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Clinical Oral Investigations

Erschienen in:

15.10.2020 | Review

Physiopathology of nitric oxide in the oral environment and its biotechnological potential for new oral treatments: a literature review

verfasst von: Jade Ormondes de Farias, Stella Maris de Freitas Lima, Taia Maria Berto Rezende

Erschienen in: Clinical Oral Investigations | Ausgabe 12/2020

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Abstract

Objectives

A narrative review on the NO properties and their relationship with the oral environment describing NO’s molecular origin, role, and perspectives regarding oral pathological, physiological, and regenerative processes for future applications and possible use as prevention or treatment in dentistry.

Materials and methods

Pubmed was searched using the word “nitric oxide.” Reviews, clinical studies, and experimental studies were eligible for the screening process. Similar search procedures were then performed with the additional search words “conservative dentistry,” “orthodontics,” “endodontics,” “implants,” “periodontics,” “oral cancer,” “pulp revascularization,” and “oral surgery.” Furthermore, references of included articles were examined to identify further relevant articles.

Results

There is a relationship between NO production and oral diseases such as caries, periodontal diseases, pulp inflammation, apical periodontitis, oral cancer, with implants, and orthodontics. Studies on this relationship and uses of NO, in diagnosis, prevention, and treatment, are being developed. Also, some NO and oral cavity patents have already registered.

Conclusions

The understanding of how NO can interfere in oral health maintenance or disease processes can contribute to elucidate the disease development and optimize treatment approaches.

Clinical relevance

NO has considerable biotechnological potential and can contribute to improving diagnostics and treating the oral environment. As a biomarker, NO has an important role in the early diagnosis of diseases. Regarding treatments, NO can possibly be used as a regulator of inflammation, anti-biofilm action, replacing antibiotics, inducing apoptosis of cancerous cells, and contributing to the angiogenesis. All these studies are initial considerations regarding the relationship between NO and dentistry.

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Titel: Physiopathology of nitric oxide in the oral environment and its biotechnological potential for new oral treatments: a literature review
verfasst von: Jade Ormondes de Farias
Stella Maris de Freitas Lima
Taia Maria Berto Rezende
Publikationsdatum: 15.10.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 12/2020
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-020-03629-2

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Physiopathology of nitric oxide in the oral environment and its biotechnological potential for new oral treatments: a literature review

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

Neu im Fachgebiet Zahnmedizin

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

Parodontalbehandlung verbessert Prognose bei Katheterablation

Invasive Zahnbehandlung: Wann eine Antibiotikaprophylaxe vor infektiöser Endokarditis schützt

Zell-Organisatoren unter Druck: Mechanismen des embryonalen Zahnwachstums aufgedeckt

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Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

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Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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