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Current Heart Failure Reports
Erschienen in: Current Heart Failure Reports 2/2013

01.06.2013 | Pathophysiology: Neuroendocrine, Vascular, and Metabolic Factors (S.D. Katz, Section Editor)

Platelet Activating Factor in Heart Failure: Potential Role in Disease Progression and Novel Target for Therapy

verfasst von: Paraskevi Detopoulou, Tzortzis Nomikos, Elizabeth Fragopoulou, Christina Chrysohoou, Smaragdi Antonopoulou

Erschienen in: Current Heart Failure Reports | Ausgabe 2/2013

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Abstract

Heart failure (HF) is a complex syndrome with cardiac, renal, neurohormonal and sympathetic nervous system’s manifestations, the pathogenesis of which among others is connected to inflammation. PAF has local and systemic effects pertaining to HF progression since it causes a negative inotropic effect, it induces arrhythmias, it induces apoptosis and it is involved in inflammation and atherosclerosis. In the present review the role of PAF in HF will be thoroughly presented along with the relevant data on PAF enzymes and the potential role of PAF metabolic circuit as a novel pharmacological target.
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Metadaten
Titel
Platelet Activating Factor in Heart Failure: Potential Role in Disease Progression and Novel Target for Therapy
verfasst von
Paraskevi Detopoulou
Tzortzis Nomikos
Elizabeth Fragopoulou
Christina Chrysohoou
Smaragdi Antonopoulou
Publikationsdatum
01.06.2013
Verlag
Current Science Inc.
Erschienen in
Current Heart Failure Reports / Ausgabe 2/2013
Print ISSN: 1546-9530
Elektronische ISSN: 1546-9549
DOI
https://doi.org/10.1007/s11897-013-0131-2

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