nach oben

Erschienen in:

01.09.2007 | Original Article

Predicting factors for severity of rheumatoid arthritis: a prospective multicenter cohort study of 172 patients over 3 years

verfasst von: E. Wagner, K. Ammer, G. Kolarz, I. Krajnc, E. Palkonyai, O. Scherak, C. Schödl, F. Singer, P. Temesvari, A. Wottawa

Erschienen in: Rheumatology International | Ausgabe 11/2007

Einloggen, um Zugang zu erhalten

Abstract

Rheumatoid arthritis may take an unfavourable course leading to rapid functional decline in a certain percentage of patients. Early identification of these patients is desirable. The aim of this study was to evaluate clinical and laboratory parameters for their value in the prediction of bad outcome. A total of 172 patients with early arthritis were followed for 3 years. Higher initial values for erythrocyte sedimentation rate, IgG and IgM rheumatoid factor, serum concentration of cartilage oligomeric matrix protein, Health Assessment Questionnaire score, Larsen score of feet, disease activity score, and swollen and tender joint count predicted worse outcome. An association with the presence of IgA rheumatoid factor or anti-cyclic-citrullinated peptide could not be established. We conclude that prognosis in an individual with rheumatoid arthritis depends on many factors. The determination of independent prognostic factors for progression of rheumatoid arthritis is a valuable tool in early arthritis to select patients for more aggressive therapy.

Emery P (1994) The optimal management of early rheumatoid disease: the key to preventing disability. Br J Rheumatol 33:765–768PubMedCrossRef

Scott DL, Symmons D, Coulton BL, Popert AJ (1987) Long-term outcome of treating rheumatoid arthritis: results after 20 years. Lancet 1:1108–1111PubMedCrossRef

Bellamy N (1991) Prognosis in rheumatoid arthritis. J Rheumatol 18:9

Albers JMC, Paimela L, Kurki P, Eberhardt KB, Emery P, van’t Hof MA, Schreuder FHJM, Leirisalo-REpo M, van Riel PLCM (2001) Treatment strategy, disease activity, and outcome in four cohorts of patients with early rheumatoid arthritis. Ann Rheum Dis 60:453–458PubMedCrossRef

Corbett M, Dalton S, Young A, Silman A, Shipley M (1993) Factors predicting death, survival and functional outcome in a prospective study of early rheumatoid disease over fifteen years. Br J Rheumatol 32:717–723PubMedCrossRef

Jäntti JK, Kaarela K, Belt EA, Kautiainen HJ (2002) Incidence of severe outcome in rheumatoid arthritis during 20 years. J Rheumatol 29:688–692PubMed

Lindquist E, Saxne T, Geborek P, Eberhardt K (2002) Ten year outcome in a cohort of patients with early rheumatoid arthritis: health status, disease process, and damage. Ann Rheum Dis 61:1055–1059CrossRef

Suarez-Almazor ME, Soskolne CL, Sounders LD, Russell AS (1994) Outcome in rheumatoid arthritis: a 1985 inception cohort study. J Rheumatol 21:1438–1446PubMed

Van der Heijde DMFM, van Riel P, van Leeuwen MA, van’t Hof MA, van Rijswijk MH, van de Putte LBA (1992) Prognostic factors for radiographic damage and physical disability in early rheumatoid arthritis, a prospective follow-up study of 147 patients. Br J Rheumatol 31(4):519–525PubMedCrossRef

10.

Van Zeben D, Hazes J, Zwinderman AH, Breedveld FC (1993) Factors predicting outcome in rheumatoid arthritis: results of a follow up study. J Rheumatol 20:1288–1296PubMed

11.

Combe B, Dougados M, Goupille P, Cantagrel A, Eliaou JF, Sibilia J, Meyer O, Sany J, Daurès JP, Dubois A (2001) Prognostic factors for radiographic damage in early rheumatoid arthritis. Arthritis Rheum 44(8):1736–1743PubMedCrossRef

12.

Hein G, Eidner G, Eidner T, Marzoll I, Klinner M (1993) Rheumafaktoraktivität, Manifestationsalter und röntgenologische Progredienz der rheumatoiden Arthritis—eine retrospektive Studie. Z Rheumatol 52:403–408PubMed

13.

Van der Heide A, Remme CA, Hofman DM, Jacobs JWG, Bijlsma JWJ (1995) Prediction of progression of radiologic damage in newly diagnosed rheumatoid arthritis. Arthritis Rheum 38(18):1466–1474PubMedCrossRef

14.

Combe B, Cantagrel A, Goupille P, Bozonnat MC, Sibilia J, Eliaou JF, Meyer O, Sany J, Dubois A, Daurès JP et al (2003) Predictive factors of 5-year health assessment questionnaire disability in early rheumatoid arthritis. J Rheumatol 30:2344–2349PubMed

15.

