Background
Methods
Study search strategy
Inclusion and exclusion criteria
Data extraction
Statistical analysis
Results
Search results
Study characteristics
Study | Study | Country | male,% | Age mean(SD) | NLR grouping | Follow-up (days) | Observation index | Quality score |
---|---|---|---|---|---|---|---|---|
Akpek, [7] 2012 | Prospective cohort study | Turkey, China, USA | 327(78.0) | 59.4 ± =12.4 | ≤3.3 > 3.3 | 6.7(mean) | In-hospital: in-stent thrombosis, MACE, nonfatal MI, no reflow, all-cause mortality | 6 |
Arbel, [8] 2014 | Prospective cohort study | Israel | 436(81.0) | 61 ± 13 | < 6.5 ≥6.5 | 1044 (median) | In-hospital: arrhythmia Long-term: all-cause mortality | 6 |
Han, [9] 2013 | Prospective cohort study | Korea | 247(75.8) | 61.9 ± 12.3 | ≤3.30 3.31–6.52 > 6.53 | 360(total) | In-hospital: MACE, nonfatal MI, no reflow, all-cause mortality Long-term: nonfatal MI, MACE, all-cause mortality | 5 |
He, [10] 2014 | Prospective cohort study | China | 546(78.9) | 60.27 | < 3.16 3.16–4.75 > 4.75 | 3395 (median) | In-hospital: arrhythmia, no reflow, cardiac mortality, all-cause mortality Long-term: cardiac mortality, all-cause mortality, MACE | 5 |
Her, [11] 2017 | Prospective cohort study | Korea | 140(81.4) | 57.1 ± 12.4 | < 5.8 ≥5.8 | 1230(median) | In-hospital: MACE 12 months follow-up: MACE, Long-term: all-cause mortality, nonfatal MI | 6 |
Park JinJoo, 2013 [12] | Prospective cohort study | Korea | 235(72.0) | 60.9 ± 13.9 | < 5.44 ≥5.44 | 1092(median) | Long-term: all-cause mortality | 6 |
Kaya, [13] 2013 | Prospective cohort study | Turkey, China, USA | 535(78.4) | 60.8 | < 2.3 2.3–4.4 > 4.4 | 1299(median) | In-hospital: in-stent thrombosis, MACE, non-fatal MI, no reflow, cardiac mortality, Long-term: Non-fatal MI,MACE, cardiac mortality | 6 |
Pan, [14] 2015 | Prospective cohort study | China | 496(78.0) | 59.27 ± 11.27 | < 3.0 3.0–6.40 > 6.40 | 360(total) | In-hospital: angina, arrhythmia, cardiac mortality, 12 months follow-up: all-cause mortality | 6 |
Sen, [15] 2013 | Prospective cohort study | Turkey | 176(86.3) | 55.8 | < 3.30 3.30–4.56 > 4.56 | 1140 (total) | In-hospital: all-cause mortality, MACE, no reflowAt three-year follow up, all-cause mortality, MACE | 6 |
Shen, [16] 2010 | Prospective cohort study | China | 329(59.7) | 61 | 1.44–3.45 3.45–4.81 4.82–6.46 6.47–22.57 | 1898 (median) | In-hospital: all-cause mortality Long-term: all-cause mortality | 6 |
Tanriverdi, [17] 2017 | Prospective cohort study | Turkey | 285(77.4) | 59.6 | < 5.47 ≥ 5.47 | 3.8(mean) | In-hospital: all-cause mortality | 6 |
Zuin, [18] 2017 | Prospective cohort study | Italy | 1724(71.8) | 64.5 | < 2.1 3.4–4.1 > 4.1 | 363(median) | Long-term: cardiovascular mortality | 6 |
Ergelen, [19] 2014 | Retrospective cohort study | Turkey | 2015(83.6) | 56.4 | ≤6.97 > 6.97 | 630 (median) | In hospital: AHF, MACE, nonfatal MI, no reflow, cardiovascular mortality, Long-term: MACE, nonfatal MI, cardiovascular mortality | 5 |
Gazi, [20] 2015 | Retrospective cohort study | Turkey | 417(79.9) | 62.57 | ≤5.77 > 5.77 | 5.7(mean) | In-hospital: AHF, angina, arrhythmia, all-cause mortality, nonfatal MI | 6 |
Incidence of mortality and cardiovascular events
Outcomes | Included studies | Heterogeneity | Test for overall effect | ||||
---|---|---|---|---|---|---|---|
χ2 | P | I2(%) | Z | P | RR 95%CI | ||
In-hospital | |||||||
AHF | 19,20 | 1.54 | 0.22 | 35 | 5.81 | < 0.00001 | 1.81[1.48,2.21] |
Angina |
14,20
| 0.08 | 0.78 | 0 | 2.71 | 0.007 | 1.67[1.15,2.41] |
Arrhythmia | 8, 10,14,20 | 0.82 | 0.84 | 0 | 3.14 | 0.002 | 1.38[1.13,1.69] |
In-stent thrombosis | 7,13 | 0.03 | 0.86 | 0 | 3.99 | < 0.0001 | 2.72[1.66,4.44] |
MACE | 7,9,11,13,15,19 | 3.83 | 0.57 | 0 | 6.53 | < 0.00001 | 2.00[1.62,2.46] |
Nonfatal MI | 7,9,13,19,20 | 4.88 | 0.30 | 18 | 4.32 | < 0.0001 | 1.93[1.43,2.61] |
No reflow | 7,9,10,13,15,19 | 40.00 | < 0.00001 | 87 | 3.63 | 0.0003 | 2.28[1.46,3.57] |
All mortality | 7,9,10,15,17,20 | 1.87 | 0.87 | 0 | 6.61 | < 0.00001 | 3.23[2.28,4.57] |
Cardiac mortality | 10,13,14,16,19 | 1.77 | 0.78 | 0 | 6.42 | < 0.00001 | 3.22[2.25,4.60] |
Long-term | |||||||
Nonfatal MI | 9, 11,13,19, | 10.90 | 0.01 | 72 | 0.75 | 0.46 | 1.32[0.63,2.75] |
MACE | 9,10,11,13,15,19 | 53.33 | < 0.00001 | 91 | 3.39 | 0.0007 | 2.49[1.47,4.23] |
All mortality | 8,9,10,11,12,14,15 | 3.85 | 0.70 | 0 | 10.06 | < 0.00001 | 3.82[2.94,4.96] |
Cardiac mortality | 10,13,16,18,19 | 43.78 | < 0.00001 | 91 | 2.85 | 0.004 | 3.02[1.41,6.45] |