Introduction
Thiopurine metabolic pathway
Thiopurine S-methyltransferase
Multidrug-resistance protein 4 and inosine triphosphatase
Nucleoside diphosphate-linked moiety X-type motif 15
What does NUDT15 do?
Additional variants of NUDT15 and their enzymatic activities
NUDT15 enzyme activity [81] | Normal | Medium | Low | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Diplotype |
*1*1
|
*1*4
|
*1*5
|
*1*6
|
*1*2
|
*1*3
|
*2*6
|
*2*5
|
*3*5
|
*2*2
|
*2*3
|
*3*3
|
Diplotype frequencies | ||||||||||||
Chinese [90] (%) | < 71.6 | na | 1.78 | 2.73 | 7.8 | 13.9 | 0.14 | 0 | 0.55 | 0 | 0.82 | 0.68 |
Korean (estimated)a (%) | 75.2 | 0.69 | 1.9 | 0.87 | 7.6 | 12.0 | 0.044 | 0.10 | 0.15 | 0.19 | 0.61 | 0.48 |
Japanese (estimated)b (%) | < 78.3 | 0.12 | 1.6 | n.a. | 18.6 | n.a. | 0.19 | 1.1 | ||||
Leukopenia frequencies [90] (%) (WBC < 3500/mm3, Chinese) | 15.1 | n.a. | 30.8 | 35.0 | 49.1 | 42.2 | 100 | n.a. | 100 | n.a. | 100 | 100 |
p.Arg139Cys test result | Normal (Arg/Arg) | Normal (Arg/Arg) | Medium (Arg/Cys) | Medium (Arg/Cys) | Low (Cys/Cys) |