J, Porceddu S, et al. Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumour hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation Oncology Group Study. J Clin Oncol 2006;24:2098–104.PubMedCrossRef Rischin D, Hicks RJ, Fisher R, Binns D, Corry J, Porceddu S, et al. Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumour hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation Oncology Group Study. J Clin Oncol 2006;24:2098–104.PubMedCrossRef
32.
Zurück zum Zitat Myerson RJ, Singh AK, Bigott HM, Cha B, Engelbach JA, Kim J, et al. Monitoring the effect of mild hyperthermia on tumour hypoxia by Cu-ATSM PET scanning. Int J Hyperthermia 2006;22:93–115.PubMedCrossRef Myerson RJ, Singh AK, Bigott HM, Cha B, Engelbach JA, Kim J, et al. Monitoring the effect of mild hyperthermia on tumour hypoxia by Cu-ATSM PET scanning. Int J Hyperthermia 2006;22:93–115.PubMedCrossRef
33.
Zurück zum Zitat Yuan H, Schroeder T, Bowsher JE, Hedlund LW, Wong T, Dewhirst MW. Intertumoural differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone). J Nucl Med 2006;47:989–98.PubMed Yuan H, Schroeder T, Bowsher JE, Hedlund LW, Wong T, Dewhirst MW. Intertumoural differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone). J Nucl Med 2006;47:989–98.PubMed
34.
Zurück zum Zitat Grosu AL, Piert M, Weber WA, Jeremic B, Picchio M, Schratzenstaller U, et al. Positron emission tomography for radiation treatment planning. Strahlenther Onkol 2005;181:483–99.PubMedCrossRef Grosu AL, Piert M, Weber WA, Jeremic B, Picchio M, Schratzenstaller U, et al. Positron emission tomography for radiation treatment planning. Strahlenther Onkol 2005;181:483–99.PubMedCrossRef
35.
Zurück zum Zitat Parodi K, Bortfeld T. A filtering approach based on Gaussian-powerlaw convolutions for local PET verification of proton radiotherapy. Phys Med Biol 2006;51:1991–2009.PubMedCrossRef Parodi K, Bortfeld T. A filtering approach based on Gaussian-powerlaw convolutions for local PET verification of proton radiotherapy. Phys Med Biol 2006;51:1991–2009.PubMedCrossRef
36.
Zurück zum Zitat Ponisch F, Parodi K, Hasch BG, Enghardt W. The modelling of positron emitter production and PET imaging during carbon ion therapy. Phys Med Biol 2004;49:5217–32.PubMedCrossRef Ponisch F, Parodi K, Hasch BG, Enghardt W. The modelling of positron emitter production and PET imaging during carbon ion therapy. Phys Med Biol 2004;49:5217–32.PubMedCrossRef
Metadaten
Titel
PET/CT in head and neck cancer
verfasst von
Liselotte Højgaard
Lena Specht
Publikationsdatum
01.09.2007
Verlag
Springer-Verlag
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 9/2007
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-007-0373-x

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