Background
Methods
Database retrieval
Inclusion and exclusion criteria
Data collecting
Tests for association, heterogeneity
Tests for publication bias
Results
Case-control study identification
First author | Year | Ethnicity | case | polymorphism | Control | Source of controls |
P
HWE
| Genotyping method | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
XX | XY | YY | XX | XY | YY | |||||||
Dayangac | 2007 | Caucasian | 12 | 29 | 10 |
rs7975232
| 30 | 55 | 15 | PB | 0.21 | PCR-RFLP |
Kaya | 2002 | Caucasian | 14 | 31 | 8 |
rs7975232
| 27 | 21 | 6 | PB | 0.54 | PCR-RFLP |
Lee | 2002 | Asian | 5 | 28 | 22 |
rs7975232
| 3 | 29 | 72 | PB | 0.97 | PCR-RFLP |
Liu | 2017 | Asian | 39 | 56 | 15 |
rs7975232
| 100 | 67 | 16 | PB | 0.33 | LDR |
Okita | 2002 | Asian | 4 | 19 | 27 |
rs7975232
| 9 | 41 | 36 | PB | 0.59 | PCR-RFLP |
Park | 1999 | Asian | 10 | 46 | 48 |
rs7975232
| 3 | 29 | 72 | PB | 0.97 | PCR-RFLP |
Richetta | 2014 | Caucasian | 37 | 50 | 21 |
rs7975232
| 88 | 136 | 44 | PB | 0.48 | Taqman assay |
Rucevic | 2012 | Caucasian | 48 | 99 | 33 |
rs7975232
| 110 | 193 | 63 | PB | 0.17 | PCR-RFLP |
Saeki | 2002 | Asian | 9 | 46 | 60 |
rs7975232
| 10 | 26 | 33 | PB | 0.21 | PCR-RFLP |
Zhao | 2015 | Asian | 159 | 148 | 17 |
rs7975232
| 92 | 54 | 12 | PB | 0.31 | gene sequencing |
Zhou | 2014 | Asian | 182 | 130 | 30 |
rs7975232
| 209 | 113 | 19 | HB | 0.47 | Multiplex SNapSHOT |
Zhu | 2002 | Asian | 22 | 30 | 60 |
rs7975232
| 8 | 48 | 52 | PB | 0.49 | PCR-RFLP |
Zuel | 2011 | African | 23 | 24 | 3 |
rs7975232
| 18 | 30 | 2 | PB | 0.02 | PCR-RFLP |
Kaya | 2002 | Caucasian | 10 | 25 | 18 |
rs1544410
| 11 | 22 | 21 | PB | 0.25 | PCR-RFLP |
Kontula | 1997 | Caucasian | 2 | 12 | 5 |
rs1544410
| 10 | 29 | 36 | PB | 0.29 | PCR-RFLP |
Lee | 2002 | Asian | 1 | 3 | 51 |
rs1544410
| 0 | 13 | 88 | PB | 0.49 | PCR-RFLP |
Liu | 2017 | Asian | 97 | 11 | 2 |
rs1544410
| 163 | 18 | 2 | PB | 0.08 | LDR |
Mee | 1998 | Caucasian | 78a | 106a |
rs1544410
| 114a | 134a | NA | > 0.05 | PCR-RFLP | ||
Okita | 2002 | Asian | 3 | 7 | 40 |
rs1544410
| 4 | 12 | 70 | PB | 0.00 | PCR-RFLP |
Richetta | 2014 | Caucasian | 42 | 42 | 24 |
rs1544410
| 87 | 124 | 57 | PB | 0.30 | Taqman assay |
Rucevic | 2012 | Caucasian | 19 | 94 | 67 |
rs1544410
| 68 | 175 | 123 | PB | 0.68 | PCR-RFLP |
Ruggiero | 2004 | Caucasian | 17 | 28 | 15 |
rs1544410
| 18 | 32 | 18 | PB | 0.63 | PCR-RFLP |
Saeki | 2002 | Asian | 4 | 12 | 99 |
rs1544410
| 8 | 10 | 51 | PB | 0.00 | PCR-RFLP |
Zhao | 2015 | Asian | 306 | 17 | 1 |
rs1544410
| 142 | 16 | 0 | PB | 0.50 | gene sequencing |
Zhou | 2014 | Asian | 311 | 29 | 2 |
