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Erschienen in: Supportive Care in Cancer 2/2019

17.07.2018 | Original Article

Quality of care in hospitalized cancer patients before and after implementation of a systematic prevention program for delirium: the DELTA exploratory trial

verfasst von: Asao Ogawa, Yasuyuki Okumura, Daisuke Fujisawa, Hiroyuki Takei, Chiyuki Sasaki, Kei Hirai, Yusuke Kanno, Kensuke Higa, Yasuhiko Ichida, Asuko Sekimoto, Chie Asanuma

Erschienen in: Supportive Care in Cancer | Ausgabe 2/2019

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Abstract

Background

We evaluated whether the DELirium Team Approach (DELTA) program—a systematic management program aimed at screening high-risk groups and preventing delirium—would improve quality of care in patients hospitalized with cancer.

Methods

A retrospective before–after study was conducted during a pre-intervention period (between October 2012 and March 2013) and a post-intervention period (between October 2013 and March 2014) at a Japanese hospital providing specialized treatments for cancer. A total of 4180 inpatients were evaluated before the implementation of the DELTA program and 3797 inpatients were evaluated after implementation.

Results

After program implementation, the incidence of delirium decreased from 7.1 to 4.3% (odds ratio [OR], 0.52; 95% CI, 0.42–0.64). The incidence of adverse events, including falls or self-extubation, also decreased, from 3.5 to 2.6% (OR, 0.71; 95% CI, 0.54–0.92). There was a significant decrease in the prescription of benzodiazepines (OR, 0.79; 95% CI, 0.71–0.87), increase in the level of independence in activities of daily living at discharge (OR, 1.94; 95% CI, 1.11–3.38), and decrease in the length of stay (risk ratio 0.90; 95% CI, 0.90–0.90).

