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01.05.2012 | Original paper

Poultry and livestock exposure and cancer risk among farmers in the agricultural health study

verfasst von: Laura E. Beane Freeman, Anneclaire J. DeRoos, Stella Koutros, Aaron Blair, Mary H. Ward, Michael Alavanja, Jane A. Hoppin

Erschienen in: Cancer Causes & Control | Ausgabe 5/2012

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Abstract

Purpose

The purpose of this study is to evaluate cancer risk associated with raising animals as commodities, which is associated with a variety of exposures, such as infectious agents and endotoxins.

Methods

Information was available for 49,884 male farmers in the Agricultural Health Study, who reported livestock and poultry production at enrollment (1993–1997). Cancer incidence data were obtained through annual linkage to state registries. Using Poisson regression analyses, we evaluated whether the number and type of animals raised on the farm impacted cancer risk.

Results

Overall, 31,848 (63.8%) male farmers reported raising any animals. Lung cancer risk decreased with increasing number of livestock on the farm (p trend = 0.04) and with raising poultry (Relative Risk (RR) = 0.6; 95% confidence interval (CI): 0.4–0.97). Raising poultry was associated with an increased risk of colon cancer (RR = 1.4; 95% CI: 0.99–2.0) with further increased with larger flocks (p trend = 0.02). Risk of non-Hodgkin lymphoma was also elevated in those who raised poultry (RR = 1.6; 95% CI: 1.0–2.4), but there was no evidence of increased risk with larger flocks (p trend = 0.5). Raising sheep was associated with a significantly increased risk of multiple myeloma (RR = 4.9; 95% CI: 2.4–12.0). Performing veterinary services increased the risk of Hodgkin lymphoma (RR = 12.2; 95% CI: 1.6–96.3).

Conclusions

We observed an inverse association between raising poultry and livestock and lung cancer risk and some evidence of increased risk of specific lymphohematopoietic malignancies with specific types of animals and performing veterinary services. Further research into associations between raising animals and cancer risk should focus on identification of etiologic agents.

Svec M et al (2005) Risk of lymphatic or hematopoietic cancer mortality with occupational exposure to animals or the public. Occup Environ Med 62:726–735PubMedCrossRef

Blair A, Beane Freeman L (2009) Epidemiologic studies of cancer in agricultural populations: observations and future directions. J Agromed 14:125–131

Koutros S et al (2010) An update of cancer incidence in the Agricultural Health Study. J Occup Environ Med 52:1098–1105

Kirychuk S et al (2006) Total dust and endotoxin in poultry operations: comparison between cage and floor housing and respiratory effects in workers. J Occup Environ Med 48:741–748PubMedCrossRef

Diefenbach H et al (2007) Airborne biological hazards in different pig fattening systems. Int J Immunopath Pharmacol 20:45–49

Burch J et al (2009) Endotoxin exposure and inflammation markers among agricultural workers in Colorado and Nebraska. J Toxicol Environ Health 73:5–22CrossRef

Lundin JI, Checkoway H (2009) Endotoxin and cancer. Environ Health Perspect 117(9):1344–1350PubMed

Mastrangelo G et al (2005) Lung cancer risk: effect of dairy farming and the consequence of removing that occupational exposure. Am J Epidemiol 161(11):1037–1046PubMedCrossRef

Laakkonen A, Pukkala E (2008) Cancer incidence among Finnish farmers. Scand J Work Environ Health 34:73–79PubMedCrossRef

10.

Kirychuk SP et al (2010) Endotoxin and dust at respirable and nonrespirable particle sizes are not consistent between cage- and floor-housed poultry operations. Ann Occup Hyg 54(7):824–832PubMedCrossRef

11.

Holst PA, Kromhout D, Brand R (1988) For debate: pet birds as an independent risk factor for lung cancer. BMJ 297(6659):1319–1321PubMedCrossRef

12.

Gardiner AJ, Forey BA, Lee PN (1992) Avian exposure and bronchogenic carcinoma. BMJ 305(6860):989–992PubMedCrossRef

13.

