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Inflammopharmacology

Erschienen in:

05.09.2019 | Review

Phytochemicals as potential IKK-β inhibitor for the treatment of cardiovascular diseases in plant preservation: terpenoids, alkaloids, and quinones

verfasst von: Fang Hua, Lingli Shi, Peng Zhou

Erschienen in: Inflammopharmacology | Ausgabe 1/2020

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Abstract

Modulation of inhibitor kappa B kinase-beta (IKK-β) kinase activity could be useful for preventing inflammation that serves an efficient role in protection against cardiovascular diseases (CVDs). IKK-β induces inflammation by activating transcription factor NF-kappa B (NF-κB) through phosphorylation of IκB. Therefore, IKK-β is considered an interesting target for protecting and treating CVDs. The cardioprotective potential of terpenoids, alkaloids and quinines may be related to modulating inflammatory responses. In this study, the interactions between different classes of inhibitors and IKK-β were investigated, through the application of SystemsDock. Molecular docking results showed that Diosgenin and Ginsenoside Re were the top docking score compounds. Diosgenin and Ginsenoside Re are the most promising IKK-β inhibitors in terpenoids, alkaloids, and quinones. Diosgenin and Ginsenoside Re could be helpful to find the lead compounds on designing and developing novel cardioprotective agents.

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Titel: Phytochemicals as potential IKK-β inhibitor for the treatment of cardiovascular diseases in plant preservation: terpenoids, alkaloids, and quinones
verfasst von: Fang Hua
Lingli Shi
Peng Zhou
Publikationsdatum: 05.09.2019
Verlag: Springer International Publishing
Erschienen in: Inflammopharmacology / Ausgabe 1/2020
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-019-00640-2

Springer Medizin

Abstract

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