Conclusions

The systematic management program for delirium decreased the incidence of delirium and improved several clinical outcomes. These data suggest that this simple cost-effective program is feasible and implementable as routine care in busy wards.
Literatur
1.
Zurück zum Zitat Akunne A, Murthy L, Young J (2012) Cost-effectiveness of multi-component interventions to prevent delirium in older people admitted to medical wards. Age Ageing 41:285–291CrossRef Akunne A, Murthy L, Young J (2012) Cost-effectiveness of multi-component interventions to prevent delirium in older people admitted to medical wards. Age Ageing 41:285–291CrossRef
2.
Zurück zum Zitat Austin PC (2011) An introduction to propensity score methods for reducing the effects of confounding in observational studies. Multivar Behav Res 46:399–424CrossRef Austin PC (2011) An introduction to propensity score methods for reducing the effects of confounding in observational studies. Multivar Behav Res 46:399–424CrossRef
3.
Zurück zum Zitat Barker AL, Morello RT, Wolfe R, Brand CA, Haines TP, Hill KD, Brauer SG, Botti M, Cumming RG, Livingston PM, Sherrington C, Zavarsek S, Lindley RI, Kamar J (2016) 6-PACK programme to decrease fall injuries in acute hospitals: cluster randomised controlled trial. BMJ 352:h6781CrossRef Barker AL, Morello RT, Wolfe R, Brand CA, Haines TP, Hill KD, Brauer SG, Botti M, Cumming RG, Livingston PM, Sherrington C, Zavarsek S, Lindley RI, Kamar J (2016) 6-PACK programme to decrease fall injuries in acute hospitals: cluster randomised controlled trial. BMJ 352:h6781CrossRef
4.
Zurück zum Zitat Board INC (2011) Report of the International Narcotics Control Board on the availability of internationally controlled drugs: ensuring adequate access for medical and scientific purposes. In: Editor (ed)^(eds) Book Report of the International Narcotics Control Board on the availability of internationally controlled drugs: ensuring adequate access for medical and scientific purposes. International Narcotics Control Board, United Nations, City Board INC (2011) Report of the International Narcotics Control Board on the availability of internationally controlled drugs: ensuring adequate access for medical and scientific purposes. In: Editor (ed)^(eds) Book Report of the International Narcotics Control Board on the availability of internationally controlled drugs: ensuring adequate access for medical and scientific purposes. International Narcotics Control Board, United Nations, City
5.
Zurück zum Zitat Breitbart W, Marotta R, Platt MM, Weisman H, Derevenco M, Grau C, Corbera K, Raymond S, Lund S, Jacobson P (1996) A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am J Psychiatry 153:231–237CrossRef Breitbart W, Marotta R, Platt MM, Weisman H, Derevenco M, Grau C, Corbera K, Raymond S, Lund S, Jacobson P (1996) A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am J Psychiatry 153:231–237CrossRef
6.
Zurück zum Zitat Centeno C, Sanz A, Bruera E (2004) Delirium in advanced cancer patients. Palliat Med 18:184–194CrossRef Centeno C, Sanz A, Bruera E (2004) Delirium in advanced cancer patients. Palliat Med 18:184–194CrossRef
7.
Zurück zum Zitat Coyle MA, Burns P, Traynor V (2017) Is it my job? The role of RNs in the assessment and identification of delirium in hospitalized older adults: an exploratory qualitative study. J Gerontol Nurs 43:29–37CrossRef Coyle MA, Burns P, Traynor V (2017) Is it my job? The role of RNs in the assessment and identification of delirium in hospitalized older adults: an exploratory qualitative study. J Gerontol Nurs 43:29–37CrossRef
8.
Zurück zum Zitat Dubois MJ, Bergeron N, Dumont M, Dial S, Skrobik Y (2001) Delirium in an intensive care unit: a study of risk factors. Intensive Care Med 27:1297–1304CrossRef Dubois MJ, Bergeron N, Dumont M, Dial S, Skrobik Y (2001) Delirium in an intensive care unit: a study of risk factors. Intensive Care Med 27:1297–1304CrossRef
