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01.11.2007 | Original Paper

Protection of mammography screening against death from breast cancer in women aged 40–64 years

verfasst von: Sandra A. Norman, A. Russell Localio, Anita L. Weber, Ralph J. Coates, Lan Zhou, Leslie Bernstein, Kathleen E. Malone, Polly A. Marchbanks, Linda K. Weiss, Nancy C. Lee, Marion R. Nadel

Erschienen in: Cancer Causes & Control | Ausgabe 9/2007

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Abstract

Objective

This study assessed the efficacy of community-based screening mammography in protecting against breast cancer death, asking whether age differences in efficacy persisted in the 1990s.

Methods

In a case–control study with follow-up, odds ratios (OR) were used to estimate the relative mortality rates from invasive breast cancer among women with at least one screening mammogram in the two years prior to a baseline reference date compared to non-screened women, adjusting for potential confounding. The multicenter population-based study included 553 black and white women diagnosed during 1994–1998 who died in the following five years, and 4016 controls without breast cancer.

Results

Efficacy for reducing the rate of breast cancer death within five years after diagnosis was greater at ages 50–64 years (OR = 0.47, 95% confidence interval (CI) 0.35–0.63) than at ages 40–49 (OR = 0.89, 95% CI 0.65–1.23), and greater among postmenopausal (OR = 0.45, 95% CI 0.33–0.62) than premenopausal women (OR = 0.74, 95% CI 0.53–1.04). Estimates of efficacy were conservative, as shown by sensitivity analyses addressing whether cancer was discovered by a screening mammogram, age at which screening was received, the length of the screening observation window, and years of follow-up after diagnosis.

Conclusions

Despite the persistence of age differences in efficacy of mammography screening, with greater observed benefit for women aged 50–64 years, these findings support current screening recommendations for women 40–64 years old.

ORs and 95% CIs for late-stage disease differ slightly from those in Norman et al. [15] because 11 cases aged 40–49 years and eight cases aged 50–64 years with diagnosis of late-stage disease were added to the data set.

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Titel: Protection of mammography screening against death from breast cancer in women aged 40–64 years
verfasst von: Sandra A. Norman
A. Russell Localio
Anita L. Weber
Ralph J. Coates
Lan Zhou
Leslie Bernstein
Kathleen E. Malone
Polly A. Marchbanks
Linda K. Weiss
Nancy C. Lee
Marion R. Nadel
Publikationsdatum: 01.11.2007
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 9/2007
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-007-9006-8

Springer Medizin

Protection of mammography screening against death from breast cancer in women aged 40–64 years