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European Journal of Nuclear Medicine and Molecular Imaging
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 9/2015

01.08.2015 | Original Article

Prognostic significance of standardized uptake value and metabolic tumour volume on 18F-FDG PET/CT in oropharyngeal squamous cell carcinoma

verfasst von: Ji Won Kim, Jungsu S. Oh, Jong-Lyel Roh, Jae Seung Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 9/2015

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Abstract

Purpose

Standardized uptake value (SUV) and metabolic tumour volume (MTV) measured by 18F-FDG PET/CT are emerging prognostic biomarkers in human solid cancers. However, their prognostic significance in oropharyngeal squamous cell carcinoma (OPSCC) has been investigated in only a few studies and with small cohorts. In the present study we evaluated the ability of SUV, MTV, and total lesion glycolysis (TLG) measured on pretreatment 18F-FDG PET/CT to predict recurrence and survival outcomes in OPSCC.

Methods

The study included 221 patients with OPSCC who underwent pretreatment 18F-FDG PET/CT imaging and received definitive treatment at our tertiary referral centre. The PET imaging parameters SUVmax, SUVpeak, MTV and TLG were measured in primary tumours with focal 18F-FDG uptake. Clinical and imaging variables significantly associated with overall survival (OS) and disease-free survival (DFS) were identified by univariate and multivariate analyses using the Cox proportional hazards model.

Results

Overall 5-year OS and DFS rates were 72.0 % and 79.5 %, respectively, during a median follow-up of 61 months (range 18 – 122 months). The cut-off values of tumour SUVmax, SUVpeak, MTV and TLG for prediction of DFS were 7.55, 6.80, 11.06 mL and 78.56 g, respectively. Univariate analyses showed that age >60 years, advanced tumour stage, and high tumour SUVmax, SUVpeak, MTV and TLG were significantly associated with decreased OS and DFS (P < 0.05 each). Age, tumour SUVmax and MTV remained independent variables for OS and DFS (P < 0.05 each) in the multivariate analyses.

Conclusion

SUVmax and MTV measured on pretreatment 18F-FDG PET/CT may be useful in predicting the clinical outcomes in OPSCC patients.

Condensed abstract

This study investigated the clinical prognostic value of imaging parameters from pretreatment 18F-FDG PET/CT in 221 patients who underwent definitive treatment for oropharyngeal squamous cell carcinoma. High maximum standardized uptake value and metabolic tumour volume were independently associated with decreased disease-free and overall survival outcomes.
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Metadaten
Titel
Prognostic significance of standardized uptake value and metabolic tumour volume on 18F-FDG PET/CT in oropharyngeal squamous cell carcinoma
verfasst von
Ji Won Kim
Jungsu S. Oh
Jong-Lyel Roh
Jae Seung Kim
Seung-Ho Choi
Soon Yuhl Nam
Sang Yoon Kim
Publikationsdatum
01.08.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 9/2015
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-015-3051-4

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