9.
Zurück zum Zitat Excellence NIfHaC (2010) Delirium: prevention, diagnosis and management. In: editor (ed)^(eds) Book delirium: prevention, diagnosis and management, City Excellence NIfHaC (2010) Delirium: prevention, diagnosis and management. In: editor (ed)^(eds) Book delirium: prevention, diagnosis and management, City
10.
Zurück zum Zitat Gagnon P, Allard P, Gagnon B, Merette C, Tardif F (2012) Delirium prevention in terminal cancer: assessment of a multicomponent intervention. Psychooncology 21:187–194CrossRef Gagnon P, Allard P, Gagnon B, Merette C, Tardif F (2012) Delirium prevention in terminal cancer: assessment of a multicomponent intervention. Psychooncology 21:187–194CrossRef
11.
Zurück zum Zitat Gamberini M, Bolliger D, Lurati Buse GA, Burkhart CS, Grapow M, Gagneux A, Filipovic M, Seeberger MD, Pargger H, Siegemund M, Carrel T, Seiler WO, Berres M, Strebel SP, Monsch AU, Steiner LA (2009) Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery—a randomized controlled trial. Crit Care Med 37:1762–1768CrossRef Gamberini M, Bolliger D, Lurati Buse GA, Burkhart CS, Grapow M, Gagneux A, Filipovic M, Seeberger MD, Pargger H, Siegemund M, Carrel T, Seiler WO, Berres M, Strebel SP, Monsch AU, Steiner LA (2009) Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery—a randomized controlled trial. Crit Care Med 37:1762–1768CrossRef
12.
Zurück zum Zitat Girard TD, Pandharipande PP, Carson SS, Schmidt GA, Wright PE, Canonico AE, Pun BT, Thompson JL, Shintani AK, Meltzer HY, Bernard GR, Dittus RS, Ely EW, Investigators MT (2010) Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med 38:428–437CrossRef Girard TD, Pandharipande PP, Carson SS, Schmidt GA, Wright PE, Canonico AE, Pun BT, Thompson JL, Shintani AK, Meltzer HY, Bernard GR, Dittus RS, Ely EW, Investigators MT (2010) Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med 38:428–437CrossRef
13.
Zurück zum Zitat Gurlit S, Mollmann M (2008) How to prevent perioperative delirium in the elderly? Z Gerontol Geriatr 41:447–452CrossRef Gurlit S, Mollmann M (2008) How to prevent perioperative delirium in the elderly? Z Gerontol Geriatr 41:447–452CrossRef
14.
Zurück zum Zitat Hakim SM, Othman AI, Naoum DO (2012) Early treatment with risperidone for subsyndromal delirium after on-pump cardiac surgery in the elderly: a randomized trial. Anesthesiology 116:987–997CrossRef Hakim SM, Othman AI, Naoum DO (2012) Early treatment with risperidone for subsyndromal delirium after on-pump cardiac surgery in the elderly: a randomized trial. Anesthesiology 116:987–997CrossRef
15.
Zurück zum Zitat Hatta K, Kishi Y, Wada K, Takeuchi T, Odawara T, Usui C, Nakamura H, Group D-J (2014) Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial. JAMA Psychiatry 71:397–403CrossRef Hatta K, Kishi Y, Wada K, Takeuchi T, Odawara T, Usui C, Nakamura H, Group D-J (2014) Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial. JAMA Psychiatry 71:397–403CrossRef
16.
Zurück zum Zitat Hempenius L, Slaets JP, van Asselt D, de Bock GH, Wiggers T, van Leeuwen BL (2013) Outcomes of a geriatric liaison intervention to prevent the development of postoperative delirium in frail elderly cancer patients: report on a multicentre, randomized, controlled trial. PLoS One 8:e64834CrossRef Hempenius L, Slaets JP, van Asselt D, de Bock GH, Wiggers T, van Leeuwen BL (2013) Outcomes of a geriatric liaison intervention to prevent the development of postoperative delirium in frail elderly cancer patients: report on a multicentre, randomized, controlled trial. PLoS One 8:e64834CrossRef
17.
