Erschienen in:
01.12.2010 | Viewpoint
Prognostic gene network modules in breast cancer hold promise
verfasst von:
Andrew E Teschendorff, Yan Jiao, Carlos Caldas
Erschienen in:
Breast Cancer Research
|
Ausgabe 6/2010
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Abstract
A substantial proportion of lymph node-negative patients who receive adjuvant chemotherapy do not derive any benefit from this aggressive and potentially toxic treatment. However, standard histopathological indices cannot reliably detect patients at low risk of relapse or distant metastasis. In the past few years several prognostic gene expression signatures have been developed and shown to potentially outperform histopathological factors in identifying low-risk patients in specific breast cancer subgroups with predictive values of around 90%, and therefore hold promise for clinical application. We envisage that further improvements and insights may come from integrative expression pathway analyses that dissect prognostic signatures into modules related to cancer hallmarks.