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Erschienen in: Tumor Biology 8/2015

01.08.2015 | Research Commentary

PP2A inhibition as a novel therapeutic target in castration-resistant prostate cancer

verfasst von: Paula González-Alonso, Ion Cristóbal, Rebeca Manso, Juan Madoz-Gúrpide, Jesús García-Foncillas, Federico Rojo

Erschienen in: Tumor Biology | Ausgabe 8/2015

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Abstract

Protein phosphatase 2A (PP2A) is a well-known tumor suppressor frequently inhibited in human cancer. Alterations affecting PP2A subunits together with the deregulation of endogenous PP2A inhibitors such as CIP2A and SET have been described as contributing mechanisms to inactivate PP2A in prostate cancer. Moreover, recent findings highlight that functional inactivation of PP2A could represent a key event in the acquisition of castration-resistant phenotype and a novel molecular target with high impact at both clinical and therapeutic levels in prostate cancer.
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Metadaten
Titel
PP2A inhibition as a novel therapeutic target in castration-resistant prostate cancer
verfasst von
Paula González-Alonso
Ion Cristóbal
Rebeca Manso
Juan Madoz-Gúrpide
Jesús García-Foncillas
Federico Rojo
Publikationsdatum
01.08.2015
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 8/2015
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3849-5

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