Zurück zum Zitat Hosie A, Davidson PM, Agar M, Sanderson CR, Phillips J (2013) Delirium prevalence, incidence, and implications for screening in specialist palliative care inpatient settings: a systematic review. Palliat Med 27:486–498CrossRef Hosie A, Davidson PM, Agar M, Sanderson CR, Phillips J (2013) Delirium prevalence, incidence, and implications for screening in specialist palliative care inpatient settings: a systematic review. Palliat Med 27:486–498CrossRef
18.
Zurück zum Zitat Hshieh TT, Yue J, Oh E, Puelle M, Dowal S, Travison T, Inouye SK (2015) Effectiveness of multicomponent nonpharmacological delirium interventions: a meta-analysis. JAMA Intern Med 175:512–520CrossRef Hshieh TT, Yue J, Oh E, Puelle M, Dowal S, Travison T, Inouye SK (2015) Effectiveness of multicomponent nonpharmacological delirium interventions: a meta-analysis. JAMA Intern Med 175:512–520CrossRef
19.
Zurück zum Zitat Inouye SK (2006) Delirium in older persons. N Engl J Med 354:1157–1165CrossRef Inouye SK (2006) Delirium in older persons. N Engl J Med 354:1157–1165CrossRef
20.
Zurück zum Zitat Inouye SK, Bogardus ST Jr, Charpentier PA, Leo-Summers L, Acampora D, Holford TR, Cooney LM Jr (1999) A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 340:669–676CrossRef Inouye SK, Bogardus ST Jr, Charpentier PA, Leo-Summers L, Acampora D, Holford TR, Cooney LM Jr (1999) A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 340:669–676CrossRef
21.
Zurück zum Zitat Inouye SK, Leo-Summers L, Zhang Y, Bogardus ST Jr, Leslie DL, Agostini JV (2005) A chart-based method for identification of delirium: validation compared with interviewer ratings using the confusion assessment method. J Am Geriatr Soc 53:312–318CrossRef Inouye SK, Leo-Summers L, Zhang Y, Bogardus ST Jr, Leslie DL, Agostini JV (2005) A chart-based method for identification of delirium: validation compared with interviewer ratings using the confusion assessment method. J Am Geriatr Soc 53:312–318CrossRef
22.
Zurück zum Zitat Inouye SK, Brown CJ, Tinetti ME (2009) Medicare nonpayment, hospital falls, and unintended consequences. N Engl J Med 360:2390–2393CrossRef Inouye SK, Brown CJ, Tinetti ME (2009) Medicare nonpayment, hospital falls, and unintended consequences. N Engl J Med 360:2390–2393CrossRef
23.
Zurück zum Zitat Inouye SK, Westendorp RG, Saczynski JS (2014) Delirium in elderly people. Lancet 383:911–922CrossRef Inouye SK, Westendorp RG, Saczynski JS (2014) Delirium in elderly people. Lancet 383:911–922CrossRef
24.
Zurück zum Zitat Kalisvaart KJ, de Jonghe JF, Bogaards MJ, Vreeswijk R, Egberts TC, Burger BJ, Eikelenboom P, van Gool WA (2005) Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study. J Am Geriatr Soc 53:1658–1666CrossRef Kalisvaart KJ, de Jonghe JF, Bogaards MJ, Vreeswijk R, Egberts TC, Burger BJ, Eikelenboom P, van Gool WA (2005) Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study. J Am Geriatr Soc 53:1658–1666CrossRef
25.
Zurück zum Zitat Korc-Grodzicki B, Sun SW, Zhou Q, Iasonos A, Lu B, Root JC, Downey RJ, Tew WP (2015) Geriatric assessment as a predictor of delirium and other outcomes in elderly patients with cancer. Ann Surg 261:1085–1090CrossRef Korc-Grodzicki B, Sun SW, Zhou Q, Iasonos A, Lu B, Root JC, Downey RJ, Tew WP (2015) Geriatric assessment as a predictor of delirium and other outcomes in elderly patients with cancer. Ann Surg 261:1085–1090CrossRef
26.
Zurück zum Zitat Lakatos BE, Capasso V, Mitchell MT, Kilroy SM, Lussier-Cushing M, Sumner L, Repper-Delisi J, Kelleher EP, Delisle LA, Cruz C, Stern TA (2009) Falls in the general hospital: association with delirium, advanced age, and specific surgical procedures. Psychosomatics 50:218–226CrossRef Lakatos BE, Capasso V, Mitchell MT, Kilroy SM, Lussier-Cushing M, Sumner L, Repper-Delisi J, Kelleher EP, Delisle LA, Cruz C, Stern TA (2009) Falls in the general hospital: association with delirium, advanced age, and specific surgical procedures. Psychosomatics 50:218–226CrossRef
27.