rs1544410
| 321 | 19 | 1 | HB | 0.22 | Multiplex SNapSHOT |
Zhu | 2002 | Asian | 0 | 36 | 76 |
rs1544410
| 0 | 16 | 92 | PB | 0.41 | PCR-RFLP |
Dayangac | 2007 | Caucasian | 28 | 20 | 3 |
rs2228570
| 55 | 36 | 9 | PB | 0.39 | PCR-RFLP |
Halsall | 2005 | Caucasian | 250a | 160a |
rs2228570
| 102a | 58a | HB | > 0.05 | PCR-RFLP | ||
Kaya | 2002 | Caucasian | 24 | 23 | 6 |
rs2228570
| 29 | 22 | 3 | PB | 0.66 | PCR-RFLP |
Liu | 2017 | Asian | 25 | 61 | 24 |
rs2228570
| 50 | 97 | 36 | PB | 0.37 | LDR |
Richetta | 2014 | Caucasian | 41 | 49 | 18 |
rs2228570
| 117 | 114 | 37 | PB | 0.28 | Taqman assay |
Saeki | 2002 | Asian | 37 | 55 | 23 |
rs2228570
| 29 | 31 | 9 | PB | 0.87 | PCR-RFLP |
Zhao | 2015 | Asian | 118 | 150 | 56 |
rs2228570
| 25 | 68 | 65 | PB | 0.31 | gene sequencing |
Zhou | 2014 | Asian | 94 | 180 | 68 |
rs2228570
| 99 | 171 | 71 | HB | 0.86 | Multiplex SNapSHOT |
Acikbas | 2012 | Caucasian | 14 | 47 | 41 |
rs731236
| 27 | 33 | 42 | PB | < 0.05 | PCR-RFLP |
Dayangac | 2007 | Caucasian | 26 | 23 | 2 |
rs731236
| 35 | 49 | 16 | PB | 0.87 | PCR-RFLP |
Halsall | 2005 | Caucasian | 262a | 148a |
rs731236
| 90a | 70a | HB | > 0.05 | PCR-RFLP | ||
Kaya | 2002 | Caucasian | 19 | 25 | 9 |
rs731236
| 22 | 24 | 8 | PB | 0.73 | PCR-RFLP |
Liu | 2017 | Asian | 101 | 9 | 0 |
rs731236
| 171 | 12 | 0 | PB | 0.65 | LDR |
Okita | 2002 | Asian | 39 | 11 | 0 |
rs731236
| 72 | 14 | 0 | PB | 0.41 | PCR-RFLP |
Richetta | 2014 | Caucasian | 42 | 44 | 22 |
rs731236
| 89 | 131 | 48 | PB | 0.99 | Taqman assay |
Rucevic | 2012 | Caucasian | 79 | 82 | 19 |
rs731236
| 139 | 175 | 52 | PB | 0.80 | PCR-RFLP |
Saeki | 2002 | Asian | 100 | 14 | 1 |
rs731236
| 51 | 16 | 2 | PB | 0.59 | PCR-RFLP |
Zhao | 2015 | Asian | 283 | 37 | 4 |
rs731236
| 129 | 27 | 2 | PB | 0.67 | gene sequencing |
Zhou | 2014 | Asian | 308 | 33 | 1 |
rs731236
| 315 | 26 | 0 | HB | 0.46 | Multiplex SNapSHOT |
Zuel | 2011 | African | 16 | 25 | 9 |
rs731236
| 19 | 26 | 5 | PB | 0.36 | PCR-RFLP |
VDR rs7975232 polymorphism
Models | M | I2 |
P
heterogeneity
| Stratification | case/control (N) | OR [95% CI] |
P
association
| BH |
---|---|---|---|---|---|---|---|---|
allele C vs. A | R | 74.2% | < 0.001 | overall | 1654/1991 (13) | 1.05 [0.85~1.30] | 0.640 | 0.960 |
83.4% | < 0.001 | Asian | 1212/1153 (8) | 0.980 [0.70~1.38] | 0.921 | 0.921 | ||
6.4% | 0.361 | Caucasian | 392/788 (4) | 1.16 [0.96~1.39] | 0.123 | 0.346 | ||
74.6% | < 0.001 | PB | 1312/1650 (12) | 1.02 [0.81~1.30] | 0.849 | 0.856 | ||
57.4% | 0.071 | China | 888/790 (4) | 1.26 [0.99~1.61] | 0.065 | 0.195 | ||
