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31.03.2021 | Original Article

Photobiomodulation exerts anti-inflammatory effects on the vascular and cellular phases of experimental inflammatory models

verfasst von: Mariana de Souza Costa, Tarcisio Vieira de Brito, Saul Barbosa de Oliveira, Isabela de Souza Brauna, José Carlos Rapozo Mazulo Neto, Ramon Handerson Gomes Teles, Yago Medeiros Dutra, Diva de Aguiar Magalhães, Stefany Guimarães Sousa, Janyere Alexandrino de Sousa, Carlos Eduardo Rodrigues Castelo Branco, Fuad Ahmad Hazime, André Luiz dos Reis Barbosa, Daniel Fernando Pereira Vasconcelos, Jand Venes Rolim Medeiros, Marcelo de Carvalho Filgueiras

Erschienen in: Lasers in Medical Science | Ausgabe 1/2022

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Abstract

Photobiomodulation therapy (PBMT) is a non-thermal therapeutic procedure widely used in clinical practice. It is considered an effective modality of treatment for the control of various inflammatory conditions with fewer adverse effects as compared to conventional therapy. However, despite the clinical effects, the mechanisms of action and dosimetric parameters of PBMT are not fully understood. This study was performed to describe the effects of two different doses of PBMT on experimental models of inflammation. Male Swiss mice were administered with 0.9% of saline or phlogistic agents (carrageenan, dextran, serotonin, histamine, or bradykinin) by intra-plantar injection and were treated with PBMT at a dose of 1 or 5 J/cm²; right after, the variation of the paw volume was made, and histopathological analysis and myeloperoxidase assay of the carrageenan-induced edematous paw tissues were performed. The action of PBMT on carrageenan-induced vascular permeability was further evaluated. Our results showed that PBMT (1 J/cm²) led to an improvement in paw edema induced by the phlogistic agents and further reduced the histological scores. Inhibition of neutrophil migration was observed following the administration of 1 and 5 J/cm² of PBMT. However, only 1 J/cm² of PBMT showed beneficial effects on carrageenan-induced edema. Laser at a dose of 1 J/cm² showed cellular and vascular effects since it was able to reverse all the inflammatory parameters, and laser at a dose of 5 J/cm² probably has only cellular effects in the presence of acute inflammation.

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Titel: Photobiomodulation exerts anti-inflammatory effects on the vascular and cellular phases of experimental inflammatory models
verfasst von: Mariana de Souza Costa
Tarcisio Vieira de Brito
Saul Barbosa de Oliveira
Isabela de Souza Brauna
José Carlos Rapozo Mazulo Neto
Ramon Handerson Gomes Teles
Yago Medeiros Dutra
Diva de Aguiar Magalhães
Stefany Guimarães Sousa
Janyere Alexandrino de Sousa
Carlos Eduardo Rodrigues Castelo Branco
Fuad Ahmad Hazime
André Luiz dos Reis Barbosa
Daniel Fernando Pereira Vasconcelos
Jand Venes Rolim Medeiros
Marcelo de Carvalho Filgueiras
Publikationsdatum: 31.03.2021
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 1/2022
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-021-03298-x

Springer Medizin

Abstract

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