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Breast Cancer Research

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01.12.2002 | Commentary

Prolactin signaling and Stat5: going their own separate ways?

verfasst von: Cathrin Brisken, Ayyakkannu Ayyanan, Wolfgang Doppler

Erschienen in: Breast Cancer Research | Ausgabe 6/2002

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Abstract

Miyoshi et al. compared the role of the prolactin receptor (PrlR) and its downstream mediator, the signal transducer and activator of transcription 5 (Stat5), in mammary epithelial cells in vivo by studying PrlR^-/- and Stat5ab^-/- mouse mammary epithelial transplants during pregnancy. At first glance, the two mutant epithelia appear to have similar defects in the differentiation of the alveolar epithelium. However, a closer examination by Miyoshi et al. revealed defects in the epithelial architecture of the smallest ducts of Stat5ab^-/- transplants not apparent in the PrlR^-/- transplants, suggesting that Stat5 is more than a simple mediator of PrlR action.

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Titel: Prolactin signaling and Stat5: going their own separate ways?
verfasst von: Cathrin Brisken
Ayyakkannu Ayyanan
Wolfgang Doppler
Publikationsdatum: 01.12.2002
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 6/2002
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr543

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