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09.01.2017 | Original Article

Prospective cohort study of cancer patients diagnosed with incidental venous thromboembolism on routine computed tomography scans

verfasst von: Carmen P. Escalante, Gregory W. Gladish, Wei Qiao, Ali Zalpour, Binara Assylbekova, Shuwei Gao, Kelechi A. Olejeme, Marsha N. Richardson, Maria E. Suarez-Almazor

Erschienen in: Supportive Care in Cancer | Ausgabe 5/2017

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Abstract

Purpose

Venous thromboembolism (VTE) is a major complication of cancer with recent increasing reports of incidental VTE. The objectives are to estimate the prevalence of incidental VTE in cancer patients on staging CT scans, identify common symptoms, and determine VTE recurrence in a prospective study.

Patients and methods

One thousand ninety patients were studied. Adult cancer patients scheduled for outpatient staging CT scans were eligible. VTE cases were followed for 6 months. Fisher’s exact test for group comparisons of categorical variables and generalized linear modeling to estimate the prevalence of incidental VTE was used.

Results

The mean age was 58 years (range 18–87 years); 50% were male. The prevalence of incidental VTE was 1.8% (CI 1.15–2.87%). Significant symptoms in patients with VTE included fatigue (p = 0.004), stress (p = 0.0195), depression (p = 0.019), poorer quality of life (p = 0.0194), and poorer physical well-being (p = 0.0007). All the patients with VTE had at least one comorbidity (p = 0.03). No patient had recurrence within 6 months.

Conclusion

The prevalence of incidental VTE on staging CT scans is lower than previously reported. Symptoms were associated with VTE; however, further work is needed to understand whether these are clinically relevant. No VTE recurrences were noted following 6 months.

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Titel: Prospective cohort study of cancer patients diagnosed with incidental venous thromboembolism on routine computed tomography scans
verfasst von: Carmen P. Escalante
Gregory W. Gladish
Wei Qiao
Ali Zalpour
Binara Assylbekova
Shuwei Gao
Kelechi A. Olejeme
Marsha N. Richardson
Maria E. Suarez-Almazor
Publikationsdatum: 09.01.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 5/2017
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-016-3559-6

Springer Medizin

Prospective cohort study of cancer patients diagnosed with incidental venous thromboembolism on routine computed tomography scans