Background
Methods
Study population
Data collection
Outcomes
Statistical analysis
Results
Patient characteristics
Variable | The inflammation score |
P value | |||
---|---|---|---|---|---|
0 (n = 45) | 1 (n = 33) | 2 (n = 41) | 3 (n = 94) | ||
Male (%) | 30 (66.7) | 18 (54.5) | 31 (75.6) | 62 (66.0) | 0.304 |
Age (y) | 52.8 ± 14.9 | 58.2 ± 11.9 | 57.3 ± 16.7 | 58.0 ± 13.8 | 0.210 |
Body mass index (kg/m2) | 22.8 ± 3.5 | 23.1 ± 3.7 | 22.8 ± 3.3 | 23.2 ± 3.4 | 0.888 |
Diabetes (%) | 12 (26.7) | 12 (36.4) | 10 (24.4) | 36 (38.3%) | 0.313 |
24 h urine output (mL) | 650 (350–1075) | 850 (550–1275) | 525 (300–750) | 725 (400–1035) |
0.011
|
Systolic pressure (mmHg) | 165 ± 28 | 162 ± 29 | 165 ± 26 | 162 ± 29 | 0.900 |
Diastolic pressure (mmHg) | 96 ± 19 | 93 ± 19 | 96 ± 16 | 96 ± 18 | 0.780 |
Mean arterial pressure (mmHg) | 119 ± 20 | 116 ± 21 | 119 ± 18 | 118 ± 21 | 0.849 |
NLR | 3.05 (2.37–3.66) | 3.71 (3.11–4.52) | 5.92 (4.91–8.40) | 10.73 (7.18–16.15) |
< 0.001
|
MLR | 0.29 (0.22–0.33) | 0.40 (0.34–0.51) | 0.46 (0.38–0.65) | 0.67 (0.50–0.93) |
< 0.001
|
PLR | 124 (86–147) | 165 (119–197) | 194 (156–262) | 286 (236–391) |
< 0.001
|
Hemoglobin (g/L) | 77.9 ± 19.5 | 84.3 ± 14.6 | 81.9 ± 20.6 | 80.1 ± 22.1 | 0.556 |
Albumin (g/L) | 33.7 ± 8.2 | 36.5 ± 5.7 | 34.2 ± 6.3 | 35.3 ± 5.8 | 0.203 |
Blood urea nitrogen (mmol/L) | 28.1 ± 10.3 | 28.1 ± 10.7 | 30.3 ± 14.2 | 33.8 ± 13.3 |
0.030
|
Serum creatinine (µmol/L) | 801 (643–1273) | 825 (667–1187) | 847 (651–1102) | 856 (656–1202) | 0.955 |
Serum uric acid (µmol/L) | 512 ± 142 | 526 ± 139 | 529 ± 144 | 548 ± 170 | 0.623 |
Calcium (mmol/L) | 1.91 ± 0.28 | 1.97 ± 0.29 | 1.87 ± 0.31 | 1.91 ± 0.30 | 0.485 |
Phosphorus (mmol/L) | 1.82 ± 0.68 | 1.80 ± 0.63 | 1.84 ± 0.70 | 1.90 ± 0.75 | 0.881 |
iPTH (pg/mL) | 161 (87–292) | 186 (115–382) | 255 (163–411) | 248 (97–414) | 0.136 |
CRP (mg/L) | 1.60 (0.00-5.15) | 3.30 (0.10–9.65) | 7.90 (3.00-31.65) | 18.80 (2.00–46.00) |
< 0.001
|
ALT (U/L) | 17 (11–24) | 15 (10–19) | 19 (12–26) | 16 (9–22) | 0.397 |
Total bilirubin (mmol/L) | 4.40 (2.93–6.93) | 5.40 (3.15–6.75) | 4.90 (3.85–7.95) | 4.90 (3.10–6.60) | 0.609 |
Total cholesterol (mmol/L) | 5.06 ± 1.89 | 4.53 ± 1.39 | 4.65 ± 1.48 | 4.40 ± 1.17 | 0.100 |
Triglyceride (mmol/L) | 1.33 (0.95–2.01) | 1.53 (0.98–2.36) | 1.17 (0.99–1.63) | 1.22 (0.89–1.86) | 0.249 |
LDL-C (mmol/L) | 2.86 ± 1.71 | 2.61 ± 1.18 | 2.67 ± 1.06 | 2.28 ± 0.83 |
0.039
|
HDL-C (mmol/L) | 1.27 ± 0.31 | 1.18 ± 0.39 | 1.27 ± 0.40 | 1.20 ± 0.46 | 0.617 |
The inflammation score and all-cause and Cardiovascular Mortality
Model 1a | Model 2b | Model 3c | Model 4d | |||||
---|---|---|---|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
All-cause mortality | ||||||||
The inflammation score = 0 | Reference | Reference | Reference | Reference | ||||
The inflammation score = 1 | 1.601 (0.537-4.774) | 0.398 | 1.573 (0.523-4.732) | 0.420 | 1.930 (0.604-6.162) | 0.267 | 2.825 (0.707-11.285) | 0.142 |
The inflammation score = 2 | 2.148 (0.794-5.814) | 0.132 | 2.018 (0.739-5.508) | 0.170 | 2.067 (0.704-6.068) | 0.186 | 3.300 (0.882-12.344) | 0.076 |
The inflammation score = 3 | 2.781 (1.153-6.708) |
0.023
| 2.640 (1.085-6.425) |
0.032
| 2.969 (1.115-7.909) |
0.029
| 4.562 (1.342-15.504) |
0.015
|
P for trend |
0.013
|
0.020
|
0.024
|
0.010
| ||||
Cardiovascular mortality | ||||||||
The inflammation score = 0 | Reference | Reference | Reference | Reference | ||||
The inflammation score = 1 | 0.801 (0.191-3.366) | 0.762 | 0.775 (0.182-3.292) | 0.730 | 1.029 (0.225-4.694) | 0.971 | 2.033 (0.324-12.764) | 0.449 |
The inflammation score = 2 | 1.629 (0.516-5.140) | 0.405 | 1.580 (0.496-5.038) | 0.439 | 1.655 (0.475-5.769) | 0.429 | 3.178 (0.619-16.302) | 0.166 |
The inflammation score = 3 | 2.049 (0.759-5.529) | 0.157 | 1.979 (0.724-5.414) | 0.184 | 2.200 (0.708-6.835) | 0.173 | 4.027 (0.882-18.384) | 0.072 |
P for trend | 0.076 | 0.087 | 0.110 |
0.047
|