Sherrer YS, Bloch DA, Mitchell DM, Young DY, Fries JF (1986) The developement of disability in rheumatoid arthritis. Arthritis Rheum 29(4):494–500PubMedCrossRef

16.

Wolfe F, Hawley DJ, Cathey MA (1991) Clinical and health status measures over time: prognosis and outcome assessment in rheumatoid arthritis. J Rheumatol 18:1290–1297PubMed

17.

Wolfe F, Cathey MA (1991) The assessment and prediction of functional disability in rheumatoid arthritis. J Rheumatol 18:1298–1306PubMed

18.

Sokka T, Häkkinen A, Krishnan E, Hannonen P (2004) Similar prediction of mortality by the health assessment questionnaire in patients with rheumatoid arthritis and the general population. Ann Rheum Dis 63:494–497PubMedCrossRef

19.

Peltomaa R, Paimela L, Kautiainen H, Leirisalo-Repo M (2002) Mortality in patients with rheumatoid arthritis treated actively from the time of diagnosis. Ann Rheum Dis 61:889–894PubMedCrossRef

20.

Mikuls TR, Saag KG, Criswell LA, Merlino LA, Kaslow RA, Shelton BJ, Cerhan JR (2002) Mortality risk associated eith rheumatoid arthritis in a prospective cohort study of older women: results from the Iowa women’s health study. Ann Rheum Dis 61:994–999PubMedCrossRef

21.

Wolfe F, Mitchell DM, Sibley JT, Fries JF, Bloch DA, Williams CA, Spitz PW, Haga M, Kleinheksel SM, Cathey MA (1994) The mortality of rheumatoid arthritis. Arthritis Rheum 37(4):481–494PubMedCrossRef

22.

Leigh JP, Fries J (1991) Mortality predictors among 263 patients with rheumatoid arthritis. J Rheumatol 18:1307–1312PubMed

23.

Möttönen T, Paimela L, Leirisalo-Repo M, Kautiainen H, Ilonen J, Hannonen P (1998) Only high disease activity and positive rheumatoid factor indicate poor prognosis in patients with early rheumatoid arthritis treated with “sawtooth” strategy. Ann Rheum Dis 57:533–539PubMedCrossRef

24.

Woolf AD, Hall ND, Goulding NJ, Kantharia B, Maymo J, Evison G, Madison PJ (1991) Predictors of the long-term outcome of early synovitis: a 5-year follow-up study. Br J Rheumatol 30:251–254PubMedCrossRef

25.

Van der Heijde DMFM, van Riel P, van Leeuwen MA, van’t Hof MA, van Rijswijk MH, van de Putte LBA (1991) Older versus younger onset rheumatoid arthritis: results at onset and after 2 years of a prospective follow-up study of early rheumatoid arthritis. J Rheumatol 18:1285–1289PubMed

26.

Van Schaardenburg D, Hazes JMW, de Boer A, Zwinderman AH, Meijers KAE, Breedveld FC (1993) Outcome of rheumatoid arthritis in relation to age and rheumatoid factor at diagnosis. J Rheumatol 20:45–52PubMed

27.

Deal CL, Meenan RF, Goldenberg DL, Anderson JJ, Sack B, Pastan RS, Cohen AS (1985) The clinical features of elderly-onset rheumatoid arthritis. Arthritis Rheum 28:987–994PubMedCrossRef

28.

Vossenaar ER, van Venrooij WW (2004) Citrullinated proteins: spark that may ignite the fire in rheumatoid arthritis. Arthritis Res Ther 6(3):107–11PubMedCrossRef

29.

Skoumal M, Kolarz G, Klingler K (2003) Serum levels of cartilage oligomeric protein (COMP): a prognostic factor and a valuable parameter for disease management in RA. Scand J Rheumatol 32:156–61PubMedCrossRef

30.

Berglin E, Padyukov L, Sundin U, Hallmans G, Stenlund H, van VEnrooij WJ, Klareskog L, Dahlqvist SR (2004) A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigen is strongly associated with future onset of RA. Arthritis Res Ther 6(4):R303–8PubMedCrossRef

31.

Arnett FC, E.S., Bloch DA; McShane DJ, Fries JF, Cooper NS et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324

32.

Plant MJ, Williams AL, O’Sullivan MM, Lewis PA, Coles EC, Jessop JD (2000) Relationship between time-integrated C-reactive protein levels and radiologic progression in patients with rheumatoid arthritis. Arthritis Rheum 43(7):1473–1477PubMedCrossRef

33.

Pepys MB (1993) Rheumatoid arthritis: the role of acute-phase proteins. Br J Rheumatol 32(suppl 3):1–2PubMed

34.

Prevoo ML, van`t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL (1995) Modified disease activity scores that include twenty-eight-joint counts. Developement and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 38(1):44–8PubMedCrossRef

35.