75.8% | < 0.001 | PHWE > 0.05 | 1604/1941 (12) | 1.07 [0.85~1.33] | 0.567 | 0.740 | ||
76.2% | < 0.001 | PCR-RFLP | 770/1041 (9) | 0.93 [0.69~1.27] | 0.668 | 0.819 | ||
CC vs. AA | R | 55.6% | 0.008 | overall | 1654/1991 (13) | 1.11 [0.76~1.64] | 0.585 | 0.960 |
71.9% | 0.001 | Asian | 1212/1153 (8) | 0.91 [0.48~1.71] | 0.761 | 0.921 | ||
0.0% | 0.653 | Caucasian | 392/788 (4) | 1.31 [0.91~1.90] | 0.147 | 0.346 | ||
55.7% | 0.010 | PB | 1312/1650 (12) | 1.04 [0.69~1.59] | 0.838 | 0.856 | ||
72.6% | 0.012 | China | 888/790 (4) | 1.11 [0.76~1.64] | 0.718 | 0.718 | ||
59.3% | 0.005 | PHWE > 0.05 | 1604/1941 (12) | 1.11 [0.74~1.65] | 0.617 | 0.740 | ||
60.5% | 0.009 | PCR-RFLP | 770/1041 (9) | 0.93 [0.52~1.66] | 0.803 | 0.819 | ||
AC vs. AA | R | 61.0% | 0.002 | overall | 1654/1991 (13) | 1.15 [0.85~1.54] | 0.370 | 0.960 |
68.2% | 0.003 | Asian | 1212/1153 (8) | 1.10 [0.70~1.72] | 0.683 | 0.921 | ||
45.9% | 0.136 | Caucasian | 392/788 (4) | 1.27 [0.84~1.91] | 0.257 | 0.346 | ||
64.0% | 0.001 | PB | 1312/1650 (12) | 1.11 [0.78~1.57] | 0.578 | 0.856 | ||
83.2% | < 0.001 | China | 888/790 (4) | 1.15 [0.64~2.07] | 0.638 | 0.718 | ||
60.6% | 0.003 | PHWE > 0.05 | 1604/1941 (12) | 1.20 [0.89~1.63] | 0.235 | 0.478 | ||
62.2% | 0.007 | PCR-RFLP | 770/1041 (9) | 0.94 [0.58~1.54] | 0.819 | 0.819 | ||
AC + CC vs. AA | R | 63.5% | 0.001 | overall | 1654/1991 (13) | 1.15 [0.86~1.54] | 0.356 | 0.960 |
71.6% | 0.001 | Asian | 1212/1153 (8) | 1.06 [0.68~1.66] | 0.800 | 0.921 | ||
43.5% | 0.151 | Caucasian | 392/788 (4) | 1.30 [0.89~1.90] | 0.179 | 0.346 | ||
66.0% | 0.001 | PB | 1312/1650 (12) | 1.10 [0.78~1.55] | 0.595 | 0.856 | ||
79.1% | 0.002 | China | 888/790 (4) | 1.24 [0.75~2.04] | 0.402 | 0.603 | ||
63.6% | 0.001 | PHWE > 0.05 | 1604/1941 (12) | 1.20 [0.89~1.62] | 0.239 | 0.478 | ||
65.8% | 0.003 | PCR-RFLP | 770/1041 (9) | 0.93 [0.57~1.52] | 0.771 | 0.819 | ||
CC vs. AA+AC | R | 63.9% | 0.001 | overall | 1654/1991 (13) | 1.01 [0.74~1.39] | 0.928 | 0.977 |
77.4% | < 0.001 | Asian | 1212/1153 (8) | 0.91 [0.57~1.47] | 0.712 | 0.921 | ||
0.0% | 0.943 | Caucasian | 392/788 (4) | 1.19 [0.86~1.64] | 0.295 | 0.346 | ||
63.8% | 0.001 | PB | 1312/1650 (12) | 0.97 [0.69~1.35] | 0.856 | 0.856 | ||
20.8% | 0.286 | China | 888/790 (4) | 1.26 [0.88~2.14] | 0.205 | 0.410 | ||
66.7% | 0.001 | PHWE > 0.05 | 1604/1941 (12) | 1.00 [0.72~1.39] | 0.977 | 0.977 | ||
69.8% | 0.001 | PCR-RFLP | 770/1041 (9) | 0.93 [0.60~1.42] | 0.727 | 0.819 | ||
carrier C vs. A | F | 42.3% | 0.053 | overall | 1654/1991 (13) | 1.08 [0.96~1.21] | 0.977 | 0.977 |
63.1% | 0.008 | Asian | 1212/1153 (8) | 1.08 [0.93~1.25] | 0.313 | 0.921 | ||
