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Quality of Life Research

Erschienen in:

01.05.2007 | Brief Communication

Quality of life findings from a multicenter, multinational, observational study of patients with metastatic hormone-refractory prostate cancer

verfasst von: Patrick W. Sullivan, Parvez M. Mulani, Mayer Fishman, Darryl Sleep

Erschienen in: Quality of Life Research | Ausgabe 4/2007

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Abstract

Background

The assessment of health-related quality of life (HRQL) for patients with hormone-refractory prostate cancer (HRPC) is of paramount importance because new treatments have a modest impact on survival but side effects of treatment and disease symptoms can significantly impact HRQL.

Methods

This was an observational, non-interventional, multi-center, multi-national cohort study of patients with metastatic HRPC. Health-related quality of life was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ C30), the Functional Assessment of Cancer Therapy-Prostate (FACT-P) and the EQ-5D index. Mean changes from baseline to month 3, 6, and 9 were computed and tested using paired t-tests.

Results

FACT-P PCS, EQ-5D index and 10 of 14 EORTC domains were statistically significantly lower (P < 0.05) than the baseline scores at the 3, 6 and 9 month visits. The domains that did not reach statistical significance were cognitive functioning, insomnia, diarrhea and financial difficulties.

Conclusions

These data demonstrate that patients with metastatic HRPC experience rapid, significant deterioration in HRQL, highlighting the need for effective palliative therapy for men with HRPC.

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Titel: Quality of life findings from a multicenter, multinational, observational study of patients with metastatic hormone-refractory prostate cancer
verfasst von: Patrick W. Sullivan
Parvez M. Mulani
Mayer Fishman
Darryl Sleep
Publikationsdatum: 01.05.2007
Verlag: Springer Netherlands
Erschienen in: Quality of Life Research / Ausgabe 4/2007
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-006-9156-2

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

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