Zurück zum Zitat Larsen KA, Kelly SE, Stern TA, Bode RH Jr, Price LL, Hunter DJ, Gulczynski D, Bierbaum BE, Sweeney GA, Hoikala KA, Cotter JJ, Potter AW (2010) Administration of olanzapine to prevent postoperative delirium in elderly joint-replacement patients: a randomized, controlled trial. Psychosomatics 51:409–418CrossRef Larsen KA, Kelly SE, Stern TA, Bode RH Jr, Price LL, Hunter DJ, Gulczynski D, Bierbaum BE, Sweeney GA, Hoikala KA, Cotter JJ, Potter AW (2010) Administration of olanzapine to prevent postoperative delirium in elderly joint-replacement patients: a randomized, controlled trial. Psychosomatics 51:409–418CrossRef
28.
Zurück zum Zitat Leslie DL, Marcantonio ER, Zhang Y, Leo-Summers L, Inouye SK (2008) One-year health care costs associated with delirium in the elderly population. Arch Intern Med 168:27–32CrossRef Leslie DL, Marcantonio ER, Zhang Y, Leo-Summers L, Inouye SK (2008) One-year health care costs associated with delirium in the elderly population. Arch Intern Med 168:27–32CrossRef
29.
Zurück zum Zitat Ljubisavljevic V, Kelly B (2003) Risk factors for development of delirium among oncology patients. Gen Hosp Psychiatry 25:345–352CrossRef Ljubisavljevic V, Kelly B (2003) Risk factors for development of delirium among oncology patients. Gen Hosp Psychiatry 25:345–352CrossRef
30.
Zurück zum Zitat Long JS (1997) Regression models for categorical and limited dependent variables. Sage, Thousand Oaks Long JS (1997) Regression models for categorical and limited dependent variables. Sage, Thousand Oaks
31.
Zurück zum Zitat Mahoney FI, Barthel DW (1965) Functional evaluation: the Barthel index Maryland state medical journal, vol 14, pp 61–65 Mahoney FI, Barthel DW (1965) Functional evaluation: the Barthel index Maryland state medical journal, vol 14, pp 61–65
32.
Zurück zum Zitat Marcantonio ER, Flacker JM, Wright RJ, Resnick NM (2001) Reducing delirium after hip fracture: a randomized trial. J Am Geriatr Soc 49:516–522CrossRef Marcantonio ER, Flacker JM, Wright RJ, Resnick NM (2001) Reducing delirium after hip fracture: a randomized trial. J Am Geriatr Soc 49:516–522CrossRef
33.
Zurück zum Zitat Martin BJ, Buth KJ, Arora RC, Baskett RJ (2010) Delirium as a predictor of sepsis in post-coronary artery bypass grafting patients: a retrospective cohort study. Crit Care 14:R171CrossRef Martin BJ, Buth KJ, Arora RC, Baskett RJ (2010) Delirium as a predictor of sepsis in post-coronary artery bypass grafting patients: a retrospective cohort study. Crit Care 14:R171CrossRef
34.
Zurück zum Zitat McCusker J, Cole M, Abrahamowicz M, Primeau F, Belzile E (2002) Delirium predicts 12-month mortality. Arch Intern Med 162:457–463CrossRef McCusker J, Cole M, Abrahamowicz M, Primeau F, Belzile E (2002) Delirium predicts 12-month mortality. Arch Intern Med 162:457–463CrossRef
35.
Zurück zum Zitat Ohta T, Waga S, Handa H, Saito I, Takeuchi H, Suzuki J, Takaku A (1974) New grading of level of disordered consciousness (in Japanese) Jpn J Neurosurg 2: 623–627 Ohta T, Waga S, Handa H, Saito I, Takeuchi H, Suzuki J, Takaku A (1974) New grading of level of disordered consciousness (in Japanese) Jpn J Neurosurg 2: 623–627
36.
Zurück zum Zitat Paulson CM, Monroe T, McDougall GJ Jr, Fick DM (2016) A family-focused delirium educational initiative with practice and research implications. Gerontol Geriatr Educ 37:4–11CrossRef Paulson CM, Monroe T, McDougall GJ Jr, Fick DM (2016) A family-focused delirium educational initiative with practice and research implications. Gerontol Geriatr Educ 37:4–11CrossRef
37.
Zurück zum Zitat Pompei P, Foreman M, Rudberg MA, Inouye SK, Braund V, Cassel CK (1994) Delirium in hospitalized older persons: outcomes and predictors. J Am Geriatr Soc 42:809–815CrossRef Pompei P, Foreman M, Rudberg MA, Inouye SK, Braund V, Cassel CK (1994) Delirium in hospitalized older persons: outcomes and predictors. J Am Geriatr Soc 42:809–815CrossRef