0.0% | 0.720 | Caucasian | 392/788 (4) | 1.10 [0.90~1.34] | 0.346 | 0.346 | ||
43.6% | 0.053 | PB | 1312/1650 (12) | 1.04 [0.92~1.19] | 0.507 | 0.856 | ||
0.0% | 0.578 | China | 888/790 (4) | 1.23 [1.03~1.47] | 0.020 | 0.120 | ||
45.9% | 0.041 | PHWE > 0.05 | 1604/1941 (12) | 1.09 [0.96~1.22] | 0.170 | 0.478 | ||
46.3% | 0.061 | PCR-RFLP | 770/1041 (9) | 0.96 [0.82~1.13] | 0.650 | 0.819 |
VDR rs1544410 polymorphism
Models | M | I2 |
P
heterogeneity
| Stratification | case/control (N) | OR [95% CI] |
P
association
| BH |
---|---|---|---|---|---|---|---|---|
allele A vs. G | R | 54.9% | 0.009 | overall | 1620/2001 (13) | 1.01 [0.82~1.26] | 0.898 | 0.925 |
71.8% | 0.002 | Asian | 1108/1046 (7) | 1.04 [0.63~1.69] | 0.889 | 0.973 | ||
4.8% | 0.386 | Caucasian | 512/955 (6) | 1.05 [0.89~1.24] | 0.547 | 0.821 | ||
58.2% | 0.008 | PB | 1186/1536 (11) | 0.95 [0.74~1.23] | 0.711 | 0.971 | ||
75.0% | 0.007 | China | 888/790 (4) | 0.82 [0.43~1.54] | 0.533 | 1.000 | ||
61.8% | 0.004 | PHWE > 0.05 | 1478/1791 (11) | 1.00 [0.78~1.30] | 0.973 | 0.973 | ||
60.0% | 0.010 | PCR-RFLP | 736/1051 (9) | 1.02 [0.77~1.36] | 0.898 | 0.898 | ||
AA vs. GG | F | 0.0% | 0.452 | overall | 1416/1769 (11) | 1.26 [0.93~1.73] | 0.151 | 0.925 |
0.0% | 0.478 | Asian | 996/938 (6) | 1.65 [0.79~3.46] | 0.186 | 0.973 | ||
13.5% | 0.328 | Caucasian | 420/831 (5) | 1.19 [0.84~1.68] | 0.339 | 0.821 | ||
7.2% | 0.375 | PB | 1074/1428 (10) | 1.25 [0.91~1.71] | 0.172 | 0.971 | ||
0.0% | 0.981 | China | 776/682 (3) | 1.74 [0.44~6.92] | 0.433 | 1.000 | ||
4.9% | 0.396 | PHWE > 0.05 | 1366/1683 (10) | 1.29 [0.93~1.77] | 0.125 | 0.375 | ||
23.6% | 0.249 | PCR-RFLP | 532/819 (7) | 1.43 [0.97~2.10] | 0.072 | 0.144 | ||
GA vs. GG | F | 41.6% | 0.071 | overall | 1416/1769 (11) | 1.08 [0.85~1.37] | 0.524 | 0.925 |
47.1% | 0.092 | Asian | 996/938 (6) | 1.01 [0.70~1.46] | 0.945 | 0.973 | ||
46.8% | 0.111 | Caucasian | 420/831 (5) | 1.13 [0.83~1.55] | 0.437 | 0.821 | ||
40.7% | 0.086 | PB | 1074/1428 (10) | 1.00 [0.78~1.30] | 0.971 | 0.971 | ||
66.7% | 0.049 | China | 776/682 (3) | 1.00 [0.68~1.48] | 1.000 | 1.000 | ||
47.1% | 0.049 | PHWE > 0.05 | 1366/1683 (10) | 1.09 [0.86~1.38] | 0.496 | 0.744 | ||
0.0% | 0.437 | PCR-RFLP | 532/819 (7) | 1.45 [0.99~2.14] | 0.050 | 0.144 | ||
GA + AA vs. GG | F | 44.1% | 0.057 | overall | 1416/1769 (11) | 1.12 [0.89~1.40] | 0.335 | 0.925 |
54.3% | 0.053 | Asian | 996/938 (6) | 1.12 [0.79~1.58] | 0.535 | 0.973 | ||
42.5% | 0.138 | Caucasian | 420/831 (5) | 1.12 [0.83~1.50] | 0.462 | 0.821 | ||
