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Current Oncology Reports

Erschienen in:

01.08.2021 | Gynecologic Cancers (J Brown and RW Naumann, Section Editors)

Progress in Gynecologic Cancers with Antibody Drug Conjugates

verfasst von: David M. O’Malley, Corinne A. Calo

Erschienen in: Current Oncology Reports | Ausgabe 8/2021

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Abstract

Purpose of review

This article provides a comprehensive review of antibody-drug conjugates (ADCs) under investigation in gynecologic cancers. The structure and function of ADCs are reviewed with a focus on clinical benefit as well as toxicity profiles.

Recent findings

Several ADCs with various target antigens have been investigated in ovarian, cervical, and endometrial cancer. ADCs have consistently demonstrated favorable safety/tolerability profiles both as monotherapy and in combination therapy. In ovarian cancer, response rates have ranged from 9 to 46% for monotherapy with response rates as high as 83% in combination therapy. In patients with cervical cancer with progressive disease despite doublet therapy and bevacizumab, response rates as high as 24% have been observed.

Summary

ADCs represent a rapidly evolving field of targeted therapy which have demonstrated notable clinical benefit both as monotherapy but also in combination therapy with an overall favorable toxicity profile. With continued refinement of the target biomarkers utilized, improved clinical benefit is likely to be observed.

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Titel: Progress in Gynecologic Cancers with Antibody Drug Conjugates
verfasst von: David M. O’Malley
Corinne A. Calo
Publikationsdatum: 01.08.2021
Verlag: Springer US
Erschienen in: Current Oncology Reports / Ausgabe 8/2021
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-021-01080-4

Springer Medizin

Progress in Gynecologic Cancers with Antibody Drug Conjugates

Abstract

Purpose of review

Recent findings

Summary

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Update Onkologie

Springer Medizin

Abstract

Purpose of review

Recent findings

Summary

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