Background
Methods
Chemicals and drugs
Animals
Plant material
Preparation of Monotheca buxifolia fruit extract
Phytochemical analysis
Antinociceptive activity
Anti-inflammatory activity
Antipyretic activity
Statistical analysis
Results
Phytochemical analysis of Monotheca buxifolia
Phytochemical class | Protocol | Result |
---|---|---|
Alkaloids | Mayer’s test | + |
Dragendorff’s test | + | |
Wagner’s test | + | |
Phenolics | Ferric chloride test | + |
Flavonoids | Lead acetate test | + |
Ethyl acetate test | + | |
Sodium hydroxide test | + | |
Anthraquinone glycosides | Borntrager’s test | + |
Saponins | Foam test | + |
Triterpenoids | Liebermann-Burchard test | + |
Monotheca buxifolia attenuates tonic visceral chemical induced nociception
Monotheca buxifolia alleviates carrageenan induced paw edema
Treatment | 1st h | 2nd h | 3rd h | 4th h | 5th h |
---|---|---|---|---|---|
Group 1 Saline | 0.235 ± 0.012 | 0.227 ± 0.026 | 0.240 ± 0.011 | 0.210 ± 0.016 | 0.230 ± 0.036 |
Group 2 Carrageenan | 0.340 ± 0.016### | 0.370 ± 0.028### | 0.395 ± 0.025### | 0.490 ± 0.057### | 0.440 ± 0.028### |
Group 3 Aspirin (150 mg/kg) | 0.255 ± 0.028** | 0.250 ± 0.035*** | 0.252 ± 0.020*** | 0.325 ± 0.052*** | 0.305 ± 0.019*** |
Group 4 (MBHE 50 mg/kg) | 0.262 ± 0.022** | 0.282 ± 0.012** | 0.287 ± 0.025*** | 0.292 ± 0.015*** | 0.352 ± 0.029** |
Group 5 (MBHE 100 mg/kg) | 0.227 ± 0.040*** | 0.277 ± 0.035** | 0.290 ± 0.046*** | 0.287 ± 0.037*** | 0.347 ± 0.029** |
Group 6 (MBHE 150 mg/kg) | 0.210 ± 0.028*** | 0.257 ± 0.026*** | 0.287 ± 0.022*** | 0.272 ± 0.044*** | 0.330 ± 0.038** |
Monotheca buxifolia relieves brewer’s yeast induced pyrexia
Treatment | 1st h | 2nd h | 3rd h | 4th h | 5th h |
---|---|---|---|---|---|
Group 1 (Brewer’s yeast + Saline) | 100.4 ± 0.358 | 100.5 ± 0.346 | 100.0 ± 0.335 | 100.4 ± 0.265 | 100.5 ± 0.341 |
Group 2 (Acetaminophen 150 mg/kg) | 96.18 ± 0.757*** | 96.62 ± 0.755*** | 95.50 ± 1.023*** | 96.07 ± 0.720*** | 95.23 ± 0.731*** |
Group 3 (MBHE 50 mg/kg) | 97.93 ± 0.449 | 98.20 ± 0.634* | 98.58 ± 0.838 | 99.27 ± 0.860 | 99.88 ± 0.812 |
Group 4 (MBHE 100 mg/kg) | 96.02 ± 0.884*** | 97.18 ± 0.570** | 97.68 ± 0.244* | 97.72 ± 0.342* | 97.42 ± 0.709* |
Group 5 (MBHE 150 mg/kg) | 93.70 ± 0.753*** | 96.93 ± 0.584*** | 96.48 ± 0.303** | 97.33 ± 0.547** | 96.35 ± 0.837** |