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Surgery Today

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14.01.2016 | Original Article

Prognostic significance of a preoperative magnetic resonance imaging assessment of the distance of mesorectal extension in clinical T3 lower rectal cancer

verfasst von: Toshinori Sueda, Masayuki Ohue, Shingo Noura, Tatsushi Shingai, Katsuyuki Nakanishi, Masahiko Yano

Erschienen in: Surgery Today | Ausgabe 11/2016

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Abstract

Purposes

The aim of this study was to evaluate the association between the mesorectal extensions on high-resolution magnetic resonance imaging (MRI) and the prognosis of patients with clinical T3 lower rectal cancer.

Methods

Fifty-eight patients with clinical T3 lower rectal cancer were investigated using high-resolution MRI. One radiologist who was blinded to the clinicopathological findings retrospectively examined the MRI-predicted circumferential resection margin (mrCRM) and the distance of mesorectal extension (mrDME) on the scans. If the imaging showed a tumor ≤1 mm from the mesorectal fascia, then the mrCRM involvement was defined as potentially present. The tumors were divided into two groups: mrDME ≤4 mm and mrDME >4 mm.

Results

A survival analysis showed that mrCRM-positive patients had a significantly poorer prognosis in the RFS (p < 0.01) and LRFS (p < 0.01). Patients with mrDME >4 mm revealed a significantly poorer prognosis than those with mrDME ≤4 mm in the OS (p = 0.04), RFS (p < 0.01), and LRFS (p = 0.04). A multivariate analysis revealed that both mrCRM and mrDME on MRI had a significant impact on the RFS (p = 0.01 and 0.03, respectively).

Conclusion

The mrDME, as well as the mrCRM, may be an important preoperative prognostic factor for patients with clinical T3 lower rectal cancer.

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Titel: Prognostic significance of a preoperative magnetic resonance imaging assessment of the distance of mesorectal extension in clinical T3 lower rectal cancer
verfasst von: Toshinori Sueda
Masayuki Ohue
Shingo Noura
Tatsushi Shingai
Katsuyuki Nakanishi
Masahiko Yano
Publikationsdatum: 14.01.2016
Verlag: Springer Japan
Erschienen in: Surgery Today / Ausgabe 11/2016
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-015-1303-3

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Abstract

Purposes

Methods

Results

Conclusion

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