38.
Zurück zum Zitat Prakanrattana U, Prapaitrakool S (2007) Efficacy of risperidone for prevention of postoperative delirium in cardiac surgery. Anaesth Intensive Care 35:714–719PubMed Prakanrattana U, Prapaitrakool S (2007) Efficacy of risperidone for prevention of postoperative delirium in cardiac surgery. Anaesth Intensive Care 35:714–719PubMed
39.
Zurück zum Zitat Rice KL, Bennett M, Gomez M, Theall KP, Knight M, Foreman MD (2011) Nurses’ recognition of delirium in the hospitalized older adult. Clin Nurse Spec 25:299–311CrossRef Rice KL, Bennett M, Gomez M, Theall KP, Knight M, Foreman MD (2011) Nurses’ recognition of delirium in the hospitalized older adult. Clin Nurse Spec 25:299–311CrossRef
40.
Zurück zum Zitat Rothschild JM, Bates DW, Leape LL (2000) Preventable medical injuries in older patients. Arch Intern Med 160:2717–2728CrossRef Rothschild JM, Bates DW, Leape LL (2000) Preventable medical injuries in older patients. Arch Intern Med 160:2717–2728CrossRef
41.
Zurück zum Zitat Siddiqi N, Cheater F, Collinson M, Farrin A, Forster A, George D, Godfrey M, Graham E, Harrison J, Heaven A, Heudtlass P, Hulme C, Meads D, North C, Sturrock A, Young J (2016) The PiTSTOP study: a feasibility cluster randomized trial of delirium prevention in care homes for older people. Age Ageing 45:652–661PubMedPubMedCentral Siddiqi N, Cheater F, Collinson M, Farrin A, Forster A, George D, Godfrey M, Graham E, Harrison J, Heaven A, Heudtlass P, Hulme C, Meads D, North C, Sturrock A, Young J (2016) The PiTSTOP study: a feasibility cluster randomized trial of delirium prevention in care homes for older people. Age Ageing 45:652–661PubMedPubMedCentral
42.
Zurück zum Zitat Speed G (2015) The impact of a delirium educational intervention with intensive care unit nurses. Clin Nurse Spec 29:89–94CrossRef Speed G (2015) The impact of a delirium educational intervention with intensive care unit nurses. Clin Nurse Spec 29:89–94CrossRef
43.
Zurück zum Zitat Sundararajan V, Quan H, Halfon P, Fushimi K, Luthi JC, Burnand B, Ghali WA, International Methodology Consortium for Coded Health I (2007) Cross-national comparative performance of three versions of the ICD-10 Charlson index. Med Care 45:1210–1215CrossRef Sundararajan V, Quan H, Halfon P, Fushimi K, Luthi JC, Burnand B, Ghali WA, International Methodology Consortium for Coded Health I (2007) Cross-national comparative performance of three versions of the ICD-10 Charlson index. Med Care 45:1210–1215CrossRef
44.
Zurück zum Zitat Vasilevskis EE, Han JH, Hughes CG, Ely EW (2012) Epidemiology and risk factors for delirium across hospital settings. Best Pract Res Clin Anaesthesiol 26:277–287CrossRef Vasilevskis EE, Han JH, Hughes CG, Ely EW (2012) Epidemiology and risk factors for delirium across hospital settings. Best Pract Res Clin Anaesthesiol 26:277–287CrossRef
45.
Zurück zum Zitat Witlox J, Eurelings LS, de Jonghe JF, Kalisvaart KJ, Eikelenboom P, van Gool WA (2010) Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysis. JAMA 304:443–451CrossRef Witlox J, Eurelings LS, de Jonghe JF, Kalisvaart KJ, Eikelenboom P, van Gool WA (2010) Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysis. JAMA 304:443–451CrossRef
Metadaten
Titel
Quality of care in hospitalized cancer patients before and after implementation of a systematic prevention program for delirium: the DELTA exploratory trial
verfasst von
Asao Ogawa
Yasuyuki Okumura
Daisuke Fujisawa
Hiroyuki Takei
Chiyuki Sasaki
Kei Hirai
Yusuke Kanno
Kensuke Higa
Yasuhiko Ichida
Asuko Sekimoto
Chie Asanuma
Publikationsdatum
17.07.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Supportive Care in Cancer / Ausgabe 2/2019
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-018-4341-8

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