Kohlmeier L et al (1992) Pet birds as an independent risk factor for lung cancer: case-control study. BMJ 305(6860):986–989PubMedCrossRef

14.

Jockel KH et al (2002) Pet birds and risk of lung cancer in North-Western Germany. Lung Cancer 37(1):29–34PubMedCrossRef

15.

Alavanja MC et al (1996) Avian exposure and risk of lung cancer in women in Missouri: population based case-control study. BMJ 313(7067):1233–1235PubMedCrossRef

16.

Cano MI, Pollan M (2001) Non-Hodgkin’s lymphomas and occupation in Sweden. Int Arch Occup Environ Health 74(6):443–449PubMedCrossRef

17.

McDuffie H et al (2002) Canadian male farm residents, pesticide safety handling practices, exposure to animals and Non-Hodgkins lymphoma. Am J Indus Med 2:54–61CrossRef

18.

Fritschi L et al (2002) Animal-related occupations and the risk of leukemia, myeloma, and non-Hodgkin’s lymphoma in Canada. Cancer Causes Control 13(6):563–571PubMedCrossRef

19.

Tranah GJ, Bracci PM, Holly EA (2008) Domestic and farm-animal exposures and risk of non-Hodgkin’s lymphoma in a population-based study in the San Francisco Bay Area. Cancer Epidemiol Biomarkers Prev 17(9):2382–2387PubMedCrossRef

20.

Rusiecki JA et al (2009) Cancer incidence among pesticide applicators exposed to permethrin in the Agricultural Health Study. Environ Health Perspect 117(4):581–586PubMed

21.

Perrotta C, Staines A, Cocco P (2008) Multiple myeloma and farming: a systematic review of 30 years of research. Where next? J Occup Med Toxicol 3:27PubMedCrossRef

22.

Pearce NE et al (1986) Non-Hodgkin’s lymphoma and exposure to phenoxyherbicides, chlorophenols, fencing work, and meat works employment: a case-control study. Br J Ind Med 43(2):75–83PubMed

23.

Eriksson M, Karlsson M (1992) Occupational and other environmental factors and multiple myeloma: a population based case-control study. Br J Ind Med 49(2):95–103PubMed

24.

Baris D et al (2004) Occupation, pesticide exposure and risk of multiple myeloma. Scand J Work Environ Health 30(3):215–222PubMedCrossRef

25.

Nanni O et al (1998) Multiple myeloma and work in agriculture: results of a case-control study in Forli, Italy. Cancer Causes Control 9(3):277–283PubMedCrossRef

26.

Pearce NE et al (1986) Case-control study of multiple myeloma and farming. Br J Cancer 54(3):493–500PubMedCrossRef

27.

Johnson ES et al (2011) Update of cancer and non-cancer mortality in the Missouri poultry cohort. Am J Ind Med 54(1):49–54PubMedCrossRef

28.

McLean D, Pearce N (2004) Cancer among meat industry workers. Scand J Work Environ Health 30:425–437

29.

Orsi L et al (2009) Occupational exposure to pesticides and lymphoid neoplasms among men: results of a French case-control study. Occup Environ Med 66(5):291–298PubMedCrossRef

30.

Blair A, Hayes HM Jr (1982) Mortality patterns among US veterinarians, 1947–1977: an expanded study. Int J Epidemiol 11(4):391–397PubMedCrossRef

31.

Mueller N, Grufferman S (2006) Hogkin lymphoma. In: Schottenfeld D, Fraumeni JF (eds) Cancer epidemiology and prevention. Oxford University Press, New York, pp 872–897

32.

Lee WJ, Sander DP et al (2007) Pesticide use and colorectal cancer risk in the Agricultural Health Study. Int J Cancer 121:339–346

Titel: Poultry and livestock exposure and cancer risk among farmers in the agricultural health study
verfasst von: Laura E. Beane Freeman
Anneclaire J. DeRoos
Stella Koutros
Aaron Blair
Mary H. Ward
Michael Alavanja
Jane A. Hoppin
Publikationsdatum: 01.05.2012
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 5/2012
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-012-9921-1

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Poultry and livestock exposure and cancer risk among farmers in the agricultural health study