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01.08.2012 | Original Article

Prophylaxis of radiotherapy-induced nausea and vomiting in the palliative treatment of bone metastases

verfasst von: Kristopher Dennis, Janet Nguyen, Roseanna Presutti, Carlo DeAngelis, May Tsao, Cyril Danjoux, Elizabeth Barnes, Arjun Sahgal, Lori Holden, Florencia Jon, Shun Wong, Edward Chow

Erschienen in: Supportive Care in Cancer | Ausgabe 8/2012

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Abstract

Purpose

To document the incidence and timing of radiotherapy-induced nausea and vomiting (RINV) in the treatment of bone metastases among patients receiving prophylaxis with a 5-HT₃ receptor antagonist.

Methods

Patients receiving single (SF) or multiple fraction (MF) palliative radiotherapy (RT) of moderate or low emetogenic risk for bone metastases were prescribed prophylactic Ondansetron. The frequency and duration of prophylaxis and the use of rescue antiemetics were left to the discretion of the treating physicians. Patients documented episodes of nausea (N) and vomiting (V) in daily diaries before and during RT, and until 10 days following RT completion. Rates of complete prophylaxis (CP) for N&V, respectively (CP = no event and no rescue medication), were calculated for the acute phase (the period from the start of RT to the first day following RT completion inclusive) and the delayed phase (the second to tenth days following RT completion inclusive).

Results

Fifty-nine patients were enrolled, and 32 were evaluable. CP rates were as follows: moderate-risk SF group (n = 16), acute phase (CP for N = 56%, CP for V = 69%) and delayed phase (CP for N = 31%, CP for V = 44%); moderate-risk MF group (n = 7), acute phase (CP for N = 71%, CP for V = 57%) and delayed phase (CP for N = 43%, CP for V = 57%); low-risk SF group (n = 8), acute phase (CP for N = 50%, CP for V = 100%) and delayed phase (CP for N = 43%, CP for V = 57%); and low-risk MF group (n = 1), acute phase (CP for N = 100%, CP for V = 100%) and delayed phase (CP for N = 100%, CP for V = 100%).

Conclusions

Despite prophylaxis, RINV was common among patients receiving palliative radiotherapy for bone metastases, especially during the delayed phase.

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Titel: Prophylaxis of radiotherapy-induced nausea and vomiting in the palliative treatment of bone metastases
verfasst von: Kristopher Dennis
Janet Nguyen
Roseanna Presutti
Carlo DeAngelis
May Tsao
Cyril Danjoux
Elizabeth Barnes
Arjun Sahgal
Lori Holden
Florencia Jon
Shun Wong
Edward Chow
Publikationsdatum: 01.08.2012
Verlag: Springer-Verlag
Erschienen in: Supportive Care in Cancer / Ausgabe 8/2012
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-011-1258-x

Springer Medizin

Prophylaxis of radiotherapy-induced nausea and vomiting in the palliative treatment of bone metastases