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Current Atherosclerosis Reports
Erschienen in: Current Atherosclerosis Reports 4/2018

01.04.2018 | Vascular Biology (J. Hamilton, Section Editor)

Pleiotropic Anti-atherosclerotic Effects of PCSK9 Inhibitors From Molecular Biology to Clinical Translation

verfasst von: Angelos D. Karagiannis, Martin Liu, Peter P. Toth, Shijia Zhao, Devendra K. Agrawal, Peter Libby, Yiannis S. Chatzizisis

Erschienen in: Current Atherosclerosis Reports | Ausgabe 4/2018

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Abstract

Purpose of Review

Clinical trials with PCSK9 inhibitors have shown a robust decrease in plasma LDL levels and a significant reduction in the incidence of cardiovascular atherosclerotic events. However, the role of PCSK9 in atherosclerosis is not well investigated and it remains unclear whether PCSK9 inhibition has direct, LDL-independent, anti-atherosclerotic effects. This review outlines the molecular pathways and targets of PCSK9 in atherosclerosis and summarizes the experimental and clinical data supporting the anti-atherosclerotic (pleiotropic) actions of PCSK9 inhibitors.

Recent Findings

PCSK9 is expressed by various cell types that are involved in atherosclerosis (e.g., endothelial cell, smooth muscle cell, and macrophage) and is detected inside human atherosclerotic plaque. Preclinical studies have shown that inhibition of PCSK9 can attenuate atherogenesis and plaque inflammation.

Summary

Besides increasing plasma LDL, PCSK9 appears to promote the initiation and progression of atherosclerosis. Inhibition of PCSK9 may confer atheroprotection that extends beyond its lipid-lowering effects.
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Metadaten
Titel
Pleiotropic Anti-atherosclerotic Effects of PCSK9 Inhibitors From Molecular Biology to Clinical Translation
verfasst von
Angelos D. Karagiannis
Martin Liu
Peter P. Toth
Shijia Zhao
Devendra K. Agrawal
Peter Libby
Yiannis S. Chatzizisis
Publikationsdatum
01.04.2018
Verlag
Springer US
Erschienen in
Current Atherosclerosis Reports / Ausgabe 4/2018
Print ISSN: 1523-3804
Elektronische ISSN: 1534-6242
DOI
https://doi.org/10.1007/s11883-018-0718-x

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