43.7% | 0.067 | PB | 1074/1428 (10) | 1.05 [0.82~1.34] | 0.710 | 0.971 | ||
65.6% | 0.055 | China | 776/682 (3) | 1.05 [0.72~1.53] | 0.813 | 1.000 | ||
49.0% | 0.039 | PHWE > 0.05 | 1366/1683 (10) | 1.13 [0.90~1.41] | 0.307 | 0.614 | ||
16.6% | 0.303 | PCR-RFLP | 532/819 (7) | 1.46 [1.03~2.08] | 0.035 | 0.144 | ||
AA vs. GG + GA | F | 40.7% | 0.070 | overall | 1528/1877 (12) | 0.98 [0.79~1.22] | 0.866 | 0.925 |
59.1% | 0.023 | Asian | 1108/1046 (7) | 0.94 [0.65~1.37] | 0.765 | 0.973 | ||
0.0% | 0.430 | Caucasian | 420/831 (5) | 1.00 [0.77~1.30] | 0.998 | 0.998 | ||
45.1% | 0.051 | PB | 1186/1536 (11) | 0.98 [0.79~1.21] | 0.823 | 0.971 | ||
24.7% | 0.263 | China | 888/790 (4) | 0.50 [0.28~0.88] | 0.901 | 1.000 | ||
46.0% | 0.047 | PHWE > 0.05 | 1478/1791 (11) | 0.99 [0.79~1.23] | 0.018 | 0.108 | ||
60.6% | 0.013 | PCR-RFLP | 644/927 (8) | 0.95 [0.75~1.20] | 0.680 | 0.898 | ||
carrier A vs. G | F | 34.8% | 0.112 | overall | 1528/1877 (12) | 1.01 [0.86~1.18] | 0.925 | 0.925 |
60.1% | 0.020 | Asian | 1108/1046 (7) | 1.00 [0.76~1.30] | 0.973 | 0.973 | ||
0.0% | 0.767 | Caucasian | 420/831 (5) | 1.01 [0.83~1.24] | 0.887 | 0.998 | ||
31.5% | 0.147 | PB | 1186/1536 (11) | 0.97 [0.82~1.15] | 0.737 | 0.971 | ||
68.3% | 0.024 | China | 888/790 (4) | 0.84 [0.61~1.16] | 0.285 | 1.000 | ||
40.6% | 0.078 | PHWE > 0.05 | 1478/1791 (11) | 1.01 [0.86~1.19] | 0.895 | 0.973 | ||
39.5% | 0.115 | PCR-RFLP | 644/927 (8) | 1.02 [0.84~1.25] | 0.815 | 0.898 |
VDR rs2228570 polymorphism
Models | M | I2 |
P
heterogeneity
| Stratification | case/control (N) | OR [95% CI] |
P
association
| BH |
---|---|---|---|---|---|---|---|---|
allele C vs. T | R | 84.7% | < 0.001 | overall | 1308/1253 (8) | 1.00 [0.73~1.38] | 0.989 | 0.989 |
92.2% | < 0.001 | Asian | 891/751 (4) | 0.89 [0.52~1.53] | 0.681 | 0.760 | ||
0.0% | 0.766 | Caucasian | 417/502 (4) | 1.16 [0.93~1.43] | 0.681 | 0.681 | ||
88.4% | < 0.001 | PB | 761/832 (6) | 0.99 [0.62~1.58] | 0.964 | 0.987 | ||
93.8 | < 0.001 | China | 776/682 (3) | 0.78 [0.41~1.46] | 0.429 | 0.521 | ||
86.6% | < 0.001 | PHWE > 0.05 | 1103/1173 (7) | 0.99 [0.69~1.42] | 0.946 | 0.955 | ||
0.0% | 0.603 | PCR-RFLP | 424/303 (4) | 1.20 [0.95~1.52] | 0.121 | 0.348 | ||
CC vs. TT | R | 84.4% | < 0.001 | overall | 1103/1173 (7) | 0.96 [0.47~1.97] | 0.914 | 0.989 |
90.9% | < 0.001 | Asian | 891/751 (4) | 0.81 [0.29~2.28] | 0.695 | 0.760 | ||
0.0% | 0.440 | Caucasian | 212/422 (3) | 1.33 [0.76~2.32] | 0.317 | 0.560 | ||
86.5% | < 0.001 | PB | 761/832 (6) | 0.97 [0.38~2.47] | 0.947 | 0.987 | ||
92.8% | < 0.001 | China | 776/682 (3) | 0.62 [0.19~2.06] | 0.438 | 0.521 | ||
