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Current Breast Cancer Reports
Erschienen in: Current Breast Cancer Reports 3/2012

01.09.2012 | Risk, Prevention, and Screening (MC Liu, Section Editor)

Prophylactic Mastectomy and Risk-Reducing Salpingo-oophorectomy in BRCA1/2 Mutation Carriers

verfasst von: Kara N. Maxwell, Susan M. Domchek

Erschienen in: Current Breast Cancer Reports | Ausgabe 3/2012

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Abstract

Women with either BRCA1 or BRCA2 germline mutations have a significantly elevated risk of breast and ovarian cancer. Approximately 60 %–70 % of BRCA1 carriers and 45 %–60 % of BRCA2 carriers will develop a breast cancer by age 70, and there is a lower but very significant risk of developing ovarian cancer in both BRCA1 and BRCA2 carriers. This review summarizes data from both retrospective and prospective studies examining the impact of bilateral prophylactic mastectomy and risk-reducing salpingo-oophorectomy on reducing the risk of developing breast and, for the latter, ovarian cancer. In addition, we review data on the mortality benefit from risk-reducing salpino-oophorectomy.
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Metadaten
Titel
Prophylactic Mastectomy and Risk-Reducing Salpingo-oophorectomy in BRCA1/2 Mutation Carriers
verfasst von
Kara N. Maxwell
Susan M. Domchek
Publikationsdatum
01.09.2012
Verlag
Current Science Inc.
Erschienen in
Current Breast Cancer Reports / Ausgabe 3/2012
Print ISSN: 1943-4588
Elektronische ISSN: 1943-4596
DOI
https://doi.org/10.1007/s12609-012-0086-4

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