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European Journal of Nuclear Medicine and Molecular Imaging
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 10/2019

18.07.2019 | Original Article

Prospective diagnostic performance of semiconductor SPECT myocardial perfusion imaging: wall thickening analysis reduces the need for an additional prone acquisition

verfasst von: Loïc Djaileb, Benjamin Dubois, Nicolas de Leiris, Julien Leenhardt, Marjorie Canu, Olivier Phan Sy, Adrien Carabelli, Bastien Boussat, Laurent Dumas, Alexis Broisat, Gérald Vanzetto, Daniel Fagret, Catherine Ghezzi, Gilles Barone-Rochette, Laurent M. Riou

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 10/2019

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Abstract

Purpose

To determine whether the assessment of regional wall thickening (WT) in addition to myocardial perfusion from stress supine acquisitions could compensate for the lack of prone acquisition and the corresponding decrease in the diagnostic performance of SPECT myocardial perfusion imaging (MPI) in patients with known or suspected coronary artery disease (CAD).

Methods

The study group comprised 41 patients (123 vessels) with known or suspected CAD prospectively recruited for systematic prone and supine 201Tl stress SPECT MPI. The diagnostic performance of SPECT MPI was determined for various image sets including nongated supine images (supine NG), nongated combined prone and supine images (prone and supine NG) and gated supine images, allowing WT evaluation from NG images in addition to perfusion (supine NG + WT) using invasive coronary angiography and fractional flow reserve as the gold standards.

Results

The rate of false positives was significantly higher among the supine NG images (20.8%) than among either the prone and supine NG or the supine NG + WT images (3.3% and 2.7%, respectively, P < 0.05 vs. supine NG). Consequently, specificity was higher for the prone and supine NG images than for the supine NG images (96.1% vs. 76.1%, P < 0.01) and was highest for the supine NG + WT images (96.8%, P not significant vs. prone and supine NG), without significant differences in sensitivity (80.0%, 86.6% and 73.3%, respectively, P not significant for all comparisons).

Conclusion

The diagnostic performance of supine stress SPECT MPI is improved when WT assessment of ischaemic segments is used as an additional diagnostic criterion to values not significantly different from those with combined prone and supine acquisitions.
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Metadaten
Titel
Prospective diagnostic performance of semiconductor SPECT myocardial perfusion imaging: wall thickening analysis reduces the need for an additional prone acquisition
verfasst von
Loïc Djaileb
Benjamin Dubois
Nicolas de Leiris
Julien Leenhardt
Marjorie Canu
Olivier Phan Sy
Adrien Carabelli
Bastien Boussat
Laurent Dumas
Alexis Broisat
Gérald Vanzetto
Daniel Fagret
Catherine Ghezzi
Gilles Barone-Rochette
Laurent M. Riou
Publikationsdatum
18.07.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 10/2019
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-019-04415-3

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