84.4% | < 0.001 | PHWE > 0.05 | 1103/1173 (7) | 0.96 [0.47~1.97] | 0.914 | 0.955 | ||
6.2% | 0.344 | PCR-RFLP | 219/223 (3) | 1.58 [0.78~3.21] | 0.204 | 0.348 | ||
TC vs. TT | F | 46.2% | 0.084 | overall | 1103/1173 (7) | 1.02 [0.84~1.25] | 0.810 | 0.989 |
70.4% | 0.017 | Asian | 891/751 (4) | 0.96 [0.75~1.21] | 0.717 | 0.760 | ||
0.0% | 0.955 | Caucasian | 212/422 (3) | 1.20 [0.84~1.72] | 0.325 | 0.560 | ||
54.3% | 0.053 | PB | 761/832 (6) | 0.99 [0.78~1.25] | 0.919 | 0.987 | ||
77.2% | 0.012 | China | 776/682 (3) | 0.90 [0.70~1.17] | 0.440 | 0.521 | ||
46.2% | 0.084 | PHWE > 0.05 | 1103/1173 (7) | 1.02 [0.84~1.25] | 0.810 | 0.955 | ||
0.0% | 0.886 | PCR-RFLP | 219/223 (3) | 1.25 [0.83~1.89] | 0.290 | 0.348 | ||
TC + CC vs. TT | R | 76.0% | < 0.001 | overall | 1103/1173 (7) | 1.01 [0.67~1.52] | 0.955 | 0.989 |
86.6% | < 0.001 | Asian | 891/751 (4) | 0.90 [0.47~1.74] | 0.760 | 0.760 | ||
0.0% | 0.790 | Caucasian | 212/422 (3) | 1.22 [0.87~1.71] | 0.253 | 0.560 | ||
79.7% | < 0.001 | PB | 761/832 (6) | 1.00 [0.60~1.69] | 0.987 | 0.987 | ||
89.5% | < 0.001 | China | 776/682 (3) | 0.77 [0.35~1.71] | 0.521 | 0.521 | ||
76.0% | < 0.001 | PHWE > 0.05 | 1103/1173 (7) | 1.01 [0.67~1.52] | 0.955 | 0.955 | ||
0.0% | 0.651 | PCR-RFLP | 219/223 (3) | 1.30 [0.88~1.92] | 0.191 | 0.348 | ||
CC vs. TT + TC | R | 79.6% | < 0.001 | overall | 1103/1173 (7) | 0.93 [0.54~1.60] | 0.782 | 0.989 |
87.7% | < 0.001 | Asian | 891/751 (4) | 0.82 [0.39~1.71] | 0.600 | 0.760 | ||
0.0% | 0.466 | Caucasian | 212/422 (3) | 1.21 [0.72~2.04] | 0.467 | 0.560 | ||
82.0% | < 0.001 | PB | 761/832 (6) | 0.94 [0.46~1.92] | 0.869 | 0.987 | ||
90.0% | < 0.001 | China | 776/682 (3) | 0.68 [0.30~1.55] | 0.358 | 0.521 | ||
79.6% | < 0.001 | PHWE > 0.05 | 1103/1173 (7) | 0.93 [0.54~1.60] | 0.782 | 0.955 | ||
0.0% | 0.396 | PCR-RFLP | 219/223 (3) | 1.41 [0.75~2.68] | 0.287 | 0.348 | ||
carrier C vs. T | R | 61.8% | 0.015 | overall | 1103/1173 (7) | 0.97 [0.76~1.25] | 0.840 | 0.989 |
77.9% | 0.004 | Asian | 891/751 (4) | 0.91 [0.63~1.32] | 0.632 | 0.760 | ||
0.0% | 0.843 | Caucasian | 212/422 (3) | 1.12 [0.84~1.49] | 0.444 | 0.560 | ||
67.2% | 0.009 | PB | 761/832 (6) | 0.98 [0.71~1.35] | 0.883 | 0.987 | ||
82.5% | 0.003 | China | 776/682 (3) | 0.84 [0.55~1.29] | 0.425 | 0.521 | ||
61.8% | 0.015 | PHWE > 0.05 | 1103/1173 (7) | 0.97 [0.76~1.25] | 0.840 | 0.955 | ||
0.0% | 0.772 | PCR-RFLP | 219/223 (3) | 1.17 [0.84~1.63] | 0.360 | 0.360 |
VDR rs731236 polymorphism
Models | M | I2 |
P
heterogeneity
| Stratification | case/control (N) | OR [95% CI] |
P
association
| BH |
---|---|---|---|---|---|---|---|---|
