Prediabetes and subsequent pancreatic fat accumulation

Excerpt

Yamazaki et al. [1] investigated the effect of prediabetes on subsequent pancreatic fat accumulation, based on the hypothesis that pancreatic fat was a manifestation of disturbed glucose metabolism. Prediabetes was defined as fasting plasma glucose of 100–125 mg/dl or hemoglobin A1c of 5.7–6.4%, and the change of pancreatic fat was evaluated by computed tomography (CT). A total of 198 nondiabetic participants were composed of 48 prediabetes and 150 non-prediabetes participants. By multiple linear regression analysis, baseline prediabetes was associated with future pancreatic fat accumulation with beta value (95% confidence interval) of 3.14 (1.25–5.03). In addition, body mass index (BMI) and impaired fasting glucose (IFG) were also risk factors of pancreatic fat accumulation. I have some queries on their study. …