Van der Heijde DM, van`t Hof MA, van Riel PL, van de Putte LB (1993) Developement of a disease activity score based on judgement in clinical practice by rheumatologists. J Rheumatol 20(3):579–81PubMed

36.

Buchbinder R, Bombardier C, Yeung M, Tugwell P (1995) Which outcome measures should be used in rheumatoid arthritis clinical trials? Arthritis Rheum 38(11):1568–1580PubMedCrossRef

37.

Emery P, Luqmani R (1993) The validity of surrogate markers in rheumatic disease. Br J Rheumatol 32(suppl3):3–8PubMed

38.

Silman A, Symmons D (1999) Reporting requirements for longitudinal observational studies in rheumatology. Journal Rheumatol 26(2):481–483

39.

Wolfe F, Lassere M, van der Heijde D, Stucki G, Suarez-Almazor M, Pincus T, Eberhardt K, Kvien T, Symmons D, Silman A, van Riel P (1999) Preliminary core set of domains and reporting requirements for longitudinal observational studies in rheumatology. J Rheumatol 26(2):484–9PubMed

40.

Larsen A, DK, Elk M (1994) Radiologic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Diag 18:481–491

41.

O’Sullivan MM, Lewis PA, Newcombe RG, Broderick NJ, Robinson DA,Coles EC, Jessop JD (1990) Precision of Larsen grading of radiographs in assessing progression of rheumatoid arthritis in individual patients. Ann Rheum Dis 49(3):286–289PubMedCrossRef

42.

The Stepdisc Procedure (1989) In: SAS/STAT User`s guide, Version 6, 4th edn. SAS Institute Inc, Cary, pp 1493–1510

43.

Wolfe F (2001) Which HAQ is best? A comparison of the HAQ, MHAQ and RA-HAQ, a difficult 8 item HAQ (DHAQ), and a rescored 20 item HAQ (HAQ20): analyses in 2491 rheumatoid arthritis patients following leflunomide initiation. J Rheumatol 28:982–989PubMed

44.

Wolfe F (2000) A reappraisal of HAQ disability in rheumatoid arthritis. Arthritis Rheum 43(12):2751–2761PubMedCrossRef

45.

Greenwood MC, Doyle DV, Ensor M (2001) Does the Stanford health assessment questionnaire have potential as a monitoring tool for subjects with rheumatoid arthritis. Ann Rheum Dis 60:344–348PubMedCrossRef

46.

Aletaha D, Nell V, Stamm T, Uffmann M, Pflugbeil S, Machold K, Smolen JS (2005) Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score. Arthritis Res Ther 7(4):R796–806PubMedCrossRef

47.

Vittecoq O, Pouplin S, Krzanowska K, Jouen-Beades F, Menard JF, Gayet A, Daragon A, Tron F, Le Loet X (2003) Rheumatoid factor is the strongest predictor of radiologic progression of rheumatoid arthritis in a three-year prospective study in community-recruited patients. Rheumatology (Oxford) 42(8):939–946CrossRef

48.

Robbins DL, Leek JC (1986) Relationship of serum IgG rheumatoid factor to IgM rheumatoid factor and disease activity in rheumatoid arthritis. J Rheumatol 13:259–262PubMed

49.

Bizzaro N (2001) Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis. Clin Chem 47(6):1089–93PubMed

50.

Kroot EJ (2000) The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis. Arthritis Rheum 43(8):1831–5PubMedCrossRef

Titel: Predicting factors for severity of rheumatoid arthritis: a prospective multicenter cohort study of 172 patients over 3 years
verfasst von: E. Wagner
K. Ammer
G. Kolarz
I. Krajnc
E. Palkonyai
O. Scherak
C. Schödl
F. Singer
P. Temesvari
A. Wottawa
Publikationsdatum: 01.09.2007
Verlag: Springer-Verlag
Erschienen in: Rheumatology International / Ausgabe 11/2007
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-007-0343-4

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypotonie | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Predicting factors for severity of rheumatoid arthritis: a prospective multicenter cohort study of 172 patients over 3 years

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Viel Bewegung in der Parkinsonforschung

Adjuvante Immuntherapie verlängert Leben bei RCC

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2007

A pravastatin dose-escalation study in systemic lupus erythematosus

Nephrotic syndrome as a clinical manifestation of systemic sclerosis

The effects of multidisciplinary therapy on positron emission tomography of the brain in fibromyalgia: a pilot study

The development of pneumomediastinum after pulmonary function testing in a patient with systemic sclerosis

Tender point count and total myalgic score in fibromyalgia: changes over a 28-day period

Seronegative Lyme arthritis

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Viel Bewegung in der Parkinsonforschung

Adjuvante Immuntherapie verlängert Leben bei RCC

Update Innere Medizin