allele C vs. T | R | 47.5% | 0.034 | overall | 1690/1857 (12) | 0.91 [0.75~1.10] | 0.325 | 0.690 |
57.2% | 0.053 | Asian | 941/837 (5) | 0.91 [0.58~1.43] | 0.689 | 0.798 | ||
47.4% | 0.090 | Caucasian | 699/970 (6) | 0.87 [0.70~1.08] | 0.216 | 0.629 | ||
47.7% | 0.045 | PB | 1143/1436 (10) | 0.90 [0.73~1.12] | 0.341 | 0.524 | ||
49.7% | 0.137 | China | 776/682 (3) | 1.01 [0.62~1.64] | 0.962 | 0.974 | ||
73.1% | 0.024 | Turkey | 206/256 (3) | 0.93 [0.54~1.61] | 0.806 | 0.824 | ||
45.7% | 0.056 | PHWE > 0.05 | 1383/1675 (10) | 0.90[0.72~1.11] | 0.324 | 0.389 | ||
57.4% | 0.021 | PCR-RFLP | 806/907 (8) | 0.88 [0.68~1.14] | 0.360 | 0.744 | ||
CC vs. TT | F | 38.2% | 0.114 | overall | 1325/1508 (9) | 0.92[0.67~1.25] | 0.581 | 0.690 |
0.0% | 0.460 | Asian | 781/568 (3) | 0.80[0.24~2.66] | 0.717 | 0.798 | ||
58.7% | 0.046 | Caucasian | 494/890 (5) | 0.87 [0.62~1.22] | 0.419 | 0.629 | ||
43.7% | 0.087 | PB | 983/1167 (8) | 0.90 [0.66~1.24] | 0.524 | 0.524 | ||
73.8% | 0.022 | Turkey | 206/256 (3) | 1.05 [0.68~1.81] | 0.868 | 0.974 | ||
0.0% | 0.511 | China | 666/499 (2) | 1.24 [0.28~5.53] | 0.775 | 0.824 | ||
24.8% | 0.231 | PHWE > 0.05 | 1223/1406 (8) | 0.79[0.56~1.12] | 0.183 | 0.386 | ||
59.8% | 0.029 | PCR-RFLP | 551/741 (6) | 0.88 [0.61~1.28] | 0.499 | 0.749 | ||
TC vs. TT | R | 46.8% | 0.043 | overall | 1485/1777 (11) | 0.95[0.72~1.24] | 0.690 | 0.690 |
51.5% | 0.083 | Asian | 941/837 (5) | 0.90[0.58~1.42] | 0.658 | 0.798 | ||
61.0% | 0.036 | Caucasian | 494/890 (5) | 0.98[0.63~1.51] | 0.918 | 0.918 | ||
46.6% | 0.051 | PB | 1143/1436 (10) | 0.91[0.68~1.22] | 0.523 | 0.524 | ||
50.4% | 0.133 | China | 776/682 (3) | 0.97[0.58~1.63] | 0.915 | 0.974 | ||
73.1% | 0.024 | Turkey | 206/256 (3) | 1.26 [0.53~2.99] | 0.593 | 0.824 | ||
15.7% | 0.299 | PHWE > 0.05 | 1383/1675 (10) | 0.85[0.69~1.06] | 0.155 | 0.386 | ||
56.3% | 0.033 | PCR-RFLP | 601/827 (7) | 0.88 [0.61~1.28] | 0.988 | 0.988 | ||
TC + CC vs. TT | R | 50.7% | 0.027 | overall | 1485/1777 (11) | 0.94[0.71~1.23] | 0.636 | 0.690 |
56.0% | 0.059 | Asian | 941/837 (5) | 0.90[0.57~1.44] | 0.671 | 0.798 | ||
61.4% | 0.035 | Caucasian | 494/890 (5) | 0.93[0.62~1.40] | 0.733 | 0.880 | ||
49.6% | 0.037 | PB | 1143/1436 (10) | 0.90 [0.67~1.19] | 0.453 | 0.524 | ||
51.4% | 0.128 | China | 776/682 (3) | 0.99[0.59~1.66] | 0.974 | 0.974 | ||
76.8% | 0.013 | Turkey | 206/256 (3) | 1.12 [0.47~2.68] | 0.794 | 0.824 | ||
32.9% | 0.145 | PHWE > 0.05 | 1383/1675 (10) | 0.86[0.67~1.09] | 0.205 | 0.386 | ||
61.7% | 0.016 | PCR-RFLP | 601/827 (7) | 0.96 [0.63~1.45] | 0.843 | 0.988 | ||
CC vs. TT + TC | F | 4.4% | 0.398 | overall | 1325/1508 (9) | 0.91[0.69~1.20] | 0.487 | 0.690 |
0.0% | 0.506 | Asian | 781/568 (3) | 0.85[0.26~2.85] | 0.798 | 0.798 | ||
25.0% | 0.254 | Caucasian | 494/890 (5) | 0.86[0.64~1.16] | 0.330 | 0.629 | ||
10.9% | 0.345 | PB | 983/1167 (8) | 0.90[0.68~1.19] | 0.442 | 0.524 | ||
0.0% | 0.543 | China | 666/499 (2) | 1.30[0.29~5.76] | 0.734 | 0.974 | ||
47.7% | 0.148 | Turkey | 206/256 (3) | 0.81 [0.52~1.27] | 0.361 | 0.824 | ||
16.3% | 0.301 | PHWE > 0.05 | 1223/1406 (8) | 0.89[0.64~1.23] | 0.472 | 0.472 | ||
27.6% | 0.228 | PCR-RFLP | 551/741 (6) | 0.82 [0.59~1.14] | 0.228 | 0.744 | ||
carrier C vs. T | F | 1.1% | 0.430 | overall | 1485/1777 (11) | 0.93[0.80~1.09] | 0.380 | 0.690 |
41.4% | 0.145 | Asian | 941/837 (5) | 0.92[0.68~1.23] | 0.558 | 0.798 | ||
0.0% | 0.617 | Caucasian | 494/890 (5) | 0.92[0.76~1.11] | 0.388 | 0.629 | ||
0.0% | 0.492 | PB | 1143/1436 (10) | 0.90[0.77~1.06] | 0.223 | 0.524 | ||
37.9% | 0.200 | China | 776/682 (3) | 0.98[0.70~1.38] | 0.922 | 0.974 | ||
16.6% | 0.302 | Turkey | 206/256 (3) | 0.96[0.70~1.32] | 0.824 | 0.824 | ||
2.6% | 0.415 | PHWE > 0.05 | 1383/1675 (10) | 0.91[0.77~1.07] | 0.257 | 0.386 | ||
11.6% | 0.341 | PCR-RFLP | 601/827 (7) | 0.92 [0.75~1.11] | 0.372 | 0.744 |
Sensitivity analysis and publication bias
polymorphism | Models | Begg’s test | Egger’s test | ||
---|---|---|---|---|---|
z |
P
Begg
| t |
P
Egger
| ||
rs7975232
| allele C vs. A | 0.43 | 0.669 | −1.10 | 0.296 |
CC vs. AA | 1.16 | 0.246 | −1.02 | 0.331 | |
AC vs. AA | 1.04 | 0.300 | −1.24 | 0.241 | |
AC + CC vs. AA | 1.40 | 0.161 | −1.48 | 0.167 | |
CC vs. AA+AC | 0.18 | 0.855 | 0.35 | 0.736 | |
carrier C vs. A | 0.67 | 0.502 | −1.11 | 0.291 | |
rs1544410
| allele A vs. G | 0.31 | 0.760 | −0.72 | 0.487 |
AA vs. GG | 0.00 | 1.000 | −0.44 | 0.669 | |
GA vs. GG | 0.47 | 0.640 | −0.22 | 0.832 | |
GA + AA vs GG | 0.00 | 1.000 | −0.13 | 0.896 | |
AA vs. GG + GA | 0.07 | 0.945 | 0.04 | 0.966 | |
carrier A vs. G | −0.07 | 1.000 | −0.35 | 0.735 | |
rs2228570
| allele C vs. T | 0.62 | 0.536 | 0.83 | 0.437 |
CC vs. TT | 0.30 | 0.764 | 0.66 | 0.539 | |
TC vs. TT | 0.00 | 1.000 | 0.24 | 0.823 | |
TC + CC vs. TT | 0.00 | 1.000 | 0.30 | 0.777 | |
CC vs. TT + TC | 0.90 | 0.368 | 0.95 | 0.387 | |
carrier C vs. T | 0.60 | 0.548 | 0.70 | 0.515 | |
rs731236
| allele C vs. T | 0.07 | 0.945 | 0.53 | 0.611 |
CC vs. TT | −0.10 | 1.000 | −0.14 | 0.895 | |
TC vs. TT | 0.62 | 0.533 | 1.13 | 0.286 | |
TC + CC vs. TT | 0.62 | 0.533 | 1.08 | 0.310 | |
CC vs. TT + TC | 0.10 | 0.917 | −0.27 | 0.795 | |
carrier C vs. T | 0.16 | 0.876 | 